TY  - JOUR
AU  - Željić, Katarina
AU  - Jovanović, Ivan G.
AU  - Jovanović, Jasmina
AU  - Magić, Zvonko
AU  - Stanković, Aleksandra
AU  - Šupić, Gordana
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/03009734.2018.1439551
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7630
AB  - Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.
T2  - Upsala Journal of Medical Sciences
T1  - MicroRNA meta-signature of oral cancer: evidence from a meta-analysis
VL  - 123
IS  - 1
SP  - 43
EP  - 49
DO  - 10.1080/03009734.2018.1439551
ER  - 

@article{
author = "Željić, Katarina and Jovanović, Ivan G. and Jovanović, Jasmina and Magić, Zvonko and Stanković, Aleksandra and Šupić, Gordana",
year = "2018",
abstract = "Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.",
journal = "Upsala Journal of Medical Sciences",
title = "MicroRNA meta-signature of oral cancer: evidence from a meta-analysis",
volume = "123",
number = "1",
pages = "43-49",
doi = "10.1080/03009734.2018.1439551"
}

Željić, K., Jovanović, I. G., Jovanović, J., Magić, Z., Stanković, A.,& Šupić, G.. (2018). MicroRNA meta-signature of oral cancer: evidence from a meta-analysis. in Upsala Journal of Medical Sciences, 123(1), 43-49.
https://doi.org/10.1080/03009734.2018.1439551

Željić K, Jovanović IG, Jovanović J, Magić Z, Stanković A, Šupić G. MicroRNA meta-signature of oral cancer: evidence from a meta-analysis. in Upsala Journal of Medical Sciences. 2018;123(1):43-49.
doi:10.1080/03009734.2018.1439551 .

Željić, Katarina, Jovanović, Ivan G., Jovanović, Jasmina, Magić, Zvonko, Stanković, Aleksandra, Šupić, Gordana, "MicroRNA meta-signature of oral cancer: evidence from a meta-analysis" in Upsala Journal of Medical Sciences, 123, no. 1 (2018):43-49,
https://doi.org/10.1080/03009734.2018.1439551 . .

TY  - JOUR
AU  - Jovanović, Ivan G.
AU  - Živković, Maja
AU  - Jovanović, Jasmina
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6047
AB  - MicroRNAs (miRs) are short, non-coding RNAs that regulate gene expression by absolute or partial binding to mRNA, which results in transcript degradation and translation blocking. Atherosclerosis, as a complex and progressive disease, represents one of the main causes of cardiovascular clinical complications and even death. We applied co-inertia analysis (CIA) as a novel computation method, to determine which miRs are potentially associated with differences in gene expression levels originating from microarray data of early and advanced atherosclerotic plaque. As the CIA has not been applied in the field of atherosclerosis yet, we hypothesized that using CIA we can get novel information about the miRs that have significant role in early phase of disease or in severe phase of disease. The characteristic split in the data along the axes of performed CIA showed the difference in the gene expression pattern between early atherosclerosis and advanced atherosclerotic plaque. The advanced atherosclerotic plaques showed more homogenous gene expression pattern than early atherosclerosis samples. In early carotid lesions five out of five algorithms predicted miR-24, four out of five predicted miR-155, miR-145, and miR-100 as early active miRs. These miRs could be protective in plaque evolution context because they were not active in advanced plaques according to our results. They were reported previously as atheroprotective, which in a way represents confirmation of CIA application in atherosclerosis. We detected 13 new miRs which could be active in early plaque phenotype according to CIA prediction. In the advanced plaques we predicted miR-221, miR-222, miR-127 and miR-146 which were previously revealed to have atherogenic properties. In addition to miRs that have literature support, we also found new 8 miRs that, with described function so far, could present a novelty in research of atherosclerotic plaque evolution. All of these examples show that CIA results have a great potential to be of interest in future research in atherosclerotic plaque progression. We validated the applicability of CIA in the field of atherosclerosis, but we also found new interesting miR competitors that have strong potential to serve as markers and plaque development factors. These results should be experimentally confirmed in further research with ultimate goal to discover new mediators and blood markers, which could improve the prevention and therapy of this complex disease. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Medical Hypotheses
T1  - The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque
VL  - 83
IS  - 1
SP  - 11
EP  - 15
DO  - 10.1016/j.mehy.2014.04.019
ER  - 

@article{
author = "Jovanović, Ivan G. and Živković, Maja and Jovanović, Jasmina and Đurić, Tamara and Stanković, Aleksandra",
year = "2014",
abstract = "MicroRNAs (miRs) are short, non-coding RNAs that regulate gene expression by absolute or partial binding to mRNA, which results in transcript degradation and translation blocking. Atherosclerosis, as a complex and progressive disease, represents one of the main causes of cardiovascular clinical complications and even death. We applied co-inertia analysis (CIA) as a novel computation method, to determine which miRs are potentially associated with differences in gene expression levels originating from microarray data of early and advanced atherosclerotic plaque. As the CIA has not been applied in the field of atherosclerosis yet, we hypothesized that using CIA we can get novel information about the miRs that have significant role in early phase of disease or in severe phase of disease. The characteristic split in the data along the axes of performed CIA showed the difference in the gene expression pattern between early atherosclerosis and advanced atherosclerotic plaque. The advanced atherosclerotic plaques showed more homogenous gene expression pattern than early atherosclerosis samples. In early carotid lesions five out of five algorithms predicted miR-24, four out of five predicted miR-155, miR-145, and miR-100 as early active miRs. These miRs could be protective in plaque evolution context because they were not active in advanced plaques according to our results. They were reported previously as atheroprotective, which in a way represents confirmation of CIA application in atherosclerosis. We detected 13 new miRs which could be active in early plaque phenotype according to CIA prediction. In the advanced plaques we predicted miR-221, miR-222, miR-127 and miR-146 which were previously revealed to have atherogenic properties. In addition to miRs that have literature support, we also found new 8 miRs that, with described function so far, could present a novelty in research of atherosclerotic plaque evolution. All of these examples show that CIA results have a great potential to be of interest in future research in atherosclerotic plaque progression. We validated the applicability of CIA in the field of atherosclerosis, but we also found new interesting miR competitors that have strong potential to serve as markers and plaque development factors. These results should be experimentally confirmed in further research with ultimate goal to discover new mediators and blood markers, which could improve the prevention and therapy of this complex disease. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Medical Hypotheses",
title = "The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque",
volume = "83",
number = "1",
pages = "11-15",
doi = "10.1016/j.mehy.2014.04.019"
}

Jovanović, I. G., Živković, M., Jovanović, J., Đurić, T.,& Stanković, A.. (2014). The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. in Medical Hypotheses, 83(1), 11-15.
https://doi.org/10.1016/j.mehy.2014.04.019

Jovanović IG, Živković M, Jovanović J, Đurić T, Stanković A. The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. in Medical Hypotheses. 2014;83(1):11-15.
doi:10.1016/j.mehy.2014.04.019 .

Jovanović, Ivan G., Živković, Maja, Jovanović, Jasmina, Đurić, Tamara, Stanković, Aleksandra, "The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque" in Medical Hypotheses, 83, no. 1 (2014):11-15,
https://doi.org/10.1016/j.mehy.2014.04.019 . .