TY  - JOUR
AU  - Živković, Maja
AU  - Starčević Čizmarević, Nada
AU  - Lovrečić, Luca
AU  - Klupka-Saric, Inge
AU  - Stanković, Aleksandra
AU  - Gasparovic, Iva
AU  - Lavtar, Polona
AU  - Dinčić, Evica
AU  - Stojković, Ljiljana S.
AU  - Rudolf, Gorazd
AU  - Jazbec, Sasa Sega
AU  - Perkovic, Olivio
AU  - Sinanovic, Osman
AU  - Sepčić, Juraj
AU  - Kapović, Miljenko
AU  - Peterlin, Borut
AU  - Ristić, Smiljana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5963
AB  - Background. Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS). Methods. The GENoMS includes four populations (Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian) sharing the same geographic location and a similar ethnic background. A total of 885 patients and 656 ethnically matched healthy blood donors with no history of MS in their families were genotyped using PCR-RFLP. Results. TPA DD homozygosity was protective (OR = 0.79, 95% CI 0.63-0.99, P = 0.037) and PAI 5G5G was a risk factor for MS (OR = 1.30, 95% CI 1.01-1.66, P = 0.038). A significant effect of the genotype/carrier combination was detected in 5G5G/I carriers (OR = 1.39 95% CI 1.06-1.82, P = 0.017). Conclusions. We found a significantly harmful effect of the combination of the PAI-1 5G/5G genotype and TPA I allele on MS susceptibility, which indicates the importance of gene-gene interactions in complex diseases such as MS.
T2  - Disease Markers
T1  - The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis
DO  - 10.1155/2014/362708
ER  - 

@article{
author = "Živković, Maja and Starčević Čizmarević, Nada and Lovrečić, Luca and Klupka-Saric, Inge and Stanković, Aleksandra and Gasparovic, Iva and Lavtar, Polona and Dinčić, Evica and Stojković, Ljiljana S. and Rudolf, Gorazd and Jazbec, Sasa Sega and Perkovic, Olivio and Sinanovic, Osman and Sepčić, Juraj and Kapović, Miljenko and Peterlin, Borut and Ristić, Smiljana",
year = "2014",
abstract = "Background. Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS). Methods. The GENoMS includes four populations (Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian) sharing the same geographic location and a similar ethnic background. A total of 885 patients and 656 ethnically matched healthy blood donors with no history of MS in their families were genotyped using PCR-RFLP. Results. TPA DD homozygosity was protective (OR = 0.79, 95% CI 0.63-0.99, P = 0.037) and PAI 5G5G was a risk factor for MS (OR = 1.30, 95% CI 1.01-1.66, P = 0.038). A significant effect of the genotype/carrier combination was detected in 5G5G/I carriers (OR = 1.39 95% CI 1.06-1.82, P = 0.017). Conclusions. We found a significantly harmful effect of the combination of the PAI-1 5G/5G genotype and TPA I allele on MS susceptibility, which indicates the importance of gene-gene interactions in complex diseases such as MS.",
journal = "Disease Markers",
title = "The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis",
doi = "10.1155/2014/362708"
}

Živković, M., Starčević Čizmarević, N., Lovrečić, L., Klupka-Saric, I., Stanković, A., Gasparovic, I., Lavtar, P., Dinčić, E., Stojković, L. S., Rudolf, G., Jazbec, S. S., Perkovic, O., Sinanovic, O., Sepčić, J., Kapović, M., Peterlin, B.,& Ristić, S.. (2014). The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis. in Disease Markers.
https://doi.org/10.1155/2014/362708

Živković M, Starčević Čizmarević N, Lovrečić L, Klupka-Saric I, Stanković A, Gasparovic I, Lavtar P, Dinčić E, Stojković LS, Rudolf G, Jazbec SS, Perkovic O, Sinanovic O, Sepčić J, Kapović M, Peterlin B, Ristić S. The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis. in Disease Markers. 2014;.
doi:10.1155/2014/362708 .

Živković, Maja, Starčević Čizmarević, Nada, Lovrečić, Luca, Klupka-Saric, Inge, Stanković, Aleksandra, Gasparovic, Iva, Lavtar, Polona, Dinčić, Evica, Stojković, Ljiljana S., Rudolf, Gorazd, Jazbec, Sasa Sega, Perkovic, Olivio, Sinanovic, Osman, Sepčić, Juraj, Kapović, Miljenko, Peterlin, Borut, Ristić, Smiljana, "The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis" in Disease Markers (2014),
https://doi.org/10.1155/2014/362708 . .