TY  - JOUR
AU  - Stokić, Edita
AU  - Romani, Andrea
AU  - Ilinčić, Branislava
AU  - Kupusinac, Aleksandar
AU  - Stošić, Zoran
AU  - Isenović, Esma R.
PY  - 2018
UR  - http://www.eurekaselect.com/155079/article
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7951
AB  - Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 +/- 4 years, 52% women) were recruited based on weight/adiposity parameters {[}i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators {[}insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) -0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH) D), vitamin D deficiency < 50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH) D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg < 0.85 mmol/L), a negative linear coefficient was found between 25(OH) D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg >= 0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.
T2  - Current Vascular Pharmacology
T1  - Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators
VL  - 16
IS  - 6
SP  - 610
EP  - 617
DO  - 10.2174/1570161115666170821154841
ER  - 

@article{
author = "Stokić, Edita and Romani, Andrea and Ilinčić, Branislava and Kupusinac, Aleksandar and Stošić, Zoran and Isenović, Esma R.",
year = "2018",
abstract = "Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 +/- 4 years, 52% women) were recruited based on weight/adiposity parameters {[}i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators {[}insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) -0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH) D), vitamin D deficiency < 50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH) D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg < 0.85 mmol/L), a negative linear coefficient was found between 25(OH) D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg >= 0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.",
journal = "Current Vascular Pharmacology",
title = "Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators",
volume = "16",
number = "6",
pages = "610-617",
doi = "10.2174/1570161115666170821154841"
}

Stokić, E., Romani, A., Ilinčić, B., Kupusinac, A., Stošić, Z.,& Isenović, E. R.. (2018). Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators. in Current Vascular Pharmacology, 16(6), 610-617.
https://doi.org/10.2174/1570161115666170821154841

Stokić E, Romani A, Ilinčić B, Kupusinac A, Stošić Z, Isenović ER. Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators. in Current Vascular Pharmacology. 2018;16(6):610-617.
doi:10.2174/1570161115666170821154841 .

Stokić, Edita, Romani, Andrea, Ilinčić, Branislava, Kupusinac, Aleksandar, Stošić, Zoran, Isenović, Esma R., "Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators" in Current Vascular Pharmacology, 16, no. 6 (2018):610-617,
https://doi.org/10.2174/1570161115666170821154841 . .

TY  - JOUR
AU  - Stokić, Edita
AU  - Hakkak, Reza
AU  - Romani, Andrea
AU  - Kupusinac, Aleksandar
AU  - Isenović, Esma R.
AU  - Tomić-Naglić, Dragana
AU  - Srdić-Galić, Biljana
AU  - Pejaković, Slađana
AU  - Radošević, Dragana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12028
AB  - Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese (body mass index [BMI]: 43.5 ± 9.2 kg/m2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2 ). Obese individuals were classified into different subgroups according to medians of observed anthropometric parameters (BMI, body fat percentage, waist circumference, and trunk fat mass). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25 (OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L, p < .001). There was a negative correlation between vitamin D and anthropometric indicators of obesity: BMI: (r = - 0.64, p < .001), waist circumference (r = -0.59; p < .001), and body fat percentage (r = -0.64; p < .001) as well with fasting plasma insulin (r = -0.35; p < .001) and homeostasis model assessment of insulin resistance (r = - 0.35; p < .001). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61; p < .01), while a positive association with adiponectin concentrations were found (r = .7; p < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. In contrast, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies.
T2  - Journal of Obesity and Chronic Diseases
T1  - Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity
VL  - 1
IS  - 2
DO  - 10.17756/jocd.2017-005
ER  - 

@article{
author = "Stokić, Edita and Hakkak, Reza and Romani, Andrea and Kupusinac, Aleksandar and Isenović, Esma R. and Tomić-Naglić, Dragana and Srdić-Galić, Biljana and Pejaković, Slađana and Radošević, Dragana",
year = "2017",
abstract = "Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese (body mass index [BMI]: 43.5 ± 9.2 kg/m2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2 ). Obese individuals were classified into different subgroups according to medians of observed anthropometric parameters (BMI, body fat percentage, waist circumference, and trunk fat mass). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25 (OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L, p < .001). There was a negative correlation between vitamin D and anthropometric indicators of obesity: BMI: (r = - 0.64, p < .001), waist circumference (r = -0.59; p < .001), and body fat percentage (r = -0.64; p < .001) as well with fasting plasma insulin (r = -0.35; p < .001) and homeostasis model assessment of insulin resistance (r = - 0.35; p < .001). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61; p < .01), while a positive association with adiponectin concentrations were found (r = .7; p < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. In contrast, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies.",
journal = "Journal of Obesity and Chronic Diseases",
title = "Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity",
volume = "1",
number = "2",
doi = "10.17756/jocd.2017-005"
}

Stokić, E., Hakkak, R., Romani, A., Kupusinac, A., Isenović, E. R., Tomić-Naglić, D., Srdić-Galić, B., Pejaković, S.,& Radošević, D.. (2017). Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity. in Journal of Obesity and Chronic Diseases, 1(2).
https://doi.org/10.17756/jocd.2017-005

Stokić E, Hakkak R, Romani A, Kupusinac A, Isenović ER, Tomić-Naglić D, Srdić-Galić B, Pejaković S, Radošević D. Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity. in Journal of Obesity and Chronic Diseases. 2017;1(2).
doi:10.17756/jocd.2017-005 .

Stokić, Edita, Hakkak, Reza, Romani, Andrea, Kupusinac, Aleksandar, Isenović, Esma R., Tomić-Naglić, Dragana, Srdić-Galić, Biljana, Pejaković, Slađana, Radošević, Dragana, "Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity" in Journal of Obesity and Chronic Diseases, 1, no. 2 (2017),
https://doi.org/10.17756/jocd.2017-005 . .