Mihajlov Krstev, Tatjana

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dfabbf32-7e1b-4e18-98be-49d4392962f6
  • Mihajlov Krstev, Tatjana (1)
  • Mihajlov-Krstev, Tatjana (1)
Projects

Author's Bibliography

Rapid bone regeneration with nano-hydroxyapatite coated with a chitosan-poly (D, L)-lactide-co-glycolide bone-filling material with osteocondactive and antimicrobial properties

Ignjatović, Nenad L.; Uskoković, Vuk; Ajduković, Zorica; Mihajlov Krstev, Tatjana; Uskoković, Dragan

(2015)

TY  - CONF
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Vuk
AU  - Ajduković, Zorica
AU  - Mihajlov Krstev, Tatjana
AU  - Uskoković, Dragan
PY  - 2015
UR  - http://dais.sanu.ac.rs/123456789/824
UR  - http://www.itn.sanu.ac.rs/opus4/frontdoor/index/index/docId/1104
UR  - http://www.itn.sanu.ac.rs/opus4/files/1104/Ignjatovic_ITNANO2015.pdf
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7541
AB  - Composite biomaterials based on nano-hydroxyapatite have an enormous potential for natural bone tissue reparation, filling and augmentation. Multifunctional nanoparticulate systems based on HAp coated with biocompatible and bioresorbable polymers make a separate group of filler systems in bone tissue engineering [1,2]. Chitosan has many physicochemical (reactive OH and NH2 groups) and biological (biocompatible, biodegradable) properties that make it an attractive material for use in bone tissue engineering. However, chitosan may induce thrombosis and it is therefore unsuitable as blood – contacting biomaterial. One of the strategies to improve the biocompatibility of chitosan is combination of this biopolymer with compounds that exhibit complementary properties. In our studies, we present the synthesis, characterization, in vitro and in vivo research of a particulate form of nano HAp-coated polymer systems. We synthesized nanoparticulate HAp coated with chitosan (Ch) and a chitosan-poly-D,L-lactide-co-glycolide (Ch-PLGA) polymer blend obtained via the solvent/non-solvent method and freeze-drying processing. We also examined the possibility of using Thermo-Gravimetric Analysis/Differential-Thermal Analysis (DTA/TGA) coupled on-line with mass spectrometry (MS) as a finger print for identification purposes in coating processes. The quantitative antimicrobial test has shown that HAp/Ch-PLGA have some antibacterial properties (MIC (mg/mL): Pseudomonas aeruginosa – 6.40, Staphylococcus aureus – 6.40, Staphylococcus epidermidis – 3.20). MTT assay was used to test cytotoxicity and cell viability. By using HAp/Ch-PLGA in the form of a filler a high level of reparatory ability, with the presence Haversian canals and cement lines in reconstructed of bone defect, was achieved in vivo. [1] N. Ignjatovic, C. Liu, J. Czernuszka, D. Uskokovic, Micro and nano/injectable composite biomaterials containing calcium phosphate coated with poly(dl-lactide-co-glycolide), Acta Biomaterialia, 3 (2007) 927-935 [2] N. Ignjatović, V. Uskoković, Z. Ajduković, D. Uskoković, Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol, Materials Science and Engineering: C 33 (2013) 943–950
C3  - ITNANO2015: 3RD International Translational Nanomedicine Conference  21-26. June. 2015, Milocer, Hotel Maestral, Montenegro: Book of abstracts
T1  - Rapid bone regeneration with nano-hydroxyapatite coated with a chitosan-poly (D, L)-lactide-co-glycolide bone-filling material with osteocondactive and antimicrobial properties
SP  - 15
EP  - 16
ER  - 
@conference{
author = "Ignjatović, Nenad L. and Uskoković, Vuk and Ajduković, Zorica and Mihajlov Krstev, Tatjana and Uskoković, Dragan",
year = "2015",
url = "http://dais.sanu.ac.rs/123456789/824, http://www.itn.sanu.ac.rs/opus4/frontdoor/index/index/docId/1104, http://www.itn.sanu.ac.rs/opus4/files/1104/Ignjatovic_ITNANO2015.pdf, http://vinar.vin.bg.ac.rs/handle/123456789/7541",
abstract = "Composite biomaterials based on nano-hydroxyapatite have an enormous potential for natural bone tissue reparation, filling and augmentation. Multifunctional nanoparticulate systems based on HAp coated with biocompatible and bioresorbable polymers make a separate group of filler systems in bone tissue engineering [1,2]. Chitosan has many physicochemical (reactive OH and NH2 groups) and biological (biocompatible, biodegradable) properties that make it an attractive material for use in bone tissue engineering. However, chitosan may induce thrombosis and it is therefore unsuitable as blood – contacting biomaterial. One of the strategies to improve the biocompatibility of chitosan is combination of this biopolymer with compounds that exhibit complementary properties. In our studies, we present the synthesis, characterization, in vitro and in vivo research of a particulate form of nano HAp-coated polymer systems. We synthesized nanoparticulate HAp coated with chitosan (Ch) and a chitosan-poly-D,L-lactide-co-glycolide (Ch-PLGA) polymer blend obtained via the solvent/non-solvent method and freeze-drying processing. We also examined the possibility of using Thermo-Gravimetric Analysis/Differential-Thermal Analysis (DTA/TGA) coupled on-line with mass spectrometry (MS) as a finger print for identification purposes in coating processes. The quantitative antimicrobial test has shown that HAp/Ch-PLGA have some antibacterial properties (MIC (mg/mL): Pseudomonas aeruginosa – 6.40, Staphylococcus aureus – 6.40, Staphylococcus epidermidis – 3.20). MTT assay was used to test cytotoxicity and cell viability. By using HAp/Ch-PLGA in the form of a filler a high level of reparatory ability, with the presence Haversian canals and cement lines in reconstructed of bone defect, was achieved in vivo. [1] N. Ignjatovic, C. Liu, J. Czernuszka, D. Uskokovic, Micro and nano/injectable composite biomaterials containing calcium phosphate coated with poly(dl-lactide-co-glycolide), Acta Biomaterialia, 3 (2007) 927-935 [2] N. Ignjatović, V. Uskoković, Z. Ajduković, D. Uskoković, Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol, Materials Science and Engineering: C 33 (2013) 943–950",
journal = "ITNANO2015: 3RD International Translational Nanomedicine Conference  21-26. June. 2015, Milocer, Hotel Maestral, Montenegro: Book of abstracts",
title = "Rapid bone regeneration with nano-hydroxyapatite coated with a chitosan-poly (D, L)-lactide-co-glycolide bone-filling material with osteocondactive and antimicrobial properties",
pages = "15-16"
}
Ignjatović, N. L., Uskoković, V., Ajduković, Z., Mihajlov Krstev, T.,& Uskoković, D. (2015). Rapid bone regeneration with nano-hydroxyapatite coated with a chitosan-poly (D, L)-lactide-co-glycolide bone-filling material with osteocondactive and antimicrobial properties.
ITNANO2015: 3RD International Translational Nanomedicine Conference  21-26. June. 2015, Milocer, Hotel Maestral, Montenegro: Book of abstracts, 15-16.
Ignjatović NL, Uskoković V, Ajduković Z, Mihajlov Krstev T, Uskoković D. Rapid bone regeneration with nano-hydroxyapatite coated with a chitosan-poly (D, L)-lactide-co-glycolide bone-filling material with osteocondactive and antimicrobial properties. ITNANO2015: 3RD International Translational Nanomedicine Conference  21-26. June. 2015, Milocer, Hotel Maestral, Montenegro: Book of abstracts. 2015;:15-16
Ignjatović Nenad L., Uskoković Vuk, Ajduković Zorica, Mihajlov Krstev Tatjana, Uskoković Dragan, "Rapid bone regeneration with nano-hydroxyapatite coated with a chitosan-poly (D, L)-lactide-co-glycolide bone-filling material with osteocondactive and antimicrobial properties" ITNANO2015: 3RD International Translational Nanomedicine Conference  21-26. June. 2015, Milocer, Hotel Maestral, Montenegro: Book of abstracts (2015):15-16

Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization

Damljanović, Ivan S.; Stevanović, Dragana D.; Pejović, Anka; Vukicevic, Mirjana; Novaković, Slađana B.; Bogdanović, Goran A.; Mihajlov-Krstev, Tatjana; Radulovic, Niko; Vukicevic, Rastko D.

(2011)

TY  - JOUR
AU  - Damljanović, Ivan S.
AU  - Stevanović, Dragana D.
AU  - Pejović, Anka
AU  - Vukicevic, Mirjana
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Mihajlov-Krstev, Tatjana
AU  - Radulovic, Niko
AU  - Vukicevic, Rastko D.
PY  - 2011
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4552
AB  - Syntheses of fourteen new 3-(arylamino)-1-ferrocenylpropan-1-ones have been achieved in good to excellent yields by an aza-Michael addition of different arylamines to acryloylferrocene. The reaction was performed by microwave (MW) irradiation (500 W/5 min) of a mixture of reactants and montmorillonite K-10, without a solvent. The obtained compounds were spectrally and electrochemically (cyclic voltammetry) fully characterized, whereas single-crystal X-ray analysis has been performed for three of them. In a microdilution assay, all of the compounds were shown to have a broad-spectrum effect on Gram-negative and -positive bacteria, although the degree of inhibition varied. A notable activity was observed for all compounds in inhibiting the growth of an important human pathogen Staphylococcus aureus. (C) 2011 Elsevier B.V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization
VL  - 696
IS  - 23
SP  - 3703
EP  - 3713
DO  - 10.1016/j.jorganchem.2011.08.016
ER  - 
@article{
author = "Damljanović, Ivan S. and Stevanović, Dragana D. and Pejović, Anka and Vukicevic, Mirjana and Novaković, Slađana B. and Bogdanović, Goran A. and Mihajlov-Krstev, Tatjana and Radulovic, Niko and Vukicevic, Rastko D.",
year = "2011",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4552",
abstract = "Syntheses of fourteen new 3-(arylamino)-1-ferrocenylpropan-1-ones have been achieved in good to excellent yields by an aza-Michael addition of different arylamines to acryloylferrocene. The reaction was performed by microwave (MW) irradiation (500 W/5 min) of a mixture of reactants and montmorillonite K-10, without a solvent. The obtained compounds were spectrally and electrochemically (cyclic voltammetry) fully characterized, whereas single-crystal X-ray analysis has been performed for three of them. In a microdilution assay, all of the compounds were shown to have a broad-spectrum effect on Gram-negative and -positive bacteria, although the degree of inhibition varied. A notable activity was observed for all compounds in inhibiting the growth of an important human pathogen Staphylococcus aureus. (C) 2011 Elsevier B.V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization",
volume = "696",
number = "23",
pages = "3703-3713",
doi = "10.1016/j.jorganchem.2011.08.016"
}
Damljanović, I. S., Stevanović, D. D., Pejović, A., Vukicevic, M., Novaković, S. B., Bogdanović, G. A., Mihajlov-Krstev, T., Radulovic, N.,& Vukicevic, R. D. (2011). Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization.
Journal of Organometallic Chemistry, 696(23), 3703-3713.
https://doi.org/10.1016/j.jorganchem.2011.08.016
Damljanović IS, Stevanović DD, Pejović A, Vukicevic M, Novaković SB, Bogdanović GA, Mihajlov-Krstev T, Radulovic N, Vukicevic RD. Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization. Journal of Organometallic Chemistry. 2011;696(23):3703-3713
Damljanović Ivan S., Stevanović Dragana D., Pejović Anka, Vukicevic Mirjana, Novaković Slađana B., Bogdanović Goran A., Mihajlov-Krstev Tatjana, Radulovic Niko, Vukicevic Rastko D., "Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization" Journal of Organometallic Chemistry, 696, no. 23 (2011):3703-3713,
https://doi.org/10.1016/j.jorganchem.2011.08.016 .
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