TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Kolaković, Ana
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Bundalo, Maja M.
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1045
AB  - Background and Aims: The principal biologic effects of the renin-angiotensin system are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R expression, with both its, and AT1Rs activity, linked to atherosclerosis. Target sites for miR-155 lie within the 3 UTR of the human AT1R gene, and include the AT1R A1166C polymorphism. Thus far, only levels of circulating miR-155 have been investigated with respect to A1166C genotypes. We hypothesized that the A1166C polymorphism could correlate with different, ultra-sonographically defined plaque phenotypes, as well as with an altered expression of AT1R mRNA and protein in human carotid plaques (CP), and altered expression of miR-155 in patients with advanced atherosclerosis. Methods: Our study cohort comprised 411 patients with advanced carotid atherosclerosis (298 hyperechoic; 113 hypoechoic plaques). PCR analyses identified A1166C genotypes; quantitative real-time PCR determined AT1R and miR-155 expression levels, with AT1R protein expression evaluated by western blot. Results: Genotypes containing the C allele bore a significant association with the hypoechoic plaque phenotype (adjusted OR 1.87, 95% CI 1.16-3.00, p = 0.01). The expression of AT1R mRNA and miR-155 were significantly up-regulated in the CPs of CC genotype carriers compared to the AA/AC genotypes (p = 0.032, p = 0.015, respectively). AT1R protein expression was also significantly higher for CC genotypes (p LT 0.01). Conclusion: Our results indicate that the AT1R A1166C polymorphism impacts an ultrasonographicallydefined human plaque phenotype, with intra-plaque AT1R and miR-155 expression altered in advanced carotid atherosclerosis. Validation and replication of these data should contribute to an improved personalized therapy with which to prevent carotid atherosclerosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier
T2  - Atherosclerosis
T1  - Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques
VL  - 248
SP  - 132
EP  - 139
DO  - 10.1016/j.atherosclerosis.2016.02.032
ER  - 

@article{
author = "Stanković, Aleksandra and Kolaković, Ana and Živković, Maja and Đurić, Tamara and Bundalo, Maja M. and Končar, Igor and Davidović, Lazar and Alavantić, Dragan",
year = "2016",
abstract = "Background and Aims: The principal biologic effects of the renin-angiotensin system are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R expression, with both its, and AT1Rs activity, linked to atherosclerosis. Target sites for miR-155 lie within the 3 UTR of the human AT1R gene, and include the AT1R A1166C polymorphism. Thus far, only levels of circulating miR-155 have been investigated with respect to A1166C genotypes. We hypothesized that the A1166C polymorphism could correlate with different, ultra-sonographically defined plaque phenotypes, as well as with an altered expression of AT1R mRNA and protein in human carotid plaques (CP), and altered expression of miR-155 in patients with advanced atherosclerosis. Methods: Our study cohort comprised 411 patients with advanced carotid atherosclerosis (298 hyperechoic; 113 hypoechoic plaques). PCR analyses identified A1166C genotypes; quantitative real-time PCR determined AT1R and miR-155 expression levels, with AT1R protein expression evaluated by western blot. Results: Genotypes containing the C allele bore a significant association with the hypoechoic plaque phenotype (adjusted OR 1.87, 95% CI 1.16-3.00, p = 0.01). The expression of AT1R mRNA and miR-155 were significantly up-regulated in the CPs of CC genotype carriers compared to the AA/AC genotypes (p = 0.032, p = 0.015, respectively). AT1R protein expression was also significantly higher for CC genotypes (p LT 0.01). Conclusion: Our results indicate that the AT1R A1166C polymorphism impacts an ultrasonographicallydefined human plaque phenotype, with intra-plaque AT1R and miR-155 expression altered in advanced carotid atherosclerosis. Validation and replication of these data should contribute to an improved personalized therapy with which to prevent carotid atherosclerosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Atherosclerosis",
title = "Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques",
volume = "248",
pages = "132-139",
doi = "10.1016/j.atherosclerosis.2016.02.032"
}

Stanković, A., Kolaković, A., Živković, M., Đurić, T., Bundalo, M. M., Končar, I., Davidović, L.,& Alavantić, D.. (2016). Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques. in Atherosclerosis
Elsevier., 248, 132-139.
https://doi.org/10.1016/j.atherosclerosis.2016.02.032

Stanković A, Kolaković A, Živković M, Đurić T, Bundalo MM, Končar I, Davidović L, Alavantić D. Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques. in Atherosclerosis. 2016;248:132-139.
doi:10.1016/j.atherosclerosis.2016.02.032 .

Stanković, Aleksandra, Kolaković, Ana, Živković, Maja, Đurić, Tamara, Bundalo, Maja M., Končar, Igor, Davidović, Lazar, Alavantić, Dragan, "Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques" in Atherosclerosis, 248 (2016):132-139,
https://doi.org/10.1016/j.atherosclerosis.2016.02.032 . .

TY  - JOUR
AU  - Kolaković, Ana
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Radak, Đorđe J.
AU  - Alavantić, Dragan
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1123
AB  - Background: The angiotensin II type 2 receptor (AT2R) - 1332 A/G polymorphism has been denoted as functional and associated with certain cardiovascular disease phenotypes. However, there are no studies considering the association of this gene polymorphism with carotid atherosclerosis (CA) and cerebrovascular events. Therefore, the aim of our study was to investigate a possible association of the AT2R - 1332 A/G polymorphism with the occurrence of carotid plaques (CPs) and history of cerebrovascular insult (CVI) in advanced CA. Methods: The study group included 381 controls and 509 patients with CA consecutively admitted for endarterectomy. Genotyping was determined by polymerase chain reaction-restriction fragment length polymorphism method. The association was analyzed separately for males and females because the AT2R gene is located on the X chromosome. Results: The AT2R - 1332 GG genotype was associated with the advanced CA in the female study group (recessive model of inheritance, AA+AG versus GG; adjusted odds ratio [OR] = 2.25; 95% confidence interval [CI] 1.17-4.33; P=.01). In the male subgroup of patients with CA, the significant overrepresentation of G/- hemizygote was detected in patients with CVI compared to male patients without this event (crude OR = 2.05, 95% CI 1.20-3.50, P=.008). Conclusions: This study suggests a gender-specific association between the AT2R -1332 A/G polymorphism and the occurrence of CP and the history of CVI in advanced CA, but further replication studies are needed. (C) 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
T2  - Journal of Stroke and Cerebrovascular Diseases
T1  - Gender-Specific Association between Angiotensin II Type 2 Receptor-1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis
VL  - 25
IS  - 7
SP  - 1622
EP  - 1630
DO  - 10.1016/j.jstrokecerebrovasdis.2016.03.011
ER  - 

@article{
author = "Kolaković, Ana and Stanković, Aleksandra and Đurić, Tamara and Živković, Maja and Končar, Igor and Davidović, Lazar and Radak, Đorđe J. and Alavantić, Dragan",
year = "2016",
abstract = "Background: The angiotensin II type 2 receptor (AT2R) - 1332 A/G polymorphism has been denoted as functional and associated with certain cardiovascular disease phenotypes. However, there are no studies considering the association of this gene polymorphism with carotid atherosclerosis (CA) and cerebrovascular events. Therefore, the aim of our study was to investigate a possible association of the AT2R - 1332 A/G polymorphism with the occurrence of carotid plaques (CPs) and history of cerebrovascular insult (CVI) in advanced CA. Methods: The study group included 381 controls and 509 patients with CA consecutively admitted for endarterectomy. Genotyping was determined by polymerase chain reaction-restriction fragment length polymorphism method. The association was analyzed separately for males and females because the AT2R gene is located on the X chromosome. Results: The AT2R - 1332 GG genotype was associated with the advanced CA in the female study group (recessive model of inheritance, AA+AG versus GG; adjusted odds ratio [OR] = 2.25; 95% confidence interval [CI] 1.17-4.33; P=.01). In the male subgroup of patients with CA, the significant overrepresentation of G/- hemizygote was detected in patients with CVI compared to male patients without this event (crude OR = 2.05, 95% CI 1.20-3.50, P=.008). Conclusions: This study suggests a gender-specific association between the AT2R -1332 A/G polymorphism and the occurrence of CP and the history of CVI in advanced CA, but further replication studies are needed. (C) 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.",
journal = "Journal of Stroke and Cerebrovascular Diseases",
title = "Gender-Specific Association between Angiotensin II Type 2 Receptor-1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis",
volume = "25",
number = "7",
pages = "1622-1630",
doi = "10.1016/j.jstrokecerebrovasdis.2016.03.011"
}

Kolaković, A., Stanković, A., Đurić, T., Živković, M., Končar, I., Davidović, L., Radak, Đ. J.,& Alavantić, D.. (2016). Gender-Specific Association between Angiotensin II Type 2 Receptor-1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases, 25(7), 1622-1630.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.011

Kolaković A, Stanković A, Đurić T, Živković M, Končar I, Davidović L, Radak ĐJ, Alavantić D. Gender-Specific Association between Angiotensin II Type 2 Receptor-1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases. 2016;25(7):1622-1630.
doi:10.1016/j.jstrokecerebrovasdis.2016.03.011 .

Kolaković, Ana, Stanković, Aleksandra, Đurić, Tamara, Živković, Maja, Končar, Igor, Davidović, Lazar, Radak, Đorđe J., Alavantić, Dragan, "Gender-Specific Association between Angiotensin II Type 2 Receptor-1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis" in Journal of Stroke and Cerebrovascular Diseases, 25, no. 7 (2016):1622-1630,
https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.011 . .

TY  - JOUR
AU  - Životić, Ivan
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Đorđević, Ana
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1126
AB  - Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis ( GT 70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20-4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.
T2  - Experimental Biology and Medicine
T1  - 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner
VL  - 241
IS  - 11
SP  - 1210
EP  - 1216
DO  - 10.1177/1535370216636718
ER  - 

@article{
author = "Životić, Ivan and Đurić, Tamara and Stanković, Aleksandra and Đorđević, Ana and Končar, Igor and Davidović, Lazar and Alavantić, Dragan and Živković, Maja",
year = "2016",
abstract = "Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis ( GT 70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20-4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.",
journal = "Experimental Biology and Medicine",
title = "9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner",
volume = "241",
number = "11",
pages = "1210-1216",
doi = "10.1177/1535370216636718"
}

Životić, I., Đurić, T., Stanković, A., Đorđević, A., Končar, I., Davidović, L., Alavantić, D.,& Živković, M.. (2016). 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner. in Experimental Biology and Medicine, 241(11), 1210-1216.
https://doi.org/10.1177/1535370216636718

Životić I, Đurić T, Stanković A, Đorđević A, Končar I, Davidović L, Alavantić D, Živković M. 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner. in Experimental Biology and Medicine. 2016;241(11):1210-1216.
doi:10.1177/1535370216636718 .

Životić, Ivan, Đurić, Tamara, Stanković, Aleksandra, Đorđević, Ana, Končar, Igor, Davidović, Lazar, Alavantić, Dragan, Živković, Maja, "9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner" in Experimental Biology and Medicine, 241, no. 11 (2016):1210-1216,
https://doi.org/10.1177/1535370216636718 . .

TY  - JOUR
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Životić, Ivan
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Đurić, Tamara
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1291
AB  - BackgroundPrevious research has shown that there is an association between galectin-3 (gal-3) protein and cardiovascular pathology. The aim of this study was to investigate the effects of rs2274273 and rs17128183 on genetic susceptibility to advanced carotid atherosclerosis (CA) and its complications. The rs2274273 has been singled out as the lead SNP of the haplotype block containing LGALS-3 (gal-3 gene) associated with gal-3 circulating levels, while rs17128183 constitutes a potentially functional SNP of the same hap-block. We further sought to determine whether these genetic variants have an impact on the expression of LGALS-3 mRNA in human carotid atherosclerotic plaque tissue. MethodsThe study encompassed 300 control subjects and 485 patients with advanced CA who had undergone carotid endarterectomy. Rs2274273, rs17128183, and LGALS-3 relative mRNA expression was detected by means of real-time PCR (TaqMan((R)) technology). ResultsThere were no statistically significant associations of the investigated genetic variants with susceptibility to advanced CA, nor did we find any associations in terms of ultrasonographically defined plaque phenotypes. The relative expression of LGALS-3 mRNA proved to be significantly higher in carriers of the rare alleles (P=0.039) for both genetic variants. ConclusionOur exploratory results suggest that while rs2274273 and rs17128183 bear no association with the risk of advanced CA or CA-related complications, these genetic variants are likely to affect LGALS-3 expression levels. In order to reach a definitive conclusion on the role played by rs2274273 and rs17128183 in advanced CA, our results should be further validated.
T2  - Journal of Clinical Laboratory Analysis
T1  - Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study
VL  - 30
IS  - 6
SP  - 1150
EP  - 1157
DO  - 10.1002/jcla.21996
ER  - 

@article{
author = "Đorđević, Ana and Živković, Maja and Stanković, Aleksandra and Životić, Ivan and Končar, Igor and Davidović, Lazar and Alavantić, Dragan and Đurić, Tamara",
year = "2016",
abstract = "BackgroundPrevious research has shown that there is an association between galectin-3 (gal-3) protein and cardiovascular pathology. The aim of this study was to investigate the effects of rs2274273 and rs17128183 on genetic susceptibility to advanced carotid atherosclerosis (CA) and its complications. The rs2274273 has been singled out as the lead SNP of the haplotype block containing LGALS-3 (gal-3 gene) associated with gal-3 circulating levels, while rs17128183 constitutes a potentially functional SNP of the same hap-block. We further sought to determine whether these genetic variants have an impact on the expression of LGALS-3 mRNA in human carotid atherosclerotic plaque tissue. MethodsThe study encompassed 300 control subjects and 485 patients with advanced CA who had undergone carotid endarterectomy. Rs2274273, rs17128183, and LGALS-3 relative mRNA expression was detected by means of real-time PCR (TaqMan((R)) technology). ResultsThere were no statistically significant associations of the investigated genetic variants with susceptibility to advanced CA, nor did we find any associations in terms of ultrasonographically defined plaque phenotypes. The relative expression of LGALS-3 mRNA proved to be significantly higher in carriers of the rare alleles (P=0.039) for both genetic variants. ConclusionOur exploratory results suggest that while rs2274273 and rs17128183 bear no association with the risk of advanced CA or CA-related complications, these genetic variants are likely to affect LGALS-3 expression levels. In order to reach a definitive conclusion on the role played by rs2274273 and rs17128183 in advanced CA, our results should be further validated.",
journal = "Journal of Clinical Laboratory Analysis",
title = "Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study",
volume = "30",
number = "6",
pages = "1150-1157",
doi = "10.1002/jcla.21996"
}

Đorđević, A., Živković, M., Stanković, A., Životić, I., Končar, I., Davidović, L., Alavantić, D.,& Đurić, T.. (2016). Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study. in Journal of Clinical Laboratory Analysis, 30(6), 1150-1157.
https://doi.org/10.1002/jcla.21996

Đorđević A, Živković M, Stanković A, Životić I, Končar I, Davidović L, Alavantić D, Đurić T. Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study. in Journal of Clinical Laboratory Analysis. 2016;30(6):1150-1157.
doi:10.1002/jcla.21996 .

Đorđević, Ana, Živković, Maja, Stanković, Aleksandra, Životić, Ivan, Končar, Igor, Davidović, Lazar, Alavantić, Dragan, Đurić, Tamara, "Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study" in Journal of Clinical Laboratory Analysis, 30, no. 6 (2016):1150-1157,
https://doi.org/10.1002/jcla.21996 . .

TY  - JOUR
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Stojković, Ljiljana S.
AU  - Jovanović, Ivan G.
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Veljković, Nevena V.
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/481
AB  - Aim: Chemokine CXC ligand 16 (CXCL16) has chemoattractive, adhesive and scavenging properties and may play a role in the formation of atherosclerotic lesions. However, studies of CXCL16 polymorphisms in patients with atherosclerosis are scarce. The missense polymorphisms I123T and A181V are potentially important factors in the regulation of presentation and shedding of the CXCL16 chemokine domain. The aim of this study was to analyze the association between I123T and A181V polymorphism haplotypes and the accumulation of carotid plaque as well as the effect of the haplotype on the CXCL16 mRNA expression in carotid plaques in patients with advanced atherosclerosis. Additionally, we performed a bioinformatic prediction analysis of the impact of CXCL16 protein sequence variation on CXCL16-CXCR6 interactions and analyzed the soluble CXCL16 plasma levels according to the CXCL16 haplotype. Methods: This study evaluated a total of 733 participants, including 283 controls and 450 patients with carotid atherosclerosis (CA) undergoing endarterectomy. Analyses of the polymorphisms and the gene expression were performed using real-time PCR. The soluble CXCL16 levels were measured with ELISA. Results: The missense allele haplotype, T123V181, was found to be significantly and independently associated with the occurrence of CA plaque (OR=1.27; 1.02-1.57, p=0.03). This haplotype was predicted to significantly change the CXCL16-CXCR6 interaction, compared to I123A181. Neither the CXCL16 mRNA expression in the human plaques nor the soluble CXCL16 plasma levels differed according to the haplotype. Conclusions: These results indicate that the CXCL16 T123V181 haplotype is a moderate genetic risk factor for the development of carotid plaque. Further functional and replication studies are needed to clarify the mechanisms by which this combination of alleles promotes advanced CA and validate its impact on disease progression.
T2  - Journal of Atherosclerosis and Thrombosis
T1  - CXCL16 Haplotypes in Patients with Human Carotid Atherosclerosis: Preliminary Results
VL  - 22
IS  - 1
SP  - 10
EP  - 20
DO  - 10.5551/jat.24299
ER  - 

@article{
author = "Živković, Maja and Đurić, Tamara and Stojković, Ljiljana S. and Jovanović, Ivan G. and Končar, Igor and Davidović, Lazar and Veljković, Nevena V. and Alavantić, Dragan and Stanković, Aleksandra",
year = "2015",
abstract = "Aim: Chemokine CXC ligand 16 (CXCL16) has chemoattractive, adhesive and scavenging properties and may play a role in the formation of atherosclerotic lesions. However, studies of CXCL16 polymorphisms in patients with atherosclerosis are scarce. The missense polymorphisms I123T and A181V are potentially important factors in the regulation of presentation and shedding of the CXCL16 chemokine domain. The aim of this study was to analyze the association between I123T and A181V polymorphism haplotypes and the accumulation of carotid plaque as well as the effect of the haplotype on the CXCL16 mRNA expression in carotid plaques in patients with advanced atherosclerosis. Additionally, we performed a bioinformatic prediction analysis of the impact of CXCL16 protein sequence variation on CXCL16-CXCR6 interactions and analyzed the soluble CXCL16 plasma levels according to the CXCL16 haplotype. Methods: This study evaluated a total of 733 participants, including 283 controls and 450 patients with carotid atherosclerosis (CA) undergoing endarterectomy. Analyses of the polymorphisms and the gene expression were performed using real-time PCR. The soluble CXCL16 levels were measured with ELISA. Results: The missense allele haplotype, T123V181, was found to be significantly and independently associated with the occurrence of CA plaque (OR=1.27; 1.02-1.57, p=0.03). This haplotype was predicted to significantly change the CXCL16-CXCR6 interaction, compared to I123A181. Neither the CXCL16 mRNA expression in the human plaques nor the soluble CXCL16 plasma levels differed according to the haplotype. Conclusions: These results indicate that the CXCL16 T123V181 haplotype is a moderate genetic risk factor for the development of carotid plaque. Further functional and replication studies are needed to clarify the mechanisms by which this combination of alleles promotes advanced CA and validate its impact on disease progression.",
journal = "Journal of Atherosclerosis and Thrombosis",
title = "CXCL16 Haplotypes in Patients with Human Carotid Atherosclerosis: Preliminary Results",
volume = "22",
number = "1",
pages = "10-20",
doi = "10.5551/jat.24299"
}

Živković, M., Đurić, T., Stojković, L. S., Jovanović, I. G., Končar, I., Davidović, L., Veljković, N. V., Alavantić, D.,& Stanković, A.. (2015). CXCL16 Haplotypes in Patients with Human Carotid Atherosclerosis: Preliminary Results. in Journal of Atherosclerosis and Thrombosis, 22(1), 10-20.
https://doi.org/10.5551/jat.24299

Živković M, Đurić T, Stojković LS, Jovanović IG, Končar I, Davidović L, Veljković NV, Alavantić D, Stanković A. CXCL16 Haplotypes in Patients with Human Carotid Atherosclerosis: Preliminary Results. in Journal of Atherosclerosis and Thrombosis. 2015;22(1):10-20.
doi:10.5551/jat.24299 .

Živković, Maja, Đurić, Tamara, Stojković, Ljiljana S., Jovanović, Ivan G., Končar, Igor, Davidović, Lazar, Veljković, Nevena V., Alavantić, Dragan, Stanković, Aleksandra, "CXCL16 Haplotypes in Patients with Human Carotid Atherosclerosis: Preliminary Results" in Journal of Atherosclerosis and Thrombosis, 22, no. 1 (2015):10-20,
https://doi.org/10.5551/jat.24299 . .

TY  - JOUR
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
AU  - Končar, Igor
AU  - Kolaković, Ana
AU  - Đurđević, Vladimir
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5869
AB  - Glutathione S-transferases (GSTs) carry out a wide range of functions in cells, such as detoxification of endogenous compounds, removal of reactive oxygen species, and even catalysis of reactions in metabolic pathways beyond detoxification. Based on previous research, GSTM1 and GSTT1 might modify the risk of atherosclerosis. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the occurrence of carotid plaque (CP); and biochemical parameters of oxidative stress, lipid profile and inflammation, in 346 consecutive patients with advanced atherosclerosis that underwent endarterectomy. A multiplex polymerase chain reaction (PCR) method was used to detect the deletions in GSTM1 and GSTT1 genes in the genomic DNA in 346 patients and 330 controls. The adjusted OR for CP presence (adjusted for age, gender, smoking, hypertension, BMI, HDLC, TG) was 0.24, 95 %CI 0.08-0.7, p LT 0.01 for GSTT1 null and 1.13, 95 %CI 0.62-2.07, p = 0.7 for GSTM1 null genotype. We found significantly lower plasma lipoprotein (a) (Lp(a)) levels in GSTT1 null compared to wild-type genotype carriers in patient group (20.68 +/- A 26.02 mg/dl vs. 40.66 +/- A 42.89 mg/dl, mean +/- A SD, p = 0.04). The serum interleukin-6 (IL-6) values were significantly influenced by both GST polymorphisms in patients with CP. Our results, showing the significant reduction of GSTT1 deletions in patients with CP, suggest involvement of GSTs in carotid atherosclerosis. This study shows additional view of the possible role of GSTs in advanced chronic inflammatory disease of vascular system, but the confirmation in a larger studies in different populations are needed.
T2  - Molecular Biology Reports
T1  - Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters
VL  - 41
IS  - 2
SP  - 1157
EP  - 1164
DO  - 10.1007/s11033-013-2962-z
ER  - 

@article{
author = "Živković, Maja and Stanković, Aleksandra and Đurić, Tamara and Končar, Igor and Kolaković, Ana and Đurđević, Vladimir and Davidović, Lazar and Alavantić, Dragan",
year = "2014",
abstract = "Glutathione S-transferases (GSTs) carry out a wide range of functions in cells, such as detoxification of endogenous compounds, removal of reactive oxygen species, and even catalysis of reactions in metabolic pathways beyond detoxification. Based on previous research, GSTM1 and GSTT1 might modify the risk of atherosclerosis. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the occurrence of carotid plaque (CP); and biochemical parameters of oxidative stress, lipid profile and inflammation, in 346 consecutive patients with advanced atherosclerosis that underwent endarterectomy. A multiplex polymerase chain reaction (PCR) method was used to detect the deletions in GSTM1 and GSTT1 genes in the genomic DNA in 346 patients and 330 controls. The adjusted OR for CP presence (adjusted for age, gender, smoking, hypertension, BMI, HDLC, TG) was 0.24, 95 %CI 0.08-0.7, p LT 0.01 for GSTT1 null and 1.13, 95 %CI 0.62-2.07, p = 0.7 for GSTM1 null genotype. We found significantly lower plasma lipoprotein (a) (Lp(a)) levels in GSTT1 null compared to wild-type genotype carriers in patient group (20.68 +/- A 26.02 mg/dl vs. 40.66 +/- A 42.89 mg/dl, mean +/- A SD, p = 0.04). The serum interleukin-6 (IL-6) values were significantly influenced by both GST polymorphisms in patients with CP. Our results, showing the significant reduction of GSTT1 deletions in patients with CP, suggest involvement of GSTs in carotid atherosclerosis. This study shows additional view of the possible role of GSTs in advanced chronic inflammatory disease of vascular system, but the confirmation in a larger studies in different populations are needed.",
journal = "Molecular Biology Reports",
title = "Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters",
volume = "41",
number = "2",
pages = "1157-1164",
doi = "10.1007/s11033-013-2962-z"
}

Živković, M., Stanković, A., Đurić, T., Končar, I., Kolaković, A., Đurđević, V., Davidović, L.,& Alavantić, D.. (2014). Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters. in Molecular Biology Reports, 41(2), 1157-1164.
https://doi.org/10.1007/s11033-013-2962-z

Živković M, Stanković A, Đurić T, Končar I, Kolaković A, Đurđević V, Davidović L, Alavantić D. Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters. in Molecular Biology Reports. 2014;41(2):1157-1164.
doi:10.1007/s11033-013-2962-z .

Živković, Maja, Stanković, Aleksandra, Đurić, Tamara, Končar, Igor, Kolaković, Ana, Đurđević, Vladimir, Davidović, Lazar, Alavantić, Dragan, "Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters" in Molecular Biology Reports, 41, no. 2 (2014):1157-1164,
https://doi.org/10.1007/s11033-013-2962-z . .

TY  - CONF
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Đorđević, Ana
AU  - Životić, Ivan
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12814
PB  - European Atherosclerosis Society
C3  - 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts
T1  - The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12814
ER  - 

@conference{
author = "Živković, Maja and Đurić, Tamara and Đorđević, Ana and Životić, Ivan and Končar, Igor and Davidović, Lazar and Alavantić, Dragan and Stanković, Aleksandra",
year = "2014",
publisher = "European Atherosclerosis Society",
journal = "82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts",
title = "The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12814"
}

Živković, M., Đurić, T., Đorđević, A., Životić, I., Končar, I., Davidović, L., Alavantić, D.,& Stanković, A.. (2014). The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study. in 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts
European Atherosclerosis Society..
https://hdl.handle.net/21.15107/rcub_vinar_12814

Živković M, Đurić T, Đorđević A, Životić I, Končar I, Davidović L, Alavantić D, Stanković A. The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study. in 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts. 2014;.
https://hdl.handle.net/21.15107/rcub_vinar_12814 .

Živković, Maja, Đurić, Tamara, Đorđević, Ana, Životić, Ivan, Končar, Igor, Davidović, Lazar, Alavantić, Dragan, Stanković, Aleksandra, "The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study" in 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts (2014),
https://hdl.handle.net/21.15107/rcub_vinar_12814 .

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Davidović, Lazar
AU  - Tanasković, Slobodan
AU  - Banzić, Igor
AU  - Matić, Predrag
AU  - Babić, Srđan
AU  - Kostić, Dušan
AU  - Isenović, Esma R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/86
AB  - BACKGROUND: To present outcomes following an operative approach of extracranial carotid artery aneurysm (ECAAs) based on anatomic types and associated kinks. METHODS: This study represents retrospective analysis of anatomic type based approach to operative repair of 84 patients with ECAA from 1994 to 2011, 28 (33.3%) with associated kinking. Patients were followed for neurological ischemic events, hematoma, cranial nerve injury, myocardial infarction, neurological, and overall mortality. The results are presented as early, within 30 days after the surgery, and long term during the follow-up. RESULTS: In the early postoperative period, there were no strokes or mortalities, cranial nerve injury rate was 2.4% while 1 patient had myocardial infarction (1.2%). During the follow-up, 4 patients (4.8%) had stroke, out of which 2 patients died (2.3%), while overall mortality was 4.6%. The average 5-year survival rate was 96 +/- 3%. CONCLUSION: Excellent outcomes can be obtained with surgical repair of ECAA, which should be tailored to the anatomic types and presence of kinks. (C) 2014 Elsevier Inc. All rights reserved.
T2  - American Journal of Surgery
T1  - A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks
VL  - 208
IS  - 2
SP  - 235
EP  - 242
DO  - 10.1016/j.amjsurg.2013.10.025
ER  - 

@article{
author = "Radak, Đorđe J. and Davidović, Lazar and Tanasković, Slobodan and Banzić, Igor and Matić, Predrag and Babić, Srđan and Kostić, Dušan and Isenović, Esma R.",
year = "2014",
abstract = "BACKGROUND: To present outcomes following an operative approach of extracranial carotid artery aneurysm (ECAAs) based on anatomic types and associated kinks. METHODS: This study represents retrospective analysis of anatomic type based approach to operative repair of 84 patients with ECAA from 1994 to 2011, 28 (33.3%) with associated kinking. Patients were followed for neurological ischemic events, hematoma, cranial nerve injury, myocardial infarction, neurological, and overall mortality. The results are presented as early, within 30 days after the surgery, and long term during the follow-up. RESULTS: In the early postoperative period, there were no strokes or mortalities, cranial nerve injury rate was 2.4% while 1 patient had myocardial infarction (1.2%). During the follow-up, 4 patients (4.8%) had stroke, out of which 2 patients died (2.3%), while overall mortality was 4.6%. The average 5-year survival rate was 96 +/- 3%. CONCLUSION: Excellent outcomes can be obtained with surgical repair of ECAA, which should be tailored to the anatomic types and presence of kinks. (C) 2014 Elsevier Inc. All rights reserved.",
journal = "American Journal of Surgery",
title = "A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks",
volume = "208",
number = "2",
pages = "235-242",
doi = "10.1016/j.amjsurg.2013.10.025"
}

Radak, Đ. J., Davidović, L., Tanasković, S., Banzić, I., Matić, P., Babić, S., Kostić, D.,& Isenović, E. R.. (2014). A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks. in American Journal of Surgery, 208(2), 235-242.
https://doi.org/10.1016/j.amjsurg.2013.10.025

Radak ĐJ, Davidović L, Tanasković S, Banzić I, Matić P, Babić S, Kostić D, Isenović ER. A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks. in American Journal of Surgery. 2014;208(2):235-242.
doi:10.1016/j.amjsurg.2013.10.025 .

Radak, Đorđe J., Davidović, Lazar, Tanasković, Slobodan, Banzić, Igor, Matić, Predrag, Babić, Srđan, Kostić, Dušan, Isenović, Esma R., "A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks" in American Journal of Surgery, 208, no. 2 (2014):235-242,
https://doi.org/10.1016/j.amjsurg.2013.10.025 . .

TY  - JOUR
AU  - Kolaković, Ana
AU  - Živković, Maja
AU  - Radak, Đorđe J.
AU  - Đurić, Tamara
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Dinčić, Dragan
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4719
AB  - Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis GT 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype.
T2  - Journal of the Renin-Angiotensin-Aldosterone System
T1  - The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy
VL  - 13
IS  - 1
SP  - 141
EP  - 147
DO  - 10.1177/1470320311423271
ER  - 

@article{
author = "Kolaković, Ana and Živković, Maja and Radak, Đorđe J. and Đurić, Tamara and Končar, Igor and Davidović, Lazar and Dinčić, Dragan and Alavantić, Dragan and Stanković, Aleksandra",
year = "2012",
abstract = "Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis GT 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype.",
journal = "Journal of the Renin-Angiotensin-Aldosterone System",
title = "The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy",
volume = "13",
number = "1",
pages = "141-147",
doi = "10.1177/1470320311423271"
}

Kolaković, A., Živković, M., Radak, Đ. J., Đurić, T., Končar, I., Davidović, L., Dinčić, D., Alavantić, D.,& Stanković, A.. (2012). The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy. in Journal of the Renin-Angiotensin-Aldosterone System, 13(1), 141-147.
https://doi.org/10.1177/1470320311423271

Kolaković A, Živković M, Radak ĐJ, Đurić T, Končar I, Davidović L, Dinčić D, Alavantić D, Stanković A. The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy. in Journal of the Renin-Angiotensin-Aldosterone System. 2012;13(1):141-147.
doi:10.1177/1470320311423271 .

Kolaković, Ana, Živković, Maja, Radak, Đorđe J., Đurić, Tamara, Končar, Igor, Davidović, Lazar, Dinčić, Dragan, Alavantić, Dragan, Stanković, Aleksandra, "The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy" in Journal of the Renin-Angiotensin-Aldosterone System, 13, no. 1 (2012):141-147,
https://doi.org/10.1177/1470320311423271 . .

TY  - JOUR
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Končar, Igor
AU  - Radak, Đorđe J.
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4641
AB  - Objective: Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix in the arterial wall. Collagen I is associated with vascular smooth muscle cell (VSMC) migration and monocyte differentiation. MMP-8 is expressed in atherosclerotic plaque and preferentially cleaves collagen type I. The aim of this study was to investigate the associations of two MMP-8 promoter polymorphisms, rs11225395 (-799 C/T) and rs1320632 (-381 A/G), with carotid plaque occurrence, and the influence of these polymorphisms on MMP-8 mRNA expression in plaque tissue. Methods: The study included a total of 766 participants: 277 controls and 489 patients with carotid atherosclerosis undergoing endarterectomy. The two investigated polymorphisms were genotyped by PCR-RFLP. The gene expression analysis was performed by real-time PCR. Results: In females only, a significantly higher frequency of the -381G allele was found in patients with carotid atherosclerosis compared to controls (OR, 1.7; 95% CI 1.1-2.9; p = 0.001). Significant up-regulation of MMP-8 gene expression was observed in patients carrying the -381G allele compared to those with the AA genotype (mean factor, 3.54; SE. range, 0.643-19.551; p = 0.007). Carotid plaque tissue of the haplotype G(-381)T(-799) showed a significantly higher mRNA level compared with the reference A(-381)C(-799) haplotype (p = 0.003). Conclusion: Our preliminary results indicate that MMP-8 -381A/G and -799 C/T gene polymorphisms could be risk factors for carotid atherosclerosis. Further validation and functional studies are needed to establish the potential regulatory role of these polymorphisms and their impact on susceptibility to carotid atherosclerosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
T2  - Atherosclerosis
T1  - Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study
VL  - 219
IS  - 2
SP  - 673
EP  - 678
DO  - 10.1016/j.atherosclerosis.2011.08.025
ER  - 

@article{
author = "Đurić, Tamara and Stanković, Aleksandra and Končar, Igor and Radak, Đorđe J. and Davidović, Lazar and Alavantić, Dragan and Živković, Maja",
year = "2011",
abstract = "Objective: Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix in the arterial wall. Collagen I is associated with vascular smooth muscle cell (VSMC) migration and monocyte differentiation. MMP-8 is expressed in atherosclerotic plaque and preferentially cleaves collagen type I. The aim of this study was to investigate the associations of two MMP-8 promoter polymorphisms, rs11225395 (-799 C/T) and rs1320632 (-381 A/G), with carotid plaque occurrence, and the influence of these polymorphisms on MMP-8 mRNA expression in plaque tissue. Methods: The study included a total of 766 participants: 277 controls and 489 patients with carotid atherosclerosis undergoing endarterectomy. The two investigated polymorphisms were genotyped by PCR-RFLP. The gene expression analysis was performed by real-time PCR. Results: In females only, a significantly higher frequency of the -381G allele was found in patients with carotid atherosclerosis compared to controls (OR, 1.7; 95% CI 1.1-2.9; p = 0.001). Significant up-regulation of MMP-8 gene expression was observed in patients carrying the -381G allele compared to those with the AA genotype (mean factor, 3.54; SE. range, 0.643-19.551; p = 0.007). Carotid plaque tissue of the haplotype G(-381)T(-799) showed a significantly higher mRNA level compared with the reference A(-381)C(-799) haplotype (p = 0.003). Conclusion: Our preliminary results indicate that MMP-8 -381A/G and -799 C/T gene polymorphisms could be risk factors for carotid atherosclerosis. Further validation and functional studies are needed to establish the potential regulatory role of these polymorphisms and their impact on susceptibility to carotid atherosclerosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.",
journal = "Atherosclerosis",
title = "Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study",
volume = "219",
number = "2",
pages = "673-678",
doi = "10.1016/j.atherosclerosis.2011.08.025"
}

Đurić, T., Stanković, A., Končar, I., Radak, Đ. J., Davidović, L., Alavantić, D.,& Živković, M.. (2011). Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study. in Atherosclerosis, 219(2), 673-678.
https://doi.org/10.1016/j.atherosclerosis.2011.08.025

Đurić T, Stanković A, Končar I, Radak ĐJ, Davidović L, Alavantić D, Živković M. Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study. in Atherosclerosis. 2011;219(2):673-678.
doi:10.1016/j.atherosclerosis.2011.08.025 .

Đurić, Tamara, Stanković, Aleksandra, Končar, Igor, Radak, Đorđe J., Davidović, Lazar, Alavantić, Dragan, Živković, Maja, "Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: Preliminary study" in Atherosclerosis, 219, no. 2 (2011):673-678,
https://doi.org/10.1016/j.atherosclerosis.2011.08.025 . .

TY  - JOUR
AU  - Đurić, Tamara
AU  - Umicevic, Masa
AU  - Končar, Igor
AU  - Živković, Maja
AU  - Vasić, Dragan
AU  - Davidović, Lazar
AU  - Stanković, Aleksandra
AU  - Alavantić, Dragan
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3835
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
VL  - 47
IS  - 12
SP  - 1573
EP  - 1575
DO  - 10.1515/CCLM.2009.343
ER  - 

@article{
author = "Đurić, Tamara and Umicevic, Masa and Končar, Igor and Živković, Maja and Vasić, Dragan and Davidović, Lazar and Stanković, Aleksandra and Alavantić, Dragan",
year = "2009",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population",
volume = "47",
number = "12",
pages = "1573-1575",
doi = "10.1515/CCLM.2009.343"
}

Đurić, T., Umicevic, M., Končar, I., Živković, M., Vasić, D., Davidović, L., Stanković, A.,& Alavantić, D.. (2009). Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population. in Clinical Chemistry and Laboratory Medicine, 47(12), 1573-1575.
https://doi.org/10.1515/CCLM.2009.343

Đurić T, Umicevic M, Končar I, Živković M, Vasić D, Davidović L, Stanković A, Alavantić D. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population. in Clinical Chemistry and Laboratory Medicine. 2009;47(12):1573-1575.
doi:10.1515/CCLM.2009.343 .

Đurić, Tamara, Umicevic, Masa, Končar, Igor, Živković, Maja, Vasić, Dragan, Davidović, Lazar, Stanković, Aleksandra, Alavantić, Dragan, "Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population" in Clinical Chemistry and Laboratory Medicine, 47, no. 12 (2009):1573-1575,
https://doi.org/10.1515/CCLM.2009.343 . .