TY  - JOUR
AU  - Metlaš, Radmila
AU  - Srdić, Tatjana
AU  - Veljković, Veljko
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3168
AB  - Immunoglobulins (Ig) of pooled healthy human sera were purified by affinity chromatography based on their reactivity with human IgG. This Ig fraction represent connected, natural antibodies (NAbs) and here are denoted as antiIgG antibodies. The data revealed that IgG, IgA and IgM isotypes arc constituents of anti-IgG fraction. The ability of antiIgG antibodies to prevent infection of PBMC by HIV-1 was demonstrated. They exhibited different neutralizing activity depending on the phenotype of the tested virus. The efficacy of neutralization was comparable to monoclonal antibodies (MAbs) IgG1b12 at least for the HIV-1 (92HT593B) Strain. These studies suggest that connected antibodies thus, constituents of immune network, could prevent infection by HIV-1. NAbs as essential components of therapeutic molecules of intravenous Ig (IVIg) have a beneficial effect on variety of immunological disorders by affecting the structure, function and dynamics of the immune network. Since, hallmark of HIV-1 infection are immunological disorders we hypothesizes that they might be corrected to some extend by anti-IgG antibodies.
T2  - Current HIV Research
T1  - Anti-IgG antibodies from sera of healthy individuals neutralize HIV-1 primary isolates
VL  - 5
IS  - 2
SP  - 261
EP  - 265
DO  - 10.2174/157016207780077093
ER  - 

@article{
author = "Metlaš, Radmila and Srdić, Tatjana and Veljković, Veljko",
year = "2007",
abstract = "Immunoglobulins (Ig) of pooled healthy human sera were purified by affinity chromatography based on their reactivity with human IgG. This Ig fraction represent connected, natural antibodies (NAbs) and here are denoted as antiIgG antibodies. The data revealed that IgG, IgA and IgM isotypes arc constituents of anti-IgG fraction. The ability of antiIgG antibodies to prevent infection of PBMC by HIV-1 was demonstrated. They exhibited different neutralizing activity depending on the phenotype of the tested virus. The efficacy of neutralization was comparable to monoclonal antibodies (MAbs) IgG1b12 at least for the HIV-1 (92HT593B) Strain. These studies suggest that connected antibodies thus, constituents of immune network, could prevent infection by HIV-1. NAbs as essential components of therapeutic molecules of intravenous Ig (IVIg) have a beneficial effect on variety of immunological disorders by affecting the structure, function and dynamics of the immune network. Since, hallmark of HIV-1 infection are immunological disorders we hypothesizes that they might be corrected to some extend by anti-IgG antibodies.",
journal = "Current HIV Research",
title = "Anti-IgG antibodies from sera of healthy individuals neutralize HIV-1 primary isolates",
volume = "5",
number = "2",
pages = "261-265",
doi = "10.2174/157016207780077093"
}

Metlaš, R., Srdić, T.,& Veljković, V.. (2007). Anti-IgG antibodies from sera of healthy individuals neutralize HIV-1 primary isolates. in Current HIV Research, 5(2), 261-265.
https://doi.org/10.2174/157016207780077093

Metlaš R, Srdić T, Veljković V. Anti-IgG antibodies from sera of healthy individuals neutralize HIV-1 primary isolates. in Current HIV Research. 2007;5(2):261-265.
doi:10.2174/157016207780077093 .

Metlaš, Radmila, Srdić, Tatjana, Veljković, Veljko, "Anti-IgG antibodies from sera of healthy individuals neutralize HIV-1 primary isolates" in Current HIV Research, 5, no. 2 (2007):261-265,
https://doi.org/10.2174/157016207780077093 . .