TY  - JOUR
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Borišev, Ivana
AU  - Srđenović, Branislava U.
AU  - Rakočević, Zlatko Lj.
AU  - Pavlović, Vladimir B.
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0014480017305890
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7688
AB  - In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.
T2  - Experimental and Molecular Pathology
T1  - Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats
VL  - 104
IS  - 3
SP  - 199
EP  - 211
DO  - 10.1016/j.yexmp.2018.04.005
ER  - 

@article{
author = "Petrović, Danijela and Seke, Mariana and Labudović-Borović, Milica and Jović, Danica S. and Borišev, Ivana and Srđenović, Branislava U. and Rakočević, Zlatko Lj. and Pavlović, Vladimir B. and Đorđević, Aleksandar N.",
year = "2018",
abstract = "In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.",
journal = "Experimental and Molecular Pathology",
title = "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats",
volume = "104",
number = "3",
pages = "199-211",
doi = "10.1016/j.yexmp.2018.04.005"
}

Petrović, D., Seke, M., Labudović-Borović, M., Jović, D. S., Borišev, I., Srđenović, B. U., Rakočević, Z. Lj., Pavlović, V. B.,& Đorđević, A. N.. (2018). Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. in Experimental and Molecular Pathology, 104(3), 199-211.
https://doi.org/10.1016/j.yexmp.2018.04.005

Petrović D, Seke M, Labudović-Borović M, Jović DS, Borišev I, Srđenović BU, Rakočević ZL, Pavlović VB, Đorđević AN. Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. in Experimental and Molecular Pathology. 2018;104(3):199-211.
doi:10.1016/j.yexmp.2018.04.005 .

Petrović, Danijela, Seke, Mariana, Labudović-Borović, Milica, Jović, Danica S., Borišev, Ivana, Srđenović, Branislava U., Rakočević, Zlatko Lj., Pavlović, Vladimir B., Đorđević, Aleksandar N., "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats" in Experimental and Molecular Pathology, 104, no. 3 (2018):199-211,
https://doi.org/10.1016/j.yexmp.2018.04.005 . .

TY  - JOUR
AU  - Borišev, Ivana
AU  - Mrđanović, Jasminka Ž.
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Jović, Danica S.
AU  - Srđenović, Branislava U.
AU  - Latinović, Nataša
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://stacks.iop.org/0957-4484/29/i=33/a=332002?key=crossref.4804877570e2609bf6333877ee495ab3
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7751
AB  - Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.
T2  - Nanotechnology
T1  - Nanoformulations of doxorubicin: How far have we come and where do we go from here?
VL  - 29
IS  - 33
SP  - 332002
DO  - 10.1088/1361-6528/aac7dd
ER  - 

@article{
author = "Borišev, Ivana and Mrđanović, Jasminka Ž. and Petrović, Danijela and Seke, Mariana and Jović, Danica S. and Srđenović, Branislava U. and Latinović, Nataša and Đorđević, Aleksandar N.",
year = "2018",
abstract = "Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.",
journal = "Nanotechnology",
title = "Nanoformulations of doxorubicin: How far have we come and where do we go from here?",
volume = "29",
number = "33",
pages = "332002",
doi = "10.1088/1361-6528/aac7dd"
}

Borišev, I., Mrđanović, J. Ž., Petrović, D., Seke, M., Jović, D. S., Srđenović, B. U., Latinović, N.,& Đorđević, A. N.. (2018). Nanoformulations of doxorubicin: How far have we come and where do we go from here?. in Nanotechnology, 29(33), 332002.
https://doi.org/10.1088/1361-6528/aac7dd

Borišev I, Mrđanović JŽ, Petrović D, Seke M, Jović DS, Srđenović BU, Latinović N, Đorđević AN. Nanoformulations of doxorubicin: How far have we come and where do we go from here?. in Nanotechnology. 2018;29(33):332002.
doi:10.1088/1361-6528/aac7dd .

Borišev, Ivana, Mrđanović, Jasminka Ž., Petrović, Danijela, Seke, Mariana, Jović, Danica S., Srđenović, Branislava U., Latinović, Nataša, Đorđević, Aleksandar N., "Nanoformulations of doxorubicin: How far have we come and where do we go from here?" in Nanotechnology, 29, no. 33 (2018):332002,
https://doi.org/10.1088/1361-6528/aac7dd . .

TY  - CONF
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Srđenović, Branislava U.
AU  - Kanacki, Zdenko
AU  - Zikić, Dragan
AU  - Đorđević, Aleksandar N.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7081
C3  - FEBS Journal
T1  - Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats
VL  - 282
SP  - 242
EP  - 242
DO  - 10.1111/febs.13339
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7081
ER  - 

@conference{
author = "Seke, Mariana and Petrović, Danijela and Labudović-Borović, Milica and Jović, Danica S. and Srđenović, Branislava U. and Kanacki, Zdenko and Zikić, Dragan and Đorđević, Aleksandar N.",
year = "2015",
journal = "FEBS Journal",
title = "Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats",
volume = "282",
pages = "242-242",
doi = "10.1111/febs.13339",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7081"
}

Seke, M., Petrović, D., Labudović-Borović, M., Jović, D. S., Srđenović, B. U., Kanacki, Z., Zikić, D.,& Đorđević, A. N.. (2015). Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats. in FEBS Journal, 282, 242-242.
https://doi.org/10.1111/febs.13339
https://hdl.handle.net/21.15107/rcub_vinar_7081

Seke M, Petrović D, Labudović-Borović M, Jović DS, Srđenović BU, Kanacki Z, Zikić D, Đorđević AN. Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats. in FEBS Journal. 2015;282:242-242.
doi:10.1111/febs.13339
https://hdl.handle.net/21.15107/rcub_vinar_7081 .

Seke, Mariana, Petrović, Danijela, Labudović-Borović, Milica, Jović, Danica S., Srđenović, Branislava U., Kanacki, Zdenko, Zikić, Dragan, Đorđević, Aleksandar N., "Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats" in FEBS Journal, 282 (2015):242-242,
https://doi.org/10.1111/febs.13339 .,
https://hdl.handle.net/21.15107/rcub_vinar_7081 .

TY  - JOUR
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Srđenović, Branislava U.
AU  - Đorđević, Aleksandar N.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/698
AB  - Fullerenes are molecules that, due to their unique structure, have very specific chemical properties which offer them very wide array of applications in nanomedicine. The most prominent are protection from radiation-induced injury, neuroprotection, drug and gene delivery, anticancer therapy, adjuvant within different treatments, photosensitizing, sonosensitizing, bone reparation, and biosensing. However, it is of crucial importance to be elucidated how fullerenes immunomodulate human system of defense. In addition, the most current research, merging immunology and nanomedicine, results in development of nanovaccines, which may represent the milestone of future treatment of diseases.
T2  - Journal of Nanomaterials
T1  - Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System
DO  - 10.1155/2015/565638
ER  - 

@article{
author = "Petrović, Danijela and Seke, Mariana and Srđenović, Branislava U. and Đorđević, Aleksandar N.",
year = "2015",
abstract = "Fullerenes are molecules that, due to their unique structure, have very specific chemical properties which offer them very wide array of applications in nanomedicine. The most prominent are protection from radiation-induced injury, neuroprotection, drug and gene delivery, anticancer therapy, adjuvant within different treatments, photosensitizing, sonosensitizing, bone reparation, and biosensing. However, it is of crucial importance to be elucidated how fullerenes immunomodulate human system of defense. In addition, the most current research, merging immunology and nanomedicine, results in development of nanovaccines, which may represent the milestone of future treatment of diseases.",
journal = "Journal of Nanomaterials",
title = "Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System",
doi = "10.1155/2015/565638"
}

Petrović, D., Seke, M., Srđenović, B. U.,& Đorđević, A. N.. (2015). Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System. in Journal of Nanomaterials.
https://doi.org/10.1155/2015/565638

Petrović D, Seke M, Srđenović BU, Đorđević AN. Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System. in Journal of Nanomaterials. 2015;.
doi:10.1155/2015/565638 .

Petrović, Danijela, Seke, Mariana, Srđenović, Branislava U., Đorđević, Aleksandar N., "Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System" in Journal of Nanomaterials (2015),
https://doi.org/10.1155/2015/565638 . .

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Srđenović, Branislava U.
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Injac, Rade
AU  - Mrđanović, Jasminka Ž.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/699
AB  - This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.
T2  - Journal of Nanomaterials
T1  - Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles
DO  - 10.1155/2015/567073
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Srđenović, Branislava U. and Seke, Mariana and Petrović, Danijela and Injac, Rade and Mrđanović, Jasminka Ž.",
year = "2015",
abstract = "This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.",
journal = "Journal of Nanomaterials",
title = "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles",
doi = "10.1155/2015/567073"
}

Đorđević, A. N., Srđenović, B. U., Seke, M., Petrović, D., Injac, R.,& Mrđanović, J. Ž.. (2015). Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. in Journal of Nanomaterials.
https://doi.org/10.1155/2015/567073

Đorđević AN, Srđenović BU, Seke M, Petrović D, Injac R, Mrđanović JŽ. Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. in Journal of Nanomaterials. 2015;.
doi:10.1155/2015/567073 .

Đorđević, Aleksandar N., Srđenović, Branislava U., Seke, Mariana, Petrović, Danijela, Injac, Rade, Mrđanović, Jasminka Ž., "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles" in Journal of Nanomaterials (2015),
https://doi.org/10.1155/2015/567073 . .

TY  - JOUR
AU  - Srđenović, Branislava U.
AU  - Slavic, Marija N.
AU  - Stankov, Karmen M.
AU  - Kladar, Nebojsa V.
AU  - Jović, Danica S.
AU  - Seke, Mariana
AU  - Bogdanović, Višnja V.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/767
AB  - Fullerenol (C-60(OH)(24)) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which have cytoprotective and anti-oxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influences the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.
T2  - Hemijska industrija
T1  - Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells
VL  - 69
IS  - 4
SP  - 425
EP  - 431
DO  - 10.2298/HEMIND131218054S
ER  - 

@article{
author = "Srđenović, Branislava U. and Slavic, Marija N. and Stankov, Karmen M. and Kladar, Nebojsa V. and Jović, Danica S. and Seke, Mariana and Bogdanović, Višnja V.",
year = "2015",
abstract = "Fullerenol (C-60(OH)(24)) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which have cytoprotective and anti-oxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influences the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.",
journal = "Hemijska industrija",
title = "Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells",
volume = "69",
number = "4",
pages = "425-431",
doi = "10.2298/HEMIND131218054S"
}

Srđenović, B. U., Slavic, M. N., Stankov, K. M., Kladar, N. V., Jović, D. S., Seke, M.,& Bogdanović, V. V.. (2015). Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells. in Hemijska industrija, 69(4), 425-431.
https://doi.org/10.2298/HEMIND131218054S

Srđenović BU, Slavic MN, Stankov KM, Kladar NV, Jović DS, Seke M, Bogdanović VV. Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells. in Hemijska industrija. 2015;69(4):425-431.
doi:10.2298/HEMIND131218054S .

Srđenović, Branislava U., Slavic, Marija N., Stankov, Karmen M., Kladar, Nebojsa V., Jović, Danica S., Seke, Mariana, Bogdanović, Višnja V., "Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells" in Hemijska industrija, 69, no. 4 (2015):425-431,
https://doi.org/10.2298/HEMIND131218054S . .