TY  - JOUR
AU  - Veljković, Nevena V.
AU  - Branch, DR
AU  - Metlaš, Radmila
AU  - Prljić, Jelena
AU  - Manfredi, R
AU  - Stringer, WW
AU  - Veljković, Veljko
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2837
AB  - It has been reported that antibodies reactive with peptide RSANFTDNAKTIIVQLNQSVEIN (peptide NTM) derived from the C-terminus of the second conserved domain of HIV-1 envelope glycoprotein gp120 could represent an important factor in control of the HIV disease. In order to check this notion we (i) tested reactivity with peptide NTM serum samples collected from 310 consecutive HIV-1 infected patients with a CD4(+) lymphocyte count ranging from 10 to 800/muL and (ii) performed the longitudinal study that included 107 sera samples collected from 29 HIV patients. Results of these studies demonstrated correlation between presence of anti-NTM antibodies in sera of HIV patients and disease progression measured by the CD4(+) cell count. Based on these findings we proposed the anti-NTM antibodies as useful prognostic marker for HIV disease. (C) 2004 Elsevier B.V. All rights reserved.
T2  - Journal of Clinical Virology
T1  - Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease
VL  - 31
SP  - S39
EP  - S44
DO  - 10.1016/j.jcv.2004.09.012
ER  - 

@article{
author = "Veljković, Nevena V. and Branch, DR and Metlaš, Radmila and Prljić, Jelena and Manfredi, R and Stringer, WW and Veljković, Veljko",
year = "2004",
abstract = "It has been reported that antibodies reactive with peptide RSANFTDNAKTIIVQLNQSVEIN (peptide NTM) derived from the C-terminus of the second conserved domain of HIV-1 envelope glycoprotein gp120 could represent an important factor in control of the HIV disease. In order to check this notion we (i) tested reactivity with peptide NTM serum samples collected from 310 consecutive HIV-1 infected patients with a CD4(+) lymphocyte count ranging from 10 to 800/muL and (ii) performed the longitudinal study that included 107 sera samples collected from 29 HIV patients. Results of these studies demonstrated correlation between presence of anti-NTM antibodies in sera of HIV patients and disease progression measured by the CD4(+) cell count. Based on these findings we proposed the anti-NTM antibodies as useful prognostic marker for HIV disease. (C) 2004 Elsevier B.V. All rights reserved.",
journal = "Journal of Clinical Virology",
title = "Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease",
volume = "31",
pages = "S39-S44",
doi = "10.1016/j.jcv.2004.09.012"
}

Veljković, N. V., Branch, D., Metlaš, R., Prljić, J., Manfredi, R., Stringer, W.,& Veljković, V.. (2004). Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease. in Journal of Clinical Virology, 31, S39-S44.
https://doi.org/10.1016/j.jcv.2004.09.012

Veljković NV, Branch D, Metlaš R, Prljić J, Manfredi R, Stringer W, Veljković V. Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease. in Journal of Clinical Virology. 2004;31:S39-S44.
doi:10.1016/j.jcv.2004.09.012 .

Veljković, Nevena V., Branch, DR, Metlaš, Radmila, Prljić, Jelena, Manfredi, R, Stringer, WW, Veljković, Veljko, "Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease" in Journal of Clinical Virology, 31 (2004):S39-S44,
https://doi.org/10.1016/j.jcv.2004.09.012 . .

TY  - JOUR
AU  - Veljković, Nevena V.
AU  - Branch, DR
AU  - Metlaš, Radmila
AU  - Prljić, Jelena
AU  - Vlahovicek, K
AU  - Pongor, S
AU  - Veljković, Veljko
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2693
AB  - It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.
T2  - Journal of Peptide Research
T1  - Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease
VL  - 62
IS  - 4
SP  - 158
EP  - 166
DO  - 10.1034/j.1399-3011.2003.00081.x
ER  - 

@article{
author = "Veljković, Nevena V. and Branch, DR and Metlaš, Radmila and Prljić, Jelena and Vlahovicek, K and Pongor, S and Veljković, Veljko",
year = "2003",
abstract = "It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.",
journal = "Journal of Peptide Research",
title = "Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease",
volume = "62",
number = "4",
pages = "158-166",
doi = "10.1034/j.1399-3011.2003.00081.x"
}

Veljković, N. V., Branch, D., Metlaš, R., Prljić, J., Vlahovicek, K., Pongor, S.,& Veljković, V.. (2003). Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease. in Journal of Peptide Research, 62(4), 158-166.
https://doi.org/10.1034/j.1399-3011.2003.00081.x

Veljković NV, Branch D, Metlaš R, Prljić J, Vlahovicek K, Pongor S, Veljković V. Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease. in Journal of Peptide Research. 2003;62(4):158-166.
doi:10.1034/j.1399-3011.2003.00081.x .

Veljković, Nevena V., Branch, DR, Metlaš, Radmila, Prljić, Jelena, Vlahovicek, K, Pongor, S, Veljković, Veljko, "Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease" in Journal of Peptide Research, 62, no. 4 (2003):158-166,
https://doi.org/10.1034/j.1399-3011.2003.00081.x . .