TY  - JOUR
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Kolaković, Ana
AU  - Jekić, Đole
AU  - Selaković, Vesna
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4129
AB  - Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.
T2  - Journal of Clinical Laboratory Analysis
T1  - Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis
VL  - 24
IS  - 4
SP  - 246
EP  - 251
DO  - 10.1002/jcla.20393
ER  - 

@article{
author = "Đurić, Tamara and Živković, Maja and Stanković, Aleksandra and Kolaković, Ana and Jekić, Đole and Selaković, Vesna and Alavantić, Dragan",
year = "2010",
abstract = "Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.",
journal = "Journal of Clinical Laboratory Analysis",
title = "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis",
volume = "24",
number = "4",
pages = "246-251",
doi = "10.1002/jcla.20393"
}

Đurić, T., Živković, M., Stanković, A., Kolaković, A., Jekić, Đ., Selaković, V.,& Alavantić, D.. (2010). Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis, 24(4), 246-251.
https://doi.org/10.1002/jcla.20393

Đurić T, Živković M, Stanković A, Kolaković A, Jekić Đ, Selaković V, Alavantić D. Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis. 2010;24(4):246-251.
doi:10.1002/jcla.20393 .

Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, Kolaković, Ana, Jekić, Đole, Selaković, Vesna, Alavantić, Dragan, "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis" in Journal of Clinical Laboratory Analysis, 24, no. 4 (2010):246-251,
https://doi.org/10.1002/jcla.20393 . .

TY  - JOUR
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Radak, Đorđe J.
AU  - Jekić, Đole
AU  - Radak, Sandra
AU  - Stojković, Ljiljana S.
AU  - Raičević, Ranko
AU  - Stanković, Aleksandra
AU  - Alavantić, Dragan
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3571
AB  - Objectives: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low-and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. Design and methods: The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR. Results: There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p LT 0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI = 1.0-5.5, p=0.048). Conclusions: Subjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis
VL  - 41
IS  - 16-17
SP  - 1326
EP  - 1329
DO  - 10.1016/j.clinbiochem.2008.08.081
ER  - 

@article{
author = "Đurić, Tamara and Živković, Maja and Radak, Đorđe J. and Jekić, Đole and Radak, Sandra and Stojković, Ljiljana S. and Raičević, Ranko and Stanković, Aleksandra and Alavantić, Dragan",
year = "2008",
abstract = "Objectives: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low-and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. Design and methods: The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR. Results: There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p LT 0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI = 1.0-5.5, p=0.048). Conclusions: Subjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis",
volume = "41",
number = "16-17",
pages = "1326-1329",
doi = "10.1016/j.clinbiochem.2008.08.081"
}

Đurić, T., Živković, M., Radak, Đ. J., Jekić, Đ., Radak, S., Stojković, L. S., Raičević, R., Stanković, A.,& Alavantić, D.. (2008). Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis. in Clinical Biochemistry, 41(16-17), 1326-1329.
https://doi.org/10.1016/j.clinbiochem.2008.08.081

Đurić T, Živković M, Radak ĐJ, Jekić Đ, Radak S, Stojković LS, Raičević R, Stanković A, Alavantić D. Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis. in Clinical Biochemistry. 2008;41(16-17):1326-1329.
doi:10.1016/j.clinbiochem.2008.08.081 .

Đurić, Tamara, Živković, Maja, Radak, Đorđe J., Jekić, Đole, Radak, Sandra, Stojković, Ljiljana S., Raičević, Ranko, Stanković, Aleksandra, Alavantić, Dragan, "Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis" in Clinical Biochemistry, 41, no. 16-17 (2008):1326-1329,
https://doi.org/10.1016/j.clinbiochem.2008.08.081 . .