TY  - JOUR
AU  - Vasić, Dragana D.
AU  - Savić, Jasmina
AU  - Bugaricic, Zivadin
AU  - Krstić, Danijela Z.
AU  - Tomić, Nenad
AU  - Čolović, Mirjana B.
AU  - Petković, Marijana
AU  - Vasić, Vesna M.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3657
AB  - The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effects of antitumour platinum drugs.
T2  - Zeitschrift fur Naturforschung. Section C: Journal of Biosciences
T1  - Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine
VL  - 64
IS  - 1-2
SP  - 103
EP  - 108
DO  - 10.1515/znc-2009-1-217
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3657
ER  - 

@article{
author = "Vasić, Dragana D. and Savić, Jasmina and Bugaricic, Zivadin and Krstić, Danijela Z. and Tomić, Nenad and Čolović, Mirjana B. and Petković, Marijana and Vasić, Vesna M.",
year = "2009",
abstract = "The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effects of antitumour platinum drugs.",
journal = "Zeitschrift fur Naturforschung. Section C: Journal of Biosciences",
title = "Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine",
volume = "64",
number = "1-2",
pages = "103-108",
doi = "10.1515/znc-2009-1-217",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3657"
}

Vasić, D. D., Savić, J., Bugaricic, Z., Krstić, D. Z., Tomić, N., Čolović, M. B., Petković, M.,& Vasić, V. M.. (2009). Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine. in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 64(1-2), 103-108.
https://doi.org/10.1515/znc-2009-1-217
https://hdl.handle.net/21.15107/rcub_vinar_3657

Vasić DD, Savić J, Bugaricic Z, Krstić DZ, Tomić N, Čolović MB, Petković M, Vasić VM. Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine. in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences. 2009;64(1-2):103-108.
doi:10.1515/znc-2009-1-217
https://hdl.handle.net/21.15107/rcub_vinar_3657 .

Vasić, Dragana D., Savić, Jasmina, Bugaricic, Zivadin, Krstić, Danijela Z., Tomić, Nenad, Čolović, Mirjana B., Petković, Marijana, Vasić, Vesna M., "Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine" in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 64, no. 1-2 (2009):103-108,
https://doi.org/10.1515/znc-2009-1-217 .,
https://hdl.handle.net/21.15107/rcub_vinar_3657 .