TY  - JOUR
AU  - Spasojević-Tišma, Vera D.
AU  - Matović, Milovan
AU  - Mihaljević, Olgica B.
AU  - Živančević-Simonović, Snežana T.
AU  - Jeremic, Marija Z.
AU  - Jakovljević, Vladimir Lj.
AU  - Todorović, Vera N.
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Todorović, Ana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1935
AB  - The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.
T2  - Nuclear technology and radiation protection
T1  - Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation
VL  - 32
IS  - 4
SP  - 358
EP  - 365
DO  - 10.2298/NTRP1704358S
ER  - 

@article{
author = "Spasojević-Tišma, Vera D. and Matović, Milovan and Mihaljević, Olgica B. and Živančević-Simonović, Snežana T. and Jeremic, Marija Z. and Jakovljević, Vladimir Lj. and Todorović, Vera N. and Pavlović, Ivan and Pejić, Snežana and Todorović, Ana",
year = "2017",
abstract = "The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.",
journal = "Nuclear technology and radiation protection",
title = "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation",
volume = "32",
number = "4",
pages = "358-365",
doi = "10.2298/NTRP1704358S"
}

Spasojević-Tišma, V. D., Matović, M., Mihaljević, O. B., Živančević-Simonović, S. T., Jeremic, M. Z., Jakovljević, V. Lj., Todorović, V. N., Pavlović, I., Pejić, S.,& Todorović, A.. (2017). Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. in Nuclear technology and radiation protection, 32(4), 358-365.
https://doi.org/10.2298/NTRP1704358S

Spasojević-Tišma VD, Matović M, Mihaljević OB, Živančević-Simonović ST, Jeremic MZ, Jakovljević VL, Todorović VN, Pavlović I, Pejić S, Todorović A. Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. in Nuclear technology and radiation protection. 2017;32(4):358-365.
doi:10.2298/NTRP1704358S .

Spasojević-Tišma, Vera D., Matović, Milovan, Mihaljević, Olgica B., Živančević-Simonović, Snežana T., Jeremic, Marija Z., Jakovljević, Vladimir Lj., Todorović, Vera N., Pavlović, Ivan, Pejić, Snežana, Todorović, Ana, "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation" in Nuclear technology and radiation protection, 32, no. 4 (2017):358-365,
https://doi.org/10.2298/NTRP1704358S . .