Jovanović, Ivan B.

Link to this page

Authority KeyName Variants
811df084-1e75-47ac-8bc0-d15500fd868c
  • Jovanović, Ivan B. (2)
  • Jovanović, Ivan (1)

Author's Bibliography

Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer

Stojković, Goran; Jovanović, Ivan; Dimitrijević, Milovan; Jovanović, Jasmina; Tomanović, Nada; Stanković, Aleksandra; Arsović, Nenad; Boričić, Ivan; Zeljić, Katarina

TY  - JOUR
AU  - Stojković, Goran
AU  - Jovanović, Ivan
AU  - Dimitrijević, Milovan
AU  - Jovanović, Jasmina
AU  - Tomanović, Nada
AU  - Stanković, Aleksandra
AU  - Arsović, Nenad
AU  - Boričić, Ivan
AU  - Zeljić, Katarina
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10217
AB  - Objectives This study aimed to experimentally validate dysregulated expression of miRNA candidates selected through updated meta-analysis of most commonly deregulated miRNAs in oral cancer and to explore their diagnostic and prognostic potential. Materials and methods Five miRNAs (miR-31-3p, miR-135b-5p, miR-18a-5p, miR-30a-5p and miR-139-5p) from updated meta-signature were selected for validation by qRT-PCR method in 35 oral cancer clinical specimens and adjacent non-cancerous tissue. Results Updated meta-analysis has identified 13 most commonly deregulated miRNAs in oral cancer. Seven miRNAs were consistently up-regulated (miR-21-5p, miR-31-3p, miR-135b-5p, miR-31-5p, miR-424-5p, miR-18a-5p and miR-21-3p), while five were down-regulated (miR-139-5p, miR-30a-3p, miR-375-3p, miR-376c-3p and miR-30a-5p). Increased expression of miR-31-3p and miR-135b-5p, and decreased expression of miR-139-5p and miR-30a-5p were confirmed in oral cancer compared to adjacent non-cancerous tissue. A three miRNAs combination (miR-31-3p, miR-139-5p and miR-30a-5p) gave the most promising diagnostic potential for discriminating oral cancer from non-cancerous tissue (AUC: 0.780 [95% CI: 0.673–0.886], p < 0.0005, sensitivity 94.3%, specificity 51.4%). High expression of miR-135b-5p, miR-18a-5p and miR-30a-5p was associated with poor survival (p = 0.003, p = 0.048, p = 0.016 respectively). Conclusion miR-31-3p, miR-139-5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. miR-135b-5p, miR-18a-5p and miR-30a-5p might serve as potential biomarkers of poor survival of oral cancer patients.
T2  - Oral Diseases
T1  - Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer
DO  - 10.1111/odi.14185
ER  - 
@article{
author = "Stojković, Goran and Jovanović, Ivan and Dimitrijević, Milovan and Jovanović, Jasmina and Tomanović, Nada and Stanković, Aleksandra and Arsović, Nenad and Boričić, Ivan and Zeljić, Katarina",
abstract = "Objectives This study aimed to experimentally validate dysregulated expression of miRNA candidates selected through updated meta-analysis of most commonly deregulated miRNAs in oral cancer and to explore their diagnostic and prognostic potential. Materials and methods Five miRNAs (miR-31-3p, miR-135b-5p, miR-18a-5p, miR-30a-5p and miR-139-5p) from updated meta-signature were selected for validation by qRT-PCR method in 35 oral cancer clinical specimens and adjacent non-cancerous tissue. Results Updated meta-analysis has identified 13 most commonly deregulated miRNAs in oral cancer. Seven miRNAs were consistently up-regulated (miR-21-5p, miR-31-3p, miR-135b-5p, miR-31-5p, miR-424-5p, miR-18a-5p and miR-21-3p), while five were down-regulated (miR-139-5p, miR-30a-3p, miR-375-3p, miR-376c-3p and miR-30a-5p). Increased expression of miR-31-3p and miR-135b-5p, and decreased expression of miR-139-5p and miR-30a-5p were confirmed in oral cancer compared to adjacent non-cancerous tissue. A three miRNAs combination (miR-31-3p, miR-139-5p and miR-30a-5p) gave the most promising diagnostic potential for discriminating oral cancer from non-cancerous tissue (AUC: 0.780 [95% CI: 0.673–0.886], p < 0.0005, sensitivity 94.3%, specificity 51.4%). High expression of miR-135b-5p, miR-18a-5p and miR-30a-5p was associated with poor survival (p = 0.003, p = 0.048, p = 0.016 respectively). Conclusion miR-31-3p, miR-139-5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. miR-135b-5p, miR-18a-5p and miR-30a-5p might serve as potential biomarkers of poor survival of oral cancer patients.",
journal = "Oral Diseases",
title = "Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer",
doi = "10.1111/odi.14185"
}
Stojković, G., Jovanović, I., Dimitrijević, M., Jovanović, J., Tomanović, N., Stanković, A., Arsović, N., Boričić, I.,& Zeljić, K..Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer. in Oral Diseases.
https://doi.org/10.1111/odi.14185
Stojković G, Jovanović I, Dimitrijević M, Jovanović J, Tomanović N, Stanković A, Arsović N, Boričić I, Zeljić K. Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer. in Oral Diseases..
doi:10.1111/odi.14185 .
Stojković, Goran, Jovanović, Ivan, Dimitrijević, Milovan, Jovanović, Jasmina, Tomanović, Nada, Stanković, Aleksandra, Arsović, Nenad, Boričić, Ivan, Zeljić, Katarina, "Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer" in Oral Diseases,
https://doi.org/10.1111/odi.14185 . .

Progesterone Concentration, Pregnancy and Calving Rate in Simmental Dairy Cows After Oestrus Synchronisation and Hcg Treatment During the Early Luteal Phase

Suluburic, Adam; Milanovic, Svetlana; Vranješ-Đurić, Sanja; Jovanović, Ivan B.; Barna, Tomislav; Stojić, Milica; Fratric, Natalija; Szenci, Otto; Gvozdic, Dragan

(2017)

TY  - JOUR
AU  - Suluburic, Adam
AU  - Milanovic, Svetlana
AU  - Vranješ-Đurić, Sanja
AU  - Jovanović, Ivan B.
AU  - Barna, Tomislav
AU  - Stojić, Milica
AU  - Fratric, Natalija
AU  - Szenci, Otto
AU  - Gvozdic, Dragan
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1757
AB  - Early embryonic development may be negatively affected by insufficient progesterone (P4) production. Therefore, the aim of our study was to increase P4 by gonadotropin-releasing hormone (GnRH) and/or human chorionic gonadotropin (hCG) treatments after inducing oestrus by prostaglandin (PG) treatment. Lactating Simmental dairy cows (n = 110), between 1 to 5 lactations, with an average milk production of 6,500 l/305 days, at 40-80 days postpartum were used and grouped as follows: (1) PG + GnRH treatment at AI (GnRH group), (2) PG + hCG treatment at day 7 after AI (hCG group), (3) PG + GnRH at AI + hCG treatment at day 7 after AI (GnRH/hCG group), and (4) spontaneous oestrus (C: control group). All animals were double inseminated (at the time of oestrus detection and 12 +/- 2 h thereafter). Blood serum and milk samples were collected at the day of observed oestrus (day 0), and 14, 21 and 28 days after AI. Serum P4 was determined using a commercial radioimmunoassay (RIA) test (INEP, Zemun), and milk P4 was determined using enzyme-linked immunoassay (ELISA) test (NIV Novi Sad). Pregnancy status was confirmed by ultrasonography between days 28 and 35 after AI. Differences of serum or milk P4 medians, pregnancy (and calving) rate were determined using Dunns Multiple Comparison Tests and Z test, respectively. Serum P4 medians were significantly higher at days 14, 21 and 28 after AI in the hCG-treated animals, indicating increased luteal activity, with a similar tendency in whole milk P4 values. Treatment with hCG during the early luteal phase significantly contributed to the maintenance of gestation at days 28-35 after AI, and also increased the calving rate in Simmental dairy cows.
T2  - Acta Veterinaria Hungarica
T1  - Progesterone Concentration, Pregnancy and Calving Rate in Simmental Dairy Cows After Oestrus Synchronisation and Hcg Treatment During the Early Luteal Phase
VL  - 65
IS  - 3
SP  - 446
EP  - 458
DO  - 10.1556/004.2017.042
ER  - 
@article{
author = "Suluburic, Adam and Milanovic, Svetlana and Vranješ-Đurić, Sanja and Jovanović, Ivan B. and Barna, Tomislav and Stojić, Milica and Fratric, Natalija and Szenci, Otto and Gvozdic, Dragan",
year = "2017",
abstract = "Early embryonic development may be negatively affected by insufficient progesterone (P4) production. Therefore, the aim of our study was to increase P4 by gonadotropin-releasing hormone (GnRH) and/or human chorionic gonadotropin (hCG) treatments after inducing oestrus by prostaglandin (PG) treatment. Lactating Simmental dairy cows (n = 110), between 1 to 5 lactations, with an average milk production of 6,500 l/305 days, at 40-80 days postpartum were used and grouped as follows: (1) PG + GnRH treatment at AI (GnRH group), (2) PG + hCG treatment at day 7 after AI (hCG group), (3) PG + GnRH at AI + hCG treatment at day 7 after AI (GnRH/hCG group), and (4) spontaneous oestrus (C: control group). All animals were double inseminated (at the time of oestrus detection and 12 +/- 2 h thereafter). Blood serum and milk samples were collected at the day of observed oestrus (day 0), and 14, 21 and 28 days after AI. Serum P4 was determined using a commercial radioimmunoassay (RIA) test (INEP, Zemun), and milk P4 was determined using enzyme-linked immunoassay (ELISA) test (NIV Novi Sad). Pregnancy status was confirmed by ultrasonography between days 28 and 35 after AI. Differences of serum or milk P4 medians, pregnancy (and calving) rate were determined using Dunns Multiple Comparison Tests and Z test, respectively. Serum P4 medians were significantly higher at days 14, 21 and 28 after AI in the hCG-treated animals, indicating increased luteal activity, with a similar tendency in whole milk P4 values. Treatment with hCG during the early luteal phase significantly contributed to the maintenance of gestation at days 28-35 after AI, and also increased the calving rate in Simmental dairy cows.",
journal = "Acta Veterinaria Hungarica",
title = "Progesterone Concentration, Pregnancy and Calving Rate in Simmental Dairy Cows After Oestrus Synchronisation and Hcg Treatment During the Early Luteal Phase",
volume = "65",
number = "3",
pages = "446-458",
doi = "10.1556/004.2017.042"
}
Suluburic, A., Milanovic, S., Vranješ-Đurić, S., Jovanović, I. B., Barna, T., Stojić, M., Fratric, N., Szenci, O.,& Gvozdic, D.. (2017). Progesterone Concentration, Pregnancy and Calving Rate in Simmental Dairy Cows After Oestrus Synchronisation and Hcg Treatment During the Early Luteal Phase. in Acta Veterinaria Hungarica, 65(3), 446-458.
https://doi.org/10.1556/004.2017.042
Suluburic A, Milanovic S, Vranješ-Đurić S, Jovanović IB, Barna T, Stojić M, Fratric N, Szenci O, Gvozdic D. Progesterone Concentration, Pregnancy and Calving Rate in Simmental Dairy Cows After Oestrus Synchronisation and Hcg Treatment During the Early Luteal Phase. in Acta Veterinaria Hungarica. 2017;65(3):446-458.
doi:10.1556/004.2017.042 .
Suluburic, Adam, Milanovic, Svetlana, Vranješ-Đurić, Sanja, Jovanović, Ivan B., Barna, Tomislav, Stojić, Milica, Fratric, Natalija, Szenci, Otto, Gvozdic, Dragan, "Progesterone Concentration, Pregnancy and Calving Rate in Simmental Dairy Cows After Oestrus Synchronisation and Hcg Treatment During the Early Luteal Phase" in Acta Veterinaria Hungarica, 65, no. 3 (2017):446-458,
https://doi.org/10.1556/004.2017.042 . .
2
3
3

Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows

Jovanović, Ivan B.; Velickovic, Miljan; Milanovic, Svetlana; Valcic, Olivera; Gvozdic, Dragan; Vranješ-Đurić, Sanja

(2015)

TY  - JOUR
AU  - Jovanović, Ivan B.
AU  - Velickovic, Miljan
AU  - Milanovic, Svetlana
AU  - Valcic, Olivera
AU  - Gvozdic, Dragan
AU  - Vranješ-Đurić, Sanja
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/626
AB  - The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation. A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intra muscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg. Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations. These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.
T2  - Acta Veterinaria, Beograd
T1  - Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows
VL  - 65
IS  - 2
SP  - 191
EP  - 201
DO  - 10.1515/acve-2015-0016
ER  - 
@article{
author = "Jovanović, Ivan B. and Velickovic, Miljan and Milanovic, Svetlana and Valcic, Olivera and Gvozdic, Dragan and Vranješ-Đurić, Sanja",
year = "2015",
abstract = "The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation. A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intra muscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg. Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations. These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.",
journal = "Acta Veterinaria, Beograd",
title = "Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows",
volume = "65",
number = "2",
pages = "191-201",
doi = "10.1515/acve-2015-0016"
}
Jovanović, I. B., Velickovic, M., Milanovic, S., Valcic, O., Gvozdic, D.,& Vranješ-Đurić, S.. (2015). Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows. in Acta Veterinaria, Beograd, 65(2), 191-201.
https://doi.org/10.1515/acve-2015-0016
Jovanović IB, Velickovic M, Milanovic S, Valcic O, Gvozdic D, Vranješ-Đurić S. Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows. in Acta Veterinaria, Beograd. 2015;65(2):191-201.
doi:10.1515/acve-2015-0016 .
Jovanović, Ivan B., Velickovic, Miljan, Milanovic, Svetlana, Valcic, Olivera, Gvozdic, Dragan, Vranješ-Đurić, Sanja, "Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows" in Acta Veterinaria, Beograd, 65, no. 2 (2015):191-201,
https://doi.org/10.1515/acve-2015-0016 . .
5
5
5