TY  - JOUR
AU  - Maksin, Danijela D.
AU  - Nastasović, Aleksandra B.
AU  - Maksin, Tatjana N.
AU  - Sandić, Zvjezdana
AU  - Loos, Katja
AU  - Ekmescic, Bojana M.
AU  - Onjia, Antonije E.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/984
AB  - Synthesis of an unconventional resin based on 4-vinylpyridine (4-VP) and its Cu(II) sorption behavior were studied. Three samples of macroporous crosslinked poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) (P4VPE) with different porosity parameters were prepared by suspension copolymerization by varying the n-heptane amount in the inert component. The samples were characterized by mercury porosimetry, elemental analysis and X-ray photoelectron spectroscopy (XPS). The sorption of P4VPE for Cu(II) ions, determined under non-competitive conditions, was relatively rapid, i.e., the maximum capacity was reached within 30 min. The maximum experimental sorption capacity for the sample with the highest values of pore diameter and specific pore volume (sample 3, Q(eq) = 89 mg g(-1)) was 17.5 times higher than for the sample with the lowest values of pore diameter and specific pore volume (sample 1, Q(eq) = 5.1 mg g(-1)). Since the values for pyridine content in all P4VPE samples were almost the same, it was concluded that the porosity parameters have predominant influence on Cu(II) sorption rates on P4VPE. The sorption behavior and the rate-controlling mechanisms were analyzed using six kinetic models (pseudo-first order, pseudo-second order, Elovich, intraparticle diffusion, Bangham and Boyd models). XPS study clarified the nature of the formed P4VPE-Cu(II) species.
T2  - Hemijska industrija
T1  - Cu(II) immobilization onto a one-step synthesized poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) resin: Kinetics and XPS analysis
VL  - 70
IS  - 1
SP  - 9
EP  - 19
DO  - 10.2298/HEMIND141203007M
ER  - 

@article{
author = "Maksin, Danijela D. and Nastasović, Aleksandra B. and Maksin, Tatjana N. and Sandić, Zvjezdana and Loos, Katja and Ekmescic, Bojana M. and Onjia, Antonije E.",
year = "2016",
abstract = "Synthesis of an unconventional resin based on 4-vinylpyridine (4-VP) and its Cu(II) sorption behavior were studied. Three samples of macroporous crosslinked poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) (P4VPE) with different porosity parameters were prepared by suspension copolymerization by varying the n-heptane amount in the inert component. The samples were characterized by mercury porosimetry, elemental analysis and X-ray photoelectron spectroscopy (XPS). The sorption of P4VPE for Cu(II) ions, determined under non-competitive conditions, was relatively rapid, i.e., the maximum capacity was reached within 30 min. The maximum experimental sorption capacity for the sample with the highest values of pore diameter and specific pore volume (sample 3, Q(eq) = 89 mg g(-1)) was 17.5 times higher than for the sample with the lowest values of pore diameter and specific pore volume (sample 1, Q(eq) = 5.1 mg g(-1)). Since the values for pyridine content in all P4VPE samples were almost the same, it was concluded that the porosity parameters have predominant influence on Cu(II) sorption rates on P4VPE. The sorption behavior and the rate-controlling mechanisms were analyzed using six kinetic models (pseudo-first order, pseudo-second order, Elovich, intraparticle diffusion, Bangham and Boyd models). XPS study clarified the nature of the formed P4VPE-Cu(II) species.",
journal = "Hemijska industrija",
title = "Cu(II) immobilization onto a one-step synthesized poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) resin: Kinetics and XPS analysis",
volume = "70",
number = "1",
pages = "9-19",
doi = "10.2298/HEMIND141203007M"
}

Maksin, D. D., Nastasović, A. B., Maksin, T. N., Sandić, Z., Loos, K., Ekmescic, B. M.,& Onjia, A. E.. (2016). Cu(II) immobilization onto a one-step synthesized poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) resin: Kinetics and XPS analysis. in Hemijska industrija, 70(1), 9-19.
https://doi.org/10.2298/HEMIND141203007M

Maksin DD, Nastasović AB, Maksin TN, Sandić Z, Loos K, Ekmescic BM, Onjia AE. Cu(II) immobilization onto a one-step synthesized poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) resin: Kinetics and XPS analysis. in Hemijska industrija. 2016;70(1):9-19.
doi:10.2298/HEMIND141203007M .

Maksin, Danijela D., Nastasović, Aleksandra B., Maksin, Tatjana N., Sandić, Zvjezdana, Loos, Katja, Ekmescic, Bojana M., Onjia, Antonije E., "Cu(II) immobilization onto a one-step synthesized poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) resin: Kinetics and XPS analysis" in Hemijska industrija, 70, no. 1 (2016):9-19,
https://doi.org/10.2298/HEMIND141203007M . .

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Ajdinovic, B.
AU  - Dopudja, M.
AU  - Trajkovic, S.
AU  - Milovanović, Z.
AU  - Maksin, Tatjana N.
AU  - Nešković, Olivera M.
AU  - Bogdanović, Višnja V.
AU  - Trpkov, Đorđe
AU  - Cvetićanin, Jelena M.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4282
AB  - In this study we performed the dynamic and static scintigraphy of the domestic dog, using the newly synthesized radiopharmaceutical, [Tc-99m(CO)(3)(H2O)(3)]-C-60(OH)(22-24). In the current study, an advanced one-step method for the functionalization of fullerenol by Tc-99m is described. Optical properties of as-prepared samples and the mechanism responsible for the functionalization were investigated using UV-VIS and FTIR spectroscopy, respectively. Also, the presence of the Tc complex on fullerenol was confirmed by using the energy dispersive X-ray spectroscopy, HPLC and MALDI TOF techniques. This simple and effective method of producing a new radiopharmaceutical is of interest not only for its application in various areas of technology and biology, but also for investigating its potential use in radiation technology for nanoengineering of materials. With dynamic scintigraphy, performed during 30 minutes (120 frames, 15 sec per frame), we obtained ratios of heart, liver and spleen counts: 222/249/168; 178/320/217; 120/348/239 respectively. By static scintigraphy after 1 hour, we detected the activity in heart, liver, spleen and intestines. After 4 hours, the radiopharmaceutical activity was detected in salivary glands. The detection after 21 hours showed the activity in kidneys and urinary bladder, while the activity in intestines was absent. After 24 hours, we detected the activity in liver, spleen, kidneys and urinary bladder. Pharmacokinetic investigations performed in this study are of key interest for the further fullerenol in vivo research.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24)
VL  - 6
IS  - 1
SP  - 99
EP  - 106
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4282
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Ajdinovic, B. and Dopudja, M. and Trajkovic, S. and Milovanović, Z. and Maksin, Tatjana N. and Nešković, Olivera M. and Bogdanović, Višnja V. and Trpkov, Đorđe and Cvetićanin, Jelena M.",
year = "2011",
abstract = "In this study we performed the dynamic and static scintigraphy of the domestic dog, using the newly synthesized radiopharmaceutical, [Tc-99m(CO)(3)(H2O)(3)]-C-60(OH)(22-24). In the current study, an advanced one-step method for the functionalization of fullerenol by Tc-99m is described. Optical properties of as-prepared samples and the mechanism responsible for the functionalization were investigated using UV-VIS and FTIR spectroscopy, respectively. Also, the presence of the Tc complex on fullerenol was confirmed by using the energy dispersive X-ray spectroscopy, HPLC and MALDI TOF techniques. This simple and effective method of producing a new radiopharmaceutical is of interest not only for its application in various areas of technology and biology, but also for investigating its potential use in radiation technology for nanoengineering of materials. With dynamic scintigraphy, performed during 30 minutes (120 frames, 15 sec per frame), we obtained ratios of heart, liver and spleen counts: 222/249/168; 178/320/217; 120/348/239 respectively. By static scintigraphy after 1 hour, we detected the activity in heart, liver, spleen and intestines. After 4 hours, the radiopharmaceutical activity was detected in salivary glands. The detection after 21 hours showed the activity in kidneys and urinary bladder, while the activity in intestines was absent. After 24 hours, we detected the activity in liver, spleen, kidneys and urinary bladder. Pharmacokinetic investigations performed in this study are of key interest for the further fullerenol in vivo research.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24)",
volume = "6",
number = "1",
pages = "99-106",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4282"
}

Đorđević, A. N., Ajdinovic, B., Dopudja, M., Trajkovic, S., Milovanović, Z., Maksin, T. N., Nešković, O. M., Bogdanović, V. V., Trpkov, Đ.,& Cvetićanin, J. M.. (2011). Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24). in Digest Journal of Nanomaterials and Biostructures, 6(1), 99-106.
https://hdl.handle.net/21.15107/rcub_vinar_4282

Đorđević AN, Ajdinovic B, Dopudja M, Trajkovic S, Milovanović Z, Maksin TN, Nešković OM, Bogdanović VV, Trpkov Đ, Cvetićanin JM. Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24). in Digest Journal of Nanomaterials and Biostructures. 2011;6(1):99-106.
https://hdl.handle.net/21.15107/rcub_vinar_4282 .

Đorđević, Aleksandar N., Ajdinovic, B., Dopudja, M., Trajkovic, S., Milovanović, Z., Maksin, Tatjana N., Nešković, Olivera M., Bogdanović, Višnja V., Trpkov, Đorđe, Cvetićanin, Jelena M., "Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24)" in Digest Journal of Nanomaterials and Biostructures, 6, no. 1 (2011):99-106,
https://hdl.handle.net/21.15107/rcub_vinar_4282 .

TY  - JOUR
AU  - Vukomanovic, Marija
AU  - Škapin, Srečo Davor
AU  - Jančar, Boštjan
AU  - Maksin, Tatjana N.
AU  - Ignjatović, Nenad L.
AU  - Uskokovic, Vuk
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4188
AB  - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
VL  - 82
IS  - 2
SP  - 404
EP  - 413
DO  - 10.1016/j.colsurfb.2010.09.011
ER  - 

@article{
author = "Vukomanovic, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana N. and Ignjatović, Nenad L. and Uskokovic, Vuk and Uskoković, Dragan",
year = "2011",
abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery",
volume = "82",
number = "2",
pages = "404-413",
doi = "10.1016/j.colsurfb.2010.09.011"
}

Vukomanovic, M., Škapin, S. D., Jančar, B., Maksin, T. N., Ignjatović, N. L., Uskokovic, V.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces. B: Biointerfaces, 82(2), 404-413.
https://doi.org/10.1016/j.colsurfb.2010.09.011

Vukomanovic M, Škapin SD, Jančar B, Maksin TN, Ignjatović NL, Uskokovic V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces. B: Biointerfaces. 2011;82(2):404-413.
doi:10.1016/j.colsurfb.2010.09.011 .

Vukomanovic, Marija, Škapin, Srečo Davor, Jančar, Boštjan, Maksin, Tatjana N., Ignjatović, Nenad L., Uskokovic, Vuk, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" in Colloids and Surfaces. B: Biointerfaces, 82, no. 2 (2011):404-413,
https://doi.org/10.1016/j.colsurfb.2010.09.011 . .

TY  - JOUR
AU  - Stevanović, Magdalena
AU  - Maksin, Tatjana N.
AU  - Petkovic, Jana
AU  - Filipic, Metka
AU  - Uskoković, Dragan
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3755
AB  - Nanoparticles of poly(DL-lactide-co-glycolide) (PLGA) in the size range 90-150 nm were produced using the physicochemical method with solvent/non-solvent systems. The encapsulation of the ascorbic acid in the polymer matrix was performed by homogenization of the water and organic phases. In vitro degradation and release tests of PLGA nanoparticles with and without encapsulated ascorbic acid were studied for more than 60 days in PBS and it has been determined that PLGA completely degrades within this period, fully releasing all encapsulated ascorbic acid. The cytotoxicity of PLGA and PLGA/ascorbic acid 85/15% nanoparticles was examined with human hepatoma cell lines (HepG2 ECACC), in vitro. The obtained results indicate that neither PLGA nanospheres nor PLGA/ascorbic acid 85/15% nanoparticles significantly affected the viability of the HepG2 cells. The investigation of the distribution and pharmacokinetics of PLGA is crucial for the effective prediction of host responses to PLGA in particular applications. Thus we present a method of labeling PLGA nanospheres and PLGA/ascorbic acid 85/15 wt% nanoparticles by (99m)Tc which binds outside, leaving the cage intact. This enables a quick and convenient investigation of the pharmacological behavior and metabolism of PLGA. The biodistribution of (99m)Tc-labeled PLGA particles with and without encapsulated ascorbic acid after different periods of time of their installation into rats was examined. PLGA nanospheres with encapsulated ascorbic acid exhibit prolonged blood circulation accompanied by time-dependent reduction in the lungs, liver and spleen, and addition in the kidney, stomach and intestine. The samples were characterized by x-ray diffraction, scanning electron microscopy, stereological analysis, transmission electron microscopy, ultraviolet spectroscopy and instant thin layer chromatography.
T2  - Nanotechnology
T1  - An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres
VL  - 20
IS  - 33
DO  - 10.1088/0957-4484/20/33/335102
ER  - 

@article{
author = "Stevanović, Magdalena and Maksin, Tatjana N. and Petkovic, Jana and Filipic, Metka and Uskoković, Dragan",
year = "2009",
abstract = "Nanoparticles of poly(DL-lactide-co-glycolide) (PLGA) in the size range 90-150 nm were produced using the physicochemical method with solvent/non-solvent systems. The encapsulation of the ascorbic acid in the polymer matrix was performed by homogenization of the water and organic phases. In vitro degradation and release tests of PLGA nanoparticles with and without encapsulated ascorbic acid were studied for more than 60 days in PBS and it has been determined that PLGA completely degrades within this period, fully releasing all encapsulated ascorbic acid. The cytotoxicity of PLGA and PLGA/ascorbic acid 85/15% nanoparticles was examined with human hepatoma cell lines (HepG2 ECACC), in vitro. The obtained results indicate that neither PLGA nanospheres nor PLGA/ascorbic acid 85/15% nanoparticles significantly affected the viability of the HepG2 cells. The investigation of the distribution and pharmacokinetics of PLGA is crucial for the effective prediction of host responses to PLGA in particular applications. Thus we present a method of labeling PLGA nanospheres and PLGA/ascorbic acid 85/15 wt% nanoparticles by (99m)Tc which binds outside, leaving the cage intact. This enables a quick and convenient investigation of the pharmacological behavior and metabolism of PLGA. The biodistribution of (99m)Tc-labeled PLGA particles with and without encapsulated ascorbic acid after different periods of time of their installation into rats was examined. PLGA nanospheres with encapsulated ascorbic acid exhibit prolonged blood circulation accompanied by time-dependent reduction in the lungs, liver and spleen, and addition in the kidney, stomach and intestine. The samples were characterized by x-ray diffraction, scanning electron microscopy, stereological analysis, transmission electron microscopy, ultraviolet spectroscopy and instant thin layer chromatography.",
journal = "Nanotechnology",
title = "An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres",
volume = "20",
number = "33",
doi = "10.1088/0957-4484/20/33/335102"
}

Stevanović, M., Maksin, T. N., Petkovic, J., Filipic, M.,& Uskoković, D.. (2009). An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres. in Nanotechnology, 20(33).
https://doi.org/10.1088/0957-4484/20/33/335102

Stevanović M, Maksin TN, Petkovic J, Filipic M, Uskoković D. An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres. in Nanotechnology. 2009;20(33).
doi:10.1088/0957-4484/20/33/335102 .

Stevanović, Magdalena, Maksin, Tatjana N., Petkovic, Jana, Filipic, Metka, Uskoković, Dragan, "An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres" in Nanotechnology, 20, no. 33 (2009),
https://doi.org/10.1088/0957-4484/20/33/335102 . .

TY  - JOUR
AU  - Janković, Drina
AU  - Maksin, Tatjana N.
AU  - Đokić, Divna Đ.
AU  - Milonjić, Slobodan K.
AU  - Nikolić, Nadežda S.
AU  - Mirković, Marija D.
AU  - Vranješ-Đurić, Sanja
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3578
AB  - Colloidal particle size is an important characteristic to consider when choosing a radiopharmaceutical for diagnosis and therapeutic purposes in nuclear medicine. Photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM) were used to determine the particle-size distribution of (90)Y- and (99m)Tc-labelled antimony trisulfide (Sb(2)S(3)) and tin colloids (Sn-colloid). (90)Y-Sb(2)S(3) and (99m)Tc-Sb(2)S(3) were found to have a diameter of 28.92 +/- 0.14 and 35.61 +/- 0.11 nm, respectively, by PCS. By TEM, (90)Y-Sb(2)S(3) particles were measured to be 14.33 +/- 0.09 nm. (90)Y-labelled Sn colloid were found to exist with a d(v(max1)) of 805 nm and a d(v(max2)) of 2590 nm, by PCS, whereas (99m)Tc-Sn colloid was shown to have more than 80% of radioactive particles of approximately 910 nm by PCS. For (90)Y-labelled Sb(2)S(3) and Sn colloid, a comparison of TEM and PCS indicates that these techniques found significantly different mean diameters. TEM has an excellent resolution necessary for radiocolloid particle-sizing analysis, and it is a desirable size-measuring technique because it is more reliable than PCS.
T2  - Journal of Microscopy, Oxford
T1  - Particle size analysis: (90)Y and (99m)Tc-labelled colloids
VL  - 232
IS  - 3
SP  - 601
EP  - 604
DO  - 10.1111/j.1365-2818.2008.02124.x
ER  - 

@article{
author = "Janković, Drina and Maksin, Tatjana N. and Đokić, Divna Đ. and Milonjić, Slobodan K. and Nikolić, Nadežda S. and Mirković, Marija D. and Vranješ-Đurić, Sanja",
year = "2008",
abstract = "Colloidal particle size is an important characteristic to consider when choosing a radiopharmaceutical for diagnosis and therapeutic purposes in nuclear medicine. Photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM) were used to determine the particle-size distribution of (90)Y- and (99m)Tc-labelled antimony trisulfide (Sb(2)S(3)) and tin colloids (Sn-colloid). (90)Y-Sb(2)S(3) and (99m)Tc-Sb(2)S(3) were found to have a diameter of 28.92 +/- 0.14 and 35.61 +/- 0.11 nm, respectively, by PCS. By TEM, (90)Y-Sb(2)S(3) particles were measured to be 14.33 +/- 0.09 nm. (90)Y-labelled Sn colloid were found to exist with a d(v(max1)) of 805 nm and a d(v(max2)) of 2590 nm, by PCS, whereas (99m)Tc-Sn colloid was shown to have more than 80% of radioactive particles of approximately 910 nm by PCS. For (90)Y-labelled Sb(2)S(3) and Sn colloid, a comparison of TEM and PCS indicates that these techniques found significantly different mean diameters. TEM has an excellent resolution necessary for radiocolloid particle-sizing analysis, and it is a desirable size-measuring technique because it is more reliable than PCS.",
journal = "Journal of Microscopy, Oxford",
title = "Particle size analysis: (90)Y and (99m)Tc-labelled colloids",
volume = "232",
number = "3",
pages = "601-604",
doi = "10.1111/j.1365-2818.2008.02124.x"
}

Janković, D., Maksin, T. N., Đokić, D. Đ., Milonjić, S. K., Nikolić, N. S., Mirković, M. D.,& Vranješ-Đurić, S.. (2008). Particle size analysis: (90)Y and (99m)Tc-labelled colloids. in Journal of Microscopy, Oxford, 232(3), 601-604.
https://doi.org/10.1111/j.1365-2818.2008.02124.x

Janković D, Maksin TN, Đokić DĐ, Milonjić SK, Nikolić NS, Mirković MD, Vranješ-Đurić S. Particle size analysis: (90)Y and (99m)Tc-labelled colloids. in Journal of Microscopy, Oxford. 2008;232(3):601-604.
doi:10.1111/j.1365-2818.2008.02124.x .

Janković, Drina, Maksin, Tatjana N., Đokić, Divna Đ., Milonjić, Slobodan K., Nikolić, Nadežda S., Mirković, Marija D., Vranješ-Đurić, Sanja, "Particle size analysis: (90)Y and (99m)Tc-labelled colloids" in Journal of Microscopy, Oxford, 232, no. 3 (2008):601-604,
https://doi.org/10.1111/j.1365-2818.2008.02124.x . .

TY  - JOUR
AU  - Maksin, Tatjana N.
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Djordjevc, A.
AU  - Nešković, Olivera M.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3265
AB  - The biological behavior of fullerene derivatives shows their considerable potential for medical application. Polyhidroxilated, water soluble fullerenol C-60(OH)(22). used in these studies, was synthesized by procedure complete substitution of bromine atoms from polybromine derivatives C60Br24 in alkaline media. In order to investigate the pharmacological behaviour and metabolism of the fullerenol, quickly and conveniently, we present the way and possibilities for its labelling with Tc-99m (T-1/2=6.02h, E-n=141keV), which bind to the outside, leaving the cage intact. Two different labelling approaches with technetium-99m were performed: direct labelling by tin (II) chloride method and labelling with Tc-99m(I) using [Tc-99m(CO)(3)(H2O)(3)](+) precursor. The radiochemical studies results have shown that content of free (TcO4-)-Tc-99m in the samples was depend on fullerenol-stannous chloride ratio and increased if ratio was higher. HPLC quality control results of Tc-99m(CO)(3)-[C-60(OH)(22)] have shown that the labelling yield, in alkaly media, was 95.35%. Protein binding to HA was species-dependent process. The biological behaviour of labelled fullerenol were different in dependence of labelling method and the time of sacrificed of animals. From recent investigations it can be concluded that oxidation state in technetium coordination complexes has a great impact on in vitro and in vivo behaviour of the these complexes.
T2  - Journal of Optoelectronics and Advanced Materials
T1  - Comparison of some physico-chemical parameters and biological behaviour of fullerenol labelled with technetium-99m
VL  - 9
IS  - 8
SP  - 2571
EP  - 2577
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3265
ER  - 

@article{
author = "Maksin, Tatjana N. and Đokić, Divna Đ. and Janković, Drina and Djordjevc, A. and Nešković, Olivera M.",
year = "2007",
abstract = "The biological behavior of fullerene derivatives shows their considerable potential for medical application. Polyhidroxilated, water soluble fullerenol C-60(OH)(22). used in these studies, was synthesized by procedure complete substitution of bromine atoms from polybromine derivatives C60Br24 in alkaline media. In order to investigate the pharmacological behaviour and metabolism of the fullerenol, quickly and conveniently, we present the way and possibilities for its labelling with Tc-99m (T-1/2=6.02h, E-n=141keV), which bind to the outside, leaving the cage intact. Two different labelling approaches with technetium-99m were performed: direct labelling by tin (II) chloride method and labelling with Tc-99m(I) using [Tc-99m(CO)(3)(H2O)(3)](+) precursor. The radiochemical studies results have shown that content of free (TcO4-)-Tc-99m in the samples was depend on fullerenol-stannous chloride ratio and increased if ratio was higher. HPLC quality control results of Tc-99m(CO)(3)-[C-60(OH)(22)] have shown that the labelling yield, in alkaly media, was 95.35%. Protein binding to HA was species-dependent process. The biological behaviour of labelled fullerenol were different in dependence of labelling method and the time of sacrificed of animals. From recent investigations it can be concluded that oxidation state in technetium coordination complexes has a great impact on in vitro and in vivo behaviour of the these complexes.",
journal = "Journal of Optoelectronics and Advanced Materials",
title = "Comparison of some physico-chemical parameters and biological behaviour of fullerenol labelled with technetium-99m",
volume = "9",
number = "8",
pages = "2571-2577",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3265"
}

Maksin, T. N., Đokić, D. Đ., Janković, D., Djordjevc, A.,& Nešković, O. M.. (2007). Comparison of some physico-chemical parameters and biological behaviour of fullerenol labelled with technetium-99m. in Journal of Optoelectronics and Advanced Materials, 9(8), 2571-2577.
https://hdl.handle.net/21.15107/rcub_vinar_3265

Maksin TN, Đokić DĐ, Janković D, Djordjevc A, Nešković OM. Comparison of some physico-chemical parameters and biological behaviour of fullerenol labelled with technetium-99m. in Journal of Optoelectronics and Advanced Materials. 2007;9(8):2571-2577.
https://hdl.handle.net/21.15107/rcub_vinar_3265 .

Maksin, Tatjana N., Đokić, Divna Đ., Janković, Drina, Djordjevc, A., Nešković, Olivera M., "Comparison of some physico-chemical parameters and biological behaviour of fullerenol labelled with technetium-99m" in Journal of Optoelectronics and Advanced Materials, 9, no. 8 (2007):2571-2577,
https://hdl.handle.net/21.15107/rcub_vinar_3265 .

TY  - JOUR
AU  - Veljković, Miomir V.
AU  - Nešković, Olivera M.
AU  - Ivetić, Tamara B.
AU  - Veličković, Suzana
AU  - Maksin, Tatjana N.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6502
UR  - https://plus.sr.cobiss.net/opac7/bib/1027650997
AB  - A new diatomic molecule-containing endohedral fullerenes were prepared by ion implantation technique (introducing negatively charged C-70 into a low temperature lithium plasma column by a strong exial magnetic field). The species prepared were Li"C-70 and Li-2"C-70 and ionized by surface ionization. Their existance was demonstrated through high sensitivity, magnetic mass spectrometer. The corresponding endohedral ions undergo the Rice shrinkwrap mechanism: a mass -analyzed ion spectrum demonstrates the loss of a C-2 unit from the cage. The observed ionization energies of endohedral molecules were 5.1 for all 0.1 eV and 5.3 for all 0.1 eV, respectively.
T2  - Materials Science Forum
T1  - Endohedral encapsulation of lithium in C-70
VL  - 480
SP  - 351
EP  - 354
DO  - 10.4028/www.scientific.net/MSF.480-481.351
ER  - 

@article{
author = "Veljković, Miomir V. and Nešković, Olivera M. and Ivetić, Tamara B. and Veličković, Suzana and Maksin, Tatjana N.",
year = "2005",
abstract = "A new diatomic molecule-containing endohedral fullerenes were prepared by ion implantation technique (introducing negatively charged C-70 into a low temperature lithium plasma column by a strong exial magnetic field). The species prepared were Li"C-70 and Li-2"C-70 and ionized by surface ionization. Their existance was demonstrated through high sensitivity, magnetic mass spectrometer. The corresponding endohedral ions undergo the Rice shrinkwrap mechanism: a mass -analyzed ion spectrum demonstrates the loss of a C-2 unit from the cage. The observed ionization energies of endohedral molecules were 5.1 for all 0.1 eV and 5.3 for all 0.1 eV, respectively.",
journal = "Materials Science Forum",
title = "Endohedral encapsulation of lithium in C-70",
volume = "480",
pages = "351-354",
doi = "10.4028/www.scientific.net/MSF.480-481.351"
}

Veljković, M. V., Nešković, O. M., Ivetić, T. B., Veličković, S.,& Maksin, T. N.. (2005). Endohedral encapsulation of lithium in C-70. in Materials Science Forum, 480, 351-354.
https://doi.org/10.4028/www.scientific.net/MSF.480-481.351

Veljković MV, Nešković OM, Ivetić TB, Veličković S, Maksin TN. Endohedral encapsulation of lithium in C-70. in Materials Science Forum. 2005;480:351-354.
doi:10.4028/www.scientific.net/MSF.480-481.351 .

Veljković, Miomir V., Nešković, Olivera M., Ivetić, Tamara B., Veličković, Suzana, Maksin, Tatjana N., "Endohedral encapsulation of lithium in C-70" in Materials Science Forum, 480 (2005):351-354,
https://doi.org/10.4028/www.scientific.net/MSF.480-481.351 . .

TY  - CONF
AU  - Maksin, Tatjana N.
AU  - Janković, Drina
AU  - Đorđević, A.
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9508
AB  - Fullerenols, water-soluble polihydroxylated fullerenes, are very important kinds of fullerene derivatives because it is suitable for biological study. In order to get convenient substance for studies (in vivo and in vitro) we investigate possibilities of labeling fullerenol. The HPLC results performed by isocratic HPLC, confirmed that hydrophilic organometallic [99mTc(CO)3(H2O)3]+ precursor allows forming of 99mTc(I) complexes with fullerenol.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
T1  - HPLC analysis of technetium(I)-99m labelled C60(OH)22
VL  - 1
SP  - 432
EP  - 434
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9508
ER  - 

@conference{
author = "Maksin, Tatjana N. and Janković, Drina and Đorđević, A.",
year = "2004",
abstract = "Fullerenols, water-soluble polihydroxylated fullerenes, are very important kinds of fullerene derivatives because it is suitable for biological study. In order to get convenient substance for studies (in vivo and in vitro) we investigate possibilities of labeling fullerenol. The HPLC results performed by isocratic HPLC, confirmed that hydrophilic organometallic [99mTc(CO)3(H2O)3]+ precursor allows forming of 99mTc(I) complexes with fullerenol.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry",
title = "HPLC analysis of technetium(I)-99m labelled C60(OH)22",
volume = "1",
pages = "432-434",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9508"
}

Maksin, T. N., Janković, D.,& Đorđević, A.. (2004). HPLC analysis of technetium(I)-99m labelled C60(OH)22. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 1, 432-434.
https://hdl.handle.net/21.15107/rcub_vinar_9508

Maksin TN, Janković D, Đorđević A. HPLC analysis of technetium(I)-99m labelled C60(OH)22. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry. 2004;1:432-434.
https://hdl.handle.net/21.15107/rcub_vinar_9508 .

Maksin, Tatjana N., Janković, Drina, Đorđević, A., "HPLC analysis of technetium(I)-99m labelled C60(OH)22" in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry, 1 (2004):432-434,
https://hdl.handle.net/21.15107/rcub_vinar_9508 .

TY  - JOUR
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Maksin, Tatjana N.
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2547
AB  - A new procedure for the aggregation of human albumin and Tc-99m-labelling of the prepared macroaggregated albumin are presented. Simple methods for quantifying of all the radiochemical impurities existing in Tc-99m-MAA were tested. Thus, 85% methanol was used as the mobile phase in paper and ITL chromatography with Whatman N-o 1 and ITLC-SA strips. A system of two solvents (acetone and 1 M NaCl or 0.9% NaCl) was used for 3 MM paper, ITLC-SA and ITLC-SG strips and silica gel plates as the stationary phase. Low-voltage paper electrophoresis with Whatman 3 MM paper sheets soaked in barbiturate buffer and the gel chromatography column method (Sephadex G-25) were also applied. Filtration through syringe filters, proposed by European and Yugoslav Pharmacopoeia, was performed for comparison. The application of the mentioned tests lead to consistent results for the labelling efficiency ( GT 98.5%) and percent radiochemical impurities of Tc-99m-MAA. Determination of the particles number in a counter chamber and their size distribution under a light microscope with a calibrated ocular scale gave the result of 300000-350000 particles per 1 mg of HA. This confirmed that the human albumin macroaggregates prepared by our new procedure is remarkably improved and convenient for routine diagnostic purposes.
T2  - Journal of the Serbian Chemical Society
T1  - Radiochemical purity and particles number determinations of modified Tc-99m-macroaggregated albumin
VL  - 67
IS  - 8-9
SP  - 573
EP  - 579
DO  - 10.2298/JSC0209573D
ER  - 

@article{
author = "Đokić, Divna Đ. and Janković, Drina and Maksin, Tatjana N.",
year = "2002",
abstract = "A new procedure for the aggregation of human albumin and Tc-99m-labelling of the prepared macroaggregated albumin are presented. Simple methods for quantifying of all the radiochemical impurities existing in Tc-99m-MAA were tested. Thus, 85% methanol was used as the mobile phase in paper and ITL chromatography with Whatman N-o 1 and ITLC-SA strips. A system of two solvents (acetone and 1 M NaCl or 0.9% NaCl) was used for 3 MM paper, ITLC-SA and ITLC-SG strips and silica gel plates as the stationary phase. Low-voltage paper electrophoresis with Whatman 3 MM paper sheets soaked in barbiturate buffer and the gel chromatography column method (Sephadex G-25) were also applied. Filtration through syringe filters, proposed by European and Yugoslav Pharmacopoeia, was performed for comparison. The application of the mentioned tests lead to consistent results for the labelling efficiency ( GT 98.5%) and percent radiochemical impurities of Tc-99m-MAA. Determination of the particles number in a counter chamber and their size distribution under a light microscope with a calibrated ocular scale gave the result of 300000-350000 particles per 1 mg of HA. This confirmed that the human albumin macroaggregates prepared by our new procedure is remarkably improved and convenient for routine diagnostic purposes.",
journal = "Journal of the Serbian Chemical Society",
title = "Radiochemical purity and particles number determinations of modified Tc-99m-macroaggregated albumin",
volume = "67",
number = "8-9",
pages = "573-579",
doi = "10.2298/JSC0209573D"
}

Đokić, D. Đ., Janković, D.,& Maksin, T. N.. (2002). Radiochemical purity and particles number determinations of modified Tc-99m-macroaggregated albumin. in Journal of the Serbian Chemical Society, 67(8-9), 573-579.
https://doi.org/10.2298/JSC0209573D

Đokić DĐ, Janković D, Maksin TN. Radiochemical purity and particles number determinations of modified Tc-99m-macroaggregated albumin. in Journal of the Serbian Chemical Society. 2002;67(8-9):573-579.
doi:10.2298/JSC0209573D .

Đokić, Divna Đ., Janković, Drina, Maksin, Tatjana N., "Radiochemical purity and particles number determinations of modified Tc-99m-macroaggregated albumin" in Journal of the Serbian Chemical Society, 67, no. 8-9 (2002):573-579,
https://doi.org/10.2298/JSC0209573D . .

TY  - JOUR
AU  - Janković, Drina
AU  - Đokić, Divna Đ.
AU  - Maksin, Tatjana N.
AU  - Orlić, Milan P.
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2508
AB  - The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH
VL  - 251
IS  - 3
SP  - 463
EP  - 466
DO  - 10.1023/A:1014894527982
ER  - 

@article{
author = "Janković, Drina and Đokić, Divna Đ. and Maksin, Tatjana N. and Orlić, Milan P.",
year = "2002",
abstract = "The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH",
volume = "251",
number = "3",
pages = "463-466",
doi = "10.1023/A:1014894527982"
}

Janković, D., Đokić, D. Đ., Maksin, T. N.,& Orlić, M. P.. (2002). Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH. in Journal of Radioanalytical and Nuclear Chemistry, 251(3), 463-466.
https://doi.org/10.1023/A:1014894527982

Janković D, Đokić DĐ, Maksin TN, Orlić MP. Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH. in Journal of Radioanalytical and Nuclear Chemistry. 2002;251(3):463-466.
doi:10.1023/A:1014894527982 .

Janković, Drina, Đokić, Divna Đ., Maksin, Tatjana N., Orlić, Milan P., "Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH" in Journal of Radioanalytical and Nuclear Chemistry, 251, no. 3 (2002):463-466,
https://doi.org/10.1023/A:1014894527982 . .

TY  - JOUR
AU  - Maksin, Tatjana N.
AU  - Vučina, Jurij L.
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2363
AB  - The results of the quality control of Tc-99m-DPD produced during five consequtive years are statistically evaluated. Radiochemical purity of the kit determined in 75 batches was 98.3+/-1.3%. TLC on silica gel with the mixture of acetone and methanole (1:1, v/v) was used to determine the content of free pertechnetate. The labeled complex and Tc-99m-hydrolyzate was separated by using ascending paper (Schleicher and Schull) chromatography and 1N NaCl as the mobile phase. Reliable results were obtained showing that the content of the impurities Tc-99m-pertechnetate and Tc-99m-hydrolyzate is 1.7+/-1.3% and 3.4+/-2.1%, respectively. The biodistribution depends on the quantity of DPD. For the animal experiments its content should be 70-80 mu g/kg b.w. The experiments revealed that the mean value of bone distribution was 8.8+/-1.9%/g and in muscles 0.043+/-0.042%/g. The uptake in liver and kidneys was below 3%, i.e., 0.65+/-0.29 and 1.71+/-0.68%/organ, respectively. The bone/muscle ratio should be at least 160. The analysis shows that the obtained values are arranged around their, statistically allowed, mean values.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD
VL  - 243
IS  - 3
SP  - 669
EP  - 671
DO  - 10.1023/A:1010614101992
ER  - 

@article{
author = "Maksin, Tatjana N. and Vučina, Jurij L. and Đokić, Divna Đ. and Janković, Drina",
year = "2000",
abstract = "The results of the quality control of Tc-99m-DPD produced during five consequtive years are statistically evaluated. Radiochemical purity of the kit determined in 75 batches was 98.3+/-1.3%. TLC on silica gel with the mixture of acetone and methanole (1:1, v/v) was used to determine the content of free pertechnetate. The labeled complex and Tc-99m-hydrolyzate was separated by using ascending paper (Schleicher and Schull) chromatography and 1N NaCl as the mobile phase. Reliable results were obtained showing that the content of the impurities Tc-99m-pertechnetate and Tc-99m-hydrolyzate is 1.7+/-1.3% and 3.4+/-2.1%, respectively. The biodistribution depends on the quantity of DPD. For the animal experiments its content should be 70-80 mu g/kg b.w. The experiments revealed that the mean value of bone distribution was 8.8+/-1.9%/g and in muscles 0.043+/-0.042%/g. The uptake in liver and kidneys was below 3%, i.e., 0.65+/-0.29 and 1.71+/-0.68%/organ, respectively. The bone/muscle ratio should be at least 160. The analysis shows that the obtained values are arranged around their, statistically allowed, mean values.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD",
volume = "243",
number = "3",
pages = "669-671",
doi = "10.1023/A:1010614101992"
}

Maksin, T. N., Vučina, J. L., Đokić, D. Đ.,& Janković, D.. (2000). Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD. in Journal of Radioanalytical and Nuclear Chemistry, 243(3), 669-671.
https://doi.org/10.1023/A:1010614101992

Maksin TN, Vučina JL, Đokić DĐ, Janković D. Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD. in Journal of Radioanalytical and Nuclear Chemistry. 2000;243(3):669-671.
doi:10.1023/A:1010614101992 .

Maksin, Tatjana N., Vučina, Jurij L., Đokić, Divna Đ., Janković, Drina, "Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD" in Journal of Radioanalytical and Nuclear Chemistry, 243, no. 3 (2000):669-671,
https://doi.org/10.1023/A:1010614101992 . .

TY  - JOUR
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Maksin, Tatjana N.
AU  - Jaksic, E
AU  - Beatovic, S
AU  - Han, R
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2311
AB  - Tc-99(m)-p-aminohippuric acid (Tc-99(m)-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate ((NaTcO4)-Tc-99-O-m. Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa(3)DTPA) and stannous chloride (SnCl2. 2H(2)O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity ( GT 95%). Its protein binding is very similar to that of I-131-OIH, but it is hydrophilic in character. Animal studies using Tc-99(m)-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to Tc-99(m)-DTPA, Tc-99(m)-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas Tc-99(m)-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of Tc-99(m)-PAH (t(1/2(alpha))) = 2.5 min, t(1/2(beta)) = 41.7 min, Cl = 5.22 ml . min(-1), K-el 5.1 x 10(-4) min(-1)) differ from those of Tc-99(m)-DTPA. Evaluation of Tc-99(m)-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration. (C) 1999 Lippincott Williams and Wilkins).
T2  - Nuclear Medicine Communications
T1  - Tc-99(m)-p-aminohippuric acid as a new renal agent
VL  - 20
IS  - 12
SP  - 1133
EP  - 1140
DO  - 10.1097/00006231-199912000-00005
ER  - 

@article{
author = "Đokić, Divna Đ. and Janković, Drina and Maksin, Tatjana N. and Jaksic, E and Beatovic, S and Han, R",
year = "1999",
abstract = "Tc-99(m)-p-aminohippuric acid (Tc-99(m)-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate ((NaTcO4)-Tc-99-O-m. Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa(3)DTPA) and stannous chloride (SnCl2. 2H(2)O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity ( GT 95%). Its protein binding is very similar to that of I-131-OIH, but it is hydrophilic in character. Animal studies using Tc-99(m)-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to Tc-99(m)-DTPA, Tc-99(m)-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas Tc-99(m)-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of Tc-99(m)-PAH (t(1/2(alpha))) = 2.5 min, t(1/2(beta)) = 41.7 min, Cl = 5.22 ml . min(-1), K-el 5.1 x 10(-4) min(-1)) differ from those of Tc-99(m)-DTPA. Evaluation of Tc-99(m)-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration. (C) 1999 Lippincott Williams and Wilkins).",
journal = "Nuclear Medicine Communications",
title = "Tc-99(m)-p-aminohippuric acid as a new renal agent",
volume = "20",
number = "12",
pages = "1133-1140",
doi = "10.1097/00006231-199912000-00005"
}

Đokić, D. Đ., Janković, D., Maksin, T. N., Jaksic, E., Beatovic, S.,& Han, R.. (1999). Tc-99(m)-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications, 20(12), 1133-1140.
https://doi.org/10.1097/00006231-199912000-00005

Đokić DĐ, Janković D, Maksin TN, Jaksic E, Beatovic S, Han R. Tc-99(m)-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications. 1999;20(12):1133-1140.
doi:10.1097/00006231-199912000-00005 .

Đokić, Divna Đ., Janković, Drina, Maksin, Tatjana N., Jaksic, E, Beatovic, S, Han, R, "Tc-99(m)-p-aminohippuric acid as a new renal agent" in Nuclear Medicine Communications, 20, no. 12 (1999):1133-1140,
https://doi.org/10.1097/00006231-199912000-00005 . .

TY  - JOUR
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Maksin, Tatjana N.
AU  - Onjia, Antonije E.
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2287
AB  - Tc-99m-Hipp as a modified Tc-99m-DTpA, and Tc-99m-PAH as a new renal agent are developed. Each veal of lyophilised kit contain hippuric (Hipp) or p-aminohippuric acid (PAH), diethyltriaminepentaacetic acid as calciumtrisodium salt (CaNa(3)DTPA) and stannouschloride (SnCl2. xH(2)O), in molar ratio Hipp/PAH:DTPA = 4:1. They are high radiochemical purity radiopharmaceuticals, with hydrophilic character and low percentage of protein binding. The ITL chromatography and HPLC analyses of these labeled compounds have shown almost identical results as Tc-99m-DTPA, but their biological behavior in rats confirm certain differences. Tc-99m-Hipp is a renal agent clearing by the glomerular system, with better pharmacokinetical parameters than Tc-99m-DTPA: t(1/2(alpha)) = 4.1 min, t(1/2(beta)) = 198.6 min, K-d = 1.2.10(-2)min(-1) and a twofold value for blood clearance (Cl=2.07 ml/min). Tc-99m-PAH is a quite different renal agent, rapidly secreted by kidney as a tubular secretion agent. Its pharmacokinetical parameters: t(1/2(alpha)) = 2.5 min, t(1/2(beta)) = 41.7 min and K-cl = 5.1.10(-4) min(-1) are almost equal to those of Tc-99m-MAG(3), but the blood clearance of Cl = 5.22 ml/min is even higher than that of IOH clearance.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA
VL  - 242
IS  - 2
SP  - 279
EP  - 285
DO  - 10.1007/BF02345554
ER  - 

@article{
author = "Đokić, Divna Đ. and Janković, Drina and Maksin, Tatjana N. and Onjia, Antonije E.",
year = "1999",
abstract = "Tc-99m-Hipp as a modified Tc-99m-DTpA, and Tc-99m-PAH as a new renal agent are developed. Each veal of lyophilised kit contain hippuric (Hipp) or p-aminohippuric acid (PAH), diethyltriaminepentaacetic acid as calciumtrisodium salt (CaNa(3)DTPA) and stannouschloride (SnCl2. xH(2)O), in molar ratio Hipp/PAH:DTPA = 4:1. They are high radiochemical purity radiopharmaceuticals, with hydrophilic character and low percentage of protein binding. The ITL chromatography and HPLC analyses of these labeled compounds have shown almost identical results as Tc-99m-DTPA, but their biological behavior in rats confirm certain differences. Tc-99m-Hipp is a renal agent clearing by the glomerular system, with better pharmacokinetical parameters than Tc-99m-DTPA: t(1/2(alpha)) = 4.1 min, t(1/2(beta)) = 198.6 min, K-d = 1.2.10(-2)min(-1) and a twofold value for blood clearance (Cl=2.07 ml/min). Tc-99m-PAH is a quite different renal agent, rapidly secreted by kidney as a tubular secretion agent. Its pharmacokinetical parameters: t(1/2(alpha)) = 2.5 min, t(1/2(beta)) = 41.7 min and K-cl = 5.1.10(-4) min(-1) are almost equal to those of Tc-99m-MAG(3), but the blood clearance of Cl = 5.22 ml/min is even higher than that of IOH clearance.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA",
volume = "242",
number = "2",
pages = "279-285",
doi = "10.1007/BF02345554"
}

Đokić, D. Đ., Janković, D., Maksin, T. N.,& Onjia, A. E.. (1999). Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA. in Journal of Radioanalytical and Nuclear Chemistry, 242(2), 279-285.
https://doi.org/10.1007/BF02345554

Đokić DĐ, Janković D, Maksin TN, Onjia AE. Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA. in Journal of Radioanalytical and Nuclear Chemistry. 1999;242(2):279-285.
doi:10.1007/BF02345554 .

Đokić, Divna Đ., Janković, Drina, Maksin, Tatjana N., Onjia, Antonije E., "Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA" in Journal of Radioanalytical and Nuclear Chemistry, 242, no. 2 (1999):279-285,
https://doi.org/10.1007/BF02345554 . .

TY  - JOUR
AU  - Đokić, Divna Đ.
AU  - Maksin, Tatjana N.
AU  - Vučina, Jurij L.
AU  - Janković, Drina
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2218
AB  - A modified Tc-99m(Sn)-pyrophosphate (PyP) kit for the application in nuclear cardiology (radioventriculography, angiocardiography, scintigraphy of blood pool) was developed. Each vial contains 12 mg PyP (Na4P2O7), 4 mg SnCl2. 2H(2)O, 2.5 mg gentisic acid and IO mg NaCl. The reconstitution is performed by dissolving the lyophilized kit in 3 mi 0.9% NaCl. In comparison with the standard pyrophosphate kit for bone scanning and detection of miocardial infarction, it contains an increased amount of Sn(Il) so that the molar ratio ligand/reductant is lowered from 25 to 2.5. The radiochemical analyses showed that the radiochemical purity of the labeled kit is high ( GT 90%) during three hours after addition of Tc-99m-activity. The shelf-life of the inactive freeze-dried preparation is up to four months providing that it is kept in vacuum and at appropriate temperature (2-8 degrees C). The biodistribution studies revealed increased accumulation in blood and low uptake by liver and kidneys. It was concluded that the modified kit performs stable and reproducible properties.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology
VL  - 238
IS  - 1-2
SP  - 155
EP  - 157
DO  - 10.1007/BF02385372
ER  - 

@article{
author = "Đokić, Divna Đ. and Maksin, Tatjana N. and Vučina, Jurij L. and Janković, Drina",
year = "1998",
abstract = "A modified Tc-99m(Sn)-pyrophosphate (PyP) kit for the application in nuclear cardiology (radioventriculography, angiocardiography, scintigraphy of blood pool) was developed. Each vial contains 12 mg PyP (Na4P2O7), 4 mg SnCl2. 2H(2)O, 2.5 mg gentisic acid and IO mg NaCl. The reconstitution is performed by dissolving the lyophilized kit in 3 mi 0.9% NaCl. In comparison with the standard pyrophosphate kit for bone scanning and detection of miocardial infarction, it contains an increased amount of Sn(Il) so that the molar ratio ligand/reductant is lowered from 25 to 2.5. The radiochemical analyses showed that the radiochemical purity of the labeled kit is high ( GT 90%) during three hours after addition of Tc-99m-activity. The shelf-life of the inactive freeze-dried preparation is up to four months providing that it is kept in vacuum and at appropriate temperature (2-8 degrees C). The biodistribution studies revealed increased accumulation in blood and low uptake by liver and kidneys. It was concluded that the modified kit performs stable and reproducible properties.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology",
volume = "238",
number = "1-2",
pages = "155-157",
doi = "10.1007/BF02385372"
}

Đokić, D. Đ., Maksin, T. N., Vučina, J. L.,& Janković, D.. (1998). Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology. in Journal of Radioanalytical and Nuclear Chemistry, 238(1-2), 155-157.
https://doi.org/10.1007/BF02385372

Đokić DĐ, Maksin TN, Vučina JL, Janković D. Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology. in Journal of Radioanalytical and Nuclear Chemistry. 1998;238(1-2):155-157.
doi:10.1007/BF02385372 .

Đokić, Divna Đ., Maksin, Tatjana N., Vučina, Jurij L., Janković, Drina, "Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology" in Journal of Radioanalytical and Nuclear Chemistry, 238, no. 1-2 (1998):155-157,
https://doi.org/10.1007/BF02385372 . .