TY  - CONF
AU  - Abu el Rub, Anamarija
AU  - Nešić, M. D.
AU  - Žakula, Jelena
AU  - Ralić, V.
AU  - Petković, M.
AU  - Popović, I.
AU  - Matijević, M.
AU  - Radoičić, Marija
AU  - Stepić, Milutin
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11810
AB  - With difficulty in early diagnosis, inaccessibility for the surgical approach, and high resistance to radio and chemotherapies, the resulting low treatment success rates are calling for new approaches in treating pancreatic cancer [1]. Photodynamic therapy (PDT), with the use of light or X-rays, is a method that has the potential to help overcome the problems that existing approaches meet [2,3]. Through activation of photo-sensitive particles with irradiation, PDT helps the production of reactive oxygen species, consequently stimulating cell death. We have synthesized and characterized Gadolinium-doped titanium dioxide nanoparticles (Gd-TiO2 NPs) and tested them as photosensitizers on two pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. Different concentrations of NP treatment, irradiation powers, and times of irradiation were trialed as parameters of activation. Cell viability was measured 48h after treatments, and although some results implied a slight decrease in the viability of treated cells, we have met difficulties in obtaining consistency in results. Statistical significance in the decrease of the viability of treated cells in most cases was not attained, suggesting that higher concentrations or irradiation power and longer illumination time might be needed to achieve a positive PDT effect with this NP system.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - PHOTONICA2023 : 9th International School and Conference on Photonics : book of abstracts; August 28 - September 1, 2023; Belgrade
T1  - In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells
SP  - 80
EP  - 80
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11810
ER  - 

@conference{
author = "Abu el Rub, Anamarija and Nešić, M. D. and Žakula, Jelena and Ralić, V. and Petković, M. and Popović, I. and Matijević, M. and Radoičić, Marija and Stepić, Milutin",
year = "2023",
abstract = "With difficulty in early diagnosis, inaccessibility for the surgical approach, and high resistance to radio and chemotherapies, the resulting low treatment success rates are calling for new approaches in treating pancreatic cancer [1]. Photodynamic therapy (PDT), with the use of light or X-rays, is a method that has the potential to help overcome the problems that existing approaches meet [2,3]. Through activation of photo-sensitive particles with irradiation, PDT helps the production of reactive oxygen species, consequently stimulating cell death. We have synthesized and characterized Gadolinium-doped titanium dioxide nanoparticles (Gd-TiO2 NPs) and tested them as photosensitizers on two pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. Different concentrations of NP treatment, irradiation powers, and times of irradiation were trialed as parameters of activation. Cell viability was measured 48h after treatments, and although some results implied a slight decrease in the viability of treated cells, we have met difficulties in obtaining consistency in results. Statistical significance in the decrease of the viability of treated cells in most cases was not attained, suggesting that higher concentrations or irradiation power and longer illumination time might be needed to achieve a positive PDT effect with this NP system.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "PHOTONICA2023 : 9th International School and Conference on Photonics : book of abstracts; August 28 - September 1, 2023; Belgrade",
title = "In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells",
pages = "80-80",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11810"
}

Abu el Rub, A., Nešić, M. D., Žakula, J., Ralić, V., Petković, M., Popović, I., Matijević, M., Radoičić, M.,& Stepić, M.. (2023). In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells. in PHOTONICA2023 : 9th International School and Conference on Photonics : book of abstracts; August 28 - September 1, 2023; Belgrade
Belgrade : Vinča Institute of Nuclear Sciences., 80-80.
https://hdl.handle.net/21.15107/rcub_vinar_11810

Abu el Rub A, Nešić MD, Žakula J, Ralić V, Petković M, Popović I, Matijević M, Radoičić M, Stepić M. In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells. in PHOTONICA2023 : 9th International School and Conference on Photonics : book of abstracts; August 28 - September 1, 2023; Belgrade. 2023;:80-80.
https://hdl.handle.net/21.15107/rcub_vinar_11810 .

Abu el Rub, Anamarija, Nešić, M. D., Žakula, Jelena, Ralić, V., Petković, M., Popović, I., Matijević, M., Radoičić, Marija, Stepić, Milutin, "In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells" in PHOTONICA2023 : 9th International School and Conference on Photonics : book of abstracts; August 28 - September 1, 2023; Belgrade (2023):80-80,
https://hdl.handle.net/21.15107/rcub_vinar_11810 .