TY  - CONF
AU  - Tomasović, Martina
AU  - Sinik, Marija
AU  - Joksimović, Bojan
AU  - Lacković, Milena
AU  - Samardžić, Vladimir
AU  - Vujović, Marina
AU  - Gluvić, Zoran
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12029
AB  - Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis.
C3  - Endocrine Abstracts
T1  - Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report
DO  - 10.1530/endoabs.81.EP1030
ER  - 

@conference{
author = "Tomasović, Martina and Sinik, Marija and Joksimović, Bojan and Lacković, Milena and Samardžić, Vladimir and Vujović, Marina and Gluvić, Zoran and Obradović, Milan and Zafirović, Sonja and Isenović, Esma R.",
year = "2022",
abstract = "Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis.",
journal = "Endocrine Abstracts",
title = "Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report",
doi = "10.1530/endoabs.81.EP1030"
}

Tomasović, M., Sinik, M., Joksimović, B., Lacković, M., Samardžić, V., Vujović, M., Gluvić, Z., Obradović, M., Zafirović, S.,& Isenović, E. R.. (2022). Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report. in Endocrine Abstracts.
https://doi.org/10.1530/endoabs.81.EP1030

Tomasović M, Sinik M, Joksimović B, Lacković M, Samardžić V, Vujović M, Gluvić Z, Obradović M, Zafirović S, Isenović ER. Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report. in Endocrine Abstracts. 2022;.
doi:10.1530/endoabs.81.EP1030 .

Tomasović, Martina, Sinik, Marija, Joksimović, Bojan, Lacković, Milena, Samardžić, Vladimir, Vujović, Marina, Gluvić, Zoran, Obradović, Milan, Zafirović, Sonja, Isenović, Esma R., "Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report" in Endocrine Abstracts (2022),
https://doi.org/10.1530/endoabs.81.EP1030 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Lacković, Milena
AU  - Samardžić, Vladimir
AU  - Mitrović, Bojan
AU  - Mladenović, Violeta
AU  - Obradović, Milan
AU  - Jevremović, Danimir
AU  - Isenović, Esma R.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12027
AB  - Congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder with mutations in genes involved in cortisol and aldosterone production. Based on overall 21-OHase activity, CAH is divided into classic (C-CAH) and non-classic (NC-CAH). Females who suffered from NC-CAH have had increased infertility rates and higher miscarriage susceptibility. The treatment of CAH in pregnancy is still debatable. We present 22-years-old pregnant female (seventh week of gestation), who is currently under dexamethasone (DEX) since almost seven years for NC-CAH. At presentation, she is normotensive, non-obese, with no signs of hirsutism and Cushing syndrome. Seven days after the first visit, an endocrinologist makes informative talk with the patient and her mother about NC-CAH, pregnancy, and drugsassociated risks. Current Clinical Practice Guideline for CAH treatment suggests the use of protocols approved by Institutional Review Boards at Centers experienced in CAH treatment. In women with CAH who are planning a pregnancy, a close relationship between endocrinologist, reproductive gynaecologist and molecular biologist is of great interest. Prenatal management with DEX is advised in particular circumstances. In remaining, the switch from DEX to other glucocorticoids that do not penetrate placenta is advised
T2  - Clinical Medical Reviews and Case Reports
T1  - Management of Non-Classic Congenital Adrenal Hyperplasia in Pregnant Woman - Non-Referral Center Experience- Case Report
VL  - 6
IS  - 2
DO  - 10.23937/2378-3656/1410257
ER  - 

@article{
author = "Gluvić, Zoran and Lacković, Milena and Samardžić, Vladimir and Mitrović, Bojan and Mladenović, Violeta and Obradović, Milan and Jevremović, Danimir and Isenović, Esma R.",
year = "2019",
abstract = "Congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder with mutations in genes involved in cortisol and aldosterone production. Based on overall 21-OHase activity, CAH is divided into classic (C-CAH) and non-classic (NC-CAH). Females who suffered from NC-CAH have had increased infertility rates and higher miscarriage susceptibility. The treatment of CAH in pregnancy is still debatable. We present 22-years-old pregnant female (seventh week of gestation), who is currently under dexamethasone (DEX) since almost seven years for NC-CAH. At presentation, she is normotensive, non-obese, with no signs of hirsutism and Cushing syndrome. Seven days after the first visit, an endocrinologist makes informative talk with the patient and her mother about NC-CAH, pregnancy, and drugsassociated risks. Current Clinical Practice Guideline for CAH treatment suggests the use of protocols approved by Institutional Review Boards at Centers experienced in CAH treatment. In women with CAH who are planning a pregnancy, a close relationship between endocrinologist, reproductive gynaecologist and molecular biologist is of great interest. Prenatal management with DEX is advised in particular circumstances. In remaining, the switch from DEX to other glucocorticoids that do not penetrate placenta is advised",
journal = "Clinical Medical Reviews and Case Reports",
title = "Management of Non-Classic Congenital Adrenal Hyperplasia in Pregnant Woman - Non-Referral Center Experience- Case Report",
volume = "6",
number = "2",
doi = "10.23937/2378-3656/1410257"
}

Gluvić, Z., Lacković, M., Samardžić, V., Mitrović, B., Mladenović, V., Obradović, M., Jevremović, D.,& Isenović, E. R.. (2019). Management of Non-Classic Congenital Adrenal Hyperplasia in Pregnant Woman - Non-Referral Center Experience- Case Report. in Clinical Medical Reviews and Case Reports, 6(2).
https://doi.org/10.23937/2378-3656/1410257

Gluvić Z, Lacković M, Samardžić V, Mitrović B, Mladenović V, Obradović M, Jevremović D, Isenović ER. Management of Non-Classic Congenital Adrenal Hyperplasia in Pregnant Woman - Non-Referral Center Experience- Case Report. in Clinical Medical Reviews and Case Reports. 2019;6(2).
doi:10.23937/2378-3656/1410257 .

Gluvić, Zoran, Lacković, Milena, Samardžić, Vladimir, Mitrović, Bojan, Mladenović, Violeta, Obradović, Milan, Jevremović, Danimir, Isenović, Esma R., "Management of Non-Classic Congenital Adrenal Hyperplasia in Pregnant Woman - Non-Referral Center Experience- Case Report" in Clinical Medical Reviews and Case Reports, 6, no. 2 (2019),
https://doi.org/10.23937/2378-3656/1410257 . .