TY  - JOUR
AU  - Stanković, Dragana
AU  - Radović, Magdalena
AU  - Stanković, Aljoša
AU  - Mirković, Marija
AU  - Vukadinović, Aleksandar
AU  - Mijović, Milica
AU  - Milanović, Zorana
AU  - Ognjanović, Miloš
AU  - Janković, Drina
AU  - Antić, Bratislav
AU  - Vranješ-Đurić, Sanja
AU  - Savić, Miroslav
AU  - Prijović, Željko
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11387
AB  - As an alternative to classical brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) has been investigated as a superior delivery method over an intravenous route for radionuclide therapy of solid tumors. We created superparamagnetic iron oxide nanoparticles (SPIONs) coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled with Lutetium-177 (177Lu), generating 177Lu-DMSA@SPIONs as a potential antitumor agent for nanobrachytherapy. Efficient radiolabeling of DMSA@SPIONS by 177Lu resulted in a stable bond with minimal leakage in vitro. After an intratumoral injection to mouse colorectal CT-26 or breast 4T1 subcutaneous tumors, the nanoparticles remained well localized at the injection site for weeks, with limited leakage. The dose of 3.70 MBq/100 µg/50 µL of 177Lu-DMSA@SPIONs applied intratumorally resulted in a high therapeutic efficacy, without signs of general toxicity. A decreased dose of 1.85 MBq/100 µg/50 µL still retained therapeutic efficacy, while an increased dose of 9.25 MBq/100 µg/50 µL did not significantly benefit the therapy. Histopathology analysis revealed that the 177Lu-DMSA@SPIONs act within a limited range around the injection site, which explains the good therapeutic efficacy achieved by a single administration of a relatively low dose without the need for increased or repeated dosing. Overall, 177Lu-DMSA@SPIONs are safe and potent agents suitable for intra-tumoral administration for localized tumor radionuclide therapy
T2  - Pharmaceutics
T1  - Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors
VL  - 15
IS  - 7
SP  - 1943
DO  - 10.3390/pharmaceutics15071943
ER  - 

@article{
author = "Stanković, Dragana and Radović, Magdalena and Stanković, Aljoša and Mirković, Marija and Vukadinović, Aleksandar and Mijović, Milica and Milanović, Zorana and Ognjanović, Miloš and Janković, Drina and Antić, Bratislav and Vranješ-Đurić, Sanja and Savić, Miroslav and Prijović, Željko",
year = "2023",
abstract = "As an alternative to classical brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) has been investigated as a superior delivery method over an intravenous route for radionuclide therapy of solid tumors. We created superparamagnetic iron oxide nanoparticles (SPIONs) coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled with Lutetium-177 (177Lu), generating 177Lu-DMSA@SPIONs as a potential antitumor agent for nanobrachytherapy. Efficient radiolabeling of DMSA@SPIONS by 177Lu resulted in a stable bond with minimal leakage in vitro. After an intratumoral injection to mouse colorectal CT-26 or breast 4T1 subcutaneous tumors, the nanoparticles remained well localized at the injection site for weeks, with limited leakage. The dose of 3.70 MBq/100 µg/50 µL of 177Lu-DMSA@SPIONs applied intratumorally resulted in a high therapeutic efficacy, without signs of general toxicity. A decreased dose of 1.85 MBq/100 µg/50 µL still retained therapeutic efficacy, while an increased dose of 9.25 MBq/100 µg/50 µL did not significantly benefit the therapy. Histopathology analysis revealed that the 177Lu-DMSA@SPIONs act within a limited range around the injection site, which explains the good therapeutic efficacy achieved by a single administration of a relatively low dose without the need for increased or repeated dosing. Overall, 177Lu-DMSA@SPIONs are safe and potent agents suitable for intra-tumoral administration for localized tumor radionuclide therapy",
journal = "Pharmaceutics",
title = "Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors",
volume = "15",
number = "7",
pages = "1943",
doi = "10.3390/pharmaceutics15071943"
}

Stanković, D., Radović, M., Stanković, A., Mirković, M., Vukadinović, A., Mijović, M., Milanović, Z., Ognjanović, M., Janković, D., Antić, B., Vranješ-Đurić, S., Savić, M.,& Prijović, Ž.. (2023). Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors. in Pharmaceutics, 15(7), 1943.
https://doi.org/10.3390/pharmaceutics15071943

Stanković D, Radović M, Stanković A, Mirković M, Vukadinović A, Mijović M, Milanović Z, Ognjanović M, Janković D, Antić B, Vranješ-Đurić S, Savić M, Prijović Ž. Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors. in Pharmaceutics. 2023;15(7):1943.
doi:10.3390/pharmaceutics15071943 .

Stanković, Dragana, Radović, Magdalena, Stanković, Aljoša, Mirković, Marija, Vukadinović, Aleksandar, Mijović, Milica, Milanović, Zorana, Ognjanović, Miloš, Janković, Drina, Antić, Bratislav, Vranješ-Đurić, Sanja, Savić, Miroslav, Prijović, Željko, "Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors" in Pharmaceutics, 15, no. 7 (2023):1943,
https://doi.org/10.3390/pharmaceutics15071943 . .

TY  - CONF
AU  - Rajković, Katarina M.
AU  - Đurašević, Mirjana
AU  - Obradović, Zorica
AU  - Milanović, Zorana
AU  - Vukadinović, Aleksandar
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Janković, Drina
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12184
AB  - Tc-99m-radiofarmaceutici se koriste u različitim dijagnostičkim procedurama u nuklearnoj medicini. Da bi se minimizirali štetni efekti jonizujućeg zračenja na zdrava tkiva, intenzivno se istražuju radioprotektivne osobine biljnih ekstrakata. Ljuska ploda crnog oraha sadrži mešavinu različitih farmakološki aktivnih jedinjenja kojа imaju antioksidativno dejstvo i za koje se pretpostavlja da mogu imati i potencijalno radioprotektivno dejstvo. U tom kontekstu, cilj rada je bio da se proceni radioprotektivni efekat ekstrakta ljuske ploda crnog oraha. U ovoj studiji primenjen je eksperimentalni model koji se zasnivao na proceni uticaja ekstrakta na biodistribuciju Tc-99m-radiofarmaceutika po organima eksperimentalnih životinja (pacovi). Ekstrakt ljuske crnog oraha doveo je do smanjenognakupljanja Tc-99m-radiofarmaceutika u pojedinim organimapacova. Rezultati dobijeni na osnovu eksperimentalnog modela sugerišu moguću upotrebu ekstrakta ljuske ploda crnog oraha kao radioprotektivnog sredstva u slučajevima planiranog izlaganja jonizujućem zračenju u nuklearnoj medicini.
AB  - Tc-99m-radiopharmaceuticals are used in various diagnostic procedures in nuclear medicine. In order to minimize the harmful effects of ionizing radiation on healthy tissues, the radioprotective properties of plant extracts are intensively researched. J. nigra husk contains a mixture of various pharmacologically active compounds that have an antioxidant effect and which are assumed to have a potential radioprotective effect. In this context, the aim of the work was to evaluate the radioprotective effect of black walnut husk extract. In this study, an experimental model was applied, which was based on the assessment of the effect of the extract on the biodistribution of Tc-99m-radiopharmaceuticals in the organs of experimental animals (rats). Black walnut husk extract led to a decrease in the accumulation of Tc-99m-radiopharmaceutical in certain organs of rats. The results obtained on the basis of the experimental model suggest that it is possible to use black walnut husk extract as a radioprotective agent in cases of planned exposure to ionizing radiation in diagnosticsnuclear medicine.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta
T1  - Experimental Model for Assessing the Possible Radioprotective Effect of Plant Extract
SP  - 321
EP  - 327
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12184
ER  - 

@conference{
author = "Rajković, Katarina M. and Đurašević, Mirjana and Obradović, Zorica and Milanović, Zorana and Vukadinović, Aleksandar and Perić, Marko and Stanković, Dragana and Janković, Drina",
year = "2023",
abstract = "Tc-99m-radiofarmaceutici se koriste u različitim dijagnostičkim procedurama u nuklearnoj medicini. Da bi se minimizirali štetni efekti jonizujućeg zračenja na zdrava tkiva, intenzivno se istražuju radioprotektivne osobine biljnih ekstrakata. Ljuska ploda crnog oraha sadrži mešavinu različitih farmakološki aktivnih jedinjenja kojа imaju antioksidativno dejstvo i za koje se pretpostavlja da mogu imati i potencijalno radioprotektivno dejstvo. U tom kontekstu, cilj rada je bio da se proceni radioprotektivni efekat ekstrakta ljuske ploda crnog oraha. U ovoj studiji primenjen je eksperimentalni model koji se zasnivao na proceni uticaja ekstrakta na biodistribuciju Tc-99m-radiofarmaceutika po organima eksperimentalnih životinja (pacovi). Ekstrakt ljuske crnog oraha doveo je do smanjenognakupljanja Tc-99m-radiofarmaceutika u pojedinim organimapacova. Rezultati dobijeni na osnovu eksperimentalnog modela sugerišu moguću upotrebu ekstrakta ljuske ploda crnog oraha kao radioprotektivnog sredstva u slučajevima planiranog izlaganja jonizujućem zračenju u nuklearnoj medicini., Tc-99m-radiopharmaceuticals are used in various diagnostic procedures in nuclear medicine. In order to minimize the harmful effects of ionizing radiation on healthy tissues, the radioprotective properties of plant extracts are intensively researched. J. nigra husk contains a mixture of various pharmacologically active compounds that have an antioxidant effect and which are assumed to have a potential radioprotective effect. In this context, the aim of the work was to evaluate the radioprotective effect of black walnut husk extract. In this study, an experimental model was applied, which was based on the assessment of the effect of the extract on the biodistribution of Tc-99m-radiopharmaceuticals in the organs of experimental animals (rats). Black walnut husk extract led to a decrease in the accumulation of Tc-99m-radiopharmaceutical in certain organs of rats. The results obtained on the basis of the experimental model suggest that it is possible to use black walnut husk extract as a radioprotective agent in cases of planned exposure to ionizing radiation in diagnosticsnuclear medicine.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta, Experimental Model for Assessing the Possible Radioprotective Effect of Plant Extract",
pages = "321-327",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12184"
}

Rajković, K. M., Đurašević, M., Obradović, Z., Milanović, Z., Vukadinović, A., Perić, M., Stanković, D.,& Janković, D.. (2023). Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 321-327.
https://hdl.handle.net/21.15107/rcub_vinar_12184

Rajković KM, Đurašević M, Obradović Z, Milanović Z, Vukadinović A, Perić M, Stanković D, Janković D. Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta. in 32. simpozijum DZZSCG : zbornik radova. 2023;:321-327.
https://hdl.handle.net/21.15107/rcub_vinar_12184 .

Rajković, Katarina M., Đurašević, Mirjana, Obradović, Zorica, Milanović, Zorana, Vukadinović, Aleksandar, Perić, Marko, Stanković, Dragana, Janković, Drina, "Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta" in 32. simpozijum DZZSCG : zbornik radova (2023):321-327,
https://hdl.handle.net/21.15107/rcub_vinar_12184 .

TY  - CONF
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Vukadinović, Aleksandar
AU  - Vranješ-Đurić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12185
AB  - Prisustvo radiohemijske nečistoće C u 99mTc-MIBI injekciji utiče na kvalitet skena, jer se radiofarmaceutik nedovoljno nakuplja u organu od interesa, dok je aktivnost okolnih organa i tkiva velika. Zbog toga je i doza zračenja koju prime okolni organi i tkiva iznad propisanih granica. Da bi se obezbedilo da je planirano izlaganje zračenju pacijenata svedeno na minimum, farmakopeja zahteva ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji neposredno pre primene radiofarmaceutika u pacijenta. Za ova ispitivanja se koriste metode hromatografije. U radu je predstavljena brza i osetljiva ITLC metoda namenjena za rutinsko ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. ITLC metoda je validirana, a ispitivani su pogodnost sistema, tačnost, preciznost, ponovljivost, specifičnost, limit detekcije, limit kvantifikacije, linearnost, robustnost i osetljivost metode. Dobre "recovery" vrednosti i niska relativna standardna devijacija potvrđuju da je predložena ITLC metoda pogodna za rutinsko određivanje nečistoće C u 99mTc-MIBI u injekciji.
AB  - The European Pharmacopoeia mandates that all radiopharmaceuticals used in nuclear medicine for diagnostic and therapeutic purposes must be of the correct radiochemical and radionuclidic purity and have the correct radioactivity present at the stated time of injection to ensure that the intended radiation exposure of patients is kept to a minimum. These factors have an effect on the overall radiation dose to the patient, as impurities of the radionuclide and/or its chemical composition may affect the biodistribution of the injected radiopharmaceutical and consequently the radiation dose to any one particular organ or the whole body dose. The presence of radiochemical impurity C in 99mTc-MIBI injection affects the quality of the image, because 99mTc-MIBI accumulates insufficiently in the organ of interest, while the activity of the surrounding organs and tissues is high. Therefore, the radiation dose received by the surrounding organs and tissues is above the permitted level. In order to avoid unnecessary irradiation of surrounding organs and tissues, the pharmacopoeia requires examination of the content of radiochemical impurity C immediately before administering of 99mTc-MIBI to the patient. Chromatographic methods are used for these tests. The paper presents a fast and sensitive ITLC method intended for routine examination of the content of radiochemical impurity C in 99mTc-MIBI injection. The ITLC method was validated, and the suitability of the system, accuracy, precision, repeatability, specificity, limit of detection, limit of quantification, linearity, robustness and sensitivity of the method were examined. Good "recovery" values and low relative standard deviation confirm that the proposed ITLC method is suitable for routine determination of impurity C in 99mTc-MIBI in injection.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji
T1  - Validation of an ITLC Method for the Determination of Radiochemical Impurities C in 99mTc-MIBI Injection
SP  - 342
EP  - 349
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12185
ER  - 

@conference{
author = "Janković, Drina and Mirković, Marija D. and Radović, Magdalena and Milanović, Zorana and Perić, Marko and Stanković, Dragana and Vukadinović, Aleksandar and Vranješ-Đurić, Sanja",
year = "2023",
abstract = "Prisustvo radiohemijske nečistoće C u 99mTc-MIBI injekciji utiče na kvalitet skena, jer se radiofarmaceutik nedovoljno nakuplja u organu od interesa, dok je aktivnost okolnih organa i tkiva velika. Zbog toga je i doza zračenja koju prime okolni organi i tkiva iznad propisanih granica. Da bi se obezbedilo da je planirano izlaganje zračenju pacijenata svedeno na minimum, farmakopeja zahteva ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji neposredno pre primene radiofarmaceutika u pacijenta. Za ova ispitivanja se koriste metode hromatografije. U radu je predstavljena brza i osetljiva ITLC metoda namenjena za rutinsko ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. ITLC metoda je validirana, a ispitivani su pogodnost sistema, tačnost, preciznost, ponovljivost, specifičnost, limit detekcije, limit kvantifikacije, linearnost, robustnost i osetljivost metode. Dobre "recovery" vrednosti i niska relativna standardna devijacija potvrđuju da je predložena ITLC metoda pogodna za rutinsko određivanje nečistoće C u 99mTc-MIBI u injekciji., The European Pharmacopoeia mandates that all radiopharmaceuticals used in nuclear medicine for diagnostic and therapeutic purposes must be of the correct radiochemical and radionuclidic purity and have the correct radioactivity present at the stated time of injection to ensure that the intended radiation exposure of patients is kept to a minimum. These factors have an effect on the overall radiation dose to the patient, as impurities of the radionuclide and/or its chemical composition may affect the biodistribution of the injected radiopharmaceutical and consequently the radiation dose to any one particular organ or the whole body dose. The presence of radiochemical impurity C in 99mTc-MIBI injection affects the quality of the image, because 99mTc-MIBI accumulates insufficiently in the organ of interest, while the activity of the surrounding organs and tissues is high. Therefore, the radiation dose received by the surrounding organs and tissues is above the permitted level. In order to avoid unnecessary irradiation of surrounding organs and tissues, the pharmacopoeia requires examination of the content of radiochemical impurity C immediately before administering of 99mTc-MIBI to the patient. Chromatographic methods are used for these tests. The paper presents a fast and sensitive ITLC method intended for routine examination of the content of radiochemical impurity C in 99mTc-MIBI injection. The ITLC method was validated, and the suitability of the system, accuracy, precision, repeatability, specificity, limit of detection, limit of quantification, linearity, robustness and sensitivity of the method were examined. Good "recovery" values and low relative standard deviation confirm that the proposed ITLC method is suitable for routine determination of impurity C in 99mTc-MIBI in injection.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji, Validation of an ITLC Method for the Determination of Radiochemical Impurities C in 99mTc-MIBI Injection",
pages = "342-349",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12185"
}

Janković, D., Mirković, M. D., Radović, M., Milanović, Z., Perić, M., Stanković, D., Vukadinović, A.,& Vranješ-Đurić, S.. (2023). Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 342-349.
https://hdl.handle.net/21.15107/rcub_vinar_12185

Janković D, Mirković MD, Radović M, Milanović Z, Perić M, Stanković D, Vukadinović A, Vranješ-Đurić S. Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. in 32. simpozijum DZZSCG : zbornik radova. 2023;:342-349.
https://hdl.handle.net/21.15107/rcub_vinar_12185 .

Janković, Drina, Mirković, Marija D., Radović, Magdalena, Milanović, Zorana, Perić, Marko, Stanković, Dragana, Vukadinović, Aleksandar, Vranješ-Đurić, Sanja, "Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji" in 32. simpozijum DZZSCG : zbornik radova (2023):342-349,
https://hdl.handle.net/21.15107/rcub_vinar_12185 .

TY  - CONF
AU  - Milanović, Zorana
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Vukadinović, Aleksandar
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12186
AB  - Radiofarmaceutici koji se koriste za ispitivanje skeletnog sistema od neprocenjivog su značaja u nuklearnoj medicini, kako za dijagnostiku primarnih tumora koštanog tkiva, tako i metastaza. Pre primene na pacijentima, ovi radiofarmaceutici podležu različitim fizičko-hemijskim i biološkim ispitivanjima. Ispitivanje fiziološke raspodele leka in vivo je od presudnog značaja jer od akumulacije leka u odgovarajućoj meri u ciljnom organu (skeletu) zavisi kvalitet dobijenog scintigrama, kao i doza zračenja koje će primiti pojedinačni organi i tkiva. U evropskoj farmakopeji (Ph.Eur.) date su metode kontrole kvaliteta kao i parametri kvaliteta sa granicama prihvatljivosti (specifikacijske granice) za 99mTc-metilendifosfonat (99mTc-MDP). Cilj ovog rada je prikaz metode ispitivanja fiziološke raspodele 99mTc-DPD koja je razvijena u Laboratoriji za radioizotope po smernicama evropske farmakopeje za 99mTc-MDP, uz manje modifikacije. Rezultati biodistribucije na Wistar pacovima su pokazali da je 99mTc-DPD proizveden u Laboratoriji za radioizotope zadovoljio sve postavljene kriterijume, kako odmah nakon proizvodnje, tako i nakon šest i dvanaest meseci od proizvodnje.
AB  - Radiopharmaceuticals used to examine the skeletal system are of invaluable importance in nuclear medicine, both for the diagnosis of primary bone tissue tumors and metastases. Before administration to patients, these radiopharmaceuticals undergo various physico-chemical and biological tests. Investigation of the physiological distribution of the drug in vivo is of crucial importance because the quality of the obtained scintigram depends on the accumulation of the drug in the target organ (skeleton), as well as the radiation dose received by individual organs and tissues. The European pharmacopoeia (Ph.Eur.) provides quality control methods and quality parameters with acceptance limits (specification limits) for 99mTc-methylenediphosphonate (99mTc-MDP). The method of testing the physiological distribution of 99mTc-DPD in the Laboratory for Radioisotopes, which is presented in this paper, is done according to the guidelines of the European Pharmacopoeia for 99mTc-MDP, with minor modifications. Results of biodistribution on Wistar rats showed that 99mTc-DPD produced in the Laboratory for Radioisotopes met all the set criteria, both immediately after the production and after six and twelve months from production.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Metoda ispitivanja fiziološke raspodele 99mTc-DPD
T1  - Method for Investigation of Physiological Distribution of 99mTc DPD
SP  - 350
EP  - 355
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12186
ER  - 

@conference{
author = "Milanović, Zorana and Mirković, Marija D. and Radović, Magdalena and Perić, Marko and Stanković, Dragana and Vukadinović, Aleksandar and Vranješ-Đurić, Sanja and Janković, Drina",
year = "2023",
abstract = "Radiofarmaceutici koji se koriste za ispitivanje skeletnog sistema od neprocenjivog su značaja u nuklearnoj medicini, kako za dijagnostiku primarnih tumora koštanog tkiva, tako i metastaza. Pre primene na pacijentima, ovi radiofarmaceutici podležu različitim fizičko-hemijskim i biološkim ispitivanjima. Ispitivanje fiziološke raspodele leka in vivo je od presudnog značaja jer od akumulacije leka u odgovarajućoj meri u ciljnom organu (skeletu) zavisi kvalitet dobijenog scintigrama, kao i doza zračenja koje će primiti pojedinačni organi i tkiva. U evropskoj farmakopeji (Ph.Eur.) date su metode kontrole kvaliteta kao i parametri kvaliteta sa granicama prihvatljivosti (specifikacijske granice) za 99mTc-metilendifosfonat (99mTc-MDP). Cilj ovog rada je prikaz metode ispitivanja fiziološke raspodele 99mTc-DPD koja je razvijena u Laboratoriji za radioizotope po smernicama evropske farmakopeje za 99mTc-MDP, uz manje modifikacije. Rezultati biodistribucije na Wistar pacovima su pokazali da je 99mTc-DPD proizveden u Laboratoriji za radioizotope zadovoljio sve postavljene kriterijume, kako odmah nakon proizvodnje, tako i nakon šest i dvanaest meseci od proizvodnje., Radiopharmaceuticals used to examine the skeletal system are of invaluable importance in nuclear medicine, both for the diagnosis of primary bone tissue tumors and metastases. Before administration to patients, these radiopharmaceuticals undergo various physico-chemical and biological tests. Investigation of the physiological distribution of the drug in vivo is of crucial importance because the quality of the obtained scintigram depends on the accumulation of the drug in the target organ (skeleton), as well as the radiation dose received by individual organs and tissues. The European pharmacopoeia (Ph.Eur.) provides quality control methods and quality parameters with acceptance limits (specification limits) for 99mTc-methylenediphosphonate (99mTc-MDP). The method of testing the physiological distribution of 99mTc-DPD in the Laboratory for Radioisotopes, which is presented in this paper, is done according to the guidelines of the European Pharmacopoeia for 99mTc-MDP, with minor modifications. Results of biodistribution on Wistar rats showed that 99mTc-DPD produced in the Laboratory for Radioisotopes met all the set criteria, both immediately after the production and after six and twelve months from production.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Metoda ispitivanja fiziološke raspodele 99mTc-DPD, Method for Investigation of Physiological Distribution of 99mTc DPD",
pages = "350-355",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12186"
}

Milanović, Z., Mirković, M. D., Radović, M., Perić, M., Stanković, D., Vukadinović, A., Vranješ-Đurić, S.,& Janković, D.. (2023). Metoda ispitivanja fiziološke raspodele 99mTc-DPD. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 350-355.
https://hdl.handle.net/21.15107/rcub_vinar_12186

Milanović Z, Mirković MD, Radović M, Perić M, Stanković D, Vukadinović A, Vranješ-Đurić S, Janković D. Metoda ispitivanja fiziološke raspodele 99mTc-DPD. in 32. simpozijum DZZSCG : zbornik radova. 2023;:350-355.
https://hdl.handle.net/21.15107/rcub_vinar_12186 .

Milanović, Zorana, Mirković, Marija D., Radović, Magdalena, Perić, Marko, Stanković, Dragana, Vukadinović, Aleksandar, Vranješ-Đurić, Sanja, Janković, Drina, "Metoda ispitivanja fiziološke raspodele 99mTc-DPD" in 32. simpozijum DZZSCG : zbornik radova (2023):350-355,
https://hdl.handle.net/21.15107/rcub_vinar_12186 .

TY  - CONF
AU  - Vukadinović, Aleksandar
AU  - Ravlić, Miroslav
AU  - Matović, Milovan
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Jevremović, Milutin
AU  - Vranješ-Đurić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12187
AB  - Laboratorija za radioizotope Instituta Vinča je jedinstven centar u regionu koji poseduje Rešenja Ministarstva zdravlja Republike Srbije i Direktorata za radijacionu i nuklearnu sigurnost i bezbednost Srbije za proizvodnju radiofarmaceutika. Radiofarmaceutik koji se proizvodi više od 40 godina u Laboratoriji za radioizotope, a primenjuje u terapiji tumora štitaste žlezde, kao i hipertireozi su kapsule natrijum-jodida (I-131). Radijacioni efekti I-131 na ćelije štitaste žlezde potiču od beta-zračenja koje emituje I-131 tokom radioaktivnog raspada u samoj štitastoj žlezdi jer se I-131 nakon oralne primene nakuplja prvenstveno u štitastoj žlezdi u kojoj ima dugu retenciju. Za efikasnu terapiju, ali u isto vreme u cilju smanjenja izloženosti nepotrebnim dozama, za svakog pacijenta određuje se odgovarajuća doza I-131 koju je neophodno da primi, odnosno primenjuje se tzv. personalizovana terapija. U radu je opisan postupak proizvodnje kapsula I-131 u Laboratoriji za radioizotope putem manuelnog punjenja kapsula rastvorom I-131, kao i osnovni zahtevi koje je neophodno da sistem za automatsku proizvodnju radiofarmaceutika ispuni, a to su pre svih, odgovarajuća zaštita operatera od zračenja, jednostavna upotreba i kompjuterska kontrola.
AB  - The Laboratory for radioisotopes of the Vinča Institute is a unique center in the region with licences of the Ministry of Health of the Republic of Serbia and the Directorate for Radiation and Nuclear Safety and Security of Serbia for the production of radiopharmaceuticals. Sodium iodide (I-131) capsules are radiopharmaceuticals that have been produced for more than 40 years in the Laboratory for Radioisotopes, and are used in the treatment of tumors of thyroid gland, as well as in hyperthyroidism. The radiation effects of I-131 on thyroid cells originate from beta-radiation emitted by I-131 during radioactive decay in the thyroid gland itself because I-131 after oral administration accumulates primarily in the thyroid gland where it has a long retention. For the effective therapy, but at the same time in order to reduce exposure to unnecessary high doses, the appropriate dose of I-131 is determined for each patient, in the so-called personalized therapy. The paper describes the current procedure for the production of I-131 capsules in the Laboratory for Radioisotopes by manually filling the capsules with I-131 solution and the basic requirements for design the system for automating the production of radiopharmaceuticals, which above all must provide adequate protection for the operator from radiation, must be user friendly and computer-controlled.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera
T1  - Automation of the Production of Radiopharmaceutical with the Aim to Reduce the Operator's Radiation Dose
SP  - 356
EP  - 360
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12187
ER  - 

@conference{
author = "Vukadinović, Aleksandar and Ravlić, Miroslav and Matović, Milovan and Janković, Drina and Mirković, Marija D. and Radović, Magdalena and Milanović, Zorana and Perić, Marko and Stanković, Dragana and Jevremović, Milutin and Vranješ-Đurić, Sanja",
year = "2023",
abstract = "Laboratorija za radioizotope Instituta Vinča je jedinstven centar u regionu koji poseduje Rešenja Ministarstva zdravlja Republike Srbije i Direktorata za radijacionu i nuklearnu sigurnost i bezbednost Srbije za proizvodnju radiofarmaceutika. Radiofarmaceutik koji se proizvodi više od 40 godina u Laboratoriji za radioizotope, a primenjuje u terapiji tumora štitaste žlezde, kao i hipertireozi su kapsule natrijum-jodida (I-131). Radijacioni efekti I-131 na ćelije štitaste žlezde potiču od beta-zračenja koje emituje I-131 tokom radioaktivnog raspada u samoj štitastoj žlezdi jer se I-131 nakon oralne primene nakuplja prvenstveno u štitastoj žlezdi u kojoj ima dugu retenciju. Za efikasnu terapiju, ali u isto vreme u cilju smanjenja izloženosti nepotrebnim dozama, za svakog pacijenta određuje se odgovarajuća doza I-131 koju je neophodno da primi, odnosno primenjuje se tzv. personalizovana terapija. U radu je opisan postupak proizvodnje kapsula I-131 u Laboratoriji za radioizotope putem manuelnog punjenja kapsula rastvorom I-131, kao i osnovni zahtevi koje je neophodno da sistem za automatsku proizvodnju radiofarmaceutika ispuni, a to su pre svih, odgovarajuća zaštita operatera od zračenja, jednostavna upotreba i kompjuterska kontrola., The Laboratory for radioisotopes of the Vinča Institute is a unique center in the region with licences of the Ministry of Health of the Republic of Serbia and the Directorate for Radiation and Nuclear Safety and Security of Serbia for the production of radiopharmaceuticals. Sodium iodide (I-131) capsules are radiopharmaceuticals that have been produced for more than 40 years in the Laboratory for Radioisotopes, and are used in the treatment of tumors of thyroid gland, as well as in hyperthyroidism. The radiation effects of I-131 on thyroid cells originate from beta-radiation emitted by I-131 during radioactive decay in the thyroid gland itself because I-131 after oral administration accumulates primarily in the thyroid gland where it has a long retention. For the effective therapy, but at the same time in order to reduce exposure to unnecessary high doses, the appropriate dose of I-131 is determined for each patient, in the so-called personalized therapy. The paper describes the current procedure for the production of I-131 capsules in the Laboratory for Radioisotopes by manually filling the capsules with I-131 solution and the basic requirements for design the system for automating the production of radiopharmaceuticals, which above all must provide adequate protection for the operator from radiation, must be user friendly and computer-controlled.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera, Automation of the Production of Radiopharmaceutical with the Aim to Reduce the Operator's Radiation Dose",
pages = "356-360",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12187"
}

Vukadinović, A., Ravlić, M., Matović, M., Janković, D., Mirković, M. D., Radović, M., Milanović, Z., Perić, M., Stanković, D., Jevremović, M.,& Vranješ-Đurić, S.. (2023). Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 356-360.
https://hdl.handle.net/21.15107/rcub_vinar_12187

Vukadinović A, Ravlić M, Matović M, Janković D, Mirković MD, Radović M, Milanović Z, Perić M, Stanković D, Jevremović M, Vranješ-Đurić S. Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera. in 32. simpozijum DZZSCG : zbornik radova. 2023;:356-360.
https://hdl.handle.net/21.15107/rcub_vinar_12187 .

Vukadinović, Aleksandar, Ravlić, Miroslav, Matović, Milovan, Janković, Drina, Mirković, Marija D., Radović, Magdalena, Milanović, Zorana, Perić, Marko, Stanković, Dragana, Jevremović, Milutin, Vranješ-Đurić, Sanja, "Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera" in 32. simpozijum DZZSCG : zbornik radova (2023):356-360,
https://hdl.handle.net/21.15107/rcub_vinar_12187 .

TY  - CONF
AU  - Perić, Marko
AU  - Milanović, Zorana
AU  - Radović, Magdalena
AU  - Mirković, M.
AU  - Vukadinović, Aleksandar
AU  - Stanković, D.
AU  - Janković, Drina
AU  - Vranješ-Đurić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11632
AB  - Metal complexes with BH4 - ligands show extravagant structural and dynamic properties, and possess many important and applicable qualities (potent reducing agents and catalysts, materials for hydrogen storage). Electron paramagnetic resonance (EPR) is very important for the characterization of complex compounds, determination of their electronic configuration and geometry. Also, Density Functional Theory (DFT) can predict EPR parameters and explain them more profoundly. Of particular importance is the analysis and prediction of hyperfine coupling constants for lanthanide complexes with BH4 - ligands, given that there is not much data in the literature. Within this paper hyperfine coupling constants of d and f metal complexes with BH4 - ligands have been determined by DFT calculations, and analyzed in detail. Calculations predicted that proton hyperfine coupling constants are very small in the case of complexes of f elements, and are present only due to weak polarization. The increase of covalence and the number of unpaired electrons does not significantly affect the change of constants of BH4 - ligands, but only of protons that are bound by σ bonds.
PB  - Belgrade : Serbian Ceramic Society
C3  - Advanced Ceramics and Application :11th Serbian Ceramic Society Conference : program and the book of abstracts; September 18-20, 2023; Belgrade
T1  - DFT Analysis of Hyperfine Couplings in d and f metal complexes with Tetrahydro Borate Ligands
SP  - 35
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11632
ER  - 

@conference{
author = "Perić, Marko and Milanović, Zorana and Radović, Magdalena and Mirković, M. and Vukadinović, Aleksandar and Stanković, D. and Janković, Drina and Vranješ-Đurić, Sanja",
year = "2023",
abstract = "Metal complexes with BH4 - ligands show extravagant structural and dynamic properties, and possess many important and applicable qualities (potent reducing agents and catalysts, materials for hydrogen storage). Electron paramagnetic resonance (EPR) is very important for the characterization of complex compounds, determination of their electronic configuration and geometry. Also, Density Functional Theory (DFT) can predict EPR parameters and explain them more profoundly. Of particular importance is the analysis and prediction of hyperfine coupling constants for lanthanide complexes with BH4 - ligands, given that there is not much data in the literature. Within this paper hyperfine coupling constants of d and f metal complexes with BH4 - ligands have been determined by DFT calculations, and analyzed in detail. Calculations predicted that proton hyperfine coupling constants are very small in the case of complexes of f elements, and are present only due to weak polarization. The increase of covalence and the number of unpaired electrons does not significantly affect the change of constants of BH4 - ligands, but only of protons that are bound by σ bonds.",
publisher = "Belgrade : Serbian Ceramic Society",
journal = "Advanced Ceramics and Application :11th Serbian Ceramic Society Conference : program and the book of abstracts; September 18-20, 2023; Belgrade",
title = "DFT Analysis of Hyperfine Couplings in d and f metal complexes with Tetrahydro Borate Ligands",
pages = "35-36",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11632"
}

Perić, M., Milanović, Z., Radović, M., Mirković, M., Vukadinović, A., Stanković, D., Janković, D.,& Vranješ-Đurić, S.. (2023). DFT Analysis of Hyperfine Couplings in d and f metal complexes with Tetrahydro Borate Ligands. in Advanced Ceramics and Application :11th Serbian Ceramic Society Conference : program and the book of abstracts; September 18-20, 2023; Belgrade
Belgrade : Serbian Ceramic Society., 35-36.
https://hdl.handle.net/21.15107/rcub_vinar_11632

Perić M, Milanović Z, Radović M, Mirković M, Vukadinović A, Stanković D, Janković D, Vranješ-Đurić S. DFT Analysis of Hyperfine Couplings in d and f metal complexes with Tetrahydro Borate Ligands. in Advanced Ceramics and Application :11th Serbian Ceramic Society Conference : program and the book of abstracts; September 18-20, 2023; Belgrade. 2023;:35-36.
https://hdl.handle.net/21.15107/rcub_vinar_11632 .

Perić, Marko, Milanović, Zorana, Radović, Magdalena, Mirković, M., Vukadinović, Aleksandar, Stanković, D., Janković, Drina, Vranješ-Đurić, Sanja, "DFT Analysis of Hyperfine Couplings in d and f metal complexes with Tetrahydro Borate Ligands" in Advanced Ceramics and Application :11th Serbian Ceramic Society Conference : program and the book of abstracts; September 18-20, 2023; Belgrade (2023):35-36,
https://hdl.handle.net/21.15107/rcub_vinar_11632 .

TY  - JOUR
AU  - Mitrović, Jelena
AU  - Bjelošević Žiberna, Maja
AU  - Vukadinović, Aleksandar
AU  - Knutson, Daniel E.
AU  - Sharmin, Dishary
AU  - Kremenović, Aleksandar
AU  - Ahlin Grabnar, Pegi
AU  - Planinšek, Odon
AU  - Lunter, Dominique
AU  - Cook, James M
AU  - Savić, Miroslav
AU  - Savić, Snežana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11440
AB  - Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms of particle size, solid state properties and morphology, while the interactions within the samples were analyzed by Fourier transform infrared spectroscopy. In the preliminary study, three formulations were selected based on the high redispersibility index values (around 95%). The temperature of primary drying had no significant effect on particle size, but stability during storage was impaired for samples dried at -10 °C. Samples dried at lower temperature were more homogeneous and remained stable for three months. It was found that the optimal ratio of sucrose or trehalose to mannitol was 3:2 at a total concentration of 10% to achieve the best stability (particle size < 1.0 μm, polydispersity index < 0.250). The amorphous state of lyoprotectants probably provided a high degree of interaction with nanocrystals, while the crystalline mannitol provided an elegant cake structure. Sucrose was superior to trehalose in maintaining particle size during freeze-drying, while trehalose was more effective in keeping particle size within limits during storage. In conclusion, results demonstrated that the appropriate combination of sucrose/trehalose and mannitol together with the appropriate selection of lyophilization process parameters could yield nanocrystals with satisfactory stability.
T2  - European Journal of Pharmaceutical Sciences
T1  - Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
VL  - 189
DO  - 10.1016/j.ejps.2023.106557
ER  - 

@article{
author = "Mitrović, Jelena and Bjelošević Žiberna, Maja and Vukadinović, Aleksandar and Knutson, Daniel E. and Sharmin, Dishary and Kremenović, Aleksandar and Ahlin Grabnar, Pegi and Planinšek, Odon and Lunter, Dominique and Cook, James M and Savić, Miroslav and Savić, Snežana",
year = "2023",
abstract = "Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms of particle size, solid state properties and morphology, while the interactions within the samples were analyzed by Fourier transform infrared spectroscopy. In the preliminary study, three formulations were selected based on the high redispersibility index values (around 95%). The temperature of primary drying had no significant effect on particle size, but stability during storage was impaired for samples dried at -10 °C. Samples dried at lower temperature were more homogeneous and remained stable for three months. It was found that the optimal ratio of sucrose or trehalose to mannitol was 3:2 at a total concentration of 10% to achieve the best stability (particle size < 1.0 μm, polydispersity index < 0.250). The amorphous state of lyoprotectants probably provided a high degree of interaction with nanocrystals, while the crystalline mannitol provided an elegant cake structure. Sucrose was superior to trehalose in maintaining particle size during freeze-drying, while trehalose was more effective in keeping particle size within limits during storage. In conclusion, results demonstrated that the appropriate combination of sucrose/trehalose and mannitol together with the appropriate selection of lyophilization process parameters could yield nanocrystals with satisfactory stability.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study",
volume = "189",
doi = "10.1016/j.ejps.2023.106557"
}

Mitrović, J., Bjelošević Žiberna, M., Vukadinović, A., Knutson, D. E., Sharmin, D., Kremenović, A., Ahlin Grabnar, P., Planinšek, O., Lunter, D., Cook, J. M., Savić, M.,& Savić, S.. (2023). Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study. in European Journal of Pharmaceutical Sciences, 189.
https://doi.org/10.1016/j.ejps.2023.106557

Mitrović J, Bjelošević Žiberna M, Vukadinović A, Knutson DE, Sharmin D, Kremenović A, Ahlin Grabnar P, Planinšek O, Lunter D, Cook JM, Savić M, Savić S. Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study. in European Journal of Pharmaceutical Sciences. 2023;189.
doi:10.1016/j.ejps.2023.106557 .

Mitrović, Jelena, Bjelošević Žiberna, Maja, Vukadinović, Aleksandar, Knutson, Daniel E., Sharmin, Dishary, Kremenović, Aleksandar, Ahlin Grabnar, Pegi, Planinšek, Odon, Lunter, Dominique, Cook, James M, Savić, Miroslav, Savić, Snežana, "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, 189 (2023),
https://doi.org/10.1016/j.ejps.2023.106557 . .

TY  - JOUR
AU  - Vukadinović, Aleksandar
AU  - Milanović, Zorana
AU  - Ognjanović, Miloš
AU  - Janković, Drina
AU  - Radović, Magdalena
AU  - Mirković, Marija D.
AU  - Karageorgou, Maria-Argyro
AU  - Bouziotis, Penelope
AU  - Erić, Slavica
AU  - Vranješ-Đurić, Sanja
AU  - Antić, Bratislav
AU  - Prijović, Željko
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10368
AB  - Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated with citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated and coated SPIONs were nontoxic to CT-26 mouse colon cancer cells up to 1.0 mg ml−1 in vitro. In an oscillating magnetic field, citrate-coated SPIONs (CA/SPIONs) displayed the highest heating rate (SAR ∼ 253 W g−1) and the strongest hyperthermia effects against CT-26 cells. Labelling of the CA/SPIONs by the 90Y radionuclide, emitting β− radiation with an average/maximum energy of 0.94/2.23 MeV, and deep tissue penetration generated 90Y-CA/SPIONs intended for the therapy of solid tumours. However, intravenous injection of 90Y-CA/SPIONs in CT-26 xenograft-bearing mice resulted in low tumour accumulation. On the contrary, intratumoural injection resulted in long-term retention at the injection site. A single intratumoural injection of 0.25 mg CA/SPIONs followed by 30-min courses of magnetic hyperthermia for four consecutive days caused a moderate antitumour effect against CT-26 and 4T1 mouse tumour xenografts. Intratumoural application of 1.85 MBq/0.25 mg 90Y-CA/SPIONs, alone or combined with hyperthermia, caused a significant (P ≤ 0.01) antitumour effect without signs of systemic toxicity. The results confirm the suitability of 90Y-CA/SPIONs for monotherapy or dual magnetic hyperthermia-radionuclide nanobrachytherapy (NBT) of solid tumours.
T2  - Nanotechnology
T1  - 90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours
VL  - 33
IS  - 40
SP  - 405102
DO  - 10.1088/1361-6528/ac7ac0
ER  - 

@article{
author = "Vukadinović, Aleksandar and Milanović, Zorana and Ognjanović, Miloš and Janković, Drina and Radović, Magdalena and Mirković, Marija D. and Karageorgou, Maria-Argyro and Bouziotis, Penelope and Erić, Slavica and Vranješ-Đurić, Sanja and Antić, Bratislav and Prijović, Željko",
year = "2022",
abstract = "Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated with citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated and coated SPIONs were nontoxic to CT-26 mouse colon cancer cells up to 1.0 mg ml−1 in vitro. In an oscillating magnetic field, citrate-coated SPIONs (CA/SPIONs) displayed the highest heating rate (SAR ∼ 253 W g−1) and the strongest hyperthermia effects against CT-26 cells. Labelling of the CA/SPIONs by the 90Y radionuclide, emitting β− radiation with an average/maximum energy of 0.94/2.23 MeV, and deep tissue penetration generated 90Y-CA/SPIONs intended for the therapy of solid tumours. However, intravenous injection of 90Y-CA/SPIONs in CT-26 xenograft-bearing mice resulted in low tumour accumulation. On the contrary, intratumoural injection resulted in long-term retention at the injection site. A single intratumoural injection of 0.25 mg CA/SPIONs followed by 30-min courses of magnetic hyperthermia for four consecutive days caused a moderate antitumour effect against CT-26 and 4T1 mouse tumour xenografts. Intratumoural application of 1.85 MBq/0.25 mg 90Y-CA/SPIONs, alone or combined with hyperthermia, caused a significant (P ≤ 0.01) antitumour effect without signs of systemic toxicity. The results confirm the suitability of 90Y-CA/SPIONs for monotherapy or dual magnetic hyperthermia-radionuclide nanobrachytherapy (NBT) of solid tumours.",
journal = "Nanotechnology",
title = "90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours",
volume = "33",
number = "40",
pages = "405102",
doi = "10.1088/1361-6528/ac7ac0"
}

Vukadinović, A., Milanović, Z., Ognjanović, M., Janković, D., Radović, M., Mirković, M. D., Karageorgou, M., Bouziotis, P., Erić, S., Vranješ-Đurić, S., Antić, B.,& Prijović, Ž.. (2022). 90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours. in Nanotechnology, 33(40), 405102.
https://doi.org/10.1088/1361-6528/ac7ac0

Vukadinović A, Milanović Z, Ognjanović M, Janković D, Radović M, Mirković MD, Karageorgou M, Bouziotis P, Erić S, Vranješ-Đurić S, Antić B, Prijović Ž. 90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours. in Nanotechnology. 2022;33(40):405102.
doi:10.1088/1361-6528/ac7ac0 .

Vukadinović, Aleksandar, Milanović, Zorana, Ognjanović, Miloš, Janković, Drina, Radović, Magdalena, Mirković, Marija D., Karageorgou, Maria-Argyro, Bouziotis, Penelope, Erić, Slavica, Vranješ-Đurić, Sanja, Antić, Bratislav, Prijović, Željko, "90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours" in Nanotechnology, 33, no. 40 (2022):405102,
https://doi.org/10.1088/1361-6528/ac7ac0 . .

TY  - JOUR
AU  - Zavišić, Gordana
AU  - Ristić, Slavica
AU  - Rikalović, Milena
AU  - Petković, Branka
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Petričević, Saša
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10379
AB  - The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome.
T2  - Journal of Functional Foods
T1  - Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome
VL  - 95
SP  - 105167
DO  - 10.1016/j.jff.2022.105167
ER  - 

@article{
author = "Zavišić, Gordana and Ristić, Slavica and Rikalović, Milena and Petković, Branka and Janković, Drina and Vukadinović, Aleksandar and Petričević, Saša",
year = "2022",
abstract = "The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome.",
journal = "Journal of Functional Foods",
title = "Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome",
volume = "95",
pages = "105167",
doi = "10.1016/j.jff.2022.105167"
}

Zavišić, G., Ristić, S., Rikalović, M., Petković, B., Janković, D., Vukadinović, A.,& Petričević, S.. (2022). Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome. in Journal of Functional Foods, 95, 105167.
https://doi.org/10.1016/j.jff.2022.105167

Zavišić G, Ristić S, Rikalović M, Petković B, Janković D, Vukadinović A, Petričević S. Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome. in Journal of Functional Foods. 2022;95:105167.
doi:10.1016/j.jff.2022.105167 .

Zavišić, Gordana, Ristić, Slavica, Rikalović, Milena, Petković, Branka, Janković, Drina, Vukadinović, Aleksandar, Petričević, Saša, "Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome" in Journal of Functional Foods, 95 (2022):105167,
https://doi.org/10.1016/j.jff.2022.105167 . .

TY  - JOUR
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Mirković, Marija D.
AU  - Stanković, Dragana
AU  - Vranješ-Đurić, Sanja
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8652
AB  - Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd
T2  - Applied Radiation and Isotopes
T1  - Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres
VL  - 156
SP  - 108984
DO  - 10.1016/j.apradiso.2019.108984
ER  - 

@article{
author = "Vukadinović, Aleksandar and Janković, Drina and Radović, Magdalena and Milanović, Zorana and Mirković, Marija D. and Stanković, Dragana and Vranješ-Đurić, Sanja",
year = "2020",
abstract = "Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd",
journal = "Applied Radiation and Isotopes",
title = "Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres",
volume = "156",
pages = "108984",
doi = "10.1016/j.apradiso.2019.108984"
}

Vukadinović, A., Janković, D., Radović, M., Milanović, Z., Mirković, M. D., Stanković, D.,& Vranješ-Đurić, S.. (2020). Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres. in Applied Radiation and Isotopes, 156, 108984.
https://doi.org/10.1016/j.apradiso.2019.108984

Vukadinović A, Janković D, Radović M, Milanović Z, Mirković MD, Stanković D, Vranješ-Đurić S. Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres. in Applied Radiation and Isotopes. 2020;156:108984.
doi:10.1016/j.apradiso.2019.108984 .

Vukadinović, Aleksandar, Janković, Drina, Radović, Magdalena, Milanović, Zorana, Mirković, Marija D., Stanković, Dragana, Vranješ-Đurić, Sanja, "Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres" in Applied Radiation and Isotopes, 156 (2020):108984,
https://doi.org/10.1016/j.apradiso.2019.108984 . .

TY  - JOUR
AU  - Stanković, Dragana
AU  - Ristić, Slavica M.
AU  - Vukadinović, Aleksandar
AU  - Mirković, Marija D.
AU  - Vladimirov, Sandra S.
AU  - Milanović, Zorana
AU  - Radović, Magdalena
AU  - Mijović, Milica
AU  - Stanković, Dalibor M.
AU  - Sabo, Tibor J.
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8492
AB  - It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes. © The Author(s) 2018.
T2  - Human and Experimental Toxicology
T1  - Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP
VL  - 38
IS  - 4
SP  - 466
EP  - 481
DO  - 10.1177/0960327118819047
ER  - 

@article{
author = "Stanković, Dragana and Ristić, Slavica M. and Vukadinović, Aleksandar and Mirković, Marija D. and Vladimirov, Sandra S. and Milanović, Zorana and Radović, Magdalena and Mijović, Milica and Stanković, Dalibor M. and Sabo, Tibor J. and Vranješ-Đurić, Sanja and Janković, Drina",
year = "2019",
abstract = "It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes. © The Author(s) 2018.",
journal = "Human and Experimental Toxicology",
title = "Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP",
volume = "38",
number = "4",
pages = "466-481",
doi = "10.1177/0960327118819047"
}

Stanković, D., Ristić, S. M., Vukadinović, A., Mirković, M. D., Vladimirov, S. S., Milanović, Z., Radović, M., Mijović, M., Stanković, D. M., Sabo, T. J., Vranješ-Đurić, S.,& Janković, D.. (2019). Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. in Human and Experimental Toxicology, 38(4), 466-481.
https://doi.org/10.1177/0960327118819047

Stanković D, Ristić SM, Vukadinović A, Mirković MD, Vladimirov SS, Milanović Z, Radović M, Mijović M, Stanković DM, Sabo TJ, Vranješ-Đurić S, Janković D. Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. in Human and Experimental Toxicology. 2019;38(4):466-481.
doi:10.1177/0960327118819047 .

Stanković, Dragana, Ristić, Slavica M., Vukadinović, Aleksandar, Mirković, Marija D., Vladimirov, Sandra S., Milanović, Zorana, Radović, Magdalena, Mijović, Milica, Stanković, Dalibor M., Sabo, Tibor J., Vranješ-Đurić, Sanja, Janković, Drina, "Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP" in Human and Experimental Toxicology, 38, no. 4 (2019):466-481,
https://doi.org/10.1177/0960327118819047 . .

TY  - CONF
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Perić, Marko R.
AU  - Vukadinović, Aleksandar
AU  - Vranješ-Đurić, Sanja
PY  - 2019
UR  - https://plus.sr.cobiss.net/opac7/bib/279687436
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8710
AB  - Doze kalibrator je jedan od osnovnih uređaja u nuklearnoj medicini, koji se koristi za merenje aktivnosti (doza) radiofarmaceutika koji se daju pacijentima bilo u dijagnostičke ili u terapijske svrhe. Aktivnosti gama i beta emitera različitih energija moraju da budu izmerene što tačnije da bi izlaganja ljudi (pacijenata) jonizujućem zračenju bila svedena na najmanji mogući nivo, a da se dobiju klinički značajni rezultati. Početna tačnost kalibratora (nesigurnost 5% ili manje) može se vremenom menjati kao rezultat promene pritiska u jonizacionoj komori ili električnog drifta. Zbog toga kontrola kvaliteta doze kalibratora treba da se sprovodi rutinski kako bi se osigurala tačnost i sledljivost merenja.U radu su prikazani rezultati procene nesigurnostipri merenjima aktivnosti radiofarmaceutika u doze kalibratoru u Laboratoriji za radioizotope. Komponente nesigurnosti, koje su važne za ova merenja, identifikuju se i uzimaju u obzir prilikom procene merne nesigurnosti. Razumevanje izvora nesigurnosti i korišćenje odgovarajućih korekcionih faktora mogu minimizirati netačna merenja.
AB  - A dose calibrator is an essential device in a nuclear medicine, utilized for measurement the activity of radiopharmaceuticals administered to patients both for diagnostic and therapeutic purposes. It has to measurethe radioactivity of gamma and beta with different energies precisely for high quality imaging and for applying the right amount of radiation to treat disease. Initial accuracy (uncertainty 5% or less) may change with time as a result of changing pressureof the chamber gas and slow electrical drift. The quality controls should be undertaken on a routine basis to ensure the accuracy and traceability of measurements of the activities of radiopharmaceuticals.The paper presents the results of estimation of uncertainty in the measurement of the activity in the dose calibrator in the Laboratory for radioisotopes. The uncertainty components, that are important for these measurements, are identified and taken into account while estimating the uncertainty of measurement. Understanding the source of uncertainty and using appropriate techniques can minimize inaccurate measurements.
PB  - Београд : Институт за нуклеарне науке "Винча" : Друштво за заштиту од зрачења Србије и Црне Горе
C3  - 30. симпозијум ДЗЗСЦГ : зборник радова
T1  - Procena merne nesigurnosti pri merenju aktivnosti radiofarmaceutika u doze kalibratoru
T1  - Estimation of measurement uncertainty in measuring radiopharmaceutical activity in dose calibrator
SP  - 366
EP  - 372
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8710
ER  - 

@conference{
author = "Janković, Drina and Mirković, Marija D. and Radović, Magdalena and Milanović, Zorana and Perić, Marko R. and Vukadinović, Aleksandar and Vranješ-Đurić, Sanja",
year = "2019",
abstract = "Doze kalibrator je jedan od osnovnih uređaja u nuklearnoj medicini, koji se koristi za merenje aktivnosti (doza) radiofarmaceutika koji se daju pacijentima bilo u dijagnostičke ili u terapijske svrhe. Aktivnosti gama i beta emitera različitih energija moraju da budu izmerene što tačnije da bi izlaganja ljudi (pacijenata) jonizujućem zračenju bila svedena na najmanji mogući nivo, a da se dobiju klinički značajni rezultati. Početna tačnost kalibratora (nesigurnost 5% ili manje) može se vremenom menjati kao rezultat promene pritiska u jonizacionoj komori ili električnog drifta. Zbog toga kontrola kvaliteta doze kalibratora treba da se sprovodi rutinski kako bi se osigurala tačnost i sledljivost merenja.U radu su prikazani rezultati procene nesigurnostipri merenjima aktivnosti radiofarmaceutika u doze kalibratoru u Laboratoriji za radioizotope. Komponente nesigurnosti, koje su važne za ova merenja, identifikuju se i uzimaju u obzir prilikom procene merne nesigurnosti. Razumevanje izvora nesigurnosti i korišćenje odgovarajućih korekcionih faktora mogu minimizirati netačna merenja., A dose calibrator is an essential device in a nuclear medicine, utilized for measurement the activity of radiopharmaceuticals administered to patients both for diagnostic and therapeutic purposes. It has to measurethe radioactivity of gamma and beta with different energies precisely for high quality imaging and for applying the right amount of radiation to treat disease. Initial accuracy (uncertainty 5% or less) may change with time as a result of changing pressureof the chamber gas and slow electrical drift. The quality controls should be undertaken on a routine basis to ensure the accuracy and traceability of measurements of the activities of radiopharmaceuticals.The paper presents the results of estimation of uncertainty in the measurement of the activity in the dose calibrator in the Laboratory for radioisotopes. The uncertainty components, that are important for these measurements, are identified and taken into account while estimating the uncertainty of measurement. Understanding the source of uncertainty and using appropriate techniques can minimize inaccurate measurements.",
publisher = "Београд : Институт за нуклеарне науке "Винча" : Друштво за заштиту од зрачења Србије и Црне Горе",
journal = "30. симпозијум ДЗЗСЦГ : зборник радова",
title = "Procena merne nesigurnosti pri merenju aktivnosti radiofarmaceutika u doze kalibratoru, Estimation of measurement uncertainty in measuring radiopharmaceutical activity in dose calibrator",
pages = "366-372",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8710"
}

Janković, D., Mirković, M. D., Radović, M., Milanović, Z., Perić, M. R., Vukadinović, A.,& Vranješ-Đurić, S.. (2019). Procena merne nesigurnosti pri merenju aktivnosti radiofarmaceutika u doze kalibratoru. in 30. симпозијум ДЗЗСЦГ : зборник радова
Београд : Институт за нуклеарне науке "Винча" : Друштво за заштиту од зрачења Србије и Црне Горе., 366-372.
https://hdl.handle.net/21.15107/rcub_vinar_8710

Janković D, Mirković MD, Radović M, Milanović Z, Perić MR, Vukadinović A, Vranješ-Đurić S. Procena merne nesigurnosti pri merenju aktivnosti radiofarmaceutika u doze kalibratoru. in 30. симпозијум ДЗЗСЦГ : зборник радова. 2019;:366-372.
https://hdl.handle.net/21.15107/rcub_vinar_8710 .

Janković, Drina, Mirković, Marija D., Radović, Magdalena, Milanović, Zorana, Perić, Marko R., Vukadinović, Aleksandar, Vranješ-Đurić, Sanja, "Procena merne nesigurnosti pri merenju aktivnosti radiofarmaceutika u doze kalibratoru" in 30. симпозијум ДЗЗСЦГ : зборник радова (2019):366-372,
https://hdl.handle.net/21.15107/rcub_vinar_8710 .

TY  - CONF
AU  - Petrović, Mirjana M.
AU  - Savić, Živorad N.
AU  - Savić, Katarina Ž.
AU  - Savić, Sofija Ž.
AU  - Vasiljević, Aleksandra R.
AU  - Petrović, Dušanka
AU  - Brakočević, Dragana
AU  - Kovljanić, Danica M.
AU  - Radunović, Valentina
AU  - Puletić, Vanja
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Antić, Vojislav
AU  - Jurišić, Vladimir
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11152
PB  - RAD Centre, Niš, Serbia
C3  - RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro
T1  - Clinical significance of radioimmunoassay (RIA) and immunoradiometric assay (IRMA) in endocrinology
SP  - 227
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11152
ER  - 

@conference{
author = "Petrović, Mirjana M. and Savić, Živorad N. and Savić, Katarina Ž. and Savić, Sofija Ž. and Vasiljević, Aleksandra R. and Petrović, Dušanka and Brakočević, Dragana and Kovljanić, Danica M. and Radunović, Valentina and Puletić, Vanja and Janković, Drina and Vukadinović, Aleksandar and Antić, Vojislav and Jurišić, Vladimir",
year = "2019",
publisher = "RAD Centre, Niš, Serbia",
journal = "RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro",
title = "Clinical significance of radioimmunoassay (RIA) and immunoradiometric assay (IRMA) in endocrinology",
pages = "227",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11152"
}

Petrović, M. M., Savić, Ž. N., Savić, K. Ž., Savić, S. Ž., Vasiljević, A. R., Petrović, D., Brakočević, D., Kovljanić, D. M., Radunović, V., Puletić, V., Janković, D., Vukadinović, A., Antić, V.,& Jurišić, V.. (2019). Clinical significance of radioimmunoassay (RIA) and immunoradiometric assay (IRMA) in endocrinology. in RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro
RAD Centre, Niš, Serbia., 227.
https://hdl.handle.net/21.15107/rcub_vinar_11152

Petrović MM, Savić ŽN, Savić KŽ, Savić SŽ, Vasiljević AR, Petrović D, Brakočević D, Kovljanić DM, Radunović V, Puletić V, Janković D, Vukadinović A, Antić V, Jurišić V. Clinical significance of radioimmunoassay (RIA) and immunoradiometric assay (IRMA) in endocrinology. in RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro. 2019;:227.
https://hdl.handle.net/21.15107/rcub_vinar_11152 .

Petrović, Mirjana M., Savić, Živorad N., Savić, Katarina Ž., Savić, Sofija Ž., Vasiljević, Aleksandra R., Petrović, Dušanka, Brakočević, Dragana, Kovljanić, Danica M., Radunović, Valentina, Puletić, Vanja, Janković, Drina, Vukadinović, Aleksandar, Antić, Vojislav, Jurišić, Vladimir, "Clinical significance of radioimmunoassay (RIA) and immunoradiometric assay (IRMA) in endocrinology" in RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro (2019):227,
https://hdl.handle.net/21.15107/rcub_vinar_11152 .

TY  - CONF
AU  - Janković, Drina
AU  - Radović, Magdalena
AU  - Mirković, M
AU  - Vukadinović, Aleksandar
AU  - Perić, Marko R.
AU  - Petrović, Đorđe
AU  - Antić, Bratislav
AU  - Vranješ-Đurić, Sanja
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8067
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals
VL  - 45
IS  - Supp. 1
SP  - S649
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8067
ER  - 

@conference{
author = "Janković, Drina and Radović, Magdalena and Mirković, M and Vukadinović, Aleksandar and Perić, Marko R. and Petrović, Đorđe and Antić, Bratislav and Vranješ-Đurić, Sanja",
year = "2018",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals",
volume = "45",
number = "Supp. 1",
pages = "S649",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8067"
}

Janković, D., Radović, M., Mirković, M., Vukadinović, A., Perić, M. R., Petrović, Đ., Antić, B.,& Vranješ-Đurić, S.. (2018). Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals. in European Journal of Nuclear Medicine and Molecular Imaging, 45(Supp. 1), S649.
https://hdl.handle.net/21.15107/rcub_vinar_8067

Janković D, Radović M, Mirković M, Vukadinović A, Perić MR, Petrović Đ, Antić B, Vranješ-Đurić S. Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals. in European Journal of Nuclear Medicine and Molecular Imaging. 2018;45(Supp. 1):S649.
https://hdl.handle.net/21.15107/rcub_vinar_8067 .

Janković, Drina, Radović, Magdalena, Mirković, M, Vukadinović, Aleksandar, Perić, Marko R., Petrović, Đorđe, Antić, Bratislav, Vranješ-Đurić, Sanja, "Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals" in European Journal of Nuclear Medicine and Molecular Imaging, 45, no. Supp. 1 (2018):S649,
https://hdl.handle.net/21.15107/rcub_vinar_8067 .

TY  - CONF
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Mirković, M
AU  - Radović, Magdalena
AU  - Perić, Marko R.
AU  - Milanović, Zorana
AU  - Stanković, D
AU  - Vranješ-Đurić, Sanja
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8068
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Preparation and radiolabeling of surface-modified magnetic nanoparticles with technetium-99m as potential radiopharmaceuticals in nuclear medicine
VL  - 45
IS  - Supp. 1
SP  - S654
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8068
ER  - 

@conference{
author = "Vukadinović, Aleksandar and Janković, Drina and Mirković, M and Radović, Magdalena and Perić, Marko R. and Milanović, Zorana and Stanković, D and Vranješ-Đurić, Sanja",
year = "2018",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Preparation and radiolabeling of surface-modified magnetic nanoparticles with technetium-99m as potential radiopharmaceuticals in nuclear medicine",
volume = "45",
number = "Supp. 1",
pages = "S654",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8068"
}

Vukadinović, A., Janković, D., Mirković, M., Radović, M., Perić, M. R., Milanović, Z., Stanković, D.,& Vranješ-Đurić, S.. (2018). Preparation and radiolabeling of surface-modified magnetic nanoparticles with technetium-99m as potential radiopharmaceuticals in nuclear medicine. in European Journal of Nuclear Medicine and Molecular Imaging, 45(Supp. 1), S654.
https://hdl.handle.net/21.15107/rcub_vinar_8068

Vukadinović A, Janković D, Mirković M, Radović M, Perić MR, Milanović Z, Stanković D, Vranješ-Đurić S. Preparation and radiolabeling of surface-modified magnetic nanoparticles with technetium-99m as potential radiopharmaceuticals in nuclear medicine. in European Journal of Nuclear Medicine and Molecular Imaging. 2018;45(Supp. 1):S654.
https://hdl.handle.net/21.15107/rcub_vinar_8068 .

Vukadinović, Aleksandar, Janković, Drina, Mirković, M, Radović, Magdalena, Perić, Marko R., Milanović, Zorana, Stanković, D, Vranješ-Đurić, Sanja, "Preparation and radiolabeling of surface-modified magnetic nanoparticles with technetium-99m as potential radiopharmaceuticals in nuclear medicine" in European Journal of Nuclear Medicine and Molecular Imaging, 45, no. Supp. 1 (2018):S654,
https://hdl.handle.net/21.15107/rcub_vinar_8068 .

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor M.
AU  - Fabian, Martin
AU  - Vukadinović, Aleksandar
AU  - Prijović, Željko
AU  - Dojčinović, Biljana P.
AU  - Antić, Bratislav
PY  - 2018
UR  - http://doi.wiley.com/10.1002/elan.201800357
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7961
AB  - In this work facile one step synthesis of magnesium ferrite (MgFe2O4) nanoparticles decorated on reduced graphene oxide (MgFe@RGO) using a microwave assisted hydrothermal procedure is reported. The synthesized material was characterized with help of several techniques and applied for the modification of glassy carbon electrode. Such prepared electrode was utilized for successive simultaneous detection of structurally similar compounds, 1,2- and 1,4-dihydroxibenzenes (catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. It was found that oxidation current increases linearly with the concentrations of both investigated compounds. Detection limits for both species are ≤0.31 μM. The best analytical response in the presence of both CC and HQ, taking into account peak shape and peak current, was obtained at pH 5.6 utilizing acetate buffer solution. The often-presented species in the surface waters as well as gallic acid and caffeine do not interfere with determination of CC and HQ, while ascorbic acid shows high interference. The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
T2  - Electroanalysis
T1  - A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone
VL  - 30
IS  - 11
SP  - 2620
EP  - 2627
DO  - 10.1002/elan.201800357
ER  - 

@article{
author = "Ognjanović, Miloš and Stanković, Dalibor M. and Fabian, Martin and Vukadinović, Aleksandar and Prijović, Željko and Dojčinović, Biljana P. and Antić, Bratislav",
year = "2018",
abstract = "In this work facile one step synthesis of magnesium ferrite (MgFe2O4) nanoparticles decorated on reduced graphene oxide (MgFe@RGO) using a microwave assisted hydrothermal procedure is reported. The synthesized material was characterized with help of several techniques and applied for the modification of glassy carbon electrode. Such prepared electrode was utilized for successive simultaneous detection of structurally similar compounds, 1,2- and 1,4-dihydroxibenzenes (catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. It was found that oxidation current increases linearly with the concentrations of both investigated compounds. Detection limits for both species are ≤0.31 μM. The best analytical response in the presence of both CC and HQ, taking into account peak shape and peak current, was obtained at pH 5.6 utilizing acetate buffer solution. The often-presented species in the surface waters as well as gallic acid and caffeine do not interfere with determination of CC and HQ, while ascorbic acid shows high interference. The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
journal = "Electroanalysis",
title = "A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone",
volume = "30",
number = "11",
pages = "2620-2627",
doi = "10.1002/elan.201800357"
}

Ognjanović, M., Stanković, D. M., Fabian, M., Vukadinović, A., Prijović, Ž., Dojčinović, B. P.,& Antić, B.. (2018). A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone. in Electroanalysis, 30(11), 2620-2627.
https://doi.org/10.1002/elan.201800357

Ognjanović M, Stanković DM, Fabian M, Vukadinović A, Prijović Ž, Dojčinović BP, Antić B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone. in Electroanalysis. 2018;30(11):2620-2627.
doi:10.1002/elan.201800357 .

Ognjanović, Miloš, Stanković, Dalibor M., Fabian, Martin, Vukadinović, Aleksandar, Prijović, Željko, Dojčinović, Biljana P., Antić, Bratislav, "A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone" in Electroanalysis, 30, no. 11 (2018):2620-2627,
https://doi.org/10.1002/elan.201800357 . .

TY  - JOUR
AU  - Radović, Magdalena
AU  - Mirković, Marija D.
AU  - Perić, Marko R.
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Stanković, Dragana
AU  - Bošković, Marko
AU  - Antić, Bratislav
AU  - Marković, Mirjana
AU  - Vranješ-Đurić, Sanja
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1830
AB  - Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.
T2  - Journal of Materials Chemistry. B
T1  - Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications
VL  - 5
IS  - 44
SP  - 8738
EP  - 8747
DO  - 10.1039/c7tb02075a
ER  - 

@article{
author = "Radović, Magdalena and Mirković, Marija D. and Perić, Marko R. and Janković, Drina and Vukadinović, Aleksandar and Stanković, Dragana and Bošković, Marko and Antić, Bratislav and Marković, Mirjana and Vranješ-Đurić, Sanja",
year = "2017",
abstract = "Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.",
journal = "Journal of Materials Chemistry. B",
title = "Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications",
volume = "5",
number = "44",
pages = "8738-8747",
doi = "10.1039/c7tb02075a"
}

Radović, M., Mirković, M. D., Perić, M. R., Janković, D., Vukadinović, A., Stanković, D., Bošković, M., Antić, B., Marković, M.,& Vranješ-Đurić, S.. (2017). Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications. in Journal of Materials Chemistry. B, 5(44), 8738-8747.
https://doi.org/10.1039/c7tb02075a

Radović M, Mirković MD, Perić MR, Janković D, Vukadinović A, Stanković D, Bošković M, Antić B, Marković M, Vranješ-Đurić S. Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications. in Journal of Materials Chemistry. B. 2017;5(44):8738-8747.
doi:10.1039/c7tb02075a .

Radović, Magdalena, Mirković, Marija D., Perić, Marko R., Janković, Drina, Vukadinović, Aleksandar, Stanković, Dragana, Bošković, Marko, Antić, Bratislav, Marković, Mirjana, Vranješ-Đurić, Sanja, "Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications" in Journal of Materials Chemistry. B, 5, no. 44 (2017):8738-8747,
https://doi.org/10.1039/c7tb02075a . .

TY  - JOUR
AU  - Marković, Bojana M.
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Ranđelović, Danijela V.
AU  - Maksin, Danijela D.
AU  - Spasojević, Vojislav
AU  - Nastasović, Aleksandra B.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1528
AB  - A novel magnetic macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (mPGME) was prepared by suspension copolymerization and functionalized with diethylenetriamine (mPGME-deta). The samples were characterized by Fourier transform infrared spectroscopy (FTIR) analysis, mercury porosimetry, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), atomic force microscopy (AFM) and SQUID magnetometry. The sorption behavior of mPGME-deta toward pertechnetate ions (TcO4-) from aqueous solution was studied. Experimental results indicated relatively fast TcO4- sorption kinetics that depends on pH and ionic strength, with a high removal efficiency of 99% within 180 min in the pH range 3.0-5.0. The pseudo-second-order model yielded the best fit for the kinetic data.
T2  - RSC Advances
T1  - A novel macroporous polymer-inorganic nanocomposite as a sorbent for pertechnetate ions
VL  - 7
IS  - 35
SP  - 21412
EP  - 21421
DO  - 10.1039/c7ra02783d
ER  - 

@article{
author = "Marković, Bojana M. and Janković, Drina and Vukadinović, Aleksandar and Ranđelović, Danijela V. and Maksin, Danijela D. and Spasojević, Vojislav and Nastasović, Aleksandra B.",
year = "2017",
abstract = "A novel magnetic macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (mPGME) was prepared by suspension copolymerization and functionalized with diethylenetriamine (mPGME-deta). The samples were characterized by Fourier transform infrared spectroscopy (FTIR) analysis, mercury porosimetry, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), atomic force microscopy (AFM) and SQUID magnetometry. The sorption behavior of mPGME-deta toward pertechnetate ions (TcO4-) from aqueous solution was studied. Experimental results indicated relatively fast TcO4- sorption kinetics that depends on pH and ionic strength, with a high removal efficiency of 99% within 180 min in the pH range 3.0-5.0. The pseudo-second-order model yielded the best fit for the kinetic data.",
journal = "RSC Advances",
title = "A novel macroporous polymer-inorganic nanocomposite as a sorbent for pertechnetate ions",
volume = "7",
number = "35",
pages = "21412-21421",
doi = "10.1039/c7ra02783d"
}

Marković, B. M., Janković, D., Vukadinović, A., Ranđelović, D. V., Maksin, D. D., Spasojević, V.,& Nastasović, A. B.. (2017). A novel macroporous polymer-inorganic nanocomposite as a sorbent for pertechnetate ions. in RSC Advances, 7(35), 21412-21421.
https://doi.org/10.1039/c7ra02783d

Marković BM, Janković D, Vukadinović A, Ranđelović DV, Maksin DD, Spasojević V, Nastasović AB. A novel macroporous polymer-inorganic nanocomposite as a sorbent for pertechnetate ions. in RSC Advances. 2017;7(35):21412-21421.
doi:10.1039/c7ra02783d .

Marković, Bojana M., Janković, Drina, Vukadinović, Aleksandar, Ranđelović, Danijela V., Maksin, Danijela D., Spasojević, Vojislav, Nastasović, Aleksandra B., "A novel macroporous polymer-inorganic nanocomposite as a sorbent for pertechnetate ions" in RSC Advances, 7, no. 35 (2017):21412-21421,
https://doi.org/10.1039/c7ra02783d . .

TY  - JOUR
AU  - Knežević, Nikola
AU  - Jimenez, Chiara Mauriello
AU  - Albino, Martin
AU  - Vukadinović, Aleksandar
AU  - Mraković, Ana Đ.
AU  - Illés, Erzsébet
AU  - Janaćković, Đorđe T.
AU  - Durand, Jean-Olivier
AU  - Sangregorio, Claudio
AU  - Peddis, Davide
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1775
AB  - Initial results en route toward construction of complex magnetic core-shell silica and organosilica nanotheranostics are presented. Magnetite nanoparticles are synthesized by three different methods and embedded within mesoporous silica and organosilica frameworks by different surfactant-templated procedures to produce three types of core-shell nanoparticles. Magnetite nanoparticles (15 nm in diameter) are embedded within mesoporous silica nanoparticles to produce cell-like material with predominantly one magnetite nuclei-resembling core per nanoparticle, with final particle diameter of ca. 150 nm, specific surface area of 573 m(2)/g and hexagonally structured tubular pores (2.6 nm predominant diameter), extended throughout the volume of nanoparticles. Two forms of spherical core-shell nanoparticles composed of magnetite cores embedded within mesoporous organosilica shells are also obtained by employing ethylene and ethane bridged organobisalkoxysilane precursors. The obtained nanomaterials are characterized by high surface area (978 and 820 m(2)/g), tubular pore morphology (2 and 2.8 nm predominant pore diameters), different diameters (386 and 100-200 nm), in case of ethylene- and ethane-composed organosilica shells, respectively. Different degree of agglomeration of magnetite nanoparticles was also observed in the obtained materials, and in the case of utilization of surfactant-pre-stabilized magnetite nanoparticles for the syntheses, their uniform and non-agglomerated distribution within the shells was noted.
T2  - MRS Advances
T1  - Synthesis and Characterization of Core-Shell Magnetic Mesoporous Silica and Organosilica Nanostructures
VL  - 2
IS  - 19-20
SP  - 1037
EP  - 1045
DO  - 10.1557/adv.2017.69
ER  - 

@article{
author = "Knežević, Nikola and Jimenez, Chiara Mauriello and Albino, Martin and Vukadinović, Aleksandar and Mraković, Ana Đ. and Illés, Erzsébet and Janaćković, Đorđe T. and Durand, Jean-Olivier and Sangregorio, Claudio and Peddis, Davide",
year = "2017",
abstract = "Initial results en route toward construction of complex magnetic core-shell silica and organosilica nanotheranostics are presented. Magnetite nanoparticles are synthesized by three different methods and embedded within mesoporous silica and organosilica frameworks by different surfactant-templated procedures to produce three types of core-shell nanoparticles. Magnetite nanoparticles (15 nm in diameter) are embedded within mesoporous silica nanoparticles to produce cell-like material with predominantly one magnetite nuclei-resembling core per nanoparticle, with final particle diameter of ca. 150 nm, specific surface area of 573 m(2)/g and hexagonally structured tubular pores (2.6 nm predominant diameter), extended throughout the volume of nanoparticles. Two forms of spherical core-shell nanoparticles composed of magnetite cores embedded within mesoporous organosilica shells are also obtained by employing ethylene and ethane bridged organobisalkoxysilane precursors. The obtained nanomaterials are characterized by high surface area (978 and 820 m(2)/g), tubular pore morphology (2 and 2.8 nm predominant pore diameters), different diameters (386 and 100-200 nm), in case of ethylene- and ethane-composed organosilica shells, respectively. Different degree of agglomeration of magnetite nanoparticles was also observed in the obtained materials, and in the case of utilization of surfactant-pre-stabilized magnetite nanoparticles for the syntheses, their uniform and non-agglomerated distribution within the shells was noted.",
journal = "MRS Advances",
title = "Synthesis and Characterization of Core-Shell Magnetic Mesoporous Silica and Organosilica Nanostructures",
volume = "2",
number = "19-20",
pages = "1037-1045",
doi = "10.1557/adv.2017.69"
}

Knežević, N., Jimenez, C. M., Albino, M., Vukadinović, A., Mraković, A. Đ., Illés, E., Janaćković, Đ. T., Durand, J., Sangregorio, C.,& Peddis, D.. (2017). Synthesis and Characterization of Core-Shell Magnetic Mesoporous Silica and Organosilica Nanostructures. in MRS Advances, 2(19-20), 1037-1045.
https://doi.org/10.1557/adv.2017.69

Knežević N, Jimenez CM, Albino M, Vukadinović A, Mraković AĐ, Illés E, Janaćković ĐT, Durand J, Sangregorio C, Peddis D. Synthesis and Characterization of Core-Shell Magnetic Mesoporous Silica and Organosilica Nanostructures. in MRS Advances. 2017;2(19-20):1037-1045.
doi:10.1557/adv.2017.69 .

Knežević, Nikola, Jimenez, Chiara Mauriello, Albino, Martin, Vukadinović, Aleksandar, Mraković, Ana Đ., Illés, Erzsébet, Janaćković, Đorđe T., Durand, Jean-Olivier, Sangregorio, Claudio, Peddis, Davide, "Synthesis and Characterization of Core-Shell Magnetic Mesoporous Silica and Organosilica Nanostructures" in MRS Advances, 2, no. 19-20 (2017):1037-1045,
https://doi.org/10.1557/adv.2017.69 . .

TY  - JOUR
AU  - Lakić, Mladen
AU  - Sabo, Ljubica
AU  - Ristic, Slavica
AU  - Savić, Aleksandar
AU  - Petricevic, Sasa
AU  - Nikolić, Nadežda S.
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Sabo, Tibor J.
AU  - Vranješ-Đurić, Sanja
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/273
AB  - The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O-diethylethylenediamine-N,N-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L) and diacid ligand (L), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley and Sons, Ltd.
T2  - Applied Organometallic Chemistry
T1  - Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent
VL  - 30
IS  - 2
SP  - 81
EP  - 88
DO  - 10.1002/aoc.3401
ER  - 

@article{
author = "Lakić, Mladen and Sabo, Ljubica and Ristic, Slavica and Savić, Aleksandar and Petricevic, Sasa and Nikolić, Nadežda S. and Vukadinović, Aleksandar and Janković, Drina and Sabo, Tibor J. and Vranješ-Đurić, Sanja",
year = "2016",
abstract = "The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O-diethylethylenediamine-N,N-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L) and diacid ligand (L), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley and Sons, Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent",
volume = "30",
number = "2",
pages = "81-88",
doi = "10.1002/aoc.3401"
}

Lakić, M., Sabo, L., Ristic, S., Savić, A., Petricevic, S., Nikolić, N. S., Vukadinović, A., Janković, D., Sabo, T. J.,& Vranješ-Đurić, S.. (2016). Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry, 30(2), 81-88.
https://doi.org/10.1002/aoc.3401

Lakić M, Sabo L, Ristic S, Savić A, Petricevic S, Nikolić NS, Vukadinović A, Janković D, Sabo TJ, Vranješ-Đurić S. Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry. 2016;30(2):81-88.
doi:10.1002/aoc.3401 .

Lakić, Mladen, Sabo, Ljubica, Ristic, Slavica, Savić, Aleksandar, Petricevic, Sasa, Nikolić, Nadežda S., Vukadinović, Aleksandar, Janković, Drina, Sabo, Tibor J., Vranješ-Đurić, Sanja, "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent" in Applied Organometallic Chemistry, 30, no. 2 (2016):81-88,
https://doi.org/10.1002/aoc.3401 . .

TY  - CONF
AU  - Ekmeščić, Bojana
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Ranđelović, Dragana
AU  - Stefanović, I. S.
AU  - Nastasović, Aleksandra B.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9254
AB  - A novel magnetic macroporous poly(glycidyl-co-ethylene glycol
dimethacrylate) (mPGME) synthesized by suspension copolymerization and
functionalized with diethylene triamine (mPGME-deta) was evaluated as
sorbent for pertechnetate ion (TcO4
-
) removal from aqueous solutions.
Atomic force microscopy (AFM) was used for characterization. The kinetics
of TcO4
-
adsorption onto mPGME-deta is relatively fast and depends on pH.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1  - A novel Tc 99m sorbent based on macroporous magnetic polymer
SP  - 641
EP  - 644
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9254
ER  - 

@conference{
author = "Ekmeščić, Bojana and Janković, Drina and Vukadinović, Aleksandar and Ranđelović, Dragana and Stefanović, I. S. and Nastasović, Aleksandra B.",
year = "2016",
abstract = "A novel magnetic macroporous poly(glycidyl-co-ethylene glycol
dimethacrylate) (mPGME) synthesized by suspension copolymerization and
functionalized with diethylene triamine (mPGME-deta) was evaluated as
sorbent for pertechnetate ion (TcO4
-
) removal from aqueous solutions.
Atomic force microscopy (AFM) was used for characterization. The kinetics
of TcO4
-
adsorption onto mPGME-deta is relatively fast and depends on pH.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "A novel Tc 99m sorbent based on macroporous magnetic polymer",
pages = "641-644",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9254"
}

Ekmeščić, B., Janković, D., Vukadinović, A., Ranđelović, D., Stefanović, I. S.,& Nastasović, A. B.. (2016). A novel Tc 99m sorbent based on macroporous magnetic polymer. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 641-644.
https://hdl.handle.net/21.15107/rcub_vinar_9254

Ekmeščić B, Janković D, Vukadinović A, Ranđelović D, Stefanović IS, Nastasović AB. A novel Tc 99m sorbent based on macroporous magnetic polymer. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:641-644.
https://hdl.handle.net/21.15107/rcub_vinar_9254 .

Ekmeščić, Bojana, Janković, Drina, Vukadinović, Aleksandar, Ranđelović, Dragana, Stefanović, I. S., Nastasović, Aleksandra B., "A novel Tc 99m sorbent based on macroporous magnetic polymer" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):641-644,
https://hdl.handle.net/21.15107/rcub_vinar_9254 .

TY  - JOUR
AU  - Lakić, Mladen
AU  - Vukadinović, Aleksandar
AU  - Kalcher, Kurt
AU  - Nikolić, Aleksandar S.
AU  - Stanković, Dalibor M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1292
AB  - This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.
T2  - Talanta
T1  - Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone
VL  - 161
SP  - 668
EP  - 674
DO  - 10.1016/j.talanta.2016.09.029
ER  - 

@article{
author = "Lakić, Mladen and Vukadinović, Aleksandar and Kalcher, Kurt and Nikolić, Aleksandar S. and Stanković, Dalibor M.",
year = "2016",
abstract = "This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.",
journal = "Talanta",
title = "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone",
volume = "161",
pages = "668-674",
doi = "10.1016/j.talanta.2016.09.029"
}

Lakić, M., Vukadinović, A., Kalcher, K., Nikolić, A. S.,& Stanković, D. M.. (2016). Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta, 161, 668-674.
https://doi.org/10.1016/j.talanta.2016.09.029

Lakić M, Vukadinović A, Kalcher K, Nikolić AS, Stanković DM. Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta. 2016;161:668-674.
doi:10.1016/j.talanta.2016.09.029 .

Lakić, Mladen, Vukadinović, Aleksandar, Kalcher, Kurt, Nikolić, Aleksandar S., Stanković, Dalibor M., "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone" in Talanta, 161 (2016):668-674,
https://doi.org/10.1016/j.talanta.2016.09.029 . .