TY  - JOUR
AU  - Marković, Zoran M.
AU  - Budimir, Milica
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Zmejkoski, Danica
AU  - Pavlović, Vladimir B.
AU  - Mojsin, Marija
AU  - Stevanović, Milena J.
AU  - Todorović-Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10632
AB  - Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as probes for bioimaging.
T2  - Beilstein Journal of Nanotechnology
T1  - Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine
VL  - 14
IS  - 1
SP  - 165
EP  - 174
DO  - 10.3762/bjnano.14.17
ER  - 

@article{
author = "Marković, Zoran M. and Budimir, Milica and Danko, Martin and Milivojević, Dušan and Kubat, Pavel and Zmejkoski, Danica and Pavlović, Vladimir B. and Mojsin, Marija and Stevanović, Milena J. and Todorović-Marković, Biljana",
year = "2023",
abstract = "Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as probes for bioimaging.",
journal = "Beilstein Journal of Nanotechnology",
title = "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine",
volume = "14",
number = "1",
pages = "165-174",
doi = "10.3762/bjnano.14.17"
}

Marković, Z. M., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V. B., Mojsin, M., Stevanović, M. J.,& Todorović-Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174.
https://doi.org/10.3762/bjnano.14.17

Marković ZM, Budimir M, Danko M, Milivojević D, Kubat P, Zmejkoski D, Pavlović VB, Mojsin M, Stevanović MJ, Todorović-Marković B. Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology. 2023;14(1):165-174.
doi:10.3762/bjnano.14.17 .

Marković, Zoran M., Budimir, Milica, Danko, Martin, Milivojević, Dušan, Kubat, Pavel, Zmejkoski, Danica, Pavlović, Vladimir B., Mojsin, Marija, Stevanović, Milena J., Todorović-Marković, Biljana, "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine" in Beilstein Journal of Nanotechnology, 14, no. 1 (2023):165-174,
https://doi.org/10.3762/bjnano.14.17 . .

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Marković, Zoran M.
AU  - Budimir, Milica
AU  - Zdravković, Nemanja M.
AU  - Trišić, Dijana 
AU  - Bugárová, Nikol
AU  - Danko, Martin
AU  - Kozyrovska, Natalia O.
AU  - Špitalský, Zdeno
AU  - Kleinová, Angela
AU  - Kuzman, Sanja
AU  - Pavlović, Vladimir B.
AU  - Todorović-Marković, Biljana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9566
AB  - Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment. © 2021 Elsevier B.V.
T2  - Materials Science and Engineering: C
T1  - Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment
VL  - 122
SP  - 111925
DO  - 10.1016/j.msec.2021.111925
ER  - 

@article{
author = "Zmejkoski, Danica and Marković, Zoran M. and Budimir, Milica and Zdravković, Nemanja M. and Trišić, Dijana  and Bugárová, Nikol and Danko, Martin and Kozyrovska, Natalia O. and Špitalský, Zdeno and Kleinová, Angela and Kuzman, Sanja and Pavlović, Vladimir B. and Todorović-Marković, Biljana",
year = "2021",
abstract = "Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment. © 2021 Elsevier B.V.",
journal = "Materials Science and Engineering: C",
title = "Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment",
volume = "122",
pages = "111925",
doi = "10.1016/j.msec.2021.111925"
}

Zmejkoski, D., Marković, Z. M., Budimir, M., Zdravković, N. M., Trišić, D., Bugárová, N., Danko, M., Kozyrovska, N. O., Špitalský, Z., Kleinová, A., Kuzman, S., Pavlović, V. B.,& Todorović-Marković, B.. (2021). Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment. in Materials Science and Engineering: C, 122, 111925.
https://doi.org/10.1016/j.msec.2021.111925

Zmejkoski D, Marković ZM, Budimir M, Zdravković NM, Trišić D, Bugárová N, Danko M, Kozyrovska NO, Špitalský Z, Kleinová A, Kuzman S, Pavlović VB, Todorović-Marković B. Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment. in Materials Science and Engineering: C. 2021;122:111925.
doi:10.1016/j.msec.2021.111925 .

Zmejkoski, Danica, Marković, Zoran M., Budimir, Milica, Zdravković, Nemanja M., Trišić, Dijana , Bugárová, Nikol, Danko, Martin, Kozyrovska, Natalia O., Špitalský, Zdeno, Kleinová, Angela, Kuzman, Sanja, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment" in Materials Science and Engineering: C, 122 (2021):111925,
https://doi.org/10.1016/j.msec.2021.111925 . .

TY  - JOUR
AU  - Budimir, Milica
AU  - Marković, Zoran M.
AU  - Vajdak, Jan
AU  - Jovanović, Svetlana P.
AU  - Kubat, Pavel
AU  - Humpoliček, Petr
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Barras, Alexandre
AU  - Milivojević, Dušan
AU  - Špitalsky, Zdenko
AU  - Boukherroub, Rabah
AU  - Todorović-Marković, Biljana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9746
AB  - Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd
T2  - Radiation Physics and Chemistry
T1  - Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment
VL  - 185
SP  - 109499
DO  - 10.1016/j.radphyschem.2021.109499
ER  - 

@article{
author = "Budimir, Milica and Marković, Zoran M. and Vajdak, Jan and Jovanović, Svetlana P. and Kubat, Pavel and Humpoliček, Petr and Mičušik, Matej and Danko, Martin and Barras, Alexandre and Milivojević, Dušan and Špitalsky, Zdenko and Boukherroub, Rabah and Todorović-Marković, Biljana",
year = "2021",
abstract = "Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd",
journal = "Radiation Physics and Chemistry",
title = "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment",
volume = "185",
pages = "109499",
doi = "10.1016/j.radphyschem.2021.109499"
}

Budimir, M., Marković, Z. M., Vajdak, J., Jovanović, S. P., Kubat, P., Humpoliček, P., Mičušik, M., Danko, M., Barras, A., Milivojević, D., Špitalsky, Z., Boukherroub, R.,& Todorović-Marković, B.. (2021). Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry, 185, 109499.
https://doi.org/10.1016/j.radphyschem.2021.109499

Budimir M, Marković ZM, Vajdak J, Jovanović SP, Kubat P, Humpoliček P, Mičušik M, Danko M, Barras A, Milivojević D, Špitalsky Z, Boukherroub R, Todorović-Marković B. Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry. 2021;185:109499.
doi:10.1016/j.radphyschem.2021.109499 .

Budimir, Milica, Marković, Zoran M., Vajdak, Jan, Jovanović, Svetlana P., Kubat, Pavel, Humpoliček, Petr, Mičušik, Matej, Danko, Martin, Barras, Alexandre, Milivojević, Dušan, Špitalsky, Zdenko, Boukherroub, Rabah, Todorović-Marković, Biljana, "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment" in Radiation Physics and Chemistry, 185 (2021):109499,
https://doi.org/10.1016/j.radphyschem.2021.109499 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kovačova, Maria
AU  - Humpoliček, Petr
AU  - Budimir, Milica
AU  - Vajdak, Jan
AU  - Kubat, Pavel
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Danko, Martin
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9615
AB  - Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]
VL  - 32
SP  - 101939
DO  - 10.1016/j.pdpdt.2020.101939
ER  - 

@article{
author = "Marković, Zoran M. and Kovačova, Maria and Humpoliček, Petr and Budimir, Milica and Vajdak, Jan and Kubat, Pavel and Mičušik, Matej and Švajdlenkova, Helena and Danko, Martin and Capakova, Zdenka and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2020",
abstract = "Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]",
volume = "32",
pages = "101939",
doi = "10.1016/j.pdpdt.2020.101939"
}

Marković, Z. M., Kovačova, M., Humpoliček, P., Budimir, M., Vajdak, J., Kubat, P., Mičušik, M., Švajdlenkova, H., Danko, M., Capakova, Z., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2020). Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]. in Photodiagnosis and Photodynamic Therapy, 32, 101939.
https://doi.org/10.1016/j.pdpdt.2020.101939

Marković ZM, Kovačova M, Humpoliček P, Budimir M, Vajdak J, Kubat P, Mičušik M, Švajdlenkova H, Danko M, Capakova Z, Lehocky M, Todorović-Marković B, Špitalsky Z. Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]. in Photodiagnosis and Photodynamic Therapy. 2020;32:101939.
doi:10.1016/j.pdpdt.2020.101939 .

Marković, Zoran M., Kovačova, Maria, Humpoliček, Petr, Budimir, Milica, Vajdak, Jan, Kubat, Pavel, Mičušik, Matej, Švajdlenkova, Helena, Danko, Martin, Capakova, Zdenka, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]" in Photodiagnosis and Photodynamic Therapy, 32 (2020):101939,
https://doi.org/10.1016/j.pdpdt.2020.101939 . .

TY  - JOUR
AU  - Budimir, Milica
AU  - Marković, Zoran M.
AU  - Jovanović, Dragana J.
AU  - Vujisić, Miloš
AU  - Mičušík, Matej
AU  - Danko, Martin
AU  - Kleinová, Angela
AU  - Švajdlenková, Helena
AU  - Špitalský, Zdeno
AU  - Todorović-Marković, Biljana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9827
T2  - RSC Advances
T1  - Erratum: Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study
VL  - 10
IS  - 12
SP  - 7125
DO  - 10.1039/D0RA90015J
ER  - 

@article{
author = "Budimir, Milica and Marković, Zoran M. and Jovanović, Dragana J. and Vujisić, Miloš and Mičušík, Matej and Danko, Martin and Kleinová, Angela and Švajdlenková, Helena and Špitalský, Zdeno and Todorović-Marković, Biljana",
year = "2020",
journal = "RSC Advances",
title = "Erratum: Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study",
volume = "10",
number = "12",
pages = "7125",
doi = "10.1039/D0RA90015J"
}

Budimir, M., Marković, Z. M., Jovanović, D. J., Vujisić, M., Mičušík, M., Danko, M., Kleinová, A., Švajdlenková, H., Špitalský, Z.,& Todorović-Marković, B.. (2020). Erratum: Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study. in RSC Advances, 10(12), 7125.
https://doi.org/10.1039/D0RA90015J

Budimir M, Marković ZM, Jovanović DJ, Vujisić M, Mičušík M, Danko M, Kleinová A, Švajdlenková H, Špitalský Z, Todorović-Marković B. Erratum: Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study. in RSC Advances. 2020;10(12):7125.
doi:10.1039/D0RA90015J .

Budimir, Milica, Marković, Zoran M., Jovanović, Dragana J., Vujisić, Miloš, Mičušík, Matej, Danko, Martin, Kleinová, Angela, Švajdlenková, Helena, Špitalský, Zdeno, Todorović-Marković, Biljana, "Erratum: Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study" in RSC Advances, 10, no. 12 (2020):7125,
https://doi.org/10.1039/D0RA90015J . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Labudová, Martina
AU  - Danko, Martin
AU  - Matijašević, Danka
AU  - Mičušík, Matej
AU  - Nádaždy, Vojtech
AU  - Kováčová, Mária
AU  - Kleinová, Angela
AU  - Špitalský, Zdeno
AU  - Pavlović, Vladimir B.
AU  - Milivojević, Dušan
AU  - Medić, Mina M.
AU  - Todorović-Marković, Biljana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9733
AB  - The addition of heteroatoms to pristine carbon quantum dots (CQDs) change their structure and optical properties. In this study, fluorine (F)- and chlorine (Cl)-doped CQDs are prepared by the one-step green hydrothermal route from sodium fluoride, sodium chloride, urea, and citric acid as the starting precursors. Microscopy analysis reveals that the average size of these quantum dots is 5 ± 2 nm, whereas the chemical study shows the existence of C–F and C–Cl bonds. The produced F- and Cl-doped CQDs have fluorescence quantum yields of 0.151 and 0.284, respectively, at an excitation wavelength of 450 nm. Charge transfer resistance of F- and Cl-doped CQDs films is 2 orders of magnitude higher than in the pristine CQD films. Transport band gap of the doped CQDs is 2 eV bigger than that of pristine CQDs. Radical scavenging activity shows very good antioxidant activity of doped CQDs. Antibacterial testing reveals poor antibacterial activity against Staphylococcus aureus and Escherichia coli. The F- and Cl-doped CQDs are successfully used as fluorescent probes for cell imaging as shown by confocal microscopy.
T2  - ACS Sustainable Chemistry and Engineering
T1  - Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging
VL  - 8
IS  - 43
SP  - 16327
EP  - 16338
DO  - 10.1021/acssuschemeng.0c06260
ER  - 

@article{
author = "Marković, Zoran M. and Labudová, Martina and Danko, Martin and Matijašević, Danka and Mičušík, Matej and Nádaždy, Vojtech and Kováčová, Mária and Kleinová, Angela and Špitalský, Zdeno and Pavlović, Vladimir B. and Milivojević, Dušan and Medić, Mina M. and Todorović-Marković, Biljana",
year = "2020",
abstract = "The addition of heteroatoms to pristine carbon quantum dots (CQDs) change their structure and optical properties. In this study, fluorine (F)- and chlorine (Cl)-doped CQDs are prepared by the one-step green hydrothermal route from sodium fluoride, sodium chloride, urea, and citric acid as the starting precursors. Microscopy analysis reveals that the average size of these quantum dots is 5 ± 2 nm, whereas the chemical study shows the existence of C–F and C–Cl bonds. The produced F- and Cl-doped CQDs have fluorescence quantum yields of 0.151 and 0.284, respectively, at an excitation wavelength of 450 nm. Charge transfer resistance of F- and Cl-doped CQDs films is 2 orders of magnitude higher than in the pristine CQD films. Transport band gap of the doped CQDs is 2 eV bigger than that of pristine CQDs. Radical scavenging activity shows very good antioxidant activity of doped CQDs. Antibacterial testing reveals poor antibacterial activity against Staphylococcus aureus and Escherichia coli. The F- and Cl-doped CQDs are successfully used as fluorescent probes for cell imaging as shown by confocal microscopy.",
journal = "ACS Sustainable Chemistry and Engineering",
title = "Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging",
volume = "8",
number = "43",
pages = "16327-16338",
doi = "10.1021/acssuschemeng.0c06260"
}

Marković, Z. M., Labudová, M., Danko, M., Matijašević, D., Mičušík, M., Nádaždy, V., Kováčová, M., Kleinová, A., Špitalský, Z., Pavlović, V. B., Milivojević, D., Medić, M. M.,& Todorović-Marković, B.. (2020). Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging. in ACS Sustainable Chemistry and Engineering, 8(43), 16327-16338.
https://doi.org/10.1021/acssuschemeng.0c06260

Marković ZM, Labudová M, Danko M, Matijašević D, Mičušík M, Nádaždy V, Kováčová M, Kleinová A, Špitalský Z, Pavlović VB, Milivojević D, Medić MM, Todorović-Marković B. Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging. in ACS Sustainable Chemistry and Engineering. 2020;8(43):16327-16338.
doi:10.1021/acssuschemeng.0c06260 .

Marković, Zoran M., Labudová, Martina, Danko, Martin, Matijašević, Danka, Mičušík, Matej, Nádaždy, Vojtech, Kováčová, Mária, Kleinová, Angela, Špitalský, Zdeno, Pavlović, Vladimir B., Milivojević, Dušan, Medić, Mina M., Todorović-Marković, Biljana, "Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging" in ACS Sustainable Chemistry and Engineering, 8, no. 43 (2020):16327-16338,
https://doi.org/10.1021/acssuschemeng.0c06260 . .

TY  - JOUR
AU  - Prekodravac, Jovana
AU  - Vasiljević, Bojana
AU  - Marković, Zoran M.
AU  - Jovanović, Dragana J.
AU  - Kleut, Duška
AU  - Špitalsky, Zdenko
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Bajuk-Bogdanović, Danica V.
AU  - Todorović-Marković, Biljana
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0272884219313598
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8211
AB  - Industrialization today leads to a significant increase in the environmental pollution, with number of phenols, pesticides, paints, solvents and other organic pollutants with potentially carcinogenic effect in natural resources. Investigation of some new semiconductor materials and their photocatalytic properties for removal of pollutants is a challenging work. However, limited usage of photoactive materials still requires the testing of new materials with photoactive properties. The current work introduces the swift and easy approach for synthesis of (metal–free) N–doped carbon quantum dots in water using microwave reactor. Synthesis was performed from glucose water solution by heating in microwave reactor for only 1 min, at low temperature and applied microwave power. The synthesized N–doped carbon quantum dots show remarkable photocatalytic activity for removal of toxic organic dye (Rose Bengal) under visible light irradiation. Almost 93% of the dye degradation is achieved after only 30 min of radiation. The uninspected result, that the pH of the medium has a significant effect on the performance of the synthesized material in the presence of organic dye, indicates that dots show dual behavior. In the neutral and basic conditions, they have the ability to degrade organic dye, whereas, by shifting the medium pH into acidic medium, they form a stable conjugate with Rose Bengal. © 2019 Elsevier Ltd and Techna Group S.r.l.
T2  - Ceramics International
T1  - Green and facile microwave assisted synthesis of (metal-free) N-doped carbon quantum dots for catalytic applications
VL  - 45
IS  - 14
SP  - 17006
EP  - 17013
DO  - 10.1016/j.ceramint.2019.05.250
ER  - 

@article{
author = "Prekodravac, Jovana and Vasiljević, Bojana and Marković, Zoran M. and Jovanović, Dragana J. and Kleut, Duška and Špitalsky, Zdenko and Mičušik, Matej and Danko, Martin and Bajuk-Bogdanović, Danica V. and Todorović-Marković, Biljana",
year = "2019",
abstract = "Industrialization today leads to a significant increase in the environmental pollution, with number of phenols, pesticides, paints, solvents and other organic pollutants with potentially carcinogenic effect in natural resources. Investigation of some new semiconductor materials and their photocatalytic properties for removal of pollutants is a challenging work. However, limited usage of photoactive materials still requires the testing of new materials with photoactive properties. The current work introduces the swift and easy approach for synthesis of (metal–free) N–doped carbon quantum dots in water using microwave reactor. Synthesis was performed from glucose water solution by heating in microwave reactor for only 1 min, at low temperature and applied microwave power. The synthesized N–doped carbon quantum dots show remarkable photocatalytic activity for removal of toxic organic dye (Rose Bengal) under visible light irradiation. Almost 93% of the dye degradation is achieved after only 30 min of radiation. The uninspected result, that the pH of the medium has a significant effect on the performance of the synthesized material in the presence of organic dye, indicates that dots show dual behavior. In the neutral and basic conditions, they have the ability to degrade organic dye, whereas, by shifting the medium pH into acidic medium, they form a stable conjugate with Rose Bengal. © 2019 Elsevier Ltd and Techna Group S.r.l.",
journal = "Ceramics International",
title = "Green and facile microwave assisted synthesis of (metal-free) N-doped carbon quantum dots for catalytic applications",
volume = "45",
number = "14",
pages = "17006-17013",
doi = "10.1016/j.ceramint.2019.05.250"
}

Prekodravac, J., Vasiljević, B., Marković, Z. M., Jovanović, D. J., Kleut, D., Špitalsky, Z., Mičušik, M., Danko, M., Bajuk-Bogdanović, D. V.,& Todorović-Marković, B.. (2019). Green and facile microwave assisted synthesis of (metal-free) N-doped carbon quantum dots for catalytic applications. in Ceramics International, 45(14), 17006-17013.
https://doi.org/10.1016/j.ceramint.2019.05.250

Prekodravac J, Vasiljević B, Marković ZM, Jovanović DJ, Kleut D, Špitalsky Z, Mičušik M, Danko M, Bajuk-Bogdanović DV, Todorović-Marković B. Green and facile microwave assisted synthesis of (metal-free) N-doped carbon quantum dots for catalytic applications. in Ceramics International. 2019;45(14):17006-17013.
doi:10.1016/j.ceramint.2019.05.250 .

Prekodravac, Jovana, Vasiljević, Bojana, Marković, Zoran M., Jovanović, Dragana J., Kleut, Duška, Špitalsky, Zdenko, Mičušik, Matej, Danko, Martin, Bajuk-Bogdanović, Danica V., Todorović-Marković, Biljana, "Green and facile microwave assisted synthesis of (metal-free) N-doped carbon quantum dots for catalytic applications" in Ceramics International, 45, no. 14 (2019):17006-17013,
https://doi.org/10.1016/j.ceramint.2019.05.250 . .

TY  - JOUR
AU  - Budimir, Milica
AU  - Marković, Zoran M.
AU  - Jovanović, Dragana J.
AU  - Vujisić, Miloš Lj.
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Kleinova, Angela
AU  - Švajdlenkova, Helena
AU  - Špitalsky, Zdenko
AU  - Todorović-Marković, Biljana
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C9RA00500E
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8086
AB  - In recent years, water pollution and contamination had become a major threat to the ecosystem. However, the use of nanostructured materials has been proven as a very promising approach in the treatment of polluted water. The present study reports the results of the gamma ray-assisted modification of hydrophobic carbon quantum dot (hCQD)/polyurethane nanocomposites for photocatalytic degradation of organic dyes. Different characterization methods were applied to investigate the influence of the different doses of gamma irradiation (1, 10 and 200 kGy) on the physical and chemical properties of nanocomposites (morphology, chemical content, mechanical properties, wettability, and potential for singlet oxygen generation). Surface morphology and mechanical properties analyses showed that gamma rays induced insignificant changes in the structure of nanocomposites, but the potential for singlet oxygen generation increased significantly. Here we also explore, in detail, the photocatalytic properties of gamma-ray modified hCQDs/polyurethane nanocomposites. UV-vis analysis showed that the removal efficiency of the rose bengal dye reached up to 97% for the nanocomposite irradiated with the dose of 200 kGy.
T2  - RSC Advances
T1  - Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study
VL  - 9
IS  - 11
SP  - 6278
EP  - 6286
DO  - 10.1039/C9RA00500E
ER  - 

@article{
author = "Budimir, Milica and Marković, Zoran M. and Jovanović, Dragana J. and Vujisić, Miloš Lj. and Mičušik, Matej and Danko, Martin and Kleinova, Angela and Švajdlenkova, Helena and Špitalsky, Zdenko and Todorović-Marković, Biljana",
year = "2019",
abstract = "In recent years, water pollution and contamination had become a major threat to the ecosystem. However, the use of nanostructured materials has been proven as a very promising approach in the treatment of polluted water. The present study reports the results of the gamma ray-assisted modification of hydrophobic carbon quantum dot (hCQD)/polyurethane nanocomposites for photocatalytic degradation of organic dyes. Different characterization methods were applied to investigate the influence of the different doses of gamma irradiation (1, 10 and 200 kGy) on the physical and chemical properties of nanocomposites (morphology, chemical content, mechanical properties, wettability, and potential for singlet oxygen generation). Surface morphology and mechanical properties analyses showed that gamma rays induced insignificant changes in the structure of nanocomposites, but the potential for singlet oxygen generation increased significantly. Here we also explore, in detail, the photocatalytic properties of gamma-ray modified hCQDs/polyurethane nanocomposites. UV-vis analysis showed that the removal efficiency of the rose bengal dye reached up to 97% for the nanocomposite irradiated with the dose of 200 kGy.",
journal = "RSC Advances",
title = "Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study",
volume = "9",
number = "11",
pages = "6278-6286",
doi = "10.1039/C9RA00500E"
}

Budimir, M., Marković, Z. M., Jovanović, D. J., Vujisić, M. Lj., Mičušik, M., Danko, M., Kleinova, A., Švajdlenkova, H., Špitalsky, Z.,& Todorović-Marković, B.. (2019). Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study. in RSC Advances, 9(11), 6278-6286.
https://doi.org/10.1039/C9RA00500E

Budimir M, Marković ZM, Jovanović DJ, Vujisić ML, Mičušik M, Danko M, Kleinova A, Švajdlenkova H, Špitalsky Z, Todorović-Marković B. Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study. in RSC Advances. 2019;9(11):6278-6286.
doi:10.1039/C9RA00500E .

Budimir, Milica, Marković, Zoran M., Jovanović, Dragana J., Vujisić, Miloš Lj., Mičušik, Matej, Danko, Martin, Kleinova, Angela, Švajdlenkova, Helena, Špitalsky, Zdenko, Todorović-Marković, Biljana, "Gamma ray assisted modification of carbon quantum dot/polyurethane nanocomposites: structural, mechanical and photocatalytic study" in RSC Advances, 9, no. 11 (2019):6278-6286,
https://doi.org/10.1039/C9RA00500E . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kovačova, Maria
AU  - Humpoliček, Petr
AU  - Budimir, Milica
AU  - Vajdak, Jan
AU  - Kubat, Pavel
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Danko, Martin
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8174
AB  - Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae
VL  - 26
SP  - 342
EP  - 349
DO  - 10.1016/j.pdpdt.2019.04.019
ER  - 

@article{
author = "Marković, Zoran M. and Kovačova, Maria and Humpoliček, Petr and Budimir, Milica and Vajdak, Jan and Kubat, Pavel and Mičušik, Matej and Švajdlenkova, Helena and Danko, Martin and Capakova, Zdenka and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2019",
abstract = "Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae",
volume = "26",
pages = "342-349",
doi = "10.1016/j.pdpdt.2019.04.019"
}

Marković, Z. M., Kovačova, M., Humpoliček, P., Budimir, M., Vajdak, J., Kubat, P., Mičušik, M., Švajdlenkova, H., Danko, M., Capakova, Z., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2019). Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy, 26, 342-349.
https://doi.org/10.1016/j.pdpdt.2019.04.019

Marković ZM, Kovačova M, Humpoliček P, Budimir M, Vajdak J, Kubat P, Mičušik M, Švajdlenkova H, Danko M, Capakova Z, Lehocky M, Todorović-Marković B, Špitalsky Z. Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy. 2019;26:342-349.
doi:10.1016/j.pdpdt.2019.04.019 .

Marković, Zoran M., Kovačova, Maria, Humpoliček, Petr, Budimir, Milica, Vajdak, Jan, Kubat, Pavel, Mičušik, Matej, Švajdlenkova, Helena, Danko, Martin, Capakova, Zdenka, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae" in Photodiagnosis and Photodynamic Therapy, 26 (2019):342-349,
https://doi.org/10.1016/j.pdpdt.2019.04.019 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kovačova, Maria
AU  - Humpoliček, Petr
AU  - Budimir, Milica
AU  - Vajdak, Jan
AU  - Kubat, Pavel
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Danko, Martin
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8187
AB  - Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae
VL  - 26
SP  - 342
EP  - 349
DO  - 10.1016/j.pdpdt.2019.04.019
ER  - 

@article{
author = "Marković, Zoran M. and Kovačova, Maria and Humpoliček, Petr and Budimir, Milica and Vajdak, Jan and Kubat, Pavel and Mičušik, Matej and Švajdlenkova, Helena and Danko, Martin and Capakova, Zdenka and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2019",
abstract = "Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae",
volume = "26",
pages = "342-349",
doi = "10.1016/j.pdpdt.2019.04.019"
}

Marković, Z. M., Kovačova, M., Humpoliček, P., Budimir, M., Vajdak, J., Kubat, P., Mičušik, M., Švajdlenkova, H., Danko, M., Capakova, Z., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2019). Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy, 26, 342-349.
https://doi.org/10.1016/j.pdpdt.2019.04.019

Marković ZM, Kovačova M, Humpoliček P, Budimir M, Vajdak J, Kubat P, Mičušik M, Švajdlenkova H, Danko M, Capakova Z, Lehocky M, Todorović-Marković B, Špitalsky Z. Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy. 2019;26:342-349.
doi:10.1016/j.pdpdt.2019.04.019 .

Marković, Zoran M., Kovačova, Maria, Humpoliček, Petr, Budimir, Milica, Vajdak, Jan, Kubat, Pavel, Mičušik, Matej, Švajdlenkova, Helena, Danko, Martin, Capakova, Zdenka, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae" in Photodiagnosis and Photodynamic Therapy, 26 (2019):342-349,
https://doi.org/10.1016/j.pdpdt.2019.04.019 . .

TY  - JOUR
AU  - Tošić, Jelena
AU  - Stanojević, Željka
AU  - Vidičević, Sašenka
AU  - Isaković, Aleksandra J.
AU  - Ćirić, Darko
AU  - Martinović, Tamara
AU  - Kravić-Stevović, Tamara K.
AU  - Bumbaširević, Vladimir Ž.
AU  - Paunović, Verica G.
AU  - Jovanović, Svetlana P.
AU  - Todorović-Marković, Biljana
AU  - Marković, Zoran M.
AU  - Danko, Martin
AU  - Mičušik, Matej
AU  - Spitalsky, Zdenko
AU  - Trajković, Vladimir S.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0028390818308621
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8015
AB  - We investigated the therapeutic capacity of nano-sized graphene sheets, called graphene quantum dots (GQD), in experimental autoimmune encephalomyelitis (EAE), an animal model of immune-mediated central nervous system (CNS) damage. Intraperitoneally administered GQD (10 mg/kg/day) accumulated in the lymph node and CNS cells of Dark Agouti rats in which EAE was induced by immunization with spinal cord homogenate in complete Freund's adjuvant. GQD significantly reduced clinical signs of EAE when applied throughout the course of the disease (day 0–32), while the protection was less pronounced if the treatment was limited to the induction (day 0–7 post-immunization) or effector (from day 8 onwards) phase of the disease. GQD treatment diminished immune infiltration, demyelination, axonal damage, and apoptotic death in the CNS of EAE animals. GQD also reduced the numbers of interferon-γ-expressing T helper (Th)1 cells, as well as the expression of Th1 transcription factor T-bet and proinflammatory cytokines tumor necrosis factor, interleukin-1, and granulocyte-macrophage colony-stimulating factor in the lymph nodes and CNS immune infitrates. The protective effect of GQD in EAE was associated with the activation of p38 and p42/44 mitogen-activated protein kinases (MAPK) and Akt in the lymph nodes and/or CNS. Finally, GQD protected oligodendrocytes and neurons from T cell-mediated damage in the in vitro conditions. Collectively, these data demonstrate the ability of GQD to gain access to both immune and CNS cells during neuroinflammation, and to alleviate immune-mediated CNS damage by modulating MAPK/Akt signaling and encephalitogenic Th1 immune response. © 2018 Elsevier Ltd
T2  - Neuropharmacology
T1  - Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats
VL  - 146
SP  - 95
EP  - 108
DO  - 10.1016/j.neuropharm.2018.11.030
ER  - 

@article{
author = "Tošić, Jelena and Stanojević, Željka and Vidičević, Sašenka and Isaković, Aleksandra J. and Ćirić, Darko and Martinović, Tamara and Kravić-Stevović, Tamara K. and Bumbaširević, Vladimir Ž. and Paunović, Verica G. and Jovanović, Svetlana P. and Todorović-Marković, Biljana and Marković, Zoran M. and Danko, Martin and Mičušik, Matej and Spitalsky, Zdenko and Trajković, Vladimir S.",
year = "2019",
abstract = "We investigated the therapeutic capacity of nano-sized graphene sheets, called graphene quantum dots (GQD), in experimental autoimmune encephalomyelitis (EAE), an animal model of immune-mediated central nervous system (CNS) damage. Intraperitoneally administered GQD (10 mg/kg/day) accumulated in the lymph node and CNS cells of Dark Agouti rats in which EAE was induced by immunization with spinal cord homogenate in complete Freund's adjuvant. GQD significantly reduced clinical signs of EAE when applied throughout the course of the disease (day 0–32), while the protection was less pronounced if the treatment was limited to the induction (day 0–7 post-immunization) or effector (from day 8 onwards) phase of the disease. GQD treatment diminished immune infiltration, demyelination, axonal damage, and apoptotic death in the CNS of EAE animals. GQD also reduced the numbers of interferon-γ-expressing T helper (Th)1 cells, as well as the expression of Th1 transcription factor T-bet and proinflammatory cytokines tumor necrosis factor, interleukin-1, and granulocyte-macrophage colony-stimulating factor in the lymph nodes and CNS immune infitrates. The protective effect of GQD in EAE was associated with the activation of p38 and p42/44 mitogen-activated protein kinases (MAPK) and Akt in the lymph nodes and/or CNS. Finally, GQD protected oligodendrocytes and neurons from T cell-mediated damage in the in vitro conditions. Collectively, these data demonstrate the ability of GQD to gain access to both immune and CNS cells during neuroinflammation, and to alleviate immune-mediated CNS damage by modulating MAPK/Akt signaling and encephalitogenic Th1 immune response. © 2018 Elsevier Ltd",
journal = "Neuropharmacology",
title = "Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats",
volume = "146",
pages = "95-108",
doi = "10.1016/j.neuropharm.2018.11.030"
}

Tošić, J., Stanojević, Ž., Vidičević, S., Isaković, A. J., Ćirić, D., Martinović, T., Kravić-Stevović, T. K., Bumbaširević, V. Ž., Paunović, V. G., Jovanović, S. P., Todorović-Marković, B., Marković, Z. M., Danko, M., Mičušik, M., Spitalsky, Z.,& Trajković, V. S.. (2019). Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats. in Neuropharmacology, 146, 95-108.
https://doi.org/10.1016/j.neuropharm.2018.11.030

Tošić J, Stanojević Ž, Vidičević S, Isaković AJ, Ćirić D, Martinović T, Kravić-Stevović TK, Bumbaširević VŽ, Paunović VG, Jovanović SP, Todorović-Marković B, Marković ZM, Danko M, Mičušik M, Spitalsky Z, Trajković VS. Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats. in Neuropharmacology. 2019;146:95-108.
doi:10.1016/j.neuropharm.2018.11.030 .

Tošić, Jelena, Stanojević, Željka, Vidičević, Sašenka, Isaković, Aleksandra J., Ćirić, Darko, Martinović, Tamara, Kravić-Stevović, Tamara K., Bumbaširević, Vladimir Ž., Paunović, Verica G., Jovanović, Svetlana P., Todorović-Marković, Biljana, Marković, Zoran M., Danko, Martin, Mičušik, Matej, Spitalsky, Zdenko, Trajković, Vladimir S., "Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats" in Neuropharmacology, 146 (2019):95-108,
https://doi.org/10.1016/j.neuropharm.2018.11.030 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Jovanović, Svetlana P.
AU  - Mašković, Pavle Z.
AU  - Mojsin, Marija
AU  - Stevanović, Milena J.
AU  - Danko, Martin
AU  - Mičušik, Matej
AU  - Jovanović, Dragana J.
AU  - Kleinova, Angela
AU  - Špitalsky, Zdeno
AU  - Pavlović, Vladimir B.
AU  - Todorović-Marković, Biljana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8591
AB  - Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV–Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.
T2  - Journal of Photochemistry and Photobiology B: Biology
T1  - Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines
VL  - 200
SP  - 111647
DO  - 10.1016/j.jphotobiol.2019.111647
ER  - 

@article{
author = "Marković, Zoran M. and Jovanović, Svetlana P. and Mašković, Pavle Z. and Mojsin, Marija and Stevanović, Milena J. and Danko, Martin and Mičušik, Matej and Jovanović, Dragana J. and Kleinova, Angela and Špitalsky, Zdeno and Pavlović, Vladimir B. and Todorović-Marković, Biljana",
year = "2019",
abstract = "Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV–Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.",
journal = "Journal of Photochemistry and Photobiology B: Biology",
title = "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines",
volume = "200",
pages = "111647",
doi = "10.1016/j.jphotobiol.2019.111647"
}

Marković, Z. M., Jovanović, S. P., Mašković, P. Z., Mojsin, M., Stevanović, M. J., Danko, M., Mičušik, M., Jovanović, D. J., Kleinova, A., Špitalsky, Z., Pavlović, V. B.,& Todorović-Marković, B.. (2019). Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B: Biology, 200, 111647.
https://doi.org/10.1016/j.jphotobiol.2019.111647

Marković ZM, Jovanović SP, Mašković PZ, Mojsin M, Stevanović MJ, Danko M, Mičušik M, Jovanović DJ, Kleinova A, Špitalsky Z, Pavlović VB, Todorović-Marković B. Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B: Biology. 2019;200:111647.
doi:10.1016/j.jphotobiol.2019.111647 .

Marković, Zoran M., Jovanović, Svetlana P., Mašković, Pavle Z., Mojsin, Marija, Stevanović, Milena J., Danko, Martin, Mičušik, Matej, Jovanović, Dragana J., Kleinova, Angela, Špitalsky, Zdeno, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines" in Journal of Photochemistry and Photobiology B: Biology, 200 (2019):111647,
https://doi.org/10.1016/j.jphotobiol.2019.111647 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kováčová, Mária
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Švajdlenkova, Helena
AU  - Kleinova, Angela
AU  - Humpoliček, Petr
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdeno
PY  - 2019
UR  - http://doi.wiley.com/10.1002/app.47283
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8445
AB  - Various types of bacteria inhabit many surfaces thus causing problems which can have very strong impact on human health. Here we present a study of photophysical, mechanical, and antibacterial properties of curcumin/polyurethane nanocomposites prepared by swell-encapsulation-shrink method. The prepared nanocomposites have been characterized for degree of swelling, surface morphology, mechanical properties, chemical contents, photoluminescence, hydrophobicity, potentials for singlet oxygen generation, and antibacterial activity. Dynamic mechanical analysis has shown slight changes of glass temperature of curcumin/polyurethane nanocomposites due to blue light irradiation. It was found that nanocomposites have very strong photoluminescence, become photoactive upon blue light irradiation at 470 nm and generate singlet oxygen. Conducted antibacterial tests have shown very strong activity of these nanocomposites especially toward Escherichia coli. These bacteria strains have been eliminated completely only after 1 h irradiation by blue light. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 47283. © 2018 Wiley Periodicals, Inc.
T2  - Journal of Applied Polymer Science
T1  - Structural, mechanical, and antibacterial features of curcumin/polyurethane nanocomposites
VL  - 136
IS  - 13
SP  - 47283
DO  - 10.1002/app.47283
ER  - 

@article{
author = "Marković, Zoran M. and Kováčová, Mária and Mičušik, Matej and Danko, Martin and Švajdlenkova, Helena and Kleinova, Angela and Humpoliček, Petr and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdeno",
year = "2019",
abstract = "Various types of bacteria inhabit many surfaces thus causing problems which can have very strong impact on human health. Here we present a study of photophysical, mechanical, and antibacterial properties of curcumin/polyurethane nanocomposites prepared by swell-encapsulation-shrink method. The prepared nanocomposites have been characterized for degree of swelling, surface morphology, mechanical properties, chemical contents, photoluminescence, hydrophobicity, potentials for singlet oxygen generation, and antibacterial activity. Dynamic mechanical analysis has shown slight changes of glass temperature of curcumin/polyurethane nanocomposites due to blue light irradiation. It was found that nanocomposites have very strong photoluminescence, become photoactive upon blue light irradiation at 470 nm and generate singlet oxygen. Conducted antibacterial tests have shown very strong activity of these nanocomposites especially toward Escherichia coli. These bacteria strains have been eliminated completely only after 1 h irradiation by blue light. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 47283. © 2018 Wiley Periodicals, Inc.",
journal = "Journal of Applied Polymer Science",
title = "Structural, mechanical, and antibacterial features of curcumin/polyurethane nanocomposites",
volume = "136",
number = "13",
pages = "47283",
doi = "10.1002/app.47283"
}

Marković, Z. M., Kováčová, M., Mičušik, M., Danko, M., Švajdlenkova, H., Kleinova, A., Humpoliček, P., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2019). Structural, mechanical, and antibacterial features of curcumin/polyurethane nanocomposites. in Journal of Applied Polymer Science, 136(13), 47283.
https://doi.org/10.1002/app.47283

Marković ZM, Kováčová M, Mičušik M, Danko M, Švajdlenkova H, Kleinova A, Humpoliček P, Lehocky M, Todorović-Marković B, Špitalsky Z. Structural, mechanical, and antibacterial features of curcumin/polyurethane nanocomposites. in Journal of Applied Polymer Science. 2019;136(13):47283.
doi:10.1002/app.47283 .

Marković, Zoran M., Kováčová, Mária, Mičušik, Matej, Danko, Martin, Švajdlenkova, Helena, Kleinova, Angela, Humpoliček, Petr, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdeno, "Structural, mechanical, and antibacterial features of curcumin/polyurethane nanocomposites" in Journal of Applied Polymer Science, 136, no. 13 (2019):47283,
https://doi.org/10.1002/app.47283 . .

TY  - JOUR
AU  - Stanković, Nenad K.
AU  - Bodik, Michal
AU  - Šiffalovič, Peter
AU  - Kotlar, Mario
AU  - Mičušik, Matej
AU  - Špitalsky, Zdenko
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kleinova, Angela
AU  - Kubat, Pavel
AU  - Capakova, Zdenka
AU  - Humpoliček, Petr
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Marković, Zoran M.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7653
AB  - Inimitable properties of carbon quantum dots as well as a cheap production contribute to their possible application in biomedicine especially as antibacterial and antibiofouling coatings. Fluorescent hydrophobic carbon quantum dots are synthesized by bottom-up condensation method and used for deposition of uniform and homogeneous Langmuir-Blodgett thin films on different substrates. It is found that this kind of quantum dots generates singlet oxygen under blue light irradiation. Antibacterial and antibiofouling testing on four different bacteria strains (Escherichia coli, Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa) reveals enhanced antibacterial and antibiofouling activity of hydrophobic carbon dots thin films under blue light irradiation. Moreover, hydrophobic quantum dots show noncytotoxic effect on mouse fibroblast cell line. These properties enable potential usage of hydrophobic carbon quantum dots thin films as excellent antibacterial and antibiofouling coatings for different biomedical applications.
T2  - ACS Sustainable Chemistry and Engineering
T1  - Antibacterial and Antibiofouling Properties of Light Triggered Fluorescent Hydrophobic Carbon Quantum Dots Langmuir–Blodgett Thin Films
VL  - 6
IS  - 3
SP  - 4154
EP  - 4163
DO  - 10.1021/acssuschemeng.7b04566
ER  - 

@article{
author = "Stanković, Nenad K. and Bodik, Michal and Šiffalovič, Peter and Kotlar, Mario and Mičušik, Matej and Špitalsky, Zdenko and Danko, Martin and Milivojević, Dušan and Kleinova, Angela and Kubat, Pavel and Capakova, Zdenka and Humpoliček, Petr and Lehocky, Marian and Todorović-Marković, Biljana and Marković, Zoran M.",
year = "2018",
abstract = "Inimitable properties of carbon quantum dots as well as a cheap production contribute to their possible application in biomedicine especially as antibacterial and antibiofouling coatings. Fluorescent hydrophobic carbon quantum dots are synthesized by bottom-up condensation method and used for deposition of uniform and homogeneous Langmuir-Blodgett thin films on different substrates. It is found that this kind of quantum dots generates singlet oxygen under blue light irradiation. Antibacterial and antibiofouling testing on four different bacteria strains (Escherichia coli, Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa) reveals enhanced antibacterial and antibiofouling activity of hydrophobic carbon dots thin films under blue light irradiation. Moreover, hydrophobic quantum dots show noncytotoxic effect on mouse fibroblast cell line. These properties enable potential usage of hydrophobic carbon quantum dots thin films as excellent antibacterial and antibiofouling coatings for different biomedical applications.",
journal = "ACS Sustainable Chemistry and Engineering",
title = "Antibacterial and Antibiofouling Properties of Light Triggered Fluorescent Hydrophobic Carbon Quantum Dots Langmuir–Blodgett Thin Films",
volume = "6",
number = "3",
pages = "4154-4163",
doi = "10.1021/acssuschemeng.7b04566"
}

Stanković, N. K., Bodik, M., Šiffalovič, P., Kotlar, M., Mičušik, M., Špitalsky, Z., Danko, M., Milivojević, D., Kleinova, A., Kubat, P., Capakova, Z., Humpoliček, P., Lehocky, M., Todorović-Marković, B.,& Marković, Z. M.. (2018). Antibacterial and Antibiofouling Properties of Light Triggered Fluorescent Hydrophobic Carbon Quantum Dots Langmuir–Blodgett Thin Films. in ACS Sustainable Chemistry and Engineering, 6(3), 4154-4163.
https://doi.org/10.1021/acssuschemeng.7b04566

Stanković NK, Bodik M, Šiffalovič P, Kotlar M, Mičušik M, Špitalsky Z, Danko M, Milivojević D, Kleinova A, Kubat P, Capakova Z, Humpoliček P, Lehocky M, Todorović-Marković B, Marković ZM. Antibacterial and Antibiofouling Properties of Light Triggered Fluorescent Hydrophobic Carbon Quantum Dots Langmuir–Blodgett Thin Films. in ACS Sustainable Chemistry and Engineering. 2018;6(3):4154-4163.
doi:10.1021/acssuschemeng.7b04566 .

Stanković, Nenad K., Bodik, Michal, Šiffalovič, Peter, Kotlar, Mario, Mičušik, Matej, Špitalsky, Zdenko, Danko, Martin, Milivojević, Dušan, Kleinova, Angela, Kubat, Pavel, Capakova, Zdenka, Humpoliček, Petr, Lehocky, Marian, Todorović-Marković, Biljana, Marković, Zoran M., "Antibacterial and Antibiofouling Properties of Light Triggered Fluorescent Hydrophobic Carbon Quantum Dots Langmuir–Blodgett Thin Films" in ACS Sustainable Chemistry and Engineering, 6, no. 3 (2018):4154-4163,
https://doi.org/10.1021/acssuschemeng.7b04566 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Jovanović, Svetlana P.
AU  - Mašković, Pavle Z.
AU  - Danko, Martin
AU  - Mičušik, Matej
AU  - Pavlović, Vladimir B.
AU  - Milivojević, Dušan
AU  - Kleinova, Angela
AU  - Špitalsky, Zdenko
AU  - Todorović-Marković, Biljana
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7880
AB  - Due to controversial reports concerning antibacterial activity of different graphene based materials it is very important to investigate their antibacterial action on a wide range of Gram-positive and Gram-negative bacteria. In this paper we have investigated the structure induced phototoxic antibacterial activity of four types of graphene based materials: graphene oxide (GO), graphene quantum dots (GQDs), carbon quantum dots (CQDs) and nitrogen doped carbon quantum dots (N-CQDs). Antibacterial activity was tested on 19 types of bacteria. It is found that nanometer-size CQDs and N-CQDs are the most potent agents whereas micrometer-size GO has very poor antibacterial activity. Electron paramagnetic resonance measurements confirmed photodynamic production of singlet oxygen for all types of used quantum dots. Detailed analysis has shown that N-CQDs are an excellent photodynamic antibacterial agent for treatment of bacterial infections induced by Enterobacter aerogenes (E. aerogenes), Proteus mirabilis (P. mirabilis), Staphylococcus saprophyticus (S. saprophyticus), Listeria monocytogenes (L. monocytogenes), Salmonella typhimurium (S. typhimurium) and Klebsiella pneumoniae.
T2  - RSC Advances
T1  - Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria
VL  - 8
IS  - 55
SP  - 31337
EP  - 31347
DO  - 10.1039/C8RA04664F
ER  - 

@article{
author = "Marković, Zoran M. and Jovanović, Svetlana P. and Mašković, Pavle Z. and Danko, Martin and Mičušik, Matej and Pavlović, Vladimir B. and Milivojević, Dušan and Kleinova, Angela and Špitalsky, Zdenko and Todorović-Marković, Biljana",
year = "2018",
abstract = "Due to controversial reports concerning antibacterial activity of different graphene based materials it is very important to investigate their antibacterial action on a wide range of Gram-positive and Gram-negative bacteria. In this paper we have investigated the structure induced phototoxic antibacterial activity of four types of graphene based materials: graphene oxide (GO), graphene quantum dots (GQDs), carbon quantum dots (CQDs) and nitrogen doped carbon quantum dots (N-CQDs). Antibacterial activity was tested on 19 types of bacteria. It is found that nanometer-size CQDs and N-CQDs are the most potent agents whereas micrometer-size GO has very poor antibacterial activity. Electron paramagnetic resonance measurements confirmed photodynamic production of singlet oxygen for all types of used quantum dots. Detailed analysis has shown that N-CQDs are an excellent photodynamic antibacterial agent for treatment of bacterial infections induced by Enterobacter aerogenes (E. aerogenes), Proteus mirabilis (P. mirabilis), Staphylococcus saprophyticus (S. saprophyticus), Listeria monocytogenes (L. monocytogenes), Salmonella typhimurium (S. typhimurium) and Klebsiella pneumoniae.",
journal = "RSC Advances",
title = "Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria",
volume = "8",
number = "55",
pages = "31337-31347",
doi = "10.1039/C8RA04664F"
}

Marković, Z. M., Jovanović, S. P., Mašković, P. Z., Danko, M., Mičušik, M., Pavlović, V. B., Milivojević, D., Kleinova, A., Špitalsky, Z.,& Todorović-Marković, B.. (2018). Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria. in RSC Advances, 8(55), 31337-31347.
https://doi.org/10.1039/C8RA04664F

Marković ZM, Jovanović SP, Mašković PZ, Danko M, Mičušik M, Pavlović VB, Milivojević D, Kleinova A, Špitalsky Z, Todorović-Marković B. Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria. in RSC Advances. 2018;8(55):31337-31347.
doi:10.1039/C8RA04664F .

Marković, Zoran M., Jovanović, Svetlana P., Mašković, Pavle Z., Danko, Martin, Mičušik, Matej, Pavlović, Vladimir B., Milivojević, Dušan, Kleinova, Angela, Špitalsky, Zdenko, Todorović-Marković, Biljana, "Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria" in RSC Advances, 8, no. 55 (2018):31337-31347,
https://doi.org/10.1039/C8RA04664F . .

TY  - JOUR
AU  - Kovačova, Maria
AU  - Marković, Zoran M.
AU  - Humpoliček, Petr
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Kleinova, Angela
AU  - Danko, Martin
AU  - Kubat, Pavel
AU  - Vajdak, Jan
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Munster, Lukaš
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2018
UR  - http://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00582
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8064
AB  - Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.
T2  - ACS Biomaterials Science and Engineering
T1  - Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents
VL  - 4
IS  - 12
SP  - 3983
EP  - 3993
DO  - 10.1021/acsbiomaterials.8b00582
ER  - 

@article{
author = "Kovačova, Maria and Marković, Zoran M. and Humpoliček, Petr and Mičušik, Matej and Švajdlenkova, Helena and Kleinova, Angela and Danko, Martin and Kubat, Pavel and Vajdak, Jan and Capakova, Zdenka and Lehocky, Marian and Munster, Lukaš and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2018",
abstract = "Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.",
journal = "ACS Biomaterials Science and Engineering",
title = "Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents",
volume = "4",
number = "12",
pages = "3983-3993",
doi = "10.1021/acsbiomaterials.8b00582"
}

Kovačova, M., Marković, Z. M., Humpoliček, P., Mičušik, M., Švajdlenkova, H., Kleinova, A., Danko, M., Kubat, P., Vajdak, J., Capakova, Z., Lehocky, M., Munster, L., Todorović-Marković, B.,& Špitalsky, Z.. (2018). Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents. in ACS Biomaterials Science and Engineering, 4(12), 3983-3993.
https://doi.org/10.1021/acsbiomaterials.8b00582

Kovačova M, Marković ZM, Humpoliček P, Mičušik M, Švajdlenkova H, Kleinova A, Danko M, Kubat P, Vajdak J, Capakova Z, Lehocky M, Munster L, Todorović-Marković B, Špitalsky Z. Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents. in ACS Biomaterials Science and Engineering. 2018;4(12):3983-3993.
doi:10.1021/acsbiomaterials.8b00582 .

Kovačova, Maria, Marković, Zoran M., Humpoliček, Petr, Mičušik, Matej, Švajdlenkova, Helena, Kleinova, Angela, Danko, Martin, Kubat, Pavel, Vajdak, Jan, Capakova, Zdenka, Lehocky, Marian, Munster, Lukaš, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents" in ACS Biomaterials Science and Engineering, 4, no. 12 (2018):3983-3993,
https://doi.org/10.1021/acsbiomaterials.8b00582 . .