TY  - JOUR
AU  - Jović Orsini, Nataša
AU  - Babić-Stojić, Branka S.
AU  - Spasojević, Vojislav
AU  - Calatayud, Maria Pilar
AU  - Cvjetićanin, Nikola
AU  - Goya, Gerardo F.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1835
AB  - Iron oxide magnetic nanoparticles with diameters d, 7 nm LT = d LT = 12 nm, were synthesized by thermal decomposition of Fe(acac)(3). Different experimental conditions, keeping constant concetration of Fe ions in solvent, showed that the heating rates is the most important parameter determining the final particle size. Use of two different solvents, 1-eicosene and 1-octadecene, yielded similar nanoparticle sizes (7.1 nm LT = d LT = 7.5 nm), but different magnetic anisotropies. All samples were superparamagnetic at room temperature. Spin disordering was inferred in samples coated with trioctylphosphine oxide (TOPO) co-ligand in addition to oleic acid and oleyamine. The heating ability of similar to 12 nm-sized nanoparticles dispersed in hexane under alternating magnetic fields (3.98 kA/m LT = H-0 LT = 23.87 kA/m; 229.3 kHz LT = f LT = 828 kHz) has been studied, finding a nearly quadratic dependence upon H-0, as expected from the linear response theory. (C) 2017 Elsevier B.V. All rights reserved.
T2  - Journal of Magnetism and Magnetic Materials
T1  - Magnetic and power absorption measurements on iron oxide nanoparticles synthesized by thermal decomposition of Fe(acac)(3)
VL  - 449
SP  - 286
EP  - 296
DO  - 10.1016/j.jmmm.2017.10.053
ER  - 

@article{
author = "Jović Orsini, Nataša and Babić-Stojić, Branka S. and Spasojević, Vojislav and Calatayud, Maria Pilar and Cvjetićanin, Nikola and Goya, Gerardo F.",
year = "2018",
abstract = "Iron oxide magnetic nanoparticles with diameters d, 7 nm LT = d LT = 12 nm, were synthesized by thermal decomposition of Fe(acac)(3). Different experimental conditions, keeping constant concetration of Fe ions in solvent, showed that the heating rates is the most important parameter determining the final particle size. Use of two different solvents, 1-eicosene and 1-octadecene, yielded similar nanoparticle sizes (7.1 nm LT = d LT = 7.5 nm), but different magnetic anisotropies. All samples were superparamagnetic at room temperature. Spin disordering was inferred in samples coated with trioctylphosphine oxide (TOPO) co-ligand in addition to oleic acid and oleyamine. The heating ability of similar to 12 nm-sized nanoparticles dispersed in hexane under alternating magnetic fields (3.98 kA/m LT = H-0 LT = 23.87 kA/m; 229.3 kHz LT = f LT = 828 kHz) has been studied, finding a nearly quadratic dependence upon H-0, as expected from the linear response theory. (C) 2017 Elsevier B.V. All rights reserved.",
journal = "Journal of Magnetism and Magnetic Materials",
title = "Magnetic and power absorption measurements on iron oxide nanoparticles synthesized by thermal decomposition of Fe(acac)(3)",
volume = "449",
pages = "286-296",
doi = "10.1016/j.jmmm.2017.10.053"
}

Jović Orsini, N., Babić-Stojić, B. S., Spasojević, V., Calatayud, M. P., Cvjetićanin, N.,& Goya, G. F.. (2018). Magnetic and power absorption measurements on iron oxide nanoparticles synthesized by thermal decomposition of Fe(acac)(3). in Journal of Magnetism and Magnetic Materials, 449, 286-296.
https://doi.org/10.1016/j.jmmm.2017.10.053

Jović Orsini N, Babić-Stojić BS, Spasojević V, Calatayud MP, Cvjetićanin N, Goya GF. Magnetic and power absorption measurements on iron oxide nanoparticles synthesized by thermal decomposition of Fe(acac)(3). in Journal of Magnetism and Magnetic Materials. 2018;449:286-296.
doi:10.1016/j.jmmm.2017.10.053 .

Jović Orsini, Nataša, Babić-Stojić, Branka S., Spasojević, Vojislav, Calatayud, Maria Pilar, Cvjetićanin, Nikola, Goya, Gerardo F., "Magnetic and power absorption measurements on iron oxide nanoparticles synthesized by thermal decomposition of Fe(acac)(3)" in Journal of Magnetism and Magnetic Materials, 449 (2018):286-296,
https://doi.org/10.1016/j.jmmm.2017.10.053 . .

TY  - JOUR
AU  - Radović, Magdalena
AU  - Calatayud, Maria Pilar
AU  - Goya, Gerardo F.
AU  - Ricardo Ibarra, Manuel
AU  - Antić, Bratislav
AU  - Spasojević, Vojislav
AU  - Nikolić, Nadežda S.
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Vranješ-Đurić, Sanja
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/234
AB  - Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 +/- 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 +/- 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe3O4-PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, in vitro stability and in vivo biodistribution profile of Y-90-MNPs were compared. Both types of MNPs were Y-90-labeled in reproducible high yield ( GT 97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for in vivo use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the liver (14.58%ID/g for Y-90-Fe3O4-Naked MNPs and 19.61%ID/g for Y-90-Fe3O4-PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of Y-90-Fe3O4-Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for Y-90-Fe3O4-PEG600 MNPs) due to their in vivo agglomeration. The studied radiolabeled magnetic complexes such as Y-90-Fe3O4-PEG600 MNPs constitute a great promise for multiple diagnostic-therapeutic uses combining, for example, MRI-magnetic hyperthermia and regional radiotherapy. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126-134, 2015.
T2  - Journal of Biomedical Materials Research. Part A
T1  - Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy
VL  - 103
IS  - 1
SP  - 126
EP  - 134
DO  - 10.1002/jbm.a.35160
ER  - 

@article{
author = "Radović, Magdalena and Calatayud, Maria Pilar and Goya, Gerardo F. and Ricardo Ibarra, Manuel and Antić, Bratislav and Spasojević, Vojislav and Nikolić, Nadežda S. and Janković, Drina and Mirković, Marija D. and Vranješ-Đurić, Sanja",
year = "2015",
abstract = "Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 +/- 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 +/- 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe3O4-PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, in vitro stability and in vivo biodistribution profile of Y-90-MNPs were compared. Both types of MNPs were Y-90-labeled in reproducible high yield ( GT 97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for in vivo use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the liver (14.58%ID/g for Y-90-Fe3O4-Naked MNPs and 19.61%ID/g for Y-90-Fe3O4-PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of Y-90-Fe3O4-Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for Y-90-Fe3O4-PEG600 MNPs) due to their in vivo agglomeration. The studied radiolabeled magnetic complexes such as Y-90-Fe3O4-PEG600 MNPs constitute a great promise for multiple diagnostic-therapeutic uses combining, for example, MRI-magnetic hyperthermia and regional radiotherapy. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126-134, 2015.",
journal = "Journal of Biomedical Materials Research. Part A",
title = "Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy",
volume = "103",
number = "1",
pages = "126-134",
doi = "10.1002/jbm.a.35160"
}

Radović, M., Calatayud, M. P., Goya, G. F., Ricardo Ibarra, M., Antić, B., Spasojević, V., Nikolić, N. S., Janković, D., Mirković, M. D.,& Vranješ-Đurić, S.. (2015). Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy. in Journal of Biomedical Materials Research. Part A, 103(1), 126-134.
https://doi.org/10.1002/jbm.a.35160

Radović M, Calatayud MP, Goya GF, Ricardo Ibarra M, Antić B, Spasojević V, Nikolić NS, Janković D, Mirković MD, Vranješ-Đurić S. Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy. in Journal of Biomedical Materials Research. Part A. 2015;103(1):126-134.
doi:10.1002/jbm.a.35160 .

Radović, Magdalena, Calatayud, Maria Pilar, Goya, Gerardo F., Ricardo Ibarra, Manuel, Antić, Bratislav, Spasojević, Vojislav, Nikolić, Nadežda S., Janković, Drina, Mirković, Marija D., Vranješ-Đurić, Sanja, "Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy" in Journal of Biomedical Materials Research. Part A, 103, no. 1 (2015):126-134,
https://doi.org/10.1002/jbm.a.35160 . .

TY  - JOUR
AU  - Jović, Nataša G.
AU  - Calatayud, Maria Pilar
AU  - Sanz, Beatriz
AU  - Montone, Amelia
AU  - Goya, Gerardo F.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/137
AB  - Hybrid structures composed of exfoliated expanded graphite (EG) and iron oxide nanocrystals were produced by an ex situ process. The iron oxide nanoparticles coated with meso-2,3-dimercaptosuccinic acid (DMSA), or poly(acrylic acid) (PAA) were integrated onto the exfoliated EG flakes by mixing their aqueous suspensions at room temperature under the support of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinnimide (NHS). EG flakes both naked and functionalized with branched polyethylenimine (PEI) were employed. Complete integration of the two constituents was achieved and stability was maintained for more than 12 months. No preferential spatial distribution of anchoring sites for attachment of iron oxide nanoparticles was observed, regardless of whether the EG flakes were used naked or functionalized with PEI molecules. The structural and physicochemical characteristics of the exfoliated expanded graphite and its hybrid nano-structures were investigated by SEM, TEM, FTIR and Raman techniques.
T2  - Journal of the Serbian Chemical Society
T1  - Ex situ integration of iron oxide nanoparticles onto exfoliated expanded graphite flakes in aqueous suspension
VL  - 79
IS  - 9
SP  - 1155
EP  - 1167
DO  - 10.2298/JSC131121019J
ER  - 

@article{
author = "Jović, Nataša G. and Calatayud, Maria Pilar and Sanz, Beatriz and Montone, Amelia and Goya, Gerardo F.",
year = "2014",
abstract = "Hybrid structures composed of exfoliated expanded graphite (EG) and iron oxide nanocrystals were produced by an ex situ process. The iron oxide nanoparticles coated with meso-2,3-dimercaptosuccinic acid (DMSA), or poly(acrylic acid) (PAA) were integrated onto the exfoliated EG flakes by mixing their aqueous suspensions at room temperature under the support of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinnimide (NHS). EG flakes both naked and functionalized with branched polyethylenimine (PEI) were employed. Complete integration of the two constituents was achieved and stability was maintained for more than 12 months. No preferential spatial distribution of anchoring sites for attachment of iron oxide nanoparticles was observed, regardless of whether the EG flakes were used naked or functionalized with PEI molecules. The structural and physicochemical characteristics of the exfoliated expanded graphite and its hybrid nano-structures were investigated by SEM, TEM, FTIR and Raman techniques.",
journal = "Journal of the Serbian Chemical Society",
title = "Ex situ integration of iron oxide nanoparticles onto exfoliated expanded graphite flakes in aqueous suspension",
volume = "79",
number = "9",
pages = "1155-1167",
doi = "10.2298/JSC131121019J"
}

Jović, N. G., Calatayud, M. P., Sanz, B., Montone, A.,& Goya, G. F.. (2014). Ex situ integration of iron oxide nanoparticles onto exfoliated expanded graphite flakes in aqueous suspension. in Journal of the Serbian Chemical Society, 79(9), 1155-1167.
https://doi.org/10.2298/JSC131121019J

Jović NG, Calatayud MP, Sanz B, Montone A, Goya GF. Ex situ integration of iron oxide nanoparticles onto exfoliated expanded graphite flakes in aqueous suspension. in Journal of the Serbian Chemical Society. 2014;79(9):1155-1167.
doi:10.2298/JSC131121019J .

Jović, Nataša G., Calatayud, Maria Pilar, Sanz, Beatriz, Montone, Amelia, Goya, Gerardo F., "Ex situ integration of iron oxide nanoparticles onto exfoliated expanded graphite flakes in aqueous suspension" in Journal of the Serbian Chemical Society, 79, no. 9 (2014):1155-1167,
https://doi.org/10.2298/JSC131121019J . .

TY  - JOUR
AU  - Radović, Magdalena
AU  - Vranješ-Đurić, Sanja
AU  - Nikolić, Nadežda S.
AU  - Janković, Drina
AU  - Goya, Gerardo F.
AU  - Torres, Teobaldo E.
AU  - Calatayud, Maria Pilar
AU  - Bruvera, Ignacio J.
AU  - Ibarra, M. Ricardo
AU  - Spasojević, Vojislav
AU  - Jančar, Boštjan
AU  - Antić, Bratislav
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5175
AB  - Radio labeled albumin microspheres with encapsulated citric acid-coated magnetite nanoparticles were developed as a targeting approach to localize both radioactivity and magnetic energy at the tumor site. We present in vitro and in vivo studies of yttrium-90 (Y-90)-labeled human scrum albumin magnetic microspheres (HSAMMS) as a multifunctional agent for possible applications in a bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS were produced using a modified emulsification-heat stabilization technique and contained 11 nm magnetite nanoparticles coated with citric acid, distributed as inhomogeneous clusters within the albumin microspheres. The size, size distribution and the morphology of magnetite nanoparticles and HSAMMS were determined by FESEM, HRTEM and SEM/FIB dual beam. The average particle size of the complete HSAMMS was 20 mu m, and they exhibited superparamagnetic behavior at room temperature. The in vitro experiments (in saline and human serum) revealed the high stability of the labeled HSAMMS in saline and human serum after 72 h. Following the intravenous administration of the Y-90-HSAMMS in rats, 88.81% of the activity localizes in the lungs after 1 h, with 82.67% remaining after 72 h. These data on Y-90-HSAMMS provide good evidence for their potential use in bimodal radionuclide-hyperthermia cancer therapy.
T2  - Journal of Materials Chemistry
T1  - Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy
VL  - 22
IS  - 45
SP  - 24017
EP  - 24025
DO  - 10.1039/c2jm35593k
ER  - 

@article{
author = "Radović, Magdalena and Vranješ-Đurić, Sanja and Nikolić, Nadežda S. and Janković, Drina and Goya, Gerardo F. and Torres, Teobaldo E. and Calatayud, Maria Pilar and Bruvera, Ignacio J. and Ibarra, M. Ricardo and Spasojević, Vojislav and Jančar, Boštjan and Antić, Bratislav",
year = "2012",
abstract = "Radio labeled albumin microspheres with encapsulated citric acid-coated magnetite nanoparticles were developed as a targeting approach to localize both radioactivity and magnetic energy at the tumor site. We present in vitro and in vivo studies of yttrium-90 (Y-90)-labeled human scrum albumin magnetic microspheres (HSAMMS) as a multifunctional agent for possible applications in a bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS were produced using a modified emulsification-heat stabilization technique and contained 11 nm magnetite nanoparticles coated with citric acid, distributed as inhomogeneous clusters within the albumin microspheres. The size, size distribution and the morphology of magnetite nanoparticles and HSAMMS were determined by FESEM, HRTEM and SEM/FIB dual beam. The average particle size of the complete HSAMMS was 20 mu m, and they exhibited superparamagnetic behavior at room temperature. The in vitro experiments (in saline and human serum) revealed the high stability of the labeled HSAMMS in saline and human serum after 72 h. Following the intravenous administration of the Y-90-HSAMMS in rats, 88.81% of the activity localizes in the lungs after 1 h, with 82.67% remaining after 72 h. These data on Y-90-HSAMMS provide good evidence for their potential use in bimodal radionuclide-hyperthermia cancer therapy.",
journal = "Journal of Materials Chemistry",
title = "Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy",
volume = "22",
number = "45",
pages = "24017-24025",
doi = "10.1039/c2jm35593k"
}

Radović, M., Vranješ-Đurić, S., Nikolić, N. S., Janković, D., Goya, G. F., Torres, T. E., Calatayud, M. P., Bruvera, I. J., Ibarra, M. R., Spasojević, V., Jančar, B.,& Antić, B.. (2012). Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy. in Journal of Materials Chemistry, 22(45), 24017-24025.
https://doi.org/10.1039/c2jm35593k

Radović M, Vranješ-Đurić S, Nikolić NS, Janković D, Goya GF, Torres TE, Calatayud MP, Bruvera IJ, Ibarra MR, Spasojević V, Jančar B, Antić B. Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy. in Journal of Materials Chemistry. 2012;22(45):24017-24025.
doi:10.1039/c2jm35593k .

Radović, Magdalena, Vranješ-Đurić, Sanja, Nikolić, Nadežda S., Janković, Drina, Goya, Gerardo F., Torres, Teobaldo E., Calatayud, Maria Pilar, Bruvera, Ignacio J., Ibarra, M. Ricardo, Spasojević, Vojislav, Jančar, Boštjan, Antić, Bratislav, "Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy" in Journal of Materials Chemistry, 22, no. 45 (2012):24017-24025,
https://doi.org/10.1039/c2jm35593k . .