TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4026
AB  - In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Chemical Engineering Journal
T1  - Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels
VL  - 160
IS  - 2
SP  - 801
EP  - 809
DO  - 10.1016/j.cej.2010.03.089
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Chemical Engineering Journal",
title = "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels",
volume = "160",
number = "2",
pages = "801-809",
doi = "10.1016/j.cej.2010.03.089"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal, 160(2), 801-809.
https://doi.org/10.1016/j.cej.2010.03.089

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal. 2010;160(2):801-809.
doi:10.1016/j.cej.2010.03.089 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels" in Chemical Engineering Journal, 160, no. 2 (2010):801-809,
https://doi.org/10.1016/j.cej.2010.03.089 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6667
AB  - The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 degrees C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 degrees C, the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 degrees C, in order to evaluate their potential for medical applications. (c) 2007 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation
VL  - 76
IS  - 8-9
SP  - 1390
EP  - 1394
DO  - 10.1016/j.radphyschem.2007.02.038
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 degrees C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 degrees C, the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 degrees C, in order to evaluate their potential for medical applications. (c) 2007 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation",
volume = "76",
number = "8-9",
pages = "1390-1394",
doi = "10.1016/j.radphyschem.2007.02.038"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation. in Radiation Physics and Chemistry, 76(8-9), 1390-1394.
https://doi.org/10.1016/j.radphyschem.2007.02.038

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation. in Radiation Physics and Chemistry. 2007;76(8-9):1390-1394.
doi:10.1016/j.radphyschem.2007.02.038 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation" in Radiation Physics and Chemistry, 76, no. 8-9 (2007):1390-1394,
https://doi.org/10.1016/j.radphyschem.2007.02.038 . .

TY  - CONF
AU  - Mićić, Maja
AU  - Tomić, Simonida
AU  - Filipović, Jovanka
AU  - Suljovrujić, Edin
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11965
AB  - Sintetisani su kopolimerni hidrogelovi na bazi 2-hidroksietil metakrilata (HEMA) i itakonske kiseline (IA) polimerizacijom indukovanom gama zračenjem. Analizirani su proces bubrenja i termodinamičke osobine PHEMA i kopolimernih P(HEMA/IA) hidrogelova sa različitim sadržajem IA (2, 3.5 i 5 mol %) u širokom opsegu pH i temperature. Preliminarne analize gelova pokazuju interesantnu pH i temperatursku osetljivost u procesima bubrenja i otpuštanja lekova. Posebna pažnja posvećena je temperaturama u okolini fiziološke (37o C), gde male promene u temperaturi značajno utiču na stepen bubrenja i proces otpuštanaj lekova. Ispitivan je P(HEMA/IA) hidrogel sa 5mol% IA sa i bez antibiotika (gentamicin) na pH 7.40 i u temperaturskom intervalu 25- 42o C, u cilju praćenja mogućnosti njihovog korišćenja u medicini.
PB  - Beograd : Institut tehničkih nauka SANU
C3  - Šesta konferencija mladih istraživača Nauka i inženjerstvo novih materijala : Program i knjiga apstrakata; Decembar 24–26, Beograd
T1  - Bubrenje i termodinamička analiza temperaturno osetljivih 2- hidroksietil metakrilat/itakonska kiselina kopolimernih hidrogelova sintetisanih gama zračenjem
SP  - 2
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11965
ER  - 

@conference{
author = "Mićić, Maja and Tomić, Simonida and Filipović, Jovanka and Suljovrujić, Edin",
year = "2007",
abstract = "Sintetisani su kopolimerni hidrogelovi na bazi 2-hidroksietil metakrilata (HEMA) i itakonske kiseline (IA) polimerizacijom indukovanom gama zračenjem. Analizirani su proces bubrenja i termodinamičke osobine PHEMA i kopolimernih P(HEMA/IA) hidrogelova sa različitim sadržajem IA (2, 3.5 i 5 mol %) u širokom opsegu pH i temperature. Preliminarne analize gelova pokazuju interesantnu pH i temperatursku osetljivost u procesima bubrenja i otpuštanja lekova. Posebna pažnja posvećena je temperaturama u okolini fiziološke (37o C), gde male promene u temperaturi značajno utiču na stepen bubrenja i proces otpuštanaj lekova. Ispitivan je P(HEMA/IA) hidrogel sa 5mol% IA sa i bez antibiotika (gentamicin) na pH 7.40 i u temperaturskom intervalu 25- 42o C, u cilju praćenja mogućnosti njihovog korišćenja u medicini.",
publisher = "Beograd : Institut tehničkih nauka SANU",
journal = "Šesta konferencija mladih istraživača Nauka i inženjerstvo novih materijala : Program i knjiga apstrakata; Decembar 24–26, Beograd",
title = "Bubrenje i termodinamička analiza temperaturno osetljivih 2- hidroksietil metakrilat/itakonska kiselina kopolimernih hidrogelova sintetisanih gama zračenjem",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11965"
}

Mićić, M., Tomić, S., Filipović, J.,& Suljovrujić, E.. (2007). Bubrenje i termodinamička analiza temperaturno osetljivih 2- hidroksietil metakrilat/itakonska kiselina kopolimernih hidrogelova sintetisanih gama zračenjem. in Šesta konferencija mladih istraživača Nauka i inženjerstvo novih materijala : Program i knjiga apstrakata; Decembar 24–26, Beograd
Beograd : Institut tehničkih nauka SANU., 2-2.
https://hdl.handle.net/21.15107/rcub_vinar_11965

Mićić M, Tomić S, Filipović J, Suljovrujić E. Bubrenje i termodinamička analiza temperaturno osetljivih 2- hidroksietil metakrilat/itakonska kiselina kopolimernih hidrogelova sintetisanih gama zračenjem. in Šesta konferencija mladih istraživača Nauka i inženjerstvo novih materijala : Program i knjiga apstrakata; Decembar 24–26, Beograd. 2007;:2-2.
https://hdl.handle.net/21.15107/rcub_vinar_11965 .

Mićić, Maja, Tomić, Simonida, Filipović, Jovanka, Suljovrujić, Edin, "Bubrenje i termodinamička analiza temperaturno osetljivih 2- hidroksietil metakrilat/itakonska kiselina kopolimernih hidrogelova sintetisanih gama zračenjem" in Šesta konferencija mladih istraživača Nauka i inženjerstvo novih materijala : Program i knjiga apstrakata; Decembar 24–26, Beograd (2007):2-2,
https://hdl.handle.net/21.15107/rcub_vinar_11965 .