TY  - JOUR
AU  - Živković, Maja
AU  - Životić, Ivan
AU  - Dinčić, Evica
AU  - Stojković, Ljiljana S.
AU  - Vojinovic, Slobodan
AU  - Stanković, Aleksandra
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5771
AB  - Background: Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls. Methods: A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes. Results: Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36% vs. 21.86%, respectively, p LT 0.0001, adjusted OR 2.13 (1.56-2.90)), as well as double deletions (15.38% vs. 10.38%, respectively, p LT 0.05). The carriers of GSTM1 deletion had significantly earlier onset of MS compared to the wild-type carriers (28.31 +/- 8.45 vs. 30.64 +/- 9.30 years, respectively, p = 0.03). Conclusion: This study suggests the potential pathogenic role of GSTT1 deletion on MS susceptibility. There are no similar data published so far, yet this study should be replicated in other populations. (C) 2013 Elsevier B.V. All rights reserved.
T2  - Journal of the Neurological Sciences
T1  - The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis
VL  - 334
IS  - 1-2
SP  - 6
EP  - 9
DO  - 10.1016/j.jns.2013.07.001
ER  - 

@article{
author = "Živković, Maja and Životić, Ivan and Dinčić, Evica and Stojković, Ljiljana S. and Vojinovic, Slobodan and Stanković, Aleksandra",
year = "2013",
abstract = "Background: Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls. Methods: A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes. Results: Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36% vs. 21.86%, respectively, p LT 0.0001, adjusted OR 2.13 (1.56-2.90)), as well as double deletions (15.38% vs. 10.38%, respectively, p LT 0.05). The carriers of GSTM1 deletion had significantly earlier onset of MS compared to the wild-type carriers (28.31 +/- 8.45 vs. 30.64 +/- 9.30 years, respectively, p = 0.03). Conclusion: This study suggests the potential pathogenic role of GSTT1 deletion on MS susceptibility. There are no similar data published so far, yet this study should be replicated in other populations. (C) 2013 Elsevier B.V. All rights reserved.",
journal = "Journal of the Neurological Sciences",
title = "The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis",
volume = "334",
number = "1-2",
pages = "6-9",
doi = "10.1016/j.jns.2013.07.001"
}

Živković, M., Životić, I., Dinčić, E., Stojković, L. S., Vojinovic, S.,& Stanković, A.. (2013). The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. in Journal of the Neurological Sciences, 334(1-2), 6-9.
https://doi.org/10.1016/j.jns.2013.07.001

Živković M, Životić I, Dinčić E, Stojković LS, Vojinovic S, Stanković A. The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. in Journal of the Neurological Sciences. 2013;334(1-2):6-9.
doi:10.1016/j.jns.2013.07.001 .

Živković, Maja, Životić, Ivan, Dinčić, Evica, Stojković, Ljiljana S., Vojinovic, Slobodan, Stanković, Aleksandra, "The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis" in Journal of the Neurological Sciences, 334, no. 1-2 (2013):6-9,
https://doi.org/10.1016/j.jns.2013.07.001 . .