TY  - JOUR
AU  - Janković, Nenad
AU  - Tadić, Julijana D.
AU  - Milović, Emilija
AU  - Marković, Zoran
AU  - Jeremić, Svetlana
AU  - Petronijević, Jelena
AU  - Joksimović, Nenad
AU  - Borović, Teona Teodora
AU  - Bukhari, Syed Nasir Abbas
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11100
AB  - Antioxidants have a significant contribution in the cell protection against free radicals which may induce oxidative stress, and permanently damage the cells causing different disorders such as tumors, degenerative diseases, and accelerated aging. Nowadays, a multi-functionalized heterocyclic framework plays an important role in drug development, and it is of great importance in organic synthesis and medicinal chemistry. Encouraged by the bioactivity of the pyrido-dipyrimidine scaffold and vanillin core, herein, we made an effort to thoroughly investigate the antioxidant potential of the vanillin-based pyrido-dipyrimidines A–E to reveal novel promising free radical inhibitors. The structural analysis and the antioxidant action of the investigated molecules were performed in silico by DFT calculations. Studied compounds were screened for their antioxidant capacity using in vitro ABTS and DPPH assays. All the investigated compounds showed remarkable antioxidant activity, especially derivative A exhibiting inhibition of free radicals at the IC50 value (ABTS and DPPH assay 0.1 mg ml−1 and 0.081 mg ml−1, respectively). Compound A has higher TEAC values implying its stronger antioxidant activity compared to a trolox standard. The applied calculation method and in vitro tests confirmed that compound A has a strong potential against free radicals and may be a novel candidate for application in antioxidant therapy.
T2  - RSC Advances
T1  - Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach
VL  - 13
IS  - 22
SP  - 15236
EP  - 15242
DO  - 10.1039/D3RA02469E
ER  - 

@article{
author = "Janković, Nenad and Tadić, Julijana D. and Milović, Emilija and Marković, Zoran and Jeremić, Svetlana and Petronijević, Jelena and Joksimović, Nenad and Borović, Teona Teodora and Bukhari, Syed Nasir Abbas",
year = "2023",
abstract = "Antioxidants have a significant contribution in the cell protection against free radicals which may induce oxidative stress, and permanently damage the cells causing different disorders such as tumors, degenerative diseases, and accelerated aging. Nowadays, a multi-functionalized heterocyclic framework plays an important role in drug development, and it is of great importance in organic synthesis and medicinal chemistry. Encouraged by the bioactivity of the pyrido-dipyrimidine scaffold and vanillin core, herein, we made an effort to thoroughly investigate the antioxidant potential of the vanillin-based pyrido-dipyrimidines A–E to reveal novel promising free radical inhibitors. The structural analysis and the antioxidant action of the investigated molecules were performed in silico by DFT calculations. Studied compounds were screened for their antioxidant capacity using in vitro ABTS and DPPH assays. All the investigated compounds showed remarkable antioxidant activity, especially derivative A exhibiting inhibition of free radicals at the IC50 value (ABTS and DPPH assay 0.1 mg ml−1 and 0.081 mg ml−1, respectively). Compound A has higher TEAC values implying its stronger antioxidant activity compared to a trolox standard. The applied calculation method and in vitro tests confirmed that compound A has a strong potential against free radicals and may be a novel candidate for application in antioxidant therapy.",
journal = "RSC Advances",
title = "Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach",
volume = "13",
number = "22",
pages = "15236-15242",
doi = "10.1039/D3RA02469E"
}

Janković, N., Tadić, J. D., Milović, E., Marković, Z., Jeremić, S., Petronijević, J., Joksimović, N., Borović, T. T.,& Bukhari, S. N. A.. (2023). Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach. in RSC Advances, 13(22), 15236-15242.
https://doi.org/10.1039/D3RA02469E

Janković N, Tadić JD, Milović E, Marković Z, Jeremić S, Petronijević J, Joksimović N, Borović TT, Bukhari SNA. Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach. in RSC Advances. 2023;13(22):15236-15242.
doi:10.1039/D3RA02469E .

Janković, Nenad, Tadić, Julijana D., Milović, Emilija, Marković, Zoran, Jeremić, Svetlana, Petronijević, Jelena, Joksimović, Nenad, Borović, Teona Teodora, Bukhari, Syed Nasir Abbas, "Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach" in RSC Advances, 13, no. 22 (2023):15236-15242,
https://doi.org/10.1039/D3RA02469E . .