TY  - JOUR
AU  - Todorović, Ana
AU  - Bobić, Katarina
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Stanković, Sanja
AU  - Milovanović, Tijana
AU  - Vukoje, Ivana
AU  - Nedeljković, Jovan
AU  - Radojević Škodrić, Sanja
AU  - Pajović, Snežana B.
AU  - Drakulić, Dunja
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13090
AB  - Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.
T2  - Antioxidants
T1  - Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats
VL  - 13
IS  - 2
SP  - 231
DO  - 10.3390/antiox13020231
ER  - 

@article{
author = "Todorović, Ana and Bobić, Katarina and Veljković, Filip and Pejić, Snežana and Glumac, Sofija and Stanković, Sanja and Milovanović, Tijana and Vukoje, Ivana and Nedeljković, Jovan and Radojević Škodrić, Sanja and Pajović, Snežana B. and Drakulić, Dunja",
year = "2024",
abstract = "Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.",
journal = "Antioxidants",
title = "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats",
volume = "13",
number = "2",
pages = "231",
doi = "10.3390/antiox13020231"
}

Todorović, A., Bobić, K., Veljković, F., Pejić, S., Glumac, S., Stanković, S., Milovanović, T., Vukoje, I., Nedeljković, J., Radojević Škodrić, S., Pajović, S. B.,& Drakulić, D.. (2024). Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants, 13(2), 231.
https://doi.org/10.3390/antiox13020231

Todorović A, Bobić K, Veljković F, Pejić S, Glumac S, Stanković S, Milovanović T, Vukoje I, Nedeljković J, Radojević Škodrić S, Pajović SB, Drakulić D. Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants. 2024;13(2):231.
doi:10.3390/antiox13020231 .

Todorović, Ana, Bobić, Katarina, Veljković, Filip, Pejić, Snežana, Glumac, Sofija, Stanković, Sanja, Milovanović, Tijana, Vukoje, Ivana, Nedeljković, Jovan, Radojević Škodrić, Sanja, Pajović, Snežana B., Drakulić, Dunja, "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats" in Antioxidants, 13, no. 2 (2024):231,
https://doi.org/10.3390/antiox13020231 . .

TY  - CONF
AU  - Bobić, Katarina
AU  - Milovanović, Tijana
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Pejić, Snežana
AU  - Veljković, Filip
AU  - Pajović, Snežana
AU  - Nedeljković, Jovan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12662
AB  - Široka primena nanočestica titanijum-dioksida (TiO2 NČ) u medicini, farmaceutskoj, prehrambenoj i hemijskoj industriji,1 čini TiO2 NČ visoko zastupljenim u životnoj sredini i svim sferama čovekovog života. Negativne efekte ostvaruju u mozgu, s obzirom da lako prolaze krvno-moždanu barijeru, akumuliraju se u različitim regionima mozga i indukuju oksidativni stres tokom kog se oštećuju svi biomolekuli, uključujući i lipide.2 Literaturni podaci ukazuju da različite modifikacije mogu ublažiti uočene efekte, stoga je cilj ovog rada bio da se uporedi odgovor odraslih Wistar pacova 14 dana nakon jednokratnog oralnog tretmana sa komercijalno dostupnim TiO2 NČ i TiO2 NČ površinski modifikovanim salicilnom (TiO2/SK NČ) odnosno 5- aminosalicilnom kiselinom (TiO2/5-ASK NČ). Odgovarajućim testovima praćene su promene parametara senzorno-motorne funkcije (SMF), kao pokazatelja neurološkog deficita, dok je oksidativni stres praćen promenom nivoa lipidne peroksidacije (LPO) u ukupnom ćelijskom ekstraktu moždanog tkiva. Dobijeni rezultati ukazuju da TiO2/SK NČ ispoljavaju slične efekte kao TiO2 NČ, povećavajući nivo LPO koji može biti uzrok narušene SMF. Sa druge strane, smanjen stepen neurološkog deficita i nivoa oksidativnog stresa nakon TiO2/5- ASK NČ tretmana, mogu se povezati sa povećanjem aktivnosti komponenti antioksidativne zaštite. Stoga, može se pretpostaviti da površinska modifikacija TiO2 NČ sa 5-ASK ima sposobnost ublažavanja štetnih efekata komercijalno dostupnih TiO2 NČ.
PB  - Beograd : Srpsko biološko društvo
C3  - Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka
T1  - Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova
SP  - 311
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12662
ER  - 

@conference{
author = "Bobić, Katarina and Milovanović, Tijana and Todorović, Ana and Drakulić, Dunja and Pejić, Snežana and Veljković, Filip and Pajović, Snežana and Nedeljković, Jovan",
year = "2022",
abstract = "Široka primena nanočestica titanijum-dioksida (TiO2 NČ) u medicini, farmaceutskoj, prehrambenoj i hemijskoj industriji,1 čini TiO2 NČ visoko zastupljenim u životnoj sredini i svim sferama čovekovog života. Negativne efekte ostvaruju u mozgu, s obzirom da lako prolaze krvno-moždanu barijeru, akumuliraju se u različitim regionima mozga i indukuju oksidativni stres tokom kog se oštećuju svi biomolekuli, uključujući i lipide.2 Literaturni podaci ukazuju da različite modifikacije mogu ublažiti uočene efekte, stoga je cilj ovog rada bio da se uporedi odgovor odraslih Wistar pacova 14 dana nakon jednokratnog oralnog tretmana sa komercijalno dostupnim TiO2 NČ i TiO2 NČ površinski modifikovanim salicilnom (TiO2/SK NČ) odnosno 5- aminosalicilnom kiselinom (TiO2/5-ASK NČ). Odgovarajućim testovima praćene su promene parametara senzorno-motorne funkcije (SMF), kao pokazatelja neurološkog deficita, dok je oksidativni stres praćen promenom nivoa lipidne peroksidacije (LPO) u ukupnom ćelijskom ekstraktu moždanog tkiva. Dobijeni rezultati ukazuju da TiO2/SK NČ ispoljavaju slične efekte kao TiO2 NČ, povećavajući nivo LPO koji može biti uzrok narušene SMF. Sa druge strane, smanjen stepen neurološkog deficita i nivoa oksidativnog stresa nakon TiO2/5- ASK NČ tretmana, mogu se povezati sa povećanjem aktivnosti komponenti antioksidativne zaštite. Stoga, može se pretpostaviti da površinska modifikacija TiO2 NČ sa 5-ASK ima sposobnost ublažavanja štetnih efekata komercijalno dostupnih TiO2 NČ.",
publisher = "Beograd : Srpsko biološko društvo",
journal = "Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka",
title = "Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova",
pages = "311-311",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12662"
}

Bobić, K., Milovanović, T., Todorović, A., Drakulić, D., Pejić, S., Veljković, F., Pajović, S.,& Nedeljković, J.. (2022). Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova. in Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka
Beograd : Srpsko biološko društvo., 311-311.
https://hdl.handle.net/21.15107/rcub_vinar_12662

Bobić K, Milovanović T, Todorović A, Drakulić D, Pejić S, Veljković F, Pajović S, Nedeljković J. Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova. in Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka. 2022;:311-311.
https://hdl.handle.net/21.15107/rcub_vinar_12662 .

Bobić, Katarina, Milovanović, Tijana, Todorović, Ana, Drakulić, Dunja, Pejić, Snežana, Veljković, Filip, Pajović, Snežana, Nedeljković, Jovan, "Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova" in Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka (2022):311-311,
https://hdl.handle.net/21.15107/rcub_vinar_12662 .

TY  - CONF
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Bobić, Katarina
AU  - Milovanović, Tijana
AU  - Stanković, Sanja
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12742
AB  - Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
T1  - Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system
SP  - 73
EP  - 73
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12742
ER  - 

@conference{
author = "Todorović, Ana and Pejić, Snežana and Bobić, Katarina and Milovanović, Tijana and Stanković, Sanja and Drakulić, Dunja",
year = "2022",
abstract = "Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts",
title = "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system",
pages = "73-73",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12742"
}

Todorović, A., Pejić, S., Bobić, K., Milovanović, T., Stanković, S.,& Drakulić, D.. (2022). Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
Belgrade : Society of Physical Chemists of Serbia., 73-73.
https://hdl.handle.net/21.15107/rcub_vinar_12742

Todorović A, Pejić S, Bobić K, Milovanović T, Stanković S, Drakulić D. Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts. 2022;:73-73.
https://hdl.handle.net/21.15107/rcub_vinar_12742 .

Todorović, Ana, Pejić, Snežana, Bobić, Katarina, Milovanović, Tijana, Stanković, Sanja, Drakulić, Dunja, "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts (2022):73-73,
https://hdl.handle.net/21.15107/rcub_vinar_12742 .