TY  - JOUR
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Kolaković, Ana
AU  - Jekić, Đole
AU  - Selaković, Vesna
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4129
AB  - Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.
T2  - Journal of Clinical Laboratory Analysis
T1  - Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis
VL  - 24
IS  - 4
SP  - 246
EP  - 251
DO  - 10.1002/jcla.20393
ER  - 

@article{
author = "Đurić, Tamara and Živković, Maja and Stanković, Aleksandra and Kolaković, Ana and Jekić, Đole and Selaković, Vesna and Alavantić, Dragan",
year = "2010",
abstract = "Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.",
journal = "Journal of Clinical Laboratory Analysis",
title = "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis",
volume = "24",
number = "4",
pages = "246-251",
doi = "10.1002/jcla.20393"
}

Đurić, T., Živković, M., Stanković, A., Kolaković, A., Jekić, Đ., Selaković, V.,& Alavantić, D.. (2010). Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis, 24(4), 246-251.
https://doi.org/10.1002/jcla.20393

Đurić T, Živković M, Stanković A, Kolaković A, Jekić Đ, Selaković V, Alavantić D. Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis. 2010;24(4):246-251.
doi:10.1002/jcla.20393 .

Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, Kolaković, Ana, Jekić, Đole, Selaković, Vesna, Alavantić, Dragan, "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis" in Journal of Clinical Laboratory Analysis, 24, no. 4 (2010):246-251,
https://doi.org/10.1002/jcla.20393 . .