Kolarov-Bjelobrk, Ivana

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  • Kolarov-Bjelobrk, Ivana (1)
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Author's Bibliography

Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting

Radić, Jelena; Kožik, Bojana; Nikolić, Ivan; Kolarov-Bjelobrk, Ivana; Vasiljević, Tijana; Vranjković, Bojana; Despotović, Sanja

(2023) 

TY  - JOUR
AU  - Radić, Jelena
AU  - Kožik, Bojana
AU  - Nikolić, Ivan
AU  - Kolarov-Bjelobrk, Ivana
AU  - Vasiljević, Tijana
AU  - Vranjković, Bojana
AU  - Despotović, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11377
AB  - LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic
target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked
with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the
mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development.
We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of
the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal
transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis,
and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2
inhibitors and discuss their potential in HCC precision treatment.
T2  - International Journal of Molecular Sciences
T1  - Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting
VL  - 24
IS  - 14
SP  - 11745
DO  - 10.3390/ijms241411745
ER  - 
@article{
author = "Radić, Jelena and Kožik, Bojana and Nikolić, Ivan and Kolarov-Bjelobrk, Ivana and Vasiljević, Tijana and Vranjković, Bojana and Despotović, Sanja",
year = "2023",
abstract = "LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic
target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked
with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the
mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development.
We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of
the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal
transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis,
and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2
inhibitors and discuss their potential in HCC precision treatment.",
journal = "International Journal of Molecular Sciences",
title = "Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting",
volume = "24",
number = "14",
pages = "11745",
doi = "10.3390/ijms241411745"
}
Radić, J., Kožik, B., Nikolić, I., Kolarov-Bjelobrk, I., Vasiljević, T., Vranjković, B.,& Despotović, S.. (2023). Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. in International Journal of Molecular Sciences, 24(14), 11745.
https://doi.org/10.3390/ijms241411745
Radić J, Kožik B, Nikolić I, Kolarov-Bjelobrk I, Vasiljević T, Vranjković B, Despotović S. Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. in International Journal of Molecular Sciences. 2023;24(14):11745.
doi:10.3390/ijms241411745 .
Radić, Jelena, Kožik, Bojana, Nikolić, Ivan, Kolarov-Bjelobrk, Ivana, Vasiljević, Tijana, Vranjković, Bojana, Despotović, Sanja, "Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting" in International Journal of Molecular Sciences, 24, no. 14 (2023):11745,
https://doi.org/10.3390/ijms241411745 . .
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