Kapetanovic, V

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  • Kapetanovic, V (2)
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Author's Bibliography

Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m

Brborić, Jasmina; Jovanović, Moma S.; Popovic, G; Kapetanovic, V; Vladimirov, Sote

(2006)

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanović, Moma S.
AU  - Popovic, G
AU  - Kapetanovic, V
AU  - Vladimirov, Sote
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2981
AB  - The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
VL  - 71
IS  - 1
SP  - 55
EP  - 65
DO  - 10.2298/JSC0601055B
ER  - 
@article{
author = "Brborić, Jasmina and Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Vladimirov, Sote",
year = "2006",
abstract = "The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m",
volume = "71",
number = "1",
pages = "55-65",
doi = "10.2298/JSC0601055B"
}
Brborić, J., Jovanović, M. S., Popovic, G., Kapetanovic, V.,& Vladimirov, S.. (2006). Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society, 71(1), 55-65.
https://doi.org/10.2298/JSC0601055B
Brborić J, Jovanović MS, Popovic G, Kapetanovic V, Vladimirov S. Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society. 2006;71(1):55-65.
doi:10.2298/JSC0601055B .
Brborić, Jasmina, Jovanović, Moma S., Popovic, G, Kapetanovic, V, Vladimirov, Sote, "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m" in Journal of the Serbian Chemical Society, 71, no. 1 (2006):55-65,
https://doi.org/10.2298/JSC0601055B . .
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Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid

Jovanović, Moma S.; Popovic, G; Kapetanovic, V; Orlić, Milan P.; Vladimirov, Sote

(2004)

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Popovic, G
AU  - Kapetanovic, V
AU  - Orlić, Milan P.
AU  - Vladimirov, Sote
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2811
AB  - In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
VL  - 35
IS  - 5
SP  - 1257
EP  - 1261
DO  - 10.1016/j.jpba.2004.03.009
ER  - 
@article{
author = "Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Orlić, Milan P. and Vladimirov, Sote",
year = "2004",
abstract = "In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid",
volume = "35",
number = "5",
pages = "1257-1261",
doi = "10.1016/j.jpba.2004.03.009"
}
Jovanović, M. S., Popovic, G., Kapetanovic, V., Orlić, M. P.,& Vladimirov, S.. (2004). Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis, 35(5), 1257-1261.
https://doi.org/10.1016/j.jpba.2004.03.009
Jovanović MS, Popovic G, Kapetanovic V, Orlić MP, Vladimirov S. Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis. 2004;35(5):1257-1261.
doi:10.1016/j.jpba.2004.03.009 .
Jovanović, Moma S., Popovic, G, Kapetanovic, V, Orlić, Milan P., Vladimirov, Sote, "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid" in Journal of Pharmaceutical and Biomedical Analysis, 35, no. 5 (2004):1257-1261,
https://doi.org/10.1016/j.jpba.2004.03.009 . .
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