Pejić, Snežana

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Authority KeyName Variants
orcid::0000-0003-4573-2371
  • Pejić, Snežana (56)
Projects
Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis
Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals
Basic and Clinical Pharmacological research of mechanisms of action and drug interactions in nervous and cardiovascular system Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy
Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA Light microscopy, electron microscopy, immunomorphologic, molecular biology and genetic investigations of malignant and nonmalignant renal diseases.
Ministry of Science and Environmental Protection of the Republic of Serbia [143035 B, 143044 B] Ministry of Science and Technology of the Republic of Serbia [143044B, 143035B]
German Research Foundation (DFG) [476/12-2] German Research Foundation (DFG) [SFB 1052/Z3]
Design, synthesis and investigations of fullerene based nanomolecular machines Bioactive natural products as potential sources of new pharmaceuticals and food supplements
Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis
Pharmacological analysis of effects of biologically active substances on isolated smooth muscles from human gastrointestinal and urogenital tract Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200178 (University of Belgrade, Faculty of Biology)
Application of biomedical engineering for preclinical and clinical practice Proučavanje poremećaja homeostaze i određivanje biomarkera oksidacionog stresa kod aerobnih organizama
Signalni putevi delovanja steroidnih hormona i uticaj endogenih i egzogenih faktora na modulaciju procesa u ćelijama sisara Ministry of Science and Technological Development, Republic of Serbia [143035 B, 143044 B]
Ministry of Science and Technology of the Republic of Srpska Ministry of Science, Technology, and Environmental Protection of the Republic of Serbia [143035 B, 143044 B]

Author's Bibliography

Antidepressants- and antipsychotics-induced hepatotoxicity

Todorović Vukotić, Nevena; Đorđević, Jelena; Pejić, Snežana; Đorđević, Neda O.; Pajović, Snežana B.

(2021)

TY  - JOUR
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Jelena
AU  - Pejić, Snežana
AU  - Đorđević, Neda O.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9078
AB  - Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
T2  - Archives of Toxicology
T1  - Antidepressants- and antipsychotics-induced hepatotoxicity
VL  - 95
IS  - 3
SP  - 767
EP  - 789
DO  - 10.1007/s00204-020-02963-4
ER  - 
@article{
author = "Todorović Vukotić, Nevena and Đorđević, Jelena and Pejić, Snežana and Đorđević, Neda O. and Pajović, Snežana B.",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9078",
abstract = "Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",
journal = "Archives of Toxicology",
title = "Antidepressants- and antipsychotics-induced hepatotoxicity",
volume = "95",
number = "3",
pages = "767-789",
doi = "10.1007/s00204-020-02963-4"
}
Todorović Vukotić, N., Đorđević, J., Pejić, S., Đorđević, N. O.,& Pajović, S. B. (2021). Antidepressants- and antipsychotics-induced hepatotoxicity.
Archives of Toxicology, 95(3), 767-789.
https://doi.org/10.1007/s00204-020-02963-4
Todorović Vukotić N, Đorđević J, Pejić S, Đorđević NO, Pajović SB. Antidepressants- and antipsychotics-induced hepatotoxicity. Archives of Toxicology. 2021;95(3):767-789
Todorović Vukotić Nevena, Đorđević Jelena, Pejić Snežana, Đorđević Neda O., Pajović Snežana B., "Antidepressants- and antipsychotics-induced hepatotoxicity" Archives of Toxicology, 95, no. 3 (2021):767-789,
https://doi.org/10.1007/s00204-020-02963-4 .
1

Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease

Miletić Vukajlović, Jadranka; Drakulić, Dunja R.; Pejić, Snežana; Ilić, Tihomir V.; Stefanović, Aleksandra; Petković, Marijana; Schiller, Jürgen

(2020)

TY  - JOUR
AU  - Miletić Vukajlović, Jadranka
AU  - Drakulić, Dunja R.
AU  - Pejić, Snežana
AU  - Ilić, Tihomir V.
AU  - Stefanović, Aleksandra
AU  - Petković, Marijana
AU  - Schiller, Jürgen
PY  - 2020
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8476
AB  - Rationale: Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine (LPC) ratios in patients with Parkinson's disease (PD) in comparison with healthy subjects and their correlation with clinico-pathological features. Methods: The study included 10 controls and 25 patients with PD. All patients were assigned to groups based on clinico-pathological characteristics (gender, age at examination, duration of disease and Hoehn and Yahr (H&Y) stage). The analysis of the PC/LPC intensity ratios in plasma lipid extracts was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: PD patients exhibited an increased PC/LPC intensity ratio in comparison with the control group of healthy subjects. Furthermore, the investigated ratio was shown to be correlated with clinico-pathological parameters, in particular with H&Y stage and disease duration. The PC/LPC intensity ratio in plasma samples of PD patients was found to be elevated in all examined H&Y stages and throughout the disease duration. Conclusions: To our knowledge, this is the first study examining the PC/LPC ratios in plasma of patients with PD and illustrating their correlation with clinico-pathological features. Although the presented results may be considered as preliminary due to the limited number of participants, the observed alterations of PC/LPC ratios in plasma might be a first step in the characterization of plasma lipid changes in PD patients and an indicator of lipid reconfiguration. © 2019 John Wiley & Sons, Ltd.
T2  - Rapid Communications in Mass Spectrometry
T1  - Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease
VL  - 34
IS  - 4
DO  - 10.1002/rcm.8595
ER  - 
@article{
author = "Miletić Vukajlović, Jadranka and Drakulić, Dunja R. and Pejić, Snežana and Ilić, Tihomir V. and Stefanović, Aleksandra and Petković, Marijana and Schiller, Jürgen",
year = "2020",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8476",
abstract = "Rationale: Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine (LPC) ratios in patients with Parkinson's disease (PD) in comparison with healthy subjects and their correlation with clinico-pathological features. Methods: The study included 10 controls and 25 patients with PD. All patients were assigned to groups based on clinico-pathological characteristics (gender, age at examination, duration of disease and Hoehn and Yahr (H&Y) stage). The analysis of the PC/LPC intensity ratios in plasma lipid extracts was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: PD patients exhibited an increased PC/LPC intensity ratio in comparison with the control group of healthy subjects. Furthermore, the investigated ratio was shown to be correlated with clinico-pathological parameters, in particular with H&Y stage and disease duration. The PC/LPC intensity ratio in plasma samples of PD patients was found to be elevated in all examined H&Y stages and throughout the disease duration. Conclusions: To our knowledge, this is the first study examining the PC/LPC ratios in plasma of patients with PD and illustrating their correlation with clinico-pathological features. Although the presented results may be considered as preliminary due to the limited number of participants, the observed alterations of PC/LPC ratios in plasma might be a first step in the characterization of plasma lipid changes in PD patients and an indicator of lipid reconfiguration. © 2019 John Wiley & Sons, Ltd.",
journal = "Rapid Communications in Mass Spectrometry",
title = "Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease",
volume = "34",
number = "4",
doi = "10.1002/rcm.8595"
}
Miletić Vukajlović, J., Drakulić, D. R., Pejić, S., Ilić, T. V., Stefanović, A., Petković, M.,& Schiller, J. (2020). Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease.
Rapid Communications in Mass Spectrometry, 34(4).
https://doi.org/10.1002/rcm.8595
Miletić Vukajlović J, Drakulić DR, Pejić S, Ilić TV, Stefanović A, Petković M, Schiller J. Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease. Rapid Communications in Mass Spectrometry. 2020;34(4)
Miletić Vukajlović Jadranka, Drakulić Dunja R., Pejić Snežana, Ilić Tihomir V., Stefanović Aleksandra, Petković Marijana, Schiller Jürgen, "Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease" Rapid Communications in Mass Spectrometry, 34, no. 4 (2020),
https://doi.org/10.1002/rcm.8595 .
11
5
3
3

Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats

Đurašević, Siniša; Nikolić, Gorana V.; Todorović, Ana; Drakulić, Dunja R.; Pejić, Snežana; Martinović, Vesna; Mitić-Ćulafić, Dragana; Milić, Dragana; Kop, Tatjana; Jasnić, Nebojša; Đorđević, Jelena D.; Todorović, Zoran

(2020)

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Nikolić, Gorana V.
AU  - Todorović, Ana
AU  - Drakulić, Dunja R.
AU  - Pejić, Snežana
AU  - Martinović, Vesna
AU  - Mitić-Ćulafić, Dragana
AU  - Milić, Dragana
AU  - Kop, Tatjana
AU  - Jasnić, Nebojša
AU  - Đorđević, Jelena D.
AU  - Todorović, Zoran
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8924
AB  - The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
T2  - Food and Chemical Toxicology
T1  - Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
VL  - 140
DO  - 10.1016/j.fct.2020.111302
ER  - 
@article{
author = "Đurašević, Siniša and Nikolić, Gorana V. and Todorović, Ana and Drakulić, Dunja R. and Pejić, Snežana and Martinović, Vesna and Mitić-Ćulafić, Dragana and Milić, Dragana and Kop, Tatjana and Jasnić, Nebojša and Đorđević, Jelena D. and Todorović, Zoran",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/8924",
abstract = "The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.",
journal = "Food and Chemical Toxicology",
title = "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats",
volume = "140",
doi = "10.1016/j.fct.2020.111302"
}
Đurašević, S., Nikolić, G. V., Todorović, A., Drakulić, D. R., Pejić, S., Martinović, V., Mitić-Ćulafić, D., Milić, D., Kop, T., Jasnić, N., Đorđević, J. D.,& Todorović, Z. (2020). Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats.
Food and Chemical Toxicology, 140.
https://doi.org/10.1016/j.fct.2020.111302
Đurašević S, Nikolić GV, Todorović A, Drakulić DR, Pejić S, Martinović V, Mitić-Ćulafić D, Milić D, Kop T, Jasnić N, Đorđević JD, Todorović Z. Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. Food and Chemical Toxicology. 2020;140
Đurašević Siniša, Nikolić Gorana V., Todorović Ana, Drakulić Dunja R., Pejić Snežana, Martinović Vesna, Mitić-Ćulafić Dragana, Milić Dragana, Kop Tatjana, Jasnić Nebojša, Đorđević Jelena D., Todorović Zoran, "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats" Food and Chemical Toxicology, 140 (2020),
https://doi.org/10.1016/j.fct.2020.111302 .
1
1

Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina

Đermanović, Mirjana; Baralić, Ivana; Pejić, Snežana

(2020)

TY  - JOUR
AU  - Đermanović, Mirjana
AU  - Baralić, Ivana
AU  - Pejić, Snežana
PY  - 2020
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8566
AB  - The mercury concentration was quantified in frozen and canned fish found in the market of the Republic of Srpska, Bosnia and Herzegovina. Using the method of amalgamation by atomic absorption spectrophotometry with a direct mercury analyzer (DMA-80), significant differences in mercury concentrations among the analyzed fish were found. Frozen pangasius and canned tuna had the highest mercury concentration (59.1 μg/kg and 54.1 μg/kg, respectively). Also, fish from Vietnam had the highest level of total mercury in comparison to fish from other countries. Determined levels of mercury in our samples were below the limit set by the European and Bosnian and Herzegovinian legislation (500 μg/kg wet weight). We have concluded that consumption of commercial fish in the market of the Republic of Srpska does not present any health risk for the average consumer. Nevertheless, a surveillance system of mercury content in fishery products, especially in certain species that concentrate mercury, is crucial for public health protection. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Biological Trace Element Research
T1  - Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina
VL  - 194
IS  - 2
SP  - 545
EP  - 551
DO  - 10.1007/s12011-019-01805-4
ER  - 
@article{
author = "Đermanović, Mirjana and Baralić, Ivana and Pejić, Snežana",
year = "2020",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8566",
abstract = "The mercury concentration was quantified in frozen and canned fish found in the market of the Republic of Srpska, Bosnia and Herzegovina. Using the method of amalgamation by atomic absorption spectrophotometry with a direct mercury analyzer (DMA-80), significant differences in mercury concentrations among the analyzed fish were found. Frozen pangasius and canned tuna had the highest mercury concentration (59.1 μg/kg and 54.1 μg/kg, respectively). Also, fish from Vietnam had the highest level of total mercury in comparison to fish from other countries. Determined levels of mercury in our samples were below the limit set by the European and Bosnian and Herzegovinian legislation (500 μg/kg wet weight). We have concluded that consumption of commercial fish in the market of the Republic of Srpska does not present any health risk for the average consumer. Nevertheless, a surveillance system of mercury content in fishery products, especially in certain species that concentrate mercury, is crucial for public health protection. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Biological Trace Element Research",
title = "Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina",
volume = "194",
number = "2",
pages = "545-551",
doi = "10.1007/s12011-019-01805-4"
}
Đermanović, M., Baralić, I.,& Pejić, S. (2020). Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina.
Biological Trace Element Research, 194(2), 545-551.
https://doi.org/10.1007/s12011-019-01805-4
Đermanović M, Baralić I, Pejić S. Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina. Biological Trace Element Research. 2020;194(2):545-551
Đermanović Mirjana, Baralić Ivana, Pejić Snežana, "Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina" Biological Trace Element Research, 194, no. 2 (2020):545-551,
https://doi.org/10.1007/s12011-019-01805-4 .
2
2
2

The effect of antioxidant status on overall survival in renal cell carcinoma

Pavlović, Ivan; Pejić, Snežana; Radojević-Škodrić, Sanja; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Basta-Jovanović, Gordana; Džamić, Zoran; Pajović, Snežana B.

(2020)


                                            

                                            
Pavlović, I., Pejić, S., Radojević-Škodrić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Basta-Jovanović, G., Džamić, Z.,& Pajović, S. B. (2020). The effect of antioxidant status on overall survival in renal cell carcinoma.
Archives of Medical Science, 16(1), 94-101.
https://doi.org/10.5114/aoms.2019.86818
Pavlović I, Pejić S, Radojević-Škodrić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Basta-Jovanović G, Džamić Z, Pajović SB. The effect of antioxidant status on overall survival in renal cell carcinoma. Archives of Medical Science. 2020;16(1):94-101
Pavlović Ivan, Pejić Snežana, Radojević-Škodrić Sanja, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Basta-Jovanović Gordana, Džamić Zoran, Pajović Snežana B., "The effect of antioxidant status on overall survival in renal cell carcinoma" Archives of Medical Science, 16, no. 1 (2020):94-101,
https://doi.org/10.5114/aoms.2019.86818 .
1
1
1
1

Effect of combined antioxidant treatment on oxidative stress, muscle damage and sport performance in female basketball players

Baralić, Ivana; Stojmenović, Tamara; Anđelković, Marija; Đorđević, Brižita; Dikić, Nenad; Radojević-Škodrić, Sanja; Pejić, Snežana

(2019)

TY  - JOUR
AU  - Baralić, Ivana
AU  - Stojmenović, Tamara
AU  - Anđelković, Marija
AU  - Đorđević, Brižita
AU  - Dikić, Nenad
AU  - Radojević-Škodrić, Sanja
AU  - Pejić, Snežana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8792
AB  - Introduction/Objective We determined the impact of antioxidant supplementation by GE132® on sports performance, oxidative stress markers, and muscle enzymes activities in professional female basketball players. Methods Repetitive strength, explosive power, anaerobic endurance, and agility performance were measured before/after the 45-day supplementation period. The FORT (Free Oxygen Radicals Test) and FORD analysis (Free Oxygen Radical Defense) were assessed before/after basketball specific exercise bout, at the beginning/end of observational period. The grade of muscle damage was evaluated by aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LDH). Results After supplementation period, significant difference was not recorded regarding the basic motor skills tests. Basketball specific exercise bout induced significant increase in FORT (p < 0.05) only at the beginning of supplementation period. Both FORT and FORD significantly decreased over the observational period (p < 0.001, p < 0.01, respectively). CK and LDH were remarkably lower at the end of observational period (p < 0.05), compared to the baseline. Conclusion Exogenous supplementation with protective nutraceuticals such as those found in GE132®, could reduce acute/chronic oxidative stress and muscle damage, but had no effect on sport performance in basketball players. © 2019, Serbia Medical Society. All rights reserved.
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Effect of combined antioxidant treatment on oxidative stress, muscle damage and sport performance in female basketball players
VL  - 147
IS  - 11-12
SP  - 729
EP  - 735
DO  - 10.2298/SARH190118063B
ER  - 
@article{
author = "Baralić, Ivana and Stojmenović, Tamara and Anđelković, Marija and Đorđević, Brižita and Dikić, Nenad and Radojević-Škodrić, Sanja and Pejić, Snežana",
year = "2019",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/8792",
abstract = "Introduction/Objective We determined the impact of antioxidant supplementation by GE132® on sports performance, oxidative stress markers, and muscle enzymes activities in professional female basketball players. Methods Repetitive strength, explosive power, anaerobic endurance, and agility performance were measured before/after the 45-day supplementation period. The FORT (Free Oxygen Radicals Test) and FORD analysis (Free Oxygen Radical Defense) were assessed before/after basketball specific exercise bout, at the beginning/end of observational period. The grade of muscle damage was evaluated by aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LDH). Results After supplementation period, significant difference was not recorded regarding the basic motor skills tests. Basketball specific exercise bout induced significant increase in FORT (p < 0.05) only at the beginning of supplementation period. Both FORT and FORD significantly decreased over the observational period (p < 0.001, p < 0.01, respectively). CK and LDH were remarkably lower at the end of observational period (p < 0.05), compared to the baseline. Conclusion Exogenous supplementation with protective nutraceuticals such as those found in GE132®, could reduce acute/chronic oxidative stress and muscle damage, but had no effect on sport performance in basketball players. © 2019, Serbia Medical Society. All rights reserved.",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Effect of combined antioxidant treatment on oxidative stress, muscle damage and sport performance in female basketball players",
volume = "147",
number = "11-12",
pages = "729-735",
doi = "10.2298/SARH190118063B"
}
Baralić, I., Stojmenović, T., Anđelković, M., Đorđević, B., Dikić, N., Radojević-Škodrić, S.,& Pejić, S. (2019). Effect of combined antioxidant treatment on oxidative stress, muscle damage and sport performance in female basketball players.
Srpski arhiv za celokupno lekarstvo, 147(11-12), 729-735.
https://doi.org/10.2298/SARH190118063B
Baralić I, Stojmenović T, Anđelković M, Đorđević B, Dikić N, Radojević-Škodrić S, Pejić S. Effect of combined antioxidant treatment on oxidative stress, muscle damage and sport performance in female basketball players. Srpski arhiv za celokupno lekarstvo. 2019;147(11-12):729-735
Baralić Ivana, Stojmenović Tamara, Anđelković Marija, Đorđević Brižita, Dikić Nenad, Radojević-Škodrić Sanja, Pejić Snežana, "Effect of combined antioxidant treatment on oxidative stress, muscle damage and sport performance in female basketball players" Srpski arhiv za celokupno lekarstvo, 147, no. 11-12 (2019):729-735,
https://doi.org/10.2298/SARH190118063B .

Immunohistochemical analysis of cyclin A expression in Wilms tumor

Radojević-Škodrić, Sanja; Brašanac, Dimitrije; Đuričić, Slaviša M.; Glumac, Sofija; Lončar, Zlatibor; Pavlović, Ivan; Todorović, Ana; Nikolić, Gorana V.; Baralić, Ivana; Pejić, Snežana

(2019)

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuričić, Slaviša M.
AU  - Glumac, Sofija
AU  - Lončar, Zlatibor
AU  - Pavlović, Ivan
AU  - Todorović, Ana
AU  - Nikolić, Gorana V.
AU  - Baralić, Ivana
AU  - Pejić, Snežana
PY  - 2019
UR  - https://peerj.com/articles/6212
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8025
AB  - Background: Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy (PrOpChTh), and overall survival (OS). Methods: This retrospective study involved 43 patients who underwent nephrectomy from January 1996 to October 2010. Tumor stage and histological subtype were determined by revised Societé International d’Oncologie Pediatrique protocol, based on histological components/alterations caused by PrOpChTh, within the prognostic group of low, intermediate and high risk, and with criteria for anaplasia. The regressive/necrotic changes in total tumor mass of primary tumor and the proportion of epithelial, blastemal, and stromal components in the remaining viable tumor tissue were also determined. Cyclin A expression was evaluated by immunohistochemistry using a polyclonal rabbit, antihuman antibody (H-432). Results: Cyclin A overexpression was found in 34.3% of WTs, with higher frequency in tumors with epithelial (31.3%) and blastemal (37.1%) components than those with stromal component (17.7%). Regarding histological type, cyclin A overexpression was found most often in focal anaplasia (100%), stromal (60%), and diffuse anaplastic (66.7) WTs. The overexpression was also more frequent in stages 3 and 4 (77.8% and 66.7%, respectively) compared to tumors in stages 1 and 2 (13.3% and 12.5%, respectively; p = 0.004) in all components, as well as in blastemal component in stages 3 and 4 (77.8% and 66.7%, respectively) vs. stages 1 and 2 (13.3% and 25%, respectively, p = 0.009). Cyclin A overexpression in all components was 66.7% in WTs with metastasis and 31.3% in WTs without metastasis (p = 0.265, Fisher test). Log-rank testing revealed differences of OS regarding stage (p = 0.000), prognostic groups (p = 0.001), and cyclin A expression in blastemal component (p = 0.025). After univariate analysis, tumor stage (p = 0.001), prognostic group (p = 0.004), and cyclin A expression in blastemal component (p = 0.042) were significant prognostic factors for OS; however, after multivariate analysis, none of these factors were confirmed as independent predictors of survival. Discussion: This study showed that cyclin A overexpression might be associated with the development and progression of WT with anaplasia. Also, cyclin A overexpression was more often observed in advanced stages (3 and 4) of WT, in the group of high-risk WTs, and in focal and diffuse anaplasia WTs. There was no relation of cyclin A overexpression and metastatic ability of WT. Although this study has not confirmed the prognostic value of cyclin A overexpression, its association with unfavorable prognosis should be further evaluated. Copyright 2019 Radojevic-Škodric et al.
T2  - PeerJ
T1  - Immunohistochemical analysis of cyclin A expression in Wilms tumor
VL  - 6
IS  - 1
SP  - e6212
DO  - 10.7717/peerj.6212
ER  - 
@article{
author = "Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuričić, Slaviša M. and Glumac, Sofija and Lončar, Zlatibor and Pavlović, Ivan and Todorović, Ana and Nikolić, Gorana V. and Baralić, Ivana and Pejić, Snežana",
year = "2019",
url = "https://peerj.com/articles/6212, http://vinar.vin.bg.ac.rs/handle/123456789/8025",
abstract = "Background: Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy (PrOpChTh), and overall survival (OS). Methods: This retrospective study involved 43 patients who underwent nephrectomy from January 1996 to October 2010. Tumor stage and histological subtype were determined by revised Societé International d’Oncologie Pediatrique protocol, based on histological components/alterations caused by PrOpChTh, within the prognostic group of low, intermediate and high risk, and with criteria for anaplasia. The regressive/necrotic changes in total tumor mass of primary tumor and the proportion of epithelial, blastemal, and stromal components in the remaining viable tumor tissue were also determined. Cyclin A expression was evaluated by immunohistochemistry using a polyclonal rabbit, antihuman antibody (H-432). Results: Cyclin A overexpression was found in 34.3% of WTs, with higher frequency in tumors with epithelial (31.3%) and blastemal (37.1%) components than those with stromal component (17.7%). Regarding histological type, cyclin A overexpression was found most often in focal anaplasia (100%), stromal (60%), and diffuse anaplastic (66.7) WTs. The overexpression was also more frequent in stages 3 and 4 (77.8% and 66.7%, respectively) compared to tumors in stages 1 and 2 (13.3% and 12.5%, respectively; p = 0.004) in all components, as well as in blastemal component in stages 3 and 4 (77.8% and 66.7%, respectively) vs. stages 1 and 2 (13.3% and 25%, respectively, p = 0.009). Cyclin A overexpression in all components was 66.7% in WTs with metastasis and 31.3% in WTs without metastasis (p = 0.265, Fisher test). Log-rank testing revealed differences of OS regarding stage (p = 0.000), prognostic groups (p = 0.001), and cyclin A expression in blastemal component (p = 0.025). After univariate analysis, tumor stage (p = 0.001), prognostic group (p = 0.004), and cyclin A expression in blastemal component (p = 0.042) were significant prognostic factors for OS; however, after multivariate analysis, none of these factors were confirmed as independent predictors of survival. Discussion: This study showed that cyclin A overexpression might be associated with the development and progression of WT with anaplasia. Also, cyclin A overexpression was more often observed in advanced stages (3 and 4) of WT, in the group of high-risk WTs, and in focal and diffuse anaplasia WTs. There was no relation of cyclin A overexpression and metastatic ability of WT. Although this study has not confirmed the prognostic value of cyclin A overexpression, its association with unfavorable prognosis should be further evaluated. Copyright 2019 Radojevic-Škodric et al.",
journal = "PeerJ",
title = "Immunohistochemical analysis of cyclin A expression in Wilms tumor",
volume = "6",
number = "1",
pages = "e6212",
doi = "10.7717/peerj.6212"
}
Radojević-Škodrić, S., Brašanac, D., Đuričić, S. M., Glumac, S., Lončar, Z., Pavlović, I., Todorović, A., Nikolić, G. V., Baralić, I.,& Pejić, S. (2019). Immunohistochemical analysis of cyclin A expression in Wilms tumor.
PeerJ, 6(1), e6212.
https://doi.org/10.7717/peerj.6212
Radojević-Škodrić S, Brašanac D, Đuričić SM, Glumac S, Lončar Z, Pavlović I, Todorović A, Nikolić GV, Baralić I, Pejić S. Immunohistochemical analysis of cyclin A expression in Wilms tumor. PeerJ. 2019;6(1):e6212
Radojević-Škodrić Sanja, Brašanac Dimitrije, Đuričić Slaviša M., Glumac Sofija, Lončar Zlatibor, Pavlović Ivan, Todorović Ana, Nikolić Gorana V., Baralić Ivana, Pejić Snežana, "Immunohistochemical analysis of cyclin A expression in Wilms tumor" PeerJ, 6, no. 1 (2019):e6212,
https://doi.org/10.7717/peerj.6212 .
1
1
1
1

Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma

Latić, Dragana; Pejić, Snežana; Savić, Slaviša; Lončar, Zlatibor; Nikolić, Ivan M.; Nikolić, Gorana V.; Pavlović, Ivan; Radojević-Škodrić, Sanja

(2019)

TY  - JOUR
AU  - Latić, Dragana
AU  - Pejić, Snežana
AU  - Savić, Slaviša
AU  - Lončar, Zlatibor
AU  - Nikolić, Ivan M.
AU  - Nikolić, Gorana V.
AU  - Pavlović, Ivan
AU  - Radojević-Škodrić, Sanja
PY  - 2019
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062383754&partnerID=40&md5=64d90794b6ba591ea6bbefd8f846beb1
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8078
AB  - Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression did not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors.
T2  - Journal of BUON
T1  - Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma
VL  - 24
IS  - 1
SP  - 301
EP  - 309
ER  - 
@article{
author = "Latić, Dragana and Pejić, Snežana and Savić, Slaviša and Lončar, Zlatibor and Nikolić, Ivan M. and Nikolić, Gorana V. and Pavlović, Ivan and Radojević-Škodrić, Sanja",
year = "2019",
url = "https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062383754&partnerID=40&md5=64d90794b6ba591ea6bbefd8f846beb1, http://vinar.vin.bg.ac.rs/handle/123456789/8078",
abstract = "Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression did not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors.",
journal = "Journal of BUON",
title = "Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma",
volume = "24",
number = "1",
pages = "301-309"
}
Latić, D., Pejić, S., Savić, S., Lončar, Z., Nikolić, I. M., Nikolić, G. V., Pavlović, I.,& Radojević-Škodrić, S. (2019). Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma.
Journal of BUON, 24(1), 301-309.
Latić D, Pejić S, Savić S, Lončar Z, Nikolić IM, Nikolić GV, Pavlović I, Radojević-Škodrić S. Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma. Journal of BUON. 2019;24(1):301-309
Latić Dragana, Pejić Snežana, Savić Slaviša, Lončar Zlatibor, Nikolić Ivan M., Nikolić Gorana V., Pavlović Ivan, Radojević-Škodrić Sanja, "Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma" Journal of BUON, 24, no. 1 (2019):301-309
1

Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium

Popović, Nataša M.; Stojiljković, Vesna; Pejić, Snežana; Todorović, Ana; Pavlović, Ivan; Gavrilović, Ljubica; Pajović, Snežana B.

(2019)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.hindawi.com/journals/omcl/2019/8745376/
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8085
AB  - This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.
T2  - Oxidative Medicine and Cellular Longevity
T1  - Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium
VL  - 2019
SP  - 1
EP  - 11
DO  - 10.1155/2019/8745376
ER  - 
@article{
author = "Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica and Pajović, Snežana B.",
year = "2019",
url = "https://www.hindawi.com/journals/omcl/2019/8745376/, http://vinar.vin.bg.ac.rs/handle/123456789/8085",
abstract = "This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium",
volume = "2019",
pages = "1-11",
doi = "10.1155/2019/8745376"
}
Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., Gavrilović, L.,& Pajović, S. B. (2019). Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium.
Oxidative Medicine and Cellular Longevity, 2019, 1-11.
https://doi.org/10.1155/2019/8745376
Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L, Pajović SB. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. Oxidative Medicine and Cellular Longevity. 2019;2019:1-11
Popović Nataša M., Stojiljković Vesna, Pejić Snežana, Todorović Ana, Pavlović Ivan, Gavrilović Ljubica, Pajović Snežana B., "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium" Oxidative Medicine and Cellular Longevity, 2019 (2019):1-11,
https://doi.org/10.1155/2019/8745376 .
4
2
3

Cadmium and Fullerenes in Liver Diseases

Đurašević, Siniša; Todorović, Zoran; Pavlović, Slađan; Pejić, Snežana

(2019)

TY  - CHAP
AU  - Đurašević, Siniša
AU  - Todorović, Zoran
AU  - Pavlović, Slađan
AU  - Pejić, Snežana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8862
AB  - Oxidative stress (OS) represents an imbalance of free radicals production and antioxidant defense in which the extensive pro-oxidant production may cause damage to cell structures. OS is the major event occurring in pathogenesis of liver disorders, ranging from metabolic to proliferative disorders. Cadmium is a highly toxic and widespread toxicant. Cadmium itself is unable to generate free radicals directly, as cadmium does not undergo redox cycling. However, indirect generation of various radicals involving the superoxide radical, hydroxyl radical, and nitric oxide has been reported. One of the biologically most relevant features of C60 fullerene is the ability to quench various free radicals, behaving as a "free radical sponge." Conversely, photosensitization of C60 yields highly reactive singlet oxygen or superoxide anion. Therefore, the dual property of fullerene to either quench or generate cell-damaging reactive oxygen species could be potentially exploited for their development as cytoprotective or cytotoxic agents. © 2019 Elsevier Inc. All rights reserved.
T2  - Dietary Interventions in Liver Disease
T1  - Cadmium and Fullerenes in Liver Diseases
SP  - 333
EP  - 344
DO  - 10.1016/B978-0-12-814466-4.00027-6
ER  - 
@article{
author = "Đurašević, Siniša and Todorović, Zoran and Pavlović, Slađan and Pejić, Snežana",
year = "2019",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/8862",
abstract = "Oxidative stress (OS) represents an imbalance of free radicals production and antioxidant defense in which the extensive pro-oxidant production may cause damage to cell structures. OS is the major event occurring in pathogenesis of liver disorders, ranging from metabolic to proliferative disorders. Cadmium is a highly toxic and widespread toxicant. Cadmium itself is unable to generate free radicals directly, as cadmium does not undergo redox cycling. However, indirect generation of various radicals involving the superoxide radical, hydroxyl radical, and nitric oxide has been reported. One of the biologically most relevant features of C60 fullerene is the ability to quench various free radicals, behaving as a "free radical sponge." Conversely, photosensitization of C60 yields highly reactive singlet oxygen or superoxide anion. Therefore, the dual property of fullerene to either quench or generate cell-damaging reactive oxygen species could be potentially exploited for their development as cytoprotective or cytotoxic agents. © 2019 Elsevier Inc. All rights reserved.",
journal = "Dietary Interventions in Liver Disease",
title = "Cadmium and Fullerenes in Liver Diseases",
pages = "333-344",
doi = "10.1016/B978-0-12-814466-4.00027-6"
}
Đurašević, S., Todorović, Z., Pavlović, S.,& Pejić, S. (2019). Cadmium and Fullerenes in Liver Diseases.
Dietary Interventions in Liver Disease, 333-344.
https://doi.org/10.1016/B978-0-12-814466-4.00027-6
Đurašević S, Todorović Z, Pavlović S, Pejić S. Cadmium and Fullerenes in Liver Diseases. Dietary Interventions in Liver Disease. 2019;:333-344
Đurašević Siniša, Todorović Zoran, Pavlović Slađan, Pejić Snežana, "Cadmium and Fullerenes in Liver Diseases" Dietary Interventions in Liver Disease (2019):333-344,
https://doi.org/10.1016/B978-0-12-814466-4.00027-6 .
5
3

Antioxidant status and clinicopathological parameters in patients with Parkinson's disease

Miletić Vukajlović, Jadranka; Pejić, Snežana; Todorović, Ana; Valenta Šobot, Ana; Drakulić, Dunja R.; Pavlović, Ivan; Stefanović, Aleksandra; Prostran, Milica; Ilić, Tihomir V.; Stojanov, Marina

(2019)

TY  - JOUR
AU  - Miletić Vukajlović, Jadranka
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Valenta Šobot, Ana
AU  - Drakulić, Dunja R.
AU  - Pavlović, Ivan
AU  - Stefanović, Aleksandra
AU  - Prostran, Milica
AU  - Ilić, Tihomir V.
AU  - Stojanov, Marina
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8407
AB  - Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.
T2  - Vojnosanitetski pregled
T1  - Antioxidant status and clinicopathological parameters in patients with Parkinson's disease
VL  - 77
IS  - 7
SP  - 724
EP  - 730
DO  - 10.2298/VSP180718148M
ER  - 
@article{
author = "Miletić Vukajlović, Jadranka and Pejić, Snežana and Todorović, Ana and Valenta Šobot, Ana and Drakulić, Dunja R. and Pavlović, Ivan and Stefanović, Aleksandra and Prostran, Milica and Ilić, Tihomir V. and Stojanov, Marina",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8407",
abstract = "Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.",
journal = "Vojnosanitetski pregled",
title = "Antioxidant status and clinicopathological parameters in patients with Parkinson's disease",
volume = "77",
number = "7",
pages = "724-730",
doi = "10.2298/VSP180718148M"
}
Miletić Vukajlović, J., Pejić, S., Todorović, A., Valenta Šobot, A., Drakulić, D. R., Pavlović, I., Stefanović, A., Prostran, M., Ilić, T. V.,& Stojanov, M. (2019). Antioxidant status and clinicopathological parameters in patients with Parkinson's disease.
Vojnosanitetski pregled, 77(7), 724-730.
https://doi.org/10.2298/VSP180718148M
Miletić Vukajlović J, Pejić S, Todorović A, Valenta Šobot A, Drakulić DR, Pavlović I, Stefanović A, Prostran M, Ilić TV, Stojanov M. Antioxidant status and clinicopathological parameters in patients with Parkinson's disease. Vojnosanitetski pregled. 2019;77(7):724-730
Miletić Vukajlović Jadranka, Pejić Snežana, Todorović Ana, Valenta Šobot Ana, Drakulić Dunja R., Pavlović Ivan, Stefanović Aleksandra, Prostran Milica, Ilić Tihomir V., Stojanov Marina, "Antioxidant status and clinicopathological parameters in patients with Parkinson's disease" Vojnosanitetski pregled, 77, no. 7 (2019):724-730,
https://doi.org/10.2298/VSP180718148M .
2
1
1

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma

Todorović, Ana; Pejić, Snežana; Gavrilović, Ljubica; Pavlović, Ivan; Stojiljković, Vesna; Popović, Nataša M.; Pajović, Snežana B.

(2019)

TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.mdpi.com/2076-3921/8/4/97
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8403
AB  - We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.
T2  - Antioxidants
T1  - Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma
VL  - 8
IS  - 4
SP  - 97
DO  - 10.3390/antiox8040097
ER  - 
@article{
author = "Todorović, Ana and Pejić, Snežana and Gavrilović, Ljubica and Pavlović, Ivan and Stojiljković, Vesna and Popović, Nataša M. and Pajović, Snežana B.",
year = "2019",
url = "https://www.mdpi.com/2076-3921/8/4/97, http://vinar.vin.bg.ac.rs/handle/123456789/8403",
abstract = "We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.",
journal = "Antioxidants",
title = "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma",
volume = "8",
number = "4",
pages = "97",
doi = "10.3390/antiox8040097"
}
Todorović, A., Pejić, S., Gavrilović, L., Pavlović, I., Stojiljković, V., Popović, N. M.,& Pajović, S. B. (2019). Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma.
Antioxidants, 8(4), 97.
https://doi.org/10.3390/antiox8040097
Todorović A, Pejić S, Gavrilović L, Pavlović I, Stojiljković V, Popović NM, Pajović SB. Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma. Antioxidants. 2019;8(4):97
Todorović Ana, Pejić Snežana, Gavrilović Ljubica, Pavlović Ivan, Stojiljković Vesna, Popović Nataša M., Pajović Snežana B., "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma" Antioxidants, 8, no. 4 (2019):97,
https://doi.org/10.3390/antiox8040097 .
4
4
4

Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease

Miletić, Jadranka; Drakulić, Dunja R.; Pejić, Snežana; Petković, Marijana; Ilić, Tihomir V.; Miljković, Milica; Stefanović, Aleksandra; Prostran, Milica; Stojanov, Marina

(2018)

TY  - JOUR
AU  - Miletić, Jadranka
AU  - Drakulić, Dunja R.
AU  - Pejić, Snežana
AU  - Petković, Marijana
AU  - Ilić, Tihomir V.
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Prostran, Milica
AU  - Stojanov, Marina
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7736
AB  - Background: Biomarkers of oxidative stress are relevant in the evaluation of the disease status and prooxidant-antioxidant balance, advanced oxidation protein products and lipid peroxidation products (malondialdehyde and 4-hydroxynonenal) are being extensively evaluated regarding their relationship with clinical presentation and disease severity.Aim of the study: The aim of this study was to evaluate the levels of the above-mentioned parameters in plasma of 39 men and 17 women with Parkinson's disease, originated from the Republic of Serbia and their relation to clinicopathological characteristics (gender, age at examination, duration of the disease, and Hoehn and Yahr score) and oxidative status.Results: The incidence of disease was 2:1 towards males. The investigated oxidative parameters were gender and Hoehn and Yahr related. Significant association of higher Hoehn and Yahr scores was observed for malondialdehyde (p = 0.01) and prooxidant-antioxidant balance (p = 0.02). Relation between oxidant-antioxidant status was further supported by observed positive correlation between 4-hydroxynonenal (p = 0.04) and prooxidant-antioxidant balance (p = 0.03). Finally, the multivariate analysis indicated that prooxidant-antioxidant balance and malondialdehyde were partially determined by gender (10.6% and 7.6%) and Hoehn and Yahr scores (13.6% and 18.8%), while Hoehn and Yahr scores contributed to the variance of advanced oxidation protein products with 13.2%.Conclusion: Our results indicate the higher level of oxidative stress (oxidant-antioxidant imbalance) and possible relation of several markers with gender and disease stage in patients with Parkinson's disease. The analyzed markers could be used to specify the severity of oxidative stress; however, their potential value should be analyzed in further studies.
T2  - International Journal of Neuroscience
T1  - Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease
VL  - 128
IS  - 7
SP  - 600
EP  - 607
DO  - 10.1080/00207454.2017.1403916
ER  - 
@article{
author = "Miletić, Jadranka and Drakulić, Dunja R. and Pejić, Snežana and Petković, Marijana and Ilić, Tihomir V. and Miljković, Milica and Stefanović, Aleksandra and Prostran, Milica and Stojanov, Marina",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7736",
abstract = "Background: Biomarkers of oxidative stress are relevant in the evaluation of the disease status and prooxidant-antioxidant balance, advanced oxidation protein products and lipid peroxidation products (malondialdehyde and 4-hydroxynonenal) are being extensively evaluated regarding their relationship with clinical presentation and disease severity.Aim of the study: The aim of this study was to evaluate the levels of the above-mentioned parameters in plasma of 39 men and 17 women with Parkinson's disease, originated from the Republic of Serbia and their relation to clinicopathological characteristics (gender, age at examination, duration of the disease, and Hoehn and Yahr score) and oxidative status.Results: The incidence of disease was 2:1 towards males. The investigated oxidative parameters were gender and Hoehn and Yahr related. Significant association of higher Hoehn and Yahr scores was observed for malondialdehyde (p = 0.01) and prooxidant-antioxidant balance (p = 0.02). Relation between oxidant-antioxidant status was further supported by observed positive correlation between 4-hydroxynonenal (p = 0.04) and prooxidant-antioxidant balance (p = 0.03). Finally, the multivariate analysis indicated that prooxidant-antioxidant balance and malondialdehyde were partially determined by gender (10.6% and 7.6%) and Hoehn and Yahr scores (13.6% and 18.8%), while Hoehn and Yahr scores contributed to the variance of advanced oxidation protein products with 13.2%.Conclusion: Our results indicate the higher level of oxidative stress (oxidant-antioxidant imbalance) and possible relation of several markers with gender and disease stage in patients with Parkinson's disease. The analyzed markers could be used to specify the severity of oxidative stress; however, their potential value should be analyzed in further studies.",
journal = "International Journal of Neuroscience",
title = "Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease",
volume = "128",
number = "7",
pages = "600-607",
doi = "10.1080/00207454.2017.1403916"
}
Miletić, J., Drakulić, D. R., Pejić, S., Petković, M., Ilić, T. V., Miljković, M., Stefanović, A., Prostran, M.,& Stojanov, M. (2018). Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease.
International Journal of Neuroscience, 128(7), 600-607.
https://doi.org/10.1080/00207454.2017.1403916
Miletić J, Drakulić DR, Pejić S, Petković M, Ilić TV, Miljković M, Stefanović A, Prostran M, Stojanov M. Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease. International Journal of Neuroscience. 2018;128(7):600-607
Miletić Jadranka, Drakulić Dunja R., Pejić Snežana, Petković Marijana, Ilić Tihomir V., Miljković Milica, Stefanović Aleksandra, Prostran Milica, Stojanov Marina, "Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease" International Journal of Neuroscience, 128, no. 7 (2018):600-607,
https://doi.org/10.1080/00207454.2017.1403916 .
13
8
11

Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Todorović, Ana; Pejić, Snežana; Pavlović, Ivan; Gavrilović, Ljubica

(2018)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8404
AB  - The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Neurophysiology
T1  - Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats
VL  - 50
IS  - 5
SP  - 332
EP  - 338
DO  - 10.1007/s11062-019-09758-z
ER  - 
@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8404",
abstract = "The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Neurophysiology",
title = "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats",
volume = "50",
number = "5",
pages = "332-338",
doi = "10.1007/s11062-019-09758-z"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L. (2018). Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats.
Neurophysiology, 50(5), 332-338.
https://doi.org/10.1007/s11062-019-09758-z
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats. Neurophysiology. 2018;50(5):332-338
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica, "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats" Neurophysiology, 50, no. 5 (2018):332-338,
https://doi.org/10.1007/s11062-019-09758-z .

Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System

Bartholomew, Ibeh; Gavrilović, Ljubica; Stojiljković, Vesna; Popović, Nataša M.; Pejić, Snežana; Todorović, Ana; Pavlović, Ivan; Pajović, Snežana B.

(IntechOpen, 2018)

TY  - CHAP
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8406
AB  - We examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl
ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2),
antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A))
and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant
enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically
stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by
100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned
concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50%
and 150%, respectively). Exercise induced the accumulation of the catecholamines and a
decrease of stress-induced oxidative stress in the spleen, which may significantly affect the
immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor,
which indicates that exercise may induce potentially positive physiological adaptations.
Our combined model of chronic social isolation and long-term daily treadmill running in
rats may be a good animal model in the research of therapeutic role of exercise in human
disease caused by chronic stress.
PB  - IntechOpen
PB  - InTech
T2  - Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
T1  - Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System
IS  - Ch. 14
SP  - 283
EP  - 310
DO  - 10.5772/intechopen.70008
ER  - 
@article{
editor = "Bartholomew, Ibeh",
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Popović, Nataša M. and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8406",
abstract = "We examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl
ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2),
antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A))
and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant
enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically
stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by
100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned
concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50%
and 150%, respectively). Exercise induced the accumulation of the catecholamines and a
decrease of stress-induced oxidative stress in the spleen, which may significantly affect the
immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor,
which indicates that exercise may induce potentially positive physiological adaptations.
Our combined model of chronic social isolation and long-term daily treadmill running in
rats may be a good animal model in the research of therapeutic role of exercise in human
disease caused by chronic stress.",
publisher = "IntechOpen, InTech",
journal = "Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh",
title = "Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System",
number = "Ch. 14",
pages = "283-310",
doi = "10.5772/intechopen.70008"
}
Bartholomew, I., Gavrilović, L., Stojiljković, V., Popović, N. M., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B. (2018). Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System.
Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
InTech.(Ch. 14), 283-310.
https://doi.org/10.5772/intechopen.70008
Bartholomew I, Gavrilović L, Stojiljković V, Popović NM, Pejić S, Todorović A, Pavlović I, Pajović SB. Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System. Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh. 2018;(Ch. 14):283-310
Bartholomew Ibeh, Gavrilović Ljubica, Stojiljković Vesna, Popović Nataša M., Pejić Snežana, Todorović Ana, Pavlović Ivan, Pajović Snežana B., "Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System" Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh, no. Ch. 14 (2018):283-310,
https://doi.org/10.5772/intechopen.70008 .
2

Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Pejić, Snežana; Todorović, Ana; Pavlović, Ivan; Gavrilović, Ljubica

(2017)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1588
AB  - This study examined the effects of chronic restraint stress (CRS) on gene expression of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), dopamine transporter (DAT), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2), catechol-O-methyltransferase (COMT) and antioxidant enzymes such as superoxide dismutase (SOD1 and SOD2), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as concentrations of dopamine (DA) and noradrenaline (NA), activities of monoamine oxidase (MAO A and MAOB) and activities of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR) in the rat prefrontal cortex (PFC). We found that CRS decreases gene expression of TH and DBH and concentrations of DA, which probably confirms the decrease of de novo synthesis of catecholamine. CRS increased protein levels of NET and VMAT2, which was followed by increased NA concentration. The increased activity of MAO A and MAO B, as well as increased protein levels of COMT probably indicate increased catecholamine degradation, which was followed by increased activity of SOD1, SOD2 and CAT, as well as decreased activity of GPx under stress conditions. Our findings confirm the increased prefrontal noradrenergic turnover in animals exposed to CRS. The molecular mechanisms by which CRS changes catecholaminergic turnover and the antioxidant defense system in the PFC may be very important for research on numerous psychiatric diseases caused by chronic stress.
T2  - Folia Biologica, Krakow
T1  - Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats
VL  - 65
IS  - 1
SP  - 43
EP  - 54
DO  - 10.3409/fb65_1.43
ER  - 
@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1588",
abstract = "This study examined the effects of chronic restraint stress (CRS) on gene expression of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), dopamine transporter (DAT), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2), catechol-O-methyltransferase (COMT) and antioxidant enzymes such as superoxide dismutase (SOD1 and SOD2), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as concentrations of dopamine (DA) and noradrenaline (NA), activities of monoamine oxidase (MAO A and MAOB) and activities of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR) in the rat prefrontal cortex (PFC). We found that CRS decreases gene expression of TH and DBH and concentrations of DA, which probably confirms the decrease of de novo synthesis of catecholamine. CRS increased protein levels of NET and VMAT2, which was followed by increased NA concentration. The increased activity of MAO A and MAO B, as well as increased protein levels of COMT probably indicate increased catecholamine degradation, which was followed by increased activity of SOD1, SOD2 and CAT, as well as decreased activity of GPx under stress conditions. Our findings confirm the increased prefrontal noradrenergic turnover in animals exposed to CRS. The molecular mechanisms by which CRS changes catecholaminergic turnover and the antioxidant defense system in the PFC may be very important for research on numerous psychiatric diseases caused by chronic stress.",
journal = "Folia Biologica, Krakow",
title = "Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats",
volume = "65",
number = "1",
pages = "43-54",
doi = "10.3409/fb65_1.43"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I.,& Gavrilović, L. (2017). Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats.
Folia Biologica, Krakow, 65(1), 43-54.
https://doi.org/10.3409/fb65_1.43
Popović NM, Pajović SB, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L. Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats. Folia Biologica, Krakow. 2017;65(1):43-54
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Pejić Snežana, Todorović Ana, Pavlović Ivan, Gavrilović Ljubica, "Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats" Folia Biologica, Krakow, 65, no. 1 (2017):43-54,
https://doi.org/10.3409/fb65_1.43 .
4
5
5

Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)

Vasić, N.; Glumac, Sofija; Pejić, Snežana; Amidžić, L. J.; Tadić Latinović, L. J.; Dožić, Branko S.; Hinić, Saša; Maksimović, Živan

(2017)

TY  - JOUR
AU  - Vasić, N.
AU  - Glumac, Sofija
AU  - Pejić, Snežana
AU  - Amidžić, L. J.
AU  - Tadić Latinović, L. J.
AU  - Dožić, Branko S.
AU  - Hinić, Saša
AU  - Maksimović, Živan
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7676
AB  - © 2017 Charles University. All rights reserved. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.
T2  - Folia Biologica (Czech Republic)
T1  - Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)
VL  - 63
IS  - 5-6
SP  - 209
EP  - 216
ER  - 
@article{
author = "Vasić, N. and Glumac, Sofija and Pejić, Snežana and Amidžić, L. J. and Tadić Latinović, L. J. and Dožić, Branko S. and Hinić, Saša and Maksimović, Živan",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7676",
abstract = "© 2017 Charles University. All rights reserved. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.",
journal = "Folia Biologica (Czech Republic)",
title = "Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)",
volume = "63",
number = "5-6",
pages = "209-216"
}
Vasić, N., Glumac, S., Pejić, S., Amidžić, L. J., Tadić Latinović, L. J., Dožić, B. S., Hinić, S.,& Maksimović, Ž. (2017). Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche).
Folia Biologica (Czech Republic), 63(5-6), 209-216.
Vasić N, Glumac S, Pejić S, Amidžić LJ, Tadić Latinović LJ, Dožić BS, Hinić S, Maksimović Ž. Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche). Folia Biologica (Czech Republic). 2017;63(5-6):209-216
Vasić N., Glumac Sofija, Pejić Snežana, Amidžić L. J., Tadić Latinović L. J., Dožić Branko S., Hinić Saša, Maksimović Živan, "Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)" Folia Biologica (Czech Republic), 63, no. 5-6 (2017):209-216

Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation

Spasojević-Tišma, Vera D.; Matovic, Milovan D.; Mihaljevic, Olgica B.; Zivancevic-Simonovic, Snezana T.; Jeremic, Marija Z.; Jakovljević, Vladimir Lj.; Todorović, Vera N.; Pavlović, Ivan; Pejić, Snežana; Todorović, Ana

(2017)

TY  - JOUR
AU  - Spasojević-Tišma, Vera D.
AU  - Matovic, Milovan D.
AU  - Mihaljevic, Olgica B.
AU  - Zivancevic-Simonovic, Snezana T.
AU  - Jeremic, Marija Z.
AU  - Jakovljević, Vladimir Lj.
AU  - Todorović, Vera N.
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Todorović, Ana
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1935
AB  - The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.
T2  - Nuclear technology and radiation protection
T1  - Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation
VL  - 32
IS  - 4
SP  - 358
EP  - 365
DO  - 10.2298/NTRP1704358S
ER  - 
@article{
author = "Spasojević-Tišma, Vera D. and Matovic, Milovan D. and Mihaljevic, Olgica B. and Zivancevic-Simonovic, Snezana T. and Jeremic, Marija Z. and Jakovljević, Vladimir Lj. and Todorović, Vera N. and Pavlović, Ivan and Pejić, Snežana and Todorović, Ana",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1935",
abstract = "The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.",
journal = "Nuclear technology and radiation protection",
title = "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation",
volume = "32",
number = "4",
pages = "358-365",
doi = "10.2298/NTRP1704358S"
}
Spasojević-Tišma, V. D., Matovic, M. D., Mihaljevic, O. B., Zivancevic-Simonovic, S. T., Jeremic, M. Z., Jakovljević, V. Lj., Todorović, V. N., Pavlović, I., Pejić, S.,& Todorović, A. (2017). Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation.
Nuclear technology and radiation protection, 32(4), 358-365.
https://doi.org/10.2298/NTRP1704358S
Spasojević-Tišma VD, Matovic MD, Mihaljevic OB, Zivancevic-Simonovic ST, Jeremic MZ, Jakovljević VL, Todorović VN, Pavlović I, Pejić S, Todorović A. Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. Nuclear technology and radiation protection. 2017;32(4):358-365
Spasojević-Tišma Vera D., Matovic Milovan D., Mihaljevic Olgica B., Zivancevic-Simonovic Snezana T., Jeremic Marija Z., Jakovljević Vladimir Lj., Todorović Vera N., Pavlović Ivan, Pejić Snežana, Todorović Ana, "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation" Nuclear technology and radiation protection, 32, no. 4 (2017):358-365,
https://doi.org/10.2298/NTRP1704358S .

Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis

Pavlović, Ivan; Pejić, Snežana; Glumac, Sofija; Todorović, Ana; Stojiljković, Vesna; Popović, Nataša M.; Gavrilović, Ljubica; Pajović, Snežana B.; Radojevic-Skodric, Sanja; Dzamic, Zoran; Basta-Jovanović, Gordana

(2017)

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
AU  - Radojevic-Skodric, Sanja
AU  - Dzamic, Zoran
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1857
AB  - Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.
T2  - Journal of BUON
T1  - Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis
VL  - 22
IS  - 6
SP  - 1434
EP  - 1440
ER  - 
@article{
author = "Pavlović, Ivan and Pejić, Snežana and Glumac, Sofija and Todorović, Ana and Stojiljković, Vesna and Popović, Nataša M. and Gavrilović, Ljubica and Pajović, Snežana B. and Radojevic-Skodric, Sanja and Dzamic, Zoran and Basta-Jovanović, Gordana",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1857",
abstract = "Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.",
journal = "Journal of BUON",
title = "Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis",
volume = "22",
number = "6",
pages = "1434-1440"
}
Pavlović, I., Pejić, S., Glumac, S., Todorović, A., Stojiljković, V., Popović, N. M., Gavrilović, L., Pajović, S. B., Radojevic-Skodric, S., Dzamic, Z.,& Basta-Jovanović, G. (2017). Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis.
Journal of BUON, 22(6), 1434-1440.
Pavlović I, Pejić S, Glumac S, Todorović A, Stojiljković V, Popović NM, Gavrilović L, Pajović SB, Radojevic-Skodric S, Dzamic Z, Basta-Jovanović G. Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis. Journal of BUON. 2017;22(6):1434-1440
Pavlović Ivan, Pejić Snežana, Glumac Sofija, Todorović Ana, Stojiljković Vesna, Popović Nataša M., Gavrilović Ljubica, Pajović Snežana B., Radojevic-Skodric Sanja, Dzamic Zoran, Basta-Jovanović Gordana, "Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis" Journal of BUON, 22, no. 6 (2017):1434-1440
2
2

Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Todorović, Ana; Pejić, Snežana; Pavlović, Ivan; Gavrilović, Ljubica

(2017)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1908
AB  - This study examined the effects of chronic restraint stress (CRS: 2 hours x 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantified by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our findings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.
T2  - Acta Veterinaria, Beograd
T1  - Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
VL  - 67
IS  - 4
SP  - 540
EP  - 550
DO  - 10.1515/acve-2017-0043
ER  - 
@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1908",
abstract = "This study examined the effects of chronic restraint stress (CRS: 2 hours x 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantified by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our findings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.",
journal = "Acta Veterinaria, Beograd",
title = "Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats",
volume = "67",
number = "4",
pages = "540-550",
doi = "10.1515/acve-2017-0043"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L. (2017). Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats.
Acta Veterinaria, Beograd, 67(4), 540-550.
https://doi.org/10.1515/acve-2017-0043
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats. Acta Veterinaria, Beograd. 2017;67(4):540-550
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica, "Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats" Acta Veterinaria, Beograd, 67, no. 4 (2017):540-550,
https://doi.org/10.1515/acve-2017-0043 .
3
3
4

Superoxide dismutase and lipid peroxidation in children affected by celiac disease

Stojiljković, Vesna; Gavrilović, Ljubica; Pejić, Snežana; Todorović, Ana; Popović, Nataša M.; Pavlović, Ivan; Pajović, Snežana B.

(RAD Association, 2017)

TY  - CONF
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=152
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7995
AB  - Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Superoxide dismutase and lipid peroxidation in children affected by celiac disease
VL  - 2
SP  - 237
EP  - 242
DO  - 10.21175/RadProc.2017.49
ER  - 
@conference{
author = "Stojiljković, Vesna and Gavrilović, Ljubica and Pejić, Snežana and Todorović, Ana and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2017",
url = "http://www.rad-proceedings.org/paper.php?id=152, http://vinar.vin.bg.ac.rs/handle/123456789/7995",
abstract = "Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Superoxide dismutase and lipid peroxidation in children affected by celiac disease",
volume = "2",
pages = "237-242",
doi = "10.21175/RadProc.2017.49"
}
Stojiljković, V., Gavrilović, L., Pejić, S., Todorović, A., Popović, N. M., Pavlović, I.,& Pajović, S. B. (2017). Superoxide dismutase and lipid peroxidation in children affected by celiac disease.
RAD Conference Proceedings
RAD Association., 2, 237-242.
https://doi.org/10.21175/RadProc.2017.49
Stojiljković V, Gavrilović L, Pejić S, Todorović A, Popović NM, Pavlović I, Pajović SB. Superoxide dismutase and lipid peroxidation in children affected by celiac disease. RAD Conference Proceedings. 2017;2:237-242
Stojiljković Vesna, Gavrilović Ljubica, Pejić Snežana, Todorović Ana, Popović Nataša M., Pavlović Ivan, Pajović Snežana B., "Superoxide dismutase and lipid peroxidation in children affected by celiac disease" RAD Conference Proceedings, 2 (2017):237-242,
https://doi.org/10.21175/RadProc.2017.49 .

Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Todorović, Ana; Pejić, Snežana; Pavlović, Ivan; Gavrilović, Ljubica

(RAD Association, 2017)

TY  - CONF
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=155
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7996
AB  - Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats
VL  - 2
SP  - 255
EP  - 259
DO  - 10.21175/RadProc.2017.52
ER  - 
@conference{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
url = "http://www.rad-proceedings.org/paper.php?id=155, http://vinar.vin.bg.ac.rs/handle/123456789/7996",
abstract = "Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats",
volume = "2",
pages = "255-259",
doi = "10.21175/RadProc.2017.52"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L. (2017). Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats.
RAD Conference Proceedings
RAD Association., 2, 255-259.
https://doi.org/10.21175/RadProc.2017.52
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats. RAD Conference Proceedings. 2017;2:255-259
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica, "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats" RAD Conference Proceedings, 2 (2017):255-259,
https://doi.org/10.21175/RadProc.2017.52 .
3
3

Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma

Pavlović, Ivan; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Pajović, Snežana B.; Pejić, Snežana

(2016)

TY  - CONF
AU  - Pavlović, Ivan
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Pejić, Snežana
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7171
AB  - Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.
C3  - RAD Conference Proceedings
T1  - Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma
SP  - 153
EP  - 155
DO  - 10.21175/RadProc.2016.36
ER  - 
@conference{
author = "Pavlović, Ivan and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B. and Pejić, Snežana",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7171",
abstract = "Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.",
journal = "RAD Conference Proceedings",
title = "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma",
pages = "153-155",
doi = "10.21175/RadProc.2016.36"
}
Pavlović, I., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pajović, S. B.,& Pejić, S. (2016). Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma.
RAD Conference Proceedings, 153-155.
https://doi.org/10.21175/RadProc.2016.36
Pavlović I, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB, Pejić S. Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma. RAD Conference Proceedings. 2016;:153-155
Pavlović Ivan, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Pajović Snežana B., Pejić Snežana, "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma" RAD Conference Proceedings (2016):153-155,
https://doi.org/10.21175/RadProc.2016.36 .

Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy

Glumac, Sofija; Pejić, Snežana; Kostadinovic, S.; Stojsic, Z.; Vasiljevic, J.

(2016)

TY  - JOUR
AU  - Glumac, Sofija
AU  - Pejić, Snežana
AU  - Kostadinovic, S.
AU  - Stojsic, Z.
AU  - Vasiljevic, J.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1398
AB  - Apoptosis is an active energy-consuming mechanism of cell death, which may contribute to heart failure in patients with dilated cardiomyopathy. Dilated cardiomyopathy is a common clinical outcome of many prolonged cardiac insults, and therefore is considered as the most prevalent form of cardiomyopathy. Loss of heart mass is highly correlated with the heart failure and mortality, thus the purpose of this study was to define the apoptotic index in patients with dilated cardiomyopathy. Apoptosis was detected by the TUNEL method in 30 patients. Biopsies were obtained from the left ventricle, and at least three specimens were taken. TUNEL-positive cardiomyocytes were found in 26 of 30 cases (86.7 %) and the mean apoptotic index for the entire specimen series was 5.41 +/- 1.70 %. The analysis showed that patients with dilated cardiomyopathy had significantly higher apoptotic index (P LT 0.001) than healthy subjects. One subject (man, 41 years old) had a markedly elevated apoptotic index of 52.2 %. In the remaining subjects, the percentage of cardiomyocyte death ranged from 0 % to 15.5 %. The high percentage of apoptosis found in our study may be in accordance with the clinically manifested cardiac failure in patients with dilated cardiomyopathy since in most patients we recorded the left ventricular ejection fraction values below 30 %.
T2  - Folia Biologica
T1  - Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy
VL  - 62
IS  - 5
SP  - 207
EP  - 211
ER  - 
@article{
author = "Glumac, Sofija and Pejić, Snežana and Kostadinovic, S. and Stojsic, Z. and Vasiljevic, J.",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1398",
abstract = "Apoptosis is an active energy-consuming mechanism of cell death, which may contribute to heart failure in patients with dilated cardiomyopathy. Dilated cardiomyopathy is a common clinical outcome of many prolonged cardiac insults, and therefore is considered as the most prevalent form of cardiomyopathy. Loss of heart mass is highly correlated with the heart failure and mortality, thus the purpose of this study was to define the apoptotic index in patients with dilated cardiomyopathy. Apoptosis was detected by the TUNEL method in 30 patients. Biopsies were obtained from the left ventricle, and at least three specimens were taken. TUNEL-positive cardiomyocytes were found in 26 of 30 cases (86.7 %) and the mean apoptotic index for the entire specimen series was 5.41 +/- 1.70 %. The analysis showed that patients with dilated cardiomyopathy had significantly higher apoptotic index (P LT 0.001) than healthy subjects. One subject (man, 41 years old) had a markedly elevated apoptotic index of 52.2 %. In the remaining subjects, the percentage of cardiomyocyte death ranged from 0 % to 15.5 %. The high percentage of apoptosis found in our study may be in accordance with the clinically manifested cardiac failure in patients with dilated cardiomyopathy since in most patients we recorded the left ventricular ejection fraction values below 30 %.",
journal = "Folia Biologica",
title = "Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy",
volume = "62",
number = "5",
pages = "207-211"
}
Glumac, S., Pejić, S., Kostadinovic, S., Stojsic, Z.,& Vasiljevic, J. (2016). Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy.
Folia Biologica, 62(5), 207-211.
Glumac S, Pejić S, Kostadinovic S, Stojsic Z, Vasiljevic J. Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy. Folia Biologica. 2016;62(5):207-211
Glumac Sofija, Pejić Snežana, Kostadinovic S., Stojsic Z., Vasiljevic J., "Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy" Folia Biologica, 62, no. 5 (2016):207-211
4

Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress

Pejić, Snežana; Stojiljković, Vesna; Todorović, Ana; Gavrilović, Ljubica; Pavlović, Ivan; Popović, Nataša M.; Pajović, Snežana B.

(2016)

TY  - JOUR
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1301
AB  - The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.
T2  - Folia Biologica, Krakow
T1  - Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress
VL  - 64
IS  - 3
SP  - 189
EP  - 195
DO  - 10.3409/fb64_3.189
ER  - 
@article{
author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Pavlović, Ivan and Popović, Nataša M. and Pajović, Snežana B.",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1301",
abstract = "The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.",
journal = "Folia Biologica, Krakow",
title = "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress",
volume = "64",
number = "3",
pages = "189-195",
doi = "10.3409/fb64_3.189"
}
Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Pavlović, I., Popović, N. M.,& Pajović, S. B. (2016). Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress.
Folia Biologica, Krakow, 64(3), 189-195.
https://doi.org/10.3409/fb64_3.189
Pejić S, Stojiljković V, Todorović A, Gavrilović L, Pavlović I, Popović NM, Pajović SB. Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress. Folia Biologica, Krakow. 2016;64(3):189-195
Pejić Snežana, Stojiljković Vesna, Todorović Ana, Gavrilović Ljubica, Pavlović Ivan, Popović Nataša M., Pajović Snežana B., "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress" Folia Biologica, Krakow, 64, no. 3 (2016):189-195,
https://doi.org/10.3409/fb64_3.189 .
5
3
3