Markelić, Milica

Link to this page

Authority KeyName Variants
0beef5a6-cf48-4adb-a97f-7f61b3031e6d
  • Markelić, Milica (2)
Projects

Author's Bibliography

Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells

Seke, Mariana; Markelić, Milica; Morina, Arian; Jović, Danica S.; Korać, Aleksandra; Miličić, Dragana; Đorđević, Aleksandar N.

(2017)

TY  - JOUR
AU  - Seke, Mariana
AU  - Markelić, Milica
AU  - Morina, Arian
AU  - Jović, Danica S.
AU  - Korać, Aleksandra
AU  - Miličić, Dragana
AU  - Đorđević, Aleksandar N.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1609
AB  - Adsorption of non-polar compounds by suspended fullerene nanoaggregates (nC(60)) may enhance their toxicity and affect the fate, transformation, and transport of non-polar compounds in the environment. The potential of stable fullerene nanoaggregates as contaminant carriers in aqueous systems and the influence of chloromethanes (trichloromethane and dichloromethane) were studied on the midgut epithelial cells of Daphnia magna by light and electron microscopy. The size and shape of fullerene nanoaggregates were observed and measured using dynamic light scattering, transmission electron microscopy, and low vacuum scanning electron microscopy. The nC(60) in suspension appeared as a bulk of aggregates of irregular shape with a surface consisting of small clumps 20-30 nm in diameter. The presence of nC(60) aggregates was confirmed in midgut lumen and epithelial cells of D. magna. After in vivo acute exposure to chloromethane, light and electron microscopy revealed an extensive cytoplasmic vacuolization with disruption and loss of specific structures of D. magna midgut epithelium (mitochondria, endoplasmic reticulum, microvilli, peritrophic membrane) and increased appearance of necrotic cells. The degree of observed changes depended on the type of treatment: trichloromethane (TCM) induced the most notable changes, whereas fullerene nanoaggregates alone had no negative effects. Transmission electron microscopy also indicated increased lysosomal degradation and severe peroxidative damages of enterocyte mitochondria following combined exposure to chloromethane and fullerene nanoaggregates. In conclusion, the adsorption of chloromethane by fullerene nanoaggregates enhances their toxicity and induces peroxidative mitochondrial damage in midgut enterocytes.
T2  - Protoplasma
T1  - Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells
VL  - 254
IS  - 4
SP  - 1607
EP  - 1616
DO  - 10.1007/s00709-016-1049-9
ER  - 
@article{
author = "Seke, Mariana and Markelić, Milica and Morina, Arian and Jović, Danica S. and Korać, Aleksandra and Miličić, Dragana and Đorđević, Aleksandar N.",
year = "2017",
abstract = "Adsorption of non-polar compounds by suspended fullerene nanoaggregates (nC(60)) may enhance their toxicity and affect the fate, transformation, and transport of non-polar compounds in the environment. The potential of stable fullerene nanoaggregates as contaminant carriers in aqueous systems and the influence of chloromethanes (trichloromethane and dichloromethane) were studied on the midgut epithelial cells of Daphnia magna by light and electron microscopy. The size and shape of fullerene nanoaggregates were observed and measured using dynamic light scattering, transmission electron microscopy, and low vacuum scanning electron microscopy. The nC(60) in suspension appeared as a bulk of aggregates of irregular shape with a surface consisting of small clumps 20-30 nm in diameter. The presence of nC(60) aggregates was confirmed in midgut lumen and epithelial cells of D. magna. After in vivo acute exposure to chloromethane, light and electron microscopy revealed an extensive cytoplasmic vacuolization with disruption and loss of specific structures of D. magna midgut epithelium (mitochondria, endoplasmic reticulum, microvilli, peritrophic membrane) and increased appearance of necrotic cells. The degree of observed changes depended on the type of treatment: trichloromethane (TCM) induced the most notable changes, whereas fullerene nanoaggregates alone had no negative effects. Transmission electron microscopy also indicated increased lysosomal degradation and severe peroxidative damages of enterocyte mitochondria following combined exposure to chloromethane and fullerene nanoaggregates. In conclusion, the adsorption of chloromethane by fullerene nanoaggregates enhances their toxicity and induces peroxidative mitochondrial damage in midgut enterocytes.",
journal = "Protoplasma",
title = "Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells",
volume = "254",
number = "4",
pages = "1607-1616",
doi = "10.1007/s00709-016-1049-9"
}
Seke, M., Markelić, M., Morina, A., Jović, D. S., Korać, A., Miličić, D.,& Đorđević, A. N.. (2017). Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells. in Protoplasma, 254(4), 1607-1616.
https://doi.org/10.1007/s00709-016-1049-9
Seke M, Markelić M, Morina A, Jović DS, Korać A, Miličić D, Đorđević AN. Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells. in Protoplasma. 2017;254(4):1607-1616.
doi:10.1007/s00709-016-1049-9 .
Seke, Mariana, Markelić, Milica, Morina, Arian, Jović, Danica S., Korać, Aleksandra, Miličić, Dragana, Đorđević, Aleksandar N., "Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells" in Protoplasma, 254, no. 4 (2017):1607-1616,
https://doi.org/10.1007/s00709-016-1049-9 . .
1
4
2
4

Deep UV fluorescence imaging study of Candida albicans cells treated with gold-riboflavin hydrocolloids

Pajović, Jelena D.; Dojčilović, Radovan; Božanić, Dušan K.; Vodnik, Vesna; Dimitrijević-Branković, Suzana I.; Kaščakova, Slavka; Refregiers, Matthieu; Markelić, Milica; Đoković, Vladimir

(2016)

TY  - JOUR
AU  - Pajović, Jelena D.
AU  - Dojčilović, Radovan
AU  - Božanić, Dušan K.
AU  - Vodnik, Vesna
AU  - Dimitrijević-Branković, Suzana I.
AU  - Kaščakova, Slavka
AU  - Refregiers, Matthieu
AU  - Markelić, Milica
AU  - Đoković, Vladimir
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1107
AB  - Fluorescent nanostructures were prepared by functionalization of gold nanoparticles with riboflavin molecules and used as probes for synchrotron radiation deep ultraviolet (SR-DUV) fluorescence imaging of gluteraldehyde-fixed Candida albicans cells. The nanoparticles were characterized by transmission electron microscopy (TEM) and optical spectroscopy techniques. The TEM analysis showed that the nanostructures were 6 nm in diameter, while the results of the fluorescence spectroscopies confirmed the photoluminescence of the nanoparticles. The SR-DUV imaging showed that it was possible to distinguish the fluorescence of the nanoparticles from the autofluorescence of the cells, as well as that the local maxima of the signal pertaining to the fluorescence of goldriboflavin nanostructures were mostly positioned on the surfaces of the C. albicans cells of spherical morphology.
T2  - Optical and Quantum Electronics
T1  - Deep UV fluorescence imaging study of Candida albicans cells treated with gold-riboflavin hydrocolloids
VL  - 48
IS  - 6
DO  - 10.1007/s11082-016-0578-y
ER  - 
@article{
author = "Pajović, Jelena D. and Dojčilović, Radovan and Božanić, Dušan K. and Vodnik, Vesna and Dimitrijević-Branković, Suzana I. and Kaščakova, Slavka and Refregiers, Matthieu and Markelić, Milica and Đoković, Vladimir",
year = "2016",
abstract = "Fluorescent nanostructures were prepared by functionalization of gold nanoparticles with riboflavin molecules and used as probes for synchrotron radiation deep ultraviolet (SR-DUV) fluorescence imaging of gluteraldehyde-fixed Candida albicans cells. The nanoparticles were characterized by transmission electron microscopy (TEM) and optical spectroscopy techniques. The TEM analysis showed that the nanostructures were 6 nm in diameter, while the results of the fluorescence spectroscopies confirmed the photoluminescence of the nanoparticles. The SR-DUV imaging showed that it was possible to distinguish the fluorescence of the nanoparticles from the autofluorescence of the cells, as well as that the local maxima of the signal pertaining to the fluorescence of goldriboflavin nanostructures were mostly positioned on the surfaces of the C. albicans cells of spherical morphology.",
journal = "Optical and Quantum Electronics",
title = "Deep UV fluorescence imaging study of Candida albicans cells treated with gold-riboflavin hydrocolloids",
volume = "48",
number = "6",
doi = "10.1007/s11082-016-0578-y"
}
Pajović, J. D., Dojčilović, R., Božanić, D. K., Vodnik, V., Dimitrijević-Branković, S. I., Kaščakova, S., Refregiers, M., Markelić, M.,& Đoković, V.. (2016). Deep UV fluorescence imaging study of Candida albicans cells treated with gold-riboflavin hydrocolloids. in Optical and Quantum Electronics, 48(6).
https://doi.org/10.1007/s11082-016-0578-y
Pajović JD, Dojčilović R, Božanić DK, Vodnik V, Dimitrijević-Branković SI, Kaščakova S, Refregiers M, Markelić M, Đoković V. Deep UV fluorescence imaging study of Candida albicans cells treated with gold-riboflavin hydrocolloids. in Optical and Quantum Electronics. 2016;48(6).
doi:10.1007/s11082-016-0578-y .
Pajović, Jelena D., Dojčilović, Radovan, Božanić, Dušan K., Vodnik, Vesna, Dimitrijević-Branković, Suzana I., Kaščakova, Slavka, Refregiers, Matthieu, Markelić, Milica, Đoković, Vladimir, "Deep UV fluorescence imaging study of Candida albicans cells treated with gold-riboflavin hydrocolloids" in Optical and Quantum Electronics, 48, no. 6 (2016),
https://doi.org/10.1007/s11082-016-0578-y . .
2
1
2