TY  - JOUR
AU  - Todorović, Lidija
AU  - Stanojević, Boban
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10607
AB  - Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, with an increasing incidence worldwide. The treatment of PTC is currently the subject of clinical controversy, making it critically important to identify molecular markers that would help improve the risk stratification of PTC patients and optimize the therapeutic approach. The Von Hippel–Lindau (VHL) tumor suppressor gene has been implicated in tumorigenesis of various types of carcinoma and linked with their aggressive biological behavior. The role of VHL in the origin and development of PTC have only recently begun to be revealed. In this narrative review, we attempt to summarize the existing knowledge that implicates VHL in PTC pathogenesis and to outline its potential significance as a candidate molecular biomarker for the grouping of PTC patients into high and low risk groups. © 2022 Todorović and Stanojević.
T2  - Bosnian Journal of Basic Medical Sciences
T1  - VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma
VL  - 23
IS  - 1
SP  - 26
EP  - 36
DO  - 10.17305/bjbms.2022.7850
ER  - 

@article{
author = "Todorović, Lidija and Stanojević, Boban",
year = "2023",
abstract = "Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, with an increasing incidence worldwide. The treatment of PTC is currently the subject of clinical controversy, making it critically important to identify molecular markers that would help improve the risk stratification of PTC patients and optimize the therapeutic approach. The Von Hippel–Lindau (VHL) tumor suppressor gene has been implicated in tumorigenesis of various types of carcinoma and linked with their aggressive biological behavior. The role of VHL in the origin and development of PTC have only recently begun to be revealed. In this narrative review, we attempt to summarize the existing knowledge that implicates VHL in PTC pathogenesis and to outline its potential significance as a candidate molecular biomarker for the grouping of PTC patients into high and low risk groups. © 2022 Todorović and Stanojević.",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma",
volume = "23",
number = "1",
pages = "26-36",
doi = "10.17305/bjbms.2022.7850"
}

Todorović, L.,& Stanojević, B.. (2023). VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma. in Bosnian Journal of Basic Medical Sciences, 23(1), 26-36.
https://doi.org/10.17305/bjbms.2022.7850

Todorović L, Stanojević B. VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma. in Bosnian Journal of Basic Medical Sciences. 2023;23(1):26-36.
doi:10.17305/bjbms.2022.7850 .

Todorović, Lidija, Stanojević, Boban, "VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma" in Bosnian Journal of Basic Medical Sciences, 23, no. 1 (2023):26-36,
https://doi.org/10.17305/bjbms.2022.7850 . .

TY  - CONF
AU  - Todorović, Lidija
AU  - Milovanović, Jelena
AU  - Mandušić, Vesna
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12634
AB  - Background: Thyroid neoplasms include benign tumors – thyroid adenoma (TA), and malignant tumors of various histological types: papillary thyroid carcinoma (PTC) – the most common and usually indolent, anaplasƟ c thyroid carcinoma (ATC) – the most aggressive, and several other types such as follicular, medullary and poorly diff erenƟ ated. Despite the progress in understanding the epidemiology and geneƟ c landscape of thyroid tumors, the diagnosis, prognosis and treatment approach require further improvement. Interleukin-6 (IL-6) is a pro-infl ammatory cytokine with a central role in the regulaƟ on of immune and infl ammatory responses including autoimmune thyroid diseases. Studies have revealed a potenƟ al impact of IL-6 in the development, progression and control of thyroid cancer. The aim of this study was to provide novel aspects for the preoperaƟ ve diff erenƟ al diagnosis and/or prognosis of thyroid cancer. To achieve this, we assessed the circulaƟ ng levels of IL-6 in paƟ ents with benign and malignant thyroid tumors of various histotypes, compared them with healthy volunteers, and correlated the results with clinicopathological parameters. PaƟ ents and Methods: The study included 43 paƟ ents with benign or malignant thyroid tumors, surgically treated at the Center for Endocrine Surgery, Clinical Center of Serbia. IL-6 protein levels were determined in plasma samples by quanƟ taƟ ve ELISA. Parametric and nonparametric staƟ sƟ cal tests were used for data analysis. Results: IL-6 concentraƟ ons in paƟ ents with either TA or carcinoma (PTC, ATC) were signifi cantly higher compared to the healthy volunteers (Mann Whitney test). The highest concentraƟ ons were detected in ATC paƟ ents (Median±SD 15.97±0.71 pg/mL), being signifi cantly higher compared to TA and PTC (2.14±1.34 pg/mL and 1.96±2.12 pg/mL, respecƟ vely). In PTC microcarcinoma, IL-6 was higher compared to controls, but there was no signifi cant diff erence compared to other PTC or TA (Mann Whitney test). The correlaƟ on analysis with clinicopathological parameters in PTC paƟ ents revealed a trend towards the associaƟ on of increased IL-6 plasma levels with the presence of nodal and distant metastases. No other signifi cant associaƟ ons were found. Conclusion: PaƟ ents with thyroid adenoma or carcinoma have increased plasma IL-6 levels that are in proporƟ on with the aggressiveness of the thyroid tumor, suggesƟ ng that IL-6 might be a candidate biomarker for diagnosis and prognosis of thyroid neoplasms.
PB  - Belgrade : Serbian Association for Cancer Research
C3  - Oncology Insights
T1  - Interleukin-6, a potential plasma biomarker for diagnosis and prognosis of thyroid neoplasms
IS  - 1
SP  - 83
EP  - 83
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12634
ER  - 

@conference{
author = "Todorović, Lidija and Milovanović, Jelena and Mandušić, Vesna and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban",
year = "2023",
abstract = "Background: Thyroid neoplasms include benign tumors – thyroid adenoma (TA), and malignant tumors of various histological types: papillary thyroid carcinoma (PTC) – the most common and usually indolent, anaplasƟ c thyroid carcinoma (ATC) – the most aggressive, and several other types such as follicular, medullary and poorly diff erenƟ ated. Despite the progress in understanding the epidemiology and geneƟ c landscape of thyroid tumors, the diagnosis, prognosis and treatment approach require further improvement. Interleukin-6 (IL-6) is a pro-infl ammatory cytokine with a central role in the regulaƟ on of immune and infl ammatory responses including autoimmune thyroid diseases. Studies have revealed a potenƟ al impact of IL-6 in the development, progression and control of thyroid cancer. The aim of this study was to provide novel aspects for the preoperaƟ ve diff erenƟ al diagnosis and/or prognosis of thyroid cancer. To achieve this, we assessed the circulaƟ ng levels of IL-6 in paƟ ents with benign and malignant thyroid tumors of various histotypes, compared them with healthy volunteers, and correlated the results with clinicopathological parameters. PaƟ ents and Methods: The study included 43 paƟ ents with benign or malignant thyroid tumors, surgically treated at the Center for Endocrine Surgery, Clinical Center of Serbia. IL-6 protein levels were determined in plasma samples by quanƟ taƟ ve ELISA. Parametric and nonparametric staƟ sƟ cal tests were used for data analysis. Results: IL-6 concentraƟ ons in paƟ ents with either TA or carcinoma (PTC, ATC) were signifi cantly higher compared to the healthy volunteers (Mann Whitney test). The highest concentraƟ ons were detected in ATC paƟ ents (Median±SD 15.97±0.71 pg/mL), being signifi cantly higher compared to TA and PTC (2.14±1.34 pg/mL and 1.96±2.12 pg/mL, respecƟ vely). In PTC microcarcinoma, IL-6 was higher compared to controls, but there was no signifi cant diff erence compared to other PTC or TA (Mann Whitney test). The correlaƟ on analysis with clinicopathological parameters in PTC paƟ ents revealed a trend towards the associaƟ on of increased IL-6 plasma levels with the presence of nodal and distant metastases. No other signifi cant associaƟ ons were found. Conclusion: PaƟ ents with thyroid adenoma or carcinoma have increased plasma IL-6 levels that are in proporƟ on with the aggressiveness of the thyroid tumor, suggesƟ ng that IL-6 might be a candidate biomarker for diagnosis and prognosis of thyroid neoplasms.",
publisher = "Belgrade : Serbian Association for Cancer Research",
journal = "Oncology Insights",
title = "Interleukin-6, a potential plasma biomarker for diagnosis and prognosis of thyroid neoplasms",
number = "1",
pages = "83-83",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12634"
}

Todorović, L., Milovanović, J., Mandušić, V., Živaljević, V., Paunović, I.,& Stanojević, B.. (2023). Interleukin-6, a potential plasma biomarker for diagnosis and prognosis of thyroid neoplasms. in Oncology Insights
Belgrade : Serbian Association for Cancer Research.(1), 83-83.
https://hdl.handle.net/21.15107/rcub_vinar_12634

Todorović L, Milovanović J, Mandušić V, Živaljević V, Paunović I, Stanojević B. Interleukin-6, a potential plasma biomarker for diagnosis and prognosis of thyroid neoplasms. in Oncology Insights. 2023;(1):83-83.
https://hdl.handle.net/21.15107/rcub_vinar_12634 .

Todorović, Lidija, Milovanović, Jelena, Mandušić, Vesna, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, "Interleukin-6, a potential plasma biomarker for diagnosis and prognosis of thyroid neoplasms" in Oncology Insights, no. 1 (2023):83-83,
https://hdl.handle.net/21.15107/rcub_vinar_12634 .

TY  - CONF
AU  - Kožik, Bojana
AU  - Božović, Ana
AU  - Kokanov, Nikola
AU  - Mandušić, Vesna
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
AU  - Todorović, Lidija
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12507
AB  - Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Identifying novel molecular parameters with prognostic value is of great clinical importance for a personalized therapeutic approach. Epigenetic changes have been proven to play an important role in cancer pathogenesis. Hypermethylation of the promoter region of p16INK4a gene has been shown to be a significant event in a number of cancer types. Several studies suggested that it might have a prognostic impact in ACC as well, however the data are relatively ambiguous.  According to the dataset from The Cancer Genome Atlas (TCGA) database, in cohort of 79 ACC patients, the analysis of the p16INK4a gene methylation showed that higher methylation was associated with shorter progression-free and overall survival. We evaluate the methylation status of p16INK4a in a preliminary cohort of 30 ACC patients by using the methylation-specific polymerase chain reaction (MSP) and aberrant methylation of p16INK4a was present in 66.7% (20/30) of cases. Our results indicate that epigenetic alteration of this gene is common event in ACC and may be important for pathogenesis of this tumor type. Although, we did not observed significant association between p16INK4a methylation status and clinico-pathological characteristics (age and gender, tumor size and weight, regional lymph node and distant metastasis), we will evaluate methylation status of this gene in another 30 ACC cases and compare it with methylation profile of adrenocortical adenoma patients, since inactivation of p16INK4a gene by promoter hypermethylation has been frequently reported as an early event in premalignant lesions in many tumor types.
PB  - Poland : The National Institute of Cardiology
C3  - The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
T1  - Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study
SP  - A17
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12507
ER  - 

@conference{
author = "Kožik, Bojana and Božović, Ana and Kokanov, Nikola and Mandušić, Vesna and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban and Todorović, Lidija",
year = "2022",
abstract = "Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Identifying novel molecular parameters with prognostic value is of great clinical importance for a personalized therapeutic approach. Epigenetic changes have been proven to play an important role in cancer pathogenesis. Hypermethylation of the promoter region of p16INK4a gene has been shown to be a significant event in a number of cancer types. Several studies suggested that it might have a prognostic impact in ACC as well, however the data are relatively ambiguous.  According to the dataset from The Cancer Genome Atlas (TCGA) database, in cohort of 79 ACC patients, the analysis of the p16INK4a gene methylation showed that higher methylation was associated with shorter progression-free and overall survival. We evaluate the methylation status of p16INK4a in a preliminary cohort of 30 ACC patients by using the methylation-specific polymerase chain reaction (MSP) and aberrant methylation of p16INK4a was present in 66.7% (20/30) of cases. Our results indicate that epigenetic alteration of this gene is common event in ACC and may be important for pathogenesis of this tumor type. Although, we did not observed significant association between p16INK4a methylation status and clinico-pathological characteristics (age and gender, tumor size and weight, regional lymph node and distant metastasis), we will evaluate methylation status of this gene in another 30 ACC cases and compare it with methylation profile of adrenocortical adenoma patients, since inactivation of p16INK4a gene by promoter hypermethylation has been frequently reported as an early event in premalignant lesions in many tumor types.",
publisher = "Poland : The National Institute of Cardiology",
journal = "The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts",
title = "Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study",
pages = "A17",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12507"
}

Kožik, B., Božović, A., Kokanov, N., Mandušić, V., Živaljević, V., Paunović, I., Stanojević, B.,& Todorović, L.. (2022). Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
Poland : The National Institute of Cardiology., A17.
https://hdl.handle.net/21.15107/rcub_vinar_12507

Kožik B, Božović A, Kokanov N, Mandušić V, Živaljević V, Paunović I, Stanojević B, Todorović L. Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts. 2022;:A17.
https://hdl.handle.net/21.15107/rcub_vinar_12507 .

Kožik, Bojana, Božović, Ana, Kokanov, Nikola, Mandušić, Vesna, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, Todorović, Lidija, "Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study" in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts (2022):A17,
https://hdl.handle.net/21.15107/rcub_vinar_12507 .

TY  - CONF
AU  - Todorović, Lidija
AU  - Kožik, Bojana
AU  - Božović, Ana
AU  - Mandušić, Vesna
AU  - Stanojević, Boban
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12509
AB  - Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with survival data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients.
PB  - Poland : The National Institute of Cardiology
C3  - The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
T1  - Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors
SP  - A39
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12509
ER  - 

@conference{
author = "Todorović, Lidija and Kožik, Bojana and Božović, Ana and Mandušić, Vesna and Stanojević, Boban and Živaljević, Vladan and Paunović, Ivan",
year = "2022",
abstract = "Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with survival data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients.",
publisher = "Poland : The National Institute of Cardiology",
journal = "The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts",
title = "Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors",
pages = "A39",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12509"
}

Todorović, L., Kožik, B., Božović, A., Mandušić, V., Stanojević, B., Živaljević, V.,& Paunović, I.. (2022). Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
Poland : The National Institute of Cardiology., A39.
https://hdl.handle.net/21.15107/rcub_vinar_12509

Todorović L, Kožik B, Božović A, Mandušić V, Stanojević B, Živaljević V, Paunović I. Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts. 2022;:A39.
https://hdl.handle.net/21.15107/rcub_vinar_12509 .

Todorović, Lidija, Kožik, Bojana, Božović, Ana, Mandušić, Vesna, Stanojević, Boban, Živaljević, Vladan, Paunović, Ivan, "Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors" in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts (2022):A39,
https://hdl.handle.net/21.15107/rcub_vinar_12509 .

TY  - JOUR
AU  - Aranđelović, Jovana
AU  - Santrač, Anja
AU  - Batinić, Bojan
AU  - Todorović, Lidija
AU  - Stevanović, Vladimir
AU  - Tiruveedhula, Veera Venkata Naga Phani Babu
AU  - Sharmin, Dishary
AU  - Rashid, Farjana
AU  - Stanojević, Boban
AU  - Cook, James M.
AU  - Savić, Miroslav M.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10360
AB  - Aims GABAergic modulation involved in cognitive processing appears to be substantially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric modulators of α5 GABAA receptors (NAM and PAM, respectively) would affect social interaction, social, object and spatial memory, and neuroinflammation. Methods After 10-day treatment with PAM, NAM, or solvent, 6-month-old transgenic and non-transgenic 5xFAD mice underwent testing in a behavioral battery. Gene expressions of IL-1β, IL-6, TNF-α, GFAP, and IBA-1 were determined in hippocampus and prefrontal cortex by qPCR. Results PAM treatment impaired spatial learning in transgenic females compared to solvent-treated transgenic females, and social recognition in transgenic and non-transgenic males. NAM treatment declined social interaction in transgenic and non-transgenic males, while had beneficial effect on cognitive flexibility in non-transgenic males compared to solvent-treated non-transgenic males. Transgenic animals have not fully displayed cognitive symptoms, but neuroinflammation was confirmed. NAM reduced proinflammatory gene expressions in transgenic females and astrogliosis in transgenic males compared to pathological controls. Conclusion PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta- and/or tau-dependent models with prominent neuroinflammation.
T2  - CNS Neuroscience & Therapeutics
T2  - CNS Neuroscience & Therapeutics
T1  - Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease
VL  - 28
IS  - 11
SP  - 1767
EP  - 1778
DO  - 10.1111/cns.13914
ER  - 

@article{
author = "Aranđelović, Jovana and Santrač, Anja and Batinić, Bojan and Todorović, Lidija and Stevanović, Vladimir and Tiruveedhula, Veera Venkata Naga Phani Babu and Sharmin, Dishary and Rashid, Farjana and Stanojević, Boban and Cook, James M. and Savić, Miroslav M.",
year = "2022",
abstract = "Aims GABAergic modulation involved in cognitive processing appears to be substantially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric modulators of α5 GABAA receptors (NAM and PAM, respectively) would affect social interaction, social, object and spatial memory, and neuroinflammation. Methods After 10-day treatment with PAM, NAM, or solvent, 6-month-old transgenic and non-transgenic 5xFAD mice underwent testing in a behavioral battery. Gene expressions of IL-1β, IL-6, TNF-α, GFAP, and IBA-1 were determined in hippocampus and prefrontal cortex by qPCR. Results PAM treatment impaired spatial learning in transgenic females compared to solvent-treated transgenic females, and social recognition in transgenic and non-transgenic males. NAM treatment declined social interaction in transgenic and non-transgenic males, while had beneficial effect on cognitive flexibility in non-transgenic males compared to solvent-treated non-transgenic males. Transgenic animals have not fully displayed cognitive symptoms, but neuroinflammation was confirmed. NAM reduced proinflammatory gene expressions in transgenic females and astrogliosis in transgenic males compared to pathological controls. Conclusion PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta- and/or tau-dependent models with prominent neuroinflammation.",
journal = "CNS Neuroscience & Therapeutics, CNS Neuroscience & Therapeutics",
title = "Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease",
volume = "28",
number = "11",
pages = "1767-1778",
doi = "10.1111/cns.13914"
}

Aranđelović, J., Santrač, A., Batinić, B., Todorović, L., Stevanović, V., Tiruveedhula, V. V. N. P. B., Sharmin, D., Rashid, F., Stanojević, B., Cook, J. M.,& Savić, M. M.. (2022). Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease. in CNS Neuroscience & Therapeutics, 28(11), 1767-1778.
https://doi.org/10.1111/cns.13914

Aranđelović J, Santrač A, Batinić B, Todorović L, Stevanović V, Tiruveedhula VVNPB, Sharmin D, Rashid F, Stanojević B, Cook JM, Savić MM. Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease. in CNS Neuroscience & Therapeutics. 2022;28(11):1767-1778.
doi:10.1111/cns.13914 .

Aranđelović, Jovana, Santrač, Anja, Batinić, Bojan, Todorović, Lidija, Stevanović, Vladimir, Tiruveedhula, Veera Venkata Naga Phani Babu, Sharmin, Dishary, Rashid, Farjana, Stanojević, Boban, Cook, James M., Savić, Miroslav M., "Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease" in CNS Neuroscience & Therapeutics, 28, no. 11 (2022):1767-1778,
https://doi.org/10.1111/cns.13914 . .

TY  - CONF
AU  - Todorović, Lidija
AU  - Petrović, Nina
AU  - Mandušić, Vesna
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12426
AB  - Although one of the rarest known malignancies, with an estimated prevalence of 0.005% of all cancers, parathyroid carcinoma (PC) represents a clinical and therapeutic challenge. The identification of novel diagnostic biomarkers able to preoperatively distinguish among different parathyroid neoplastic types is of great clinical importance. However, there is a lack of both experimental and bioinformatics data in this field. In the present study, we examined the expression levels of two microRNAs frequently implicated in cancer, miR-30a-3p and miR-92a-3p, in 10 PC and 10 parathyroid adenoma (PA) tissues using reverse transcription quantitative (RT-qPCR). In addition, we analyzed their association with clinical and histopathological parameters. For statistical analysis we used non-parametric tests – Mann–Whitney U test and Spearman’s correlation test. Furthermore, by using several online tools such as miRNet, miRror Suit, and DisGeNET we analyzed combinatorial target genes of the two miRs and investigated their potential roles in parathyroid carcinoma and adenoma. The expression levels of both miR-30a-3p and miR-92a-3p were upregulated in PC compared to PA (p= 0.017 and p=0.0015 respectively). A positive correlation between their expression levels was identified both in PC (p=0.025, r=0.697) and PA (p=0.008, r=0745), indicating their combined action. There were no significant associations between the expression levels of these two miRs and clinicopathological characteristics in the PC group. According to the in silico analysis, the two miRs share a number of target genes, predominantly included in gene expression, cell cycle regulation, and several signalling pathways such as WNT/β catenin, which was found to be frequently aberrant in PC. Although their role and diagnostic utility remain to be elucidated, the data here reported suggest that miR-30a-3p and miR-92a-3p might be involved in parathyroid cancer pathogenesis and that they might be candidates for differential diagnosis between parathyroid carcinoma and adenoma.
C3  - 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts
T1  - miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12426
ER  - 

@conference{
author = "Todorović, Lidija and Petrović, Nina and Mandušić, Vesna and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban",
year = "2022",
abstract = "Although one of the rarest known malignancies, with an estimated prevalence of 0.005% of all cancers, parathyroid carcinoma (PC) represents a clinical and therapeutic challenge. The identification of novel diagnostic biomarkers able to preoperatively distinguish among different parathyroid neoplastic types is of great clinical importance. However, there is a lack of both experimental and bioinformatics data in this field. In the present study, we examined the expression levels of two microRNAs frequently implicated in cancer, miR-30a-3p and miR-92a-3p, in 10 PC and 10 parathyroid adenoma (PA) tissues using reverse transcription quantitative (RT-qPCR). In addition, we analyzed their association with clinical and histopathological parameters. For statistical analysis we used non-parametric tests – Mann–Whitney U test and Spearman’s correlation test. Furthermore, by using several online tools such as miRNet, miRror Suit, and DisGeNET we analyzed combinatorial target genes of the two miRs and investigated their potential roles in parathyroid carcinoma and adenoma. The expression levels of both miR-30a-3p and miR-92a-3p were upregulated in PC compared to PA (p= 0.017 and p=0.0015 respectively). A positive correlation between their expression levels was identified both in PC (p=0.025, r=0.697) and PA (p=0.008, r=0745), indicating their combined action. There were no significant associations between the expression levels of these two miRs and clinicopathological characteristics in the PC group. According to the in silico analysis, the two miRs share a number of target genes, predominantly included in gene expression, cell cycle regulation, and several signalling pathways such as WNT/β catenin, which was found to be frequently aberrant in PC. Although their role and diagnostic utility remain to be elucidated, the data here reported suggest that miR-30a-3p and miR-92a-3p might be involved in parathyroid cancer pathogenesis and that they might be candidates for differential diagnosis between parathyroid carcinoma and adenoma.",
journal = "5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts",
title = "miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12426"
}

Todorović, L., Petrović, N., Mandušić, V., Živaljević, V., Paunović, I.,& Stanojević, B.. (2022). miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma. in 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts.
https://hdl.handle.net/21.15107/rcub_vinar_12426

Todorović L, Petrović N, Mandušić V, Živaljević V, Paunović I, Stanojević B. miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma. in 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts. 2022;.
https://hdl.handle.net/21.15107/rcub_vinar_12426 .

Todorović, Lidija, Petrović, Nina, Mandušić, Vesna, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, "miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma" in 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12426 .

TY  - JOUR
AU  - Divović Matović, Branka
AU  - Knutson, Dan
AU  - Mitrović, Jelena
AU  - Stevanović, Vladimir
AU  - Stanojević, Boban
AU  - Savić, Snežana
AU  - Cook, James M.
AU  - Savić, Miroslav M.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10454
AB  - Several pyrazoloquinolinone (PQ) ligands were recently discovered as functionally selective positive modulators at the PQ site of α6-containing GABAA receptors. PQs are also neutral modulators at the benzodiazepine site. We assessed the influence of PQ compounds from three structural groups (PZ-II-029 and related deuterated analogues DK-I-56-1, RV-I-029, DK-I-60-3 and DK-I-86-1; LAU 463 and related analogues DK-I-58-1 and DK-II-58-1; and DK-I-87-1), alone and in combination with diazepam, on the behaviour of male Sprague–Dawley rats. An excellent behavioural safety profile of all tested PQs was demonstrated in the spontaneous locomotor activity, rotarod, loss of righting reflex and pentylenetetrazol tests. In interaction studies, only PZ-II-029 and its analogues prevented the ataxic effects of the benzodiazepine, as assessed in the rotarod test and during monitoring of rat locomotor activity after awakening from the loss of righting reflex. Published electrophysiological profiles of PQ ligands imply that positive modulation elicited at α6-GABAA receptors that contain the γ2 and δ subunit, rather than their neutral modulatory action at the benzodiazepine site, may prevent the ataxic action of diazepam. Thus, PZ-II-029 and its deuterated analogues are not prone to untoward interactions with benzodiazepines and may indeed completely abolish their ataxic action, seen at therapeutic, and especially toxic concentrations.
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature
VL  - 131
IS  - 6
SP  - 514
EP  - 524
DO  - 10.1111/bcpt.13801
ER  - 

@article{
author = "Divović Matović, Branka and Knutson, Dan and Mitrović, Jelena and Stevanović, Vladimir and Stanojević, Boban and Savić, Snežana and Cook, James M. and Savić, Miroslav M.",
year = "2022",
abstract = "Several pyrazoloquinolinone (PQ) ligands were recently discovered as functionally selective positive modulators at the PQ site of α6-containing GABAA receptors. PQs are also neutral modulators at the benzodiazepine site. We assessed the influence of PQ compounds from three structural groups (PZ-II-029 and related deuterated analogues DK-I-56-1, RV-I-029, DK-I-60-3 and DK-I-86-1; LAU 463 and related analogues DK-I-58-1 and DK-II-58-1; and DK-I-87-1), alone and in combination with diazepam, on the behaviour of male Sprague–Dawley rats. An excellent behavioural safety profile of all tested PQs was demonstrated in the spontaneous locomotor activity, rotarod, loss of righting reflex and pentylenetetrazol tests. In interaction studies, only PZ-II-029 and its analogues prevented the ataxic effects of the benzodiazepine, as assessed in the rotarod test and during monitoring of rat locomotor activity after awakening from the loss of righting reflex. Published electrophysiological profiles of PQ ligands imply that positive modulation elicited at α6-GABAA receptors that contain the γ2 and δ subunit, rather than their neutral modulatory action at the benzodiazepine site, may prevent the ataxic action of diazepam. Thus, PZ-II-029 and its deuterated analogues are not prone to untoward interactions with benzodiazepines and may indeed completely abolish their ataxic action, seen at therapeutic, and especially toxic concentrations.",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature",
volume = "131",
number = "6",
pages = "514-524",
doi = "10.1111/bcpt.13801"
}

Divović Matović, B., Knutson, D., Mitrović, J., Stevanović, V., Stanojević, B., Savić, S., Cook, J. M.,& Savić, M. M.. (2022). Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature. in Basic & Clinical Pharmacology & Toxicology, 131(6), 514-524.
https://doi.org/10.1111/bcpt.13801

Divović Matović B, Knutson D, Mitrović J, Stevanović V, Stanojević B, Savić S, Cook JM, Savić MM. Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature. in Basic & Clinical Pharmacology & Toxicology. 2022;131(6):514-524.
doi:10.1111/bcpt.13801 .

Divović Matović, Branka, Knutson, Dan, Mitrović, Jelena, Stevanović, Vladimir, Stanojević, Boban, Savić, Snežana, Cook, James M., Savić, Miroslav M., "Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature" in Basic & Clinical Pharmacology & Toxicology, 131, no. 6 (2022):514-524,
https://doi.org/10.1111/bcpt.13801 . .

TY  - JOUR
AU  - Pavlović, Miloš
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Đurić, Ana
AU  - Stanojević, Boban
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9915
AB  - Background/Aim. Exposure of living organisms to γ-radiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes radioprotective role based on the evaluation of the status of oxidative stress (OS) in the brain and 8-hydroxyguanosine (8-OH-dG) in the plasma of the rats exposed to the single γ-ray irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a four-week normal or 5% MZC supplemented diet and afterward exposed to the single γ-ray irradiation of 2 and 10 Gy. Groups of rats were: a) on a normal diet (the control group, and 2Gy and 10Gy groups); b) on 5% MZC supplemented diet (the control group – MZC, MZC + 2Gy, and MZC + 10Gy groups). We measured malondialdehyde (MDA), glutathione (GSH) total, and activity of total super-oxide dismutase (tSOD) and manganese superoxide dismutase (MnSOD) in vulnerable brain regions (cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma. Results. Lower MDA was found in the MZC+2Gy and MZC+10Gy groups compared to the 2Gy and 10Gy groups. Activity od total SOD was higher in the MZC+10Gy group than in the 10Gy one. GSH was the highest in the 10Gy group. Compared to the control group, 8-OH-dG was extremely higher in groups radiated with 10 Gy regardless of a diet, but slightly lower in the MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished partial radioprotective effect in irradiated rats compared to non-irradiated rats, based on suppressed SOD activity at 2 Gy, and reduced brain MDA when exposed to 2 Gy and 10 Gy.
AB  - Uvod/Cilj. Izlaganje živih organizama gama zračenju rezultira hiperprodukcijom slobodnih radikala. Cilj istraživanja je bio da se ispita da li subakutna ishrana dopunjena sa 5% mikronizovanog zeolita (MZC) ispoljava radiozaštitnu ulogu na osnovu statusa oksidativnog stresa (OS) u mozgu i 8-hidroksiguanozina (8-OH-dG) u plazmi pacova izloženih pojedinačnim dozama jonizujućeg zračenja od 2 i 10 Gray (Gy). Metode. Wistar pacovi su bili na četvoronedeljnoj normalnoj ishrani ili ishrani obogaćenoj sa 5% MZC, posle čega su bili izloženi pojedinačnom jonizujućem zračenju od 2 Gy, odnosno 10 Gy. Grupe pacova bile su: a) grupa pacova na normalnoj ishrani (kontrolna grupa i grupe 2Gy i 10Gy); b) grupa pacova na ishrani obogaćenoj sa 5% MZC (kontrolna grupa – MZC i grupe MZC+2Gy i MZC+10Gy). Meren je malondialdehid (MDA), glutation (GSH) i aktivnost ukupne (tSOD) i mangan superoksid dizmutaze (MnSOD) u osetljivim strukturama mozga (cerebelum, hipokampus i cerebralni korteks), a 8-OH-dG u plazmi. Rezultati. Biomarker MDA je bio niži u MZC+2Gy i MZC+10Gy grupama, u odnosu na grupe 2Gy i 10Gy. Aktivnost ukupne SOD je bila viša u grupi MZC+10Gy, u odnosu na grupu 10Gy. Najviši nivo GSH bio je u grupi 10Gy. U pređenju sa kontrolnom grupom, 8-OH-dG je bio izuzetno viši u grupama ozračenim sa 10 Gy, bez obzira na dijetetski režim i niži u grupama MZC+2Gy i 2Gy. Zaključak. Pacovi koji su bili na režimu ishrane obogaćene sa 5% MZC bili su delimično zaštićeni od zračenja, shodno redukovanoj moždanoj aktivnosti SOD pri 2 Gy i sniženom nivou MDA pri izlaganju zračenju od 2 i 10 Gy.
T2  - Vojnosanitetski pregled
T1  - Moderate radioprotective role of zeolite in rats
T1  - Umerena radioprotektivna uloga zeolita kod pacova
VL  - 78
IS  - 7
SP  - 760
EP  - 768
DO  - 10.2298/VSP190702136P
ER  - 

@article{
author = "Pavlović, Miloš and Đukić, Mirjana and Vojvodić, Danilo and Ninković, Milica and Stevanović, Ivana and Đurić, Ana and Stanojević, Boban",
year = "2021",
abstract = "Background/Aim. Exposure of living organisms to γ-radiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes radioprotective role based on the evaluation of the status of oxidative stress (OS) in the brain and 8-hydroxyguanosine (8-OH-dG) in the plasma of the rats exposed to the single γ-ray irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a four-week normal or 5% MZC supplemented diet and afterward exposed to the single γ-ray irradiation of 2 and 10 Gy. Groups of rats were: a) on a normal diet (the control group, and 2Gy and 10Gy groups); b) on 5% MZC supplemented diet (the control group – MZC, MZC + 2Gy, and MZC + 10Gy groups). We measured malondialdehyde (MDA), glutathione (GSH) total, and activity of total super-oxide dismutase (tSOD) and manganese superoxide dismutase (MnSOD) in vulnerable brain regions (cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma. Results. Lower MDA was found in the MZC+2Gy and MZC+10Gy groups compared to the 2Gy and 10Gy groups. Activity od total SOD was higher in the MZC+10Gy group than in the 10Gy one. GSH was the highest in the 10Gy group. Compared to the control group, 8-OH-dG was extremely higher in groups radiated with 10 Gy regardless of a diet, but slightly lower in the MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished partial radioprotective effect in irradiated rats compared to non-irradiated rats, based on suppressed SOD activity at 2 Gy, and reduced brain MDA when exposed to 2 Gy and 10 Gy., Uvod/Cilj. Izlaganje živih organizama gama zračenju rezultira hiperprodukcijom slobodnih radikala. Cilj istraživanja je bio da se ispita da li subakutna ishrana dopunjena sa 5% mikronizovanog zeolita (MZC) ispoljava radiozaštitnu ulogu na osnovu statusa oksidativnog stresa (OS) u mozgu i 8-hidroksiguanozina (8-OH-dG) u plazmi pacova izloženih pojedinačnim dozama jonizujućeg zračenja od 2 i 10 Gray (Gy). Metode. Wistar pacovi su bili na četvoronedeljnoj normalnoj ishrani ili ishrani obogaćenoj sa 5% MZC, posle čega su bili izloženi pojedinačnom jonizujućem zračenju od 2 Gy, odnosno 10 Gy. Grupe pacova bile su: a) grupa pacova na normalnoj ishrani (kontrolna grupa i grupe 2Gy i 10Gy); b) grupa pacova na ishrani obogaćenoj sa 5% MZC (kontrolna grupa – MZC i grupe MZC+2Gy i MZC+10Gy). Meren je malondialdehid (MDA), glutation (GSH) i aktivnost ukupne (tSOD) i mangan superoksid dizmutaze (MnSOD) u osetljivim strukturama mozga (cerebelum, hipokampus i cerebralni korteks), a 8-OH-dG u plazmi. Rezultati. Biomarker MDA je bio niži u MZC+2Gy i MZC+10Gy grupama, u odnosu na grupe 2Gy i 10Gy. Aktivnost ukupne SOD je bila viša u grupi MZC+10Gy, u odnosu na grupu 10Gy. Najviši nivo GSH bio je u grupi 10Gy. U pređenju sa kontrolnom grupom, 8-OH-dG je bio izuzetno viši u grupama ozračenim sa 10 Gy, bez obzira na dijetetski režim i niži u grupama MZC+2Gy i 2Gy. Zaključak. Pacovi koji su bili na režimu ishrane obogaćene sa 5% MZC bili su delimično zaštićeni od zračenja, shodno redukovanoj moždanoj aktivnosti SOD pri 2 Gy i sniženom nivou MDA pri izlaganju zračenju od 2 i 10 Gy.",
journal = "Vojnosanitetski pregled",
title = "Moderate radioprotective role of zeolite in rats, Umerena radioprotektivna uloga zeolita kod pacova",
volume = "78",
number = "7",
pages = "760-768",
doi = "10.2298/VSP190702136P"
}

Pavlović, M., Đukić, M., Vojvodić, D., Ninković, M., Stevanović, I., Đurić, A.,& Stanojević, B.. (2021). Moderate radioprotective role of zeolite in rats. in Vojnosanitetski pregled, 78(7), 760-768.
https://doi.org/10.2298/VSP190702136P

Pavlović M, Đukić M, Vojvodić D, Ninković M, Stevanović I, Đurić A, Stanojević B. Moderate radioprotective role of zeolite in rats. in Vojnosanitetski pregled. 2021;78(7):760-768.
doi:10.2298/VSP190702136P .

Pavlović, Miloš, Đukić, Mirjana, Vojvodić, Danilo, Ninković, Milica, Stevanović, Ivana, Đurić, Ana, Stanojević, Boban, "Moderate radioprotective role of zeolite in rats" in Vojnosanitetski pregled, 78, no. 7 (2021):760-768,
https://doi.org/10.2298/VSP190702136P . .

TY  - CONF
AU  - Todorović, Lidija
AU  - Stanojević, Boban
AU  - Kožik, Bojana
AU  - Božović, Ana
AU  - Mandušić, Vesna
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12510
AB  - Background: A number of studies point to a significant role of microRNAs (miRNAs) in papillary thyroid cancer (PTC), where specific miRNA expression profiles associate with distinct clinical and biological phenotypes of the lesion. One of the microRNAs deregulated in PTC is miR-30a-3p. Evidence suggests that estrogen receptor β (ERβ), also found to be deregulated in PTCs, may directly regulate microRNA-30a-3p biogenesis and expression. Considering the possibility that ERβ might influence PTC cell behavior via miRNAs, in particular, miR-30a-3p, we have investigated their expression and correlation in PTCs with different clinico-pathological characteristics. Patients and Methods: Quantitative PCR was used to determine the relative miR-30a-3p and ERβ expression levels in 37 pairs of PTCs and matched non-tumor thyroid tissues. Results: The expression levels of miR-30a and ERβ were significantly altered in tumors compared with non-tumor tissues. A negative correlation between miR-30 and ERβ was detected in tumors with pT4 category (P=0.038, r = - 0.738) and capsular invasion (only in women) (P=0.041. r= -0.552) compared to positive correlations (or trends) found in tumors with lower pT categories (pT1+pT2) (P=0.061, r=0.463) and tumors with no capsular invasion (P=0.019, r=0.618). Similar trend was found in tumors with classic papillary pattern in the group of women (P=0.09, r= - 0.432) while in women with histovariants other than classic there was a trend towards positive correlation (P=0.066, r=0.486). Conclusion: The results suggest that in some PTCs, ERβ might negatively regulate miR-30a expression, and the opposite roles they may play are associated with more aggressive tumor features.
PB  - Belgrade : Serbian Association for Cancer Research (SDIR)
C3  - SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts
T1  - The expression of microRNA-30a-3p and estrogen receptor β in papillary thyroid cancer
SP  - 42
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12510
ER  - 

@conference{
author = "Todorović, Lidija and Stanojević, Boban and Kožik, Bojana and Božović, Ana and Mandušić, Vesna",
year = "2021",
abstract = "Background: A number of studies point to a significant role of microRNAs (miRNAs) in papillary thyroid cancer (PTC), where specific miRNA expression profiles associate with distinct clinical and biological phenotypes of the lesion. One of the microRNAs deregulated in PTC is miR-30a-3p. Evidence suggests that estrogen receptor β (ERβ), also found to be deregulated in PTCs, may directly regulate microRNA-30a-3p biogenesis and expression. Considering the possibility that ERβ might influence PTC cell behavior via miRNAs, in particular, miR-30a-3p, we have investigated their expression and correlation in PTCs with different clinico-pathological characteristics. Patients and Methods: Quantitative PCR was used to determine the relative miR-30a-3p and ERβ expression levels in 37 pairs of PTCs and matched non-tumor thyroid tissues. Results: The expression levels of miR-30a and ERβ were significantly altered in tumors compared with non-tumor tissues. A negative correlation between miR-30 and ERβ was detected in tumors with pT4 category (P=0.038, r = - 0.738) and capsular invasion (only in women) (P=0.041. r= -0.552) compared to positive correlations (or trends) found in tumors with lower pT categories (pT1+pT2) (P=0.061, r=0.463) and tumors with no capsular invasion (P=0.019, r=0.618). Similar trend was found in tumors with classic papillary pattern in the group of women (P=0.09, r= - 0.432) while in women with histovariants other than classic there was a trend towards positive correlation (P=0.066, r=0.486). Conclusion: The results suggest that in some PTCs, ERβ might negatively regulate miR-30a expression, and the opposite roles they may play are associated with more aggressive tumor features.",
publisher = "Belgrade : Serbian Association for Cancer Research (SDIR)",
journal = "SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts",
title = "The expression of microRNA-30a-3p and estrogen receptor β in papillary thyroid cancer",
pages = "42-42",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12510"
}

Todorović, L., Stanojević, B., Kožik, B., Božović, A.,& Mandušić, V.. (2021). The expression of microRNA-30a-3p and estrogen receptor β in papillary thyroid cancer. in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts
Belgrade : Serbian Association for Cancer Research (SDIR)., 42-42.
https://hdl.handle.net/21.15107/rcub_vinar_12510

Todorović L, Stanojević B, Kožik B, Božović A, Mandušić V. The expression of microRNA-30a-3p and estrogen receptor β in papillary thyroid cancer. in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts. 2021;:42-42.
https://hdl.handle.net/21.15107/rcub_vinar_12510 .

Todorović, Lidija, Stanojević, Boban, Kožik, Bojana, Božović, Ana, Mandušić, Vesna, "The expression of microRNA-30a-3p and estrogen receptor β in papillary thyroid cancer" in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts (2021):42-42,
https://hdl.handle.net/21.15107/rcub_vinar_12510 .

TY  - JOUR
AU  - Todorović, Lidija
AU  - Stamenković, Gorana
AU  - Vučetić-Tadić, Biljana
AU  - Umezawa, Kazuo
AU  - Božović, Ana M.
AU  - Yamashita, Shunichi
AU  - Stanojević, Boban
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9413
AB  - The use of targeted inhibitors has shown promise as an effective approach in cancer therapy. However, targeted therapies based only on one drug, such as 17-allylamino-17-demethoxygeldanamycin (17-AAG), have limited success, partly because cancer cells engage alternate pathways for survival and proliferation. In the present study, we evaluated whether dehydroxymethylepoxyquinomicin (DHMEQ), a nuclear factor ?B (NF-?B) inhibitor, can enhance the antitumor activities of 17-AAG, a 90 kDa heat shock protein (Hsp90) inhibitor, in the anaplastic thyroid cancer cell line KTC2. We examined the effect of combined drug treatment vs single drug treatment on cell survival. Isobologram analysis was performed to distinguish the additive vs synergistic effects of the drug combination. Western blotting was performed to investigate apoptosis markers: caspase 3, poly(ADP-ribose) polymerase-one (PARP-1), B-cell lymphoma-extra large (Bcl-XL), X-linked inhibitor of apoptosis (XIAP) and cellular inhibitor of apoptosis 2 (cIAP-2). Compared to monotherapy, the combined treatment enhanced growth-inhibitory effects in a synergistic manner and strongly potentiated apoptosis. These results demonstrate the first in vitro evidence that a combination of Hsp90 and NF-?B inhibitors is a more effective modality for inhibiting cell proliferation and survival in anaplastic thyroid carcinoma cells than either agent alone, warranting further investigations.
T2  - Archives of Biological Sciences
T1  - Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2
VL  - 73
IS  - 1
SP  - 31
EP  - 38
DO  - 10.2298/ABS201010055T
ER  - 

@article{
author = "Todorović, Lidija and Stamenković, Gorana and Vučetić-Tadić, Biljana and Umezawa, Kazuo and Božović, Ana M. and Yamashita, Shunichi and Stanojević, Boban",
year = "2021",
abstract = "The use of targeted inhibitors has shown promise as an effective approach in cancer therapy. However, targeted therapies based only on one drug, such as 17-allylamino-17-demethoxygeldanamycin (17-AAG), have limited success, partly because cancer cells engage alternate pathways for survival and proliferation. In the present study, we evaluated whether dehydroxymethylepoxyquinomicin (DHMEQ), a nuclear factor ?B (NF-?B) inhibitor, can enhance the antitumor activities of 17-AAG, a 90 kDa heat shock protein (Hsp90) inhibitor, in the anaplastic thyroid cancer cell line KTC2. We examined the effect of combined drug treatment vs single drug treatment on cell survival. Isobologram analysis was performed to distinguish the additive vs synergistic effects of the drug combination. Western blotting was performed to investigate apoptosis markers: caspase 3, poly(ADP-ribose) polymerase-one (PARP-1), B-cell lymphoma-extra large (Bcl-XL), X-linked inhibitor of apoptosis (XIAP) and cellular inhibitor of apoptosis 2 (cIAP-2). Compared to monotherapy, the combined treatment enhanced growth-inhibitory effects in a synergistic manner and strongly potentiated apoptosis. These results demonstrate the first in vitro evidence that a combination of Hsp90 and NF-?B inhibitors is a more effective modality for inhibiting cell proliferation and survival in anaplastic thyroid carcinoma cells than either agent alone, warranting further investigations.",
journal = "Archives of Biological Sciences",
title = "Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2",
volume = "73",
number = "1",
pages = "31-38",
doi = "10.2298/ABS201010055T"
}

Todorović, L., Stamenković, G., Vučetić-Tadić, B., Umezawa, K., Božović, A. M., Yamashita, S.,& Stanojević, B.. (2021). Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2. in Archives of Biological Sciences, 73(1), 31-38.
https://doi.org/10.2298/ABS201010055T

Todorović L, Stamenković G, Vučetić-Tadić B, Umezawa K, Božović AM, Yamashita S, Stanojević B. Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2. in Archives of Biological Sciences. 2021;73(1):31-38.
doi:10.2298/ABS201010055T .

Todorović, Lidija, Stamenković, Gorana, Vučetić-Tadić, Biljana, Umezawa, Kazuo, Božović, Ana M., Yamashita, Shunichi, Stanojević, Boban, "Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2" in Archives of Biological Sciences, 73, no. 1 (2021):31-38,
https://doi.org/10.2298/ABS201010055T . .

TY  - JOUR
AU  - Burmester, Victoria
AU  - Nicholls, Dasha
AU  - Buckle, Alexis
AU  - Stanojević, Boban
AU  - Crous-Bou, Marta
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9872
AB  - Oxytocin, a nine amino acid peptide synthesised in the hypothalamus, has been widely recognised for its role in anxiolysis, bonding, sociality, and appetite. It binds to the oxytocin receptor (OXTR)—a G-protein coupled receptor—that is stimulated by the actions of oestrogen both peripherally and centrally. Studies have implicated OXTR genotypes in conferring either a risk or protective effect in autism, schizophrenia, and eating disorders (ED). There are numerous DNA variations of this receptor, with the most common DNA variation being in the form of the single nucleotide polymorphisms (SNPs). Two OXTR SNPs have been most studied in relation to ED: rs53576 and rs2254298. Each SNP has the same allelic variant that produces genotypes AA, AG, and GG. In this critical review we will evaluate the putative role of rs53576 and rs2254298 SNPs in ED. Additionally, this narrative review will consider the role of gene-environment interactions in the development of ED pathology.
T2  - Journal of Eating Disorders
T1  - Review of eating disorders and oxytocin receptor polymorphisms
VL  - 9
IS  - 1
SP  - 85
DO  - 10.1186/s40337-021-00438-0
ER  - 

@article{
author = "Burmester, Victoria and Nicholls, Dasha and Buckle, Alexis and Stanojević, Boban and Crous-Bou, Marta",
year = "2021",
abstract = "Oxytocin, a nine amino acid peptide synthesised in the hypothalamus, has been widely recognised for its role in anxiolysis, bonding, sociality, and appetite. It binds to the oxytocin receptor (OXTR)—a G-protein coupled receptor—that is stimulated by the actions of oestrogen both peripherally and centrally. Studies have implicated OXTR genotypes in conferring either a risk or protective effect in autism, schizophrenia, and eating disorders (ED). There are numerous DNA variations of this receptor, with the most common DNA variation being in the form of the single nucleotide polymorphisms (SNPs). Two OXTR SNPs have been most studied in relation to ED: rs53576 and rs2254298. Each SNP has the same allelic variant that produces genotypes AA, AG, and GG. In this critical review we will evaluate the putative role of rs53576 and rs2254298 SNPs in ED. Additionally, this narrative review will consider the role of gene-environment interactions in the development of ED pathology.",
journal = "Journal of Eating Disorders",
title = "Review of eating disorders and oxytocin receptor polymorphisms",
volume = "9",
number = "1",
pages = "85",
doi = "10.1186/s40337-021-00438-0"
}

Burmester, V., Nicholls, D., Buckle, A., Stanojević, B.,& Crous-Bou, M.. (2021). Review of eating disorders and oxytocin receptor polymorphisms. in Journal of Eating Disorders, 9(1), 85.
https://doi.org/10.1186/s40337-021-00438-0

Burmester V, Nicholls D, Buckle A, Stanojević B, Crous-Bou M. Review of eating disorders and oxytocin receptor polymorphisms. in Journal of Eating Disorders. 2021;9(1):85.
doi:10.1186/s40337-021-00438-0 .

Burmester, Victoria, Nicholls, Dasha, Buckle, Alexis, Stanojević, Boban, Crous-Bou, Marta, "Review of eating disorders and oxytocin receptor polymorphisms" in Journal of Eating Disorders, 9, no. 1 (2021):85,
https://doi.org/10.1186/s40337-021-00438-0 . .

TY  - JOUR
AU  - Zeisig, Bernd B.
AU  - Fung, Tsz Kan
AU  - Zarowiecki, Magdalena
AU  - Tsai, Chiou Tsun
AU  - Luo, Huacheng
AU  - Stanojević, Boban
AU  - Lynn, Claire
AU  - Leung, Anskar Y.H.
AU  - Zuna, Jan
AU  - Zaliova, Marketa
AU  - Bornhauser, Martin
AU  - von Bonin, Malte
AU  - Lenhard, Boris
AU  - Huang, Suming
AU  - Mufti, Ghulam J.
AU  - So, Chi Wai Eric
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9142
AB  - Chemoresistance remains the major challenge for successful treatment of acute myeloid leukemia (AML). Although recent mouse studies suggest that treatment response of genetically and immunophenotypically indistinguishable AML can be influenced by their different cells of origin, corresponding evidence in human disease is still largely lacking. By combining prospective disease modeling using highly purified human hematopoietic stem or progenitor cells with retrospective deconvolution study of leukemia stem cells (LSCs) from primary patient samples, we identified human hematopoietic stem cells (HSCs) and common myeloid progenitors (CMPs) as two distinctive origins of human AML driven by Mixed Lineage Leukemia (MLL) gene fusions (MLL-AML). Despite LSCs from either MLL-rearranged HSCs or MLL-rearranged CMPs having a mature CD34 −/lo /CD38 + immunophenotype in both a humanized mouse model and primary patient samples, the resulting AML cells exhibited contrasting responses to chemotherapy. HSC-derived MLL-AML was highly resistant to chemotherapy and expressed elevated amounts of the multispecific anion transporter ABCC3. Inhibition of ABCC3 by shRNA-mediated knockdown or with small-molecule inhibitor fidaxomicin, currently used for diarrhea associated with Clostridium difficile infection, effectively resensitized HSC-derived MLL-AML toward standard chemotherapeutic drugs. This study not only functionally established two distinctive origins of human LSCs for MLL-AML and their role in mediating chemoresistance but also identified a potential therapeutic avenue for stem cell–associated treatment resistance by repurposing a well-tolerated antidiarrhea drug already used in the clinic.
T2  - Science Translational Medicine
T1  - Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia
VL  - 13
IS  - 582
SP  - eabc4822
DO  - 10.1126/scitranslmed.abc4822
ER  - 

@article{
author = "Zeisig, Bernd B. and Fung, Tsz Kan and Zarowiecki, Magdalena and Tsai, Chiou Tsun and Luo, Huacheng and Stanojević, Boban and Lynn, Claire and Leung, Anskar Y.H. and Zuna, Jan and Zaliova, Marketa and Bornhauser, Martin and von Bonin, Malte and Lenhard, Boris and Huang, Suming and Mufti, Ghulam J. and So, Chi Wai Eric",
year = "2021",
abstract = "Chemoresistance remains the major challenge for successful treatment of acute myeloid leukemia (AML). Although recent mouse studies suggest that treatment response of genetically and immunophenotypically indistinguishable AML can be influenced by their different cells of origin, corresponding evidence in human disease is still largely lacking. By combining prospective disease modeling using highly purified human hematopoietic stem or progenitor cells with retrospective deconvolution study of leukemia stem cells (LSCs) from primary patient samples, we identified human hematopoietic stem cells (HSCs) and common myeloid progenitors (CMPs) as two distinctive origins of human AML driven by Mixed Lineage Leukemia (MLL) gene fusions (MLL-AML). Despite LSCs from either MLL-rearranged HSCs or MLL-rearranged CMPs having a mature CD34 −/lo /CD38 + immunophenotype in both a humanized mouse model and primary patient samples, the resulting AML cells exhibited contrasting responses to chemotherapy. HSC-derived MLL-AML was highly resistant to chemotherapy and expressed elevated amounts of the multispecific anion transporter ABCC3. Inhibition of ABCC3 by shRNA-mediated knockdown or with small-molecule inhibitor fidaxomicin, currently used for diarrhea associated with Clostridium difficile infection, effectively resensitized HSC-derived MLL-AML toward standard chemotherapeutic drugs. This study not only functionally established two distinctive origins of human LSCs for MLL-AML and their role in mediating chemoresistance but also identified a potential therapeutic avenue for stem cell–associated treatment resistance by repurposing a well-tolerated antidiarrhea drug already used in the clinic.",
journal = "Science Translational Medicine",
title = "Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia",
volume = "13",
number = "582",
pages = "eabc4822",
doi = "10.1126/scitranslmed.abc4822"
}

Zeisig, B. B., Fung, T. K., Zarowiecki, M., Tsai, C. T., Luo, H., Stanojević, B., Lynn, C., Leung, A. Y.H., Zuna, J., Zaliova, M., Bornhauser, M., von Bonin, M., Lenhard, B., Huang, S., Mufti, G. J.,& So, C. W. E.. (2021). Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia. in Science Translational Medicine, 13(582), eabc4822.
https://doi.org/10.1126/scitranslmed.abc4822

Zeisig BB, Fung TK, Zarowiecki M, Tsai CT, Luo H, Stanojević B, Lynn C, Leung AY, Zuna J, Zaliova M, Bornhauser M, von Bonin M, Lenhard B, Huang S, Mufti GJ, So CWE. Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia. in Science Translational Medicine. 2021;13(582):eabc4822.
doi:10.1126/scitranslmed.abc4822 .

Zeisig, Bernd B., Fung, Tsz Kan, Zarowiecki, Magdalena, Tsai, Chiou Tsun, Luo, Huacheng, Stanojević, Boban, Lynn, Claire, Leung, Anskar Y.H., Zuna, Jan, Zaliova, Marketa, Bornhauser, Martin, von Bonin, Malte, Lenhard, Boris, Huang, Suming, Mufti, Ghulam J., So, Chi Wai Eric, "Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia" in Science Translational Medicine, 13, no. 582 (2021):eabc4822,
https://doi.org/10.1126/scitranslmed.abc4822 . .

TY  - JOUR
AU  - Todorović, Lidija
AU  - Mandušić, Vesna
AU  - Vučetić-Tadić, Biljana
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9055
AB  - A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.
T2  - Archives of Biological Sciences
T1  - Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics
VL  - 72
IS  - 1
SP  - 31
EP  - 36
DO  - 10.2298/ABS191004063T
ER  - 

@article{
author = "Todorović, Lidija and Mandušić, Vesna and Vučetić-Tadić, Biljana and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban",
year = "2020",
abstract = "A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.",
journal = "Archives of Biological Sciences",
title = "Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics",
volume = "72",
number = "1",
pages = "31-36",
doi = "10.2298/ABS191004063T"
}

Todorović, L., Mandušić, V., Vučetić-Tadić, B., Živaljević, V., Paunović, I.,& Stanojević, B.. (2020). Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics. in Archives of Biological Sciences, 72(1), 31-36.
https://doi.org/10.2298/ABS191004063T

Todorović L, Mandušić V, Vučetić-Tadić B, Živaljević V, Paunović I, Stanojević B. Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics. in Archives of Biological Sciences. 2020;72(1):31-36.
doi:10.2298/ABS191004063T .

Todorović, Lidija, Mandušić, Vesna, Vučetić-Tadić, Biljana, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, "Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics" in Archives of Biological Sciences, 72, no. 1 (2020):31-36,
https://doi.org/10.2298/ABS191004063T . .

TY  - JOUR
AU  - Todorović, Lidija
AU  - Stanojević, Boban
AU  - Mandušić, Vesna
AU  - Petrović, Nina
AU  - Živaljević, Vladan R.
AU  - Paunović, Ivan R.
AU  - Diklić, Aleksandar
AU  - Saenko, Vladimir
AU  - Yamashita, Shunichi
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1944
AB  - A growing body of evidence suggests a role of the von Hippel-Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigenetic modifications. Several studies pointed to a role of microRNA-92a (miR-92a) in the regulation of VHL expression in different cancers. In the present study, we examined the expression levels of VHL mRNA and miR-92a in 42 pairs of PTCs and matched non-tumor thyroid tissues by means of quantitative RT-PCR. We explored the correlation between them and their association with clinicopathological parameters. The results revealed that both VHL and miR-92a were either up-or downregulated in PTCs compared to corresponding non-tumor tissues. On univariate analysis, lower VHL levels were significantly associated with extrathyroid spread (P = 0.022) and capsular invasion (P = 0.032). Multivariate analysis confirmed the association of low VHL with extrathyroid spread (OR 0.246, 95% CI 0.069-0.872, P = 0.038). Higher miR-92a among PTC tissues associated with the presence of nodal metastases (univariate analysis: P = 0.012; multivariate: OR 4.703, 95% CI 1.109-19.938, P = 0.036). A negative correlation between VHL and miR-92a was observed in a subgroup of PTCs having vascular invasion (P = 0.033, r = -0.673). The data here reported demonstrate that the expression of both VHL and miR-92a is deregulated in PTC tissues and that in some PTCs they may have opposite roles. These roles, as well as their diagnostic and/or prognostic utility, remain to be clarified.
T2  - Medical Oncology
T1  - Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters
VL  - 35
IS  - 2
DO  - 10.1007/s12032-017-1066-3
ER  - 

@article{
author = "Todorović, Lidija and Stanojević, Boban and Mandušić, Vesna and Petrović, Nina and Živaljević, Vladan R. and Paunović, Ivan R. and Diklić, Aleksandar and Saenko, Vladimir and Yamashita, Shunichi",
year = "2018",
abstract = "A growing body of evidence suggests a role of the von Hippel-Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigenetic modifications. Several studies pointed to a role of microRNA-92a (miR-92a) in the regulation of VHL expression in different cancers. In the present study, we examined the expression levels of VHL mRNA and miR-92a in 42 pairs of PTCs and matched non-tumor thyroid tissues by means of quantitative RT-PCR. We explored the correlation between them and their association with clinicopathological parameters. The results revealed that both VHL and miR-92a were either up-or downregulated in PTCs compared to corresponding non-tumor tissues. On univariate analysis, lower VHL levels were significantly associated with extrathyroid spread (P = 0.022) and capsular invasion (P = 0.032). Multivariate analysis confirmed the association of low VHL with extrathyroid spread (OR 0.246, 95% CI 0.069-0.872, P = 0.038). Higher miR-92a among PTC tissues associated with the presence of nodal metastases (univariate analysis: P = 0.012; multivariate: OR 4.703, 95% CI 1.109-19.938, P = 0.036). A negative correlation between VHL and miR-92a was observed in a subgroup of PTCs having vascular invasion (P = 0.033, r = -0.673). The data here reported demonstrate that the expression of both VHL and miR-92a is deregulated in PTC tissues and that in some PTCs they may have opposite roles. These roles, as well as their diagnostic and/or prognostic utility, remain to be clarified.",
journal = "Medical Oncology",
title = "Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters",
volume = "35",
number = "2",
doi = "10.1007/s12032-017-1066-3"
}

Todorović, L., Stanojević, B., Mandušić, V., Petrović, N., Živaljević, V. R., Paunović, I. R., Diklić, A., Saenko, V.,& Yamashita, S.. (2018). Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters. in Medical Oncology, 35(2).
https://doi.org/10.1007/s12032-017-1066-3

Todorović L, Stanojević B, Mandušić V, Petrović N, Živaljević VR, Paunović IR, Diklić A, Saenko V, Yamashita S. Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters. in Medical Oncology. 2018;35(2).
doi:10.1007/s12032-017-1066-3 .

Todorović, Lidija, Stanojević, Boban, Mandušić, Vesna, Petrović, Nina, Živaljević, Vladan R., Paunović, Ivan R., Diklić, Aleksandar, Saenko, Vladimir, Yamashita, Shunichi, "Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters" in Medical Oncology, 35, no. 2 (2018),
https://doi.org/10.1007/s12032-017-1066-3 . .

TY  - JOUR
AU  - Stanojević, Boban
AU  - Đukić, Mirjana
AU  - Stevanović, Ivana
AU  - Ninković, Milica
AU  - Đurić, Ana
AU  - Gobeljić, Borko
AU  - Apostolović, Milan
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Todorović, Lidija
AU  - Bojić, Tijana
AU  - Savovski, Kiril
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8863
AB  - The aim of our study was to test the effect of subacutely applied micronized zeolite [micronized clinoptilolite (MZC)] on brain status of iron (Fe), reactive oxygen and nitrogen species (ROS, RNS), and radioprotective role against brain oxidative/nitrosative stress (OS/NS) initiated by single ionizing radiation of 2 or 10Gray (Gy). Wistar rats on normal (n=18) and 5% MZC supplemented diet (n=18), during 4 weeks, were internally subdivided into 3 subgroups (6 rats in each subgroup), with one of subgroup remaining as a control, and the other two subjected to single ionizing radiation of 2Gy or 10Gy. Thus, we had groups on normal diet: C – controls, 2Gy and 10Gy; and on 5% MZC supplemented diet: MZC, MZC+2Gy and MZC+10Gy. Concentrations of nitrates (a final RNS metabolite) and superoxide anion radical (O2 •-) (an initial ROS) were measured in homogenates of selective vulnerable brain regions (cerebellum, hippocampus and forebrain cortex), while Fe was determined in whole brain of rats. Results documented a significant drop of Fe in MZC and MZC+2Gy/10Gy groups; decrease of O2 •- and nitrate in MZC group; almost equal drop of O2 •- , in 2Gy and MZC+2Gy groups; and nitrate increase in 10Gy and MZC+10Gy groups. We confirmed that subacute MZC pretreatment contributes to partially accomplished brain radioprotective effect in rats exposed to single radiation dose of 2Gy and 10Gy, probably due to reduced OS/NS and Fe.
T2  - Hrana i ishrana
T1  - Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats
VL  - 59
IS  - 2
SP  - 26
EP  - 32
DO  - 10.5937/hraish1801026s
ER  - 

@article{
author = "Stanojević, Boban and Đukić, Mirjana and Stevanović, Ivana and Ninković, Milica and Đurić, Ana and Gobeljić, Borko and Apostolović, Milan and Pantelić, Ana and Zebić, Goran and Todorović, Lidija and Bojić, Tijana and Savovski, Kiril",
year = "2018",
abstract = "The aim of our study was to test the effect of subacutely applied micronized zeolite [micronized clinoptilolite (MZC)] on brain status of iron (Fe), reactive oxygen and nitrogen species (ROS, RNS), and radioprotective role against brain oxidative/nitrosative stress (OS/NS) initiated by single ionizing radiation of 2 or 10Gray (Gy). Wistar rats on normal (n=18) and 5% MZC supplemented diet (n=18), during 4 weeks, were internally subdivided into 3 subgroups (6 rats in each subgroup), with one of subgroup remaining as a control, and the other two subjected to single ionizing radiation of 2Gy or 10Gy. Thus, we had groups on normal diet: C – controls, 2Gy and 10Gy; and on 5% MZC supplemented diet: MZC, MZC+2Gy and MZC+10Gy. Concentrations of nitrates (a final RNS metabolite) and superoxide anion radical (O2 •-) (an initial ROS) were measured in homogenates of selective vulnerable brain regions (cerebellum, hippocampus and forebrain cortex), while Fe was determined in whole brain of rats. Results documented a significant drop of Fe in MZC and MZC+2Gy/10Gy groups; decrease of O2 •- and nitrate in MZC group; almost equal drop of O2 •- , in 2Gy and MZC+2Gy groups; and nitrate increase in 10Gy and MZC+10Gy groups. We confirmed that subacute MZC pretreatment contributes to partially accomplished brain radioprotective effect in rats exposed to single radiation dose of 2Gy and 10Gy, probably due to reduced OS/NS and Fe.",
journal = "Hrana i ishrana",
title = "Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats",
volume = "59",
number = "2",
pages = "26-32",
doi = "10.5937/hraish1801026s"
}

Stanojević, B., Đukić, M., Stevanović, I., Ninković, M., Đurić, A., Gobeljić, B., Apostolović, M., Pantelić, A., Zebić, G., Todorović, L., Bojić, T.,& Savovski, K.. (2018). Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats. in Hrana i ishrana, 59(2), 26-32.
https://doi.org/10.5937/hraish1801026s

Stanojević B, Đukić M, Stevanović I, Ninković M, Đurić A, Gobeljić B, Apostolović M, Pantelić A, Zebić G, Todorović L, Bojić T, Savovski K. Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats. in Hrana i ishrana. 2018;59(2):26-32.
doi:10.5937/hraish1801026s .

Stanojević, Boban, Đukić, Mirjana, Stevanović, Ivana, Ninković, Milica, Đurić, Ana, Gobeljić, Borko, Apostolović, Milan, Pantelić, Ana, Zebić, Goran, Todorović, Lidija, Bojić, Tijana, Savovski, Kiril, "Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats" in Hrana i ishrana, 59, no. 2 (2018):26-32,
https://doi.org/10.5937/hraish1801026s . .

TY  - JOUR
AU  - Okuda, Hiroshi
AU  - Stanojević, Boban
AU  - Kanai, Akinori
AU  - Kawamura, Takeshi
AU  - Takahashi, Satoshi
AU  - Matsui, Hirotaka
AU  - Takaori-Kondo, Akifumi
AU  - Yokoyama, Akihiko
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1538
AB  - The eleven-nineteen leukemia (ENL) protein family, composed of ENL and AF9, is a common component of 3 transcriptional modulators: AF4-ENL-P-TEFb complex (AEP), DOT1L-AF10-ENL complex (referred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1). Each complex associates with chromatin via distinct mechanisms, conferring different transcriptional properties including activation, maintenance, and repression. The mixed-lineage leukemia (MLL) gene often fuses with ENL and AF10 family genes in leukemia. However, the functional interrelationship among those 3 complexes in leukemic transformation remains largely elusive. Here, we have shown that MLL-ENL and MLL-AF10 constitutively activate transcription by aberrantly inducing both AEP-dependent transcriptional activation and DOT1L-dependent transcriptional maintenance, mostly in the absence of PRC1, to fully transform hematopoietic progenitors. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.
T2  - Journal of Clinical Investigation
T1  - Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia
VL  - 127
IS  - 5
SP  - 1918
EP  - 1931
DO  - 10.1172/JCI91406
ER  - 

@article{
author = "Okuda, Hiroshi and Stanojević, Boban and Kanai, Akinori and Kawamura, Takeshi and Takahashi, Satoshi and Matsui, Hirotaka and Takaori-Kondo, Akifumi and Yokoyama, Akihiko",
year = "2017",
abstract = "The eleven-nineteen leukemia (ENL) protein family, composed of ENL and AF9, is a common component of 3 transcriptional modulators: AF4-ENL-P-TEFb complex (AEP), DOT1L-AF10-ENL complex (referred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1). Each complex associates with chromatin via distinct mechanisms, conferring different transcriptional properties including activation, maintenance, and repression. The mixed-lineage leukemia (MLL) gene often fuses with ENL and AF10 family genes in leukemia. However, the functional interrelationship among those 3 complexes in leukemic transformation remains largely elusive. Here, we have shown that MLL-ENL and MLL-AF10 constitutively activate transcription by aberrantly inducing both AEP-dependent transcriptional activation and DOT1L-dependent transcriptional maintenance, mostly in the absence of PRC1, to fully transform hematopoietic progenitors. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.",
journal = "Journal of Clinical Investigation",
title = "Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia",
volume = "127",
number = "5",
pages = "1918-1931",
doi = "10.1172/JCI91406"
}

Okuda, H., Stanojević, B., Kanai, A., Kawamura, T., Takahashi, S., Matsui, H., Takaori-Kondo, A.,& Yokoyama, A.. (2017). Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. in Journal of Clinical Investigation, 127(5), 1918-1931.
https://doi.org/10.1172/JCI91406

Okuda H, Stanojević B, Kanai A, Kawamura T, Takahashi S, Matsui H, Takaori-Kondo A, Yokoyama A. Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. in Journal of Clinical Investigation. 2017;127(5):1918-1931.
doi:10.1172/JCI91406 .

Okuda, Hiroshi, Stanojević, Boban, Kanai, Akinori, Kawamura, Takeshi, Takahashi, Satoshi, Matsui, Hirotaka, Takaori-Kondo, Akifumi, Yokoyama, Akihiko, "Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia" in Journal of Clinical Investigation, 127, no. 5 (2017):1918-1931,
https://doi.org/10.1172/JCI91406 . .

TY  - CONF
AU  - Šami, A.
AU  - Petrović, Nina
AU  - Mandušić, Vesna
AU  - Todorović, Lidija
AU  - Jovanović-Ćupić, Snežana
AU  - Stanojević, Boban
AU  - Dimitrijević, Bogomir
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12453
C3  - 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program
T1  - Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mRNA levels significantly differ in three breast cancer groups formed according to its invasiveness and normal breast cancer samples
SP  - 30
EP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12453
ER  - 

@conference{
author = "Šami, A. and Petrović, Nina and Mandušić, Vesna and Todorović, Lidija and Jovanović-Ćupić, Snežana and Stanojević, Boban and Dimitrijević, Bogomir",
year = "2015",
journal = "1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program",
title = "Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mRNA levels significantly differ in three breast cancer groups formed according to its invasiveness and normal breast cancer samples",
pages = "30-30",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12453"
}

Šami, A., Petrović, N., Mandušić, V., Todorović, L., Jovanović-Ćupić, S., Stanojević, B.,& Dimitrijević, B.. (2015). Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mRNA levels significantly differ in three breast cancer groups formed according to its invasiveness and normal breast cancer samples. in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program, 30-30.
https://hdl.handle.net/21.15107/rcub_vinar_12453

Šami A, Petrović N, Mandušić V, Todorović L, Jovanović-Ćupić S, Stanojević B, Dimitrijević B. Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mRNA levels significantly differ in three breast cancer groups formed according to its invasiveness and normal breast cancer samples. in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program. 2015;:30-30.
https://hdl.handle.net/21.15107/rcub_vinar_12453 .

Šami, A., Petrović, Nina, Mandušić, Vesna, Todorović, Lidija, Jovanović-Ćupić, Snežana, Stanojević, Boban, Dimitrijević, Bogomir, "Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mRNA levels significantly differ in three breast cancer groups formed according to its invasiveness and normal breast cancer samples" in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program (2015):30-30,
https://hdl.handle.net/21.15107/rcub_vinar_12453 .

TY  - CONF
AU  - Todorović, Lidija
AU  - Stanojević, Boban
AU  - Mandušić, Vesna
AU  - Petrović, Nina
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Dimitrijević, Bogomir
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12454
C3  - 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program
T1  - Quantitative analysis of von Hippel-Lindau messenger RNA expression in thyroid tumor tissue by real time PCR
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12454
ER  - 

@conference{
author = "Todorović, Lidija and Stanojević, Boban and Mandušić, Vesna and Petrović, Nina and Živaljević, Vladan and Paunović, Ivan and Dimitrijević, Bogomir",
year = "2015",
journal = "1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program",
title = "Quantitative analysis of von Hippel-Lindau messenger RNA expression in thyroid tumor tissue by real time PCR",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12454"
}

Todorović, L., Stanojević, B., Mandušić, V., Petrović, N., Živaljević, V., Paunović, I.,& Dimitrijević, B.. (2015). Quantitative analysis of von Hippel-Lindau messenger RNA expression in thyroid tumor tissue by real time PCR. in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program.
https://hdl.handle.net/21.15107/rcub_vinar_12454

Todorović L, Stanojević B, Mandušić V, Petrović N, Živaljević V, Paunović I, Dimitrijević B. Quantitative analysis of von Hippel-Lindau messenger RNA expression in thyroid tumor tissue by real time PCR. in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program. 2015;.
https://hdl.handle.net/21.15107/rcub_vinar_12454 .

Todorović, Lidija, Stanojević, Boban, Mandušić, Vesna, Petrović, Nina, Živaljević, Vladan, Paunović, Ivan, Dimitrijević, Bogomir, "Quantitative analysis of von Hippel-Lindau messenger RNA expression in thyroid tumor tissue by real time PCR" in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program (2015),
https://hdl.handle.net/21.15107/rcub_vinar_12454 .

TY  - CONF
AU  - Todorović, Lidija
AU  - Mandušić, Vesna
AU  - Stanojević, Boban
AU  - Petrović, Nina
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Dimitrijević, Bogomir
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12456
C3  - 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program
T1  - Expression of estrogen receptor α and estrogen receptor β mRNAs in matched tumor and normal thyroid tissue
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12456
ER  - 

@conference{
author = "Todorović, Lidija and Mandušić, Vesna and Stanojević, Boban and Petrović, Nina and Živaljević, Vladan and Paunović, Ivan and Dimitrijević, Bogomir",
year = "2015",
journal = "1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program",
title = "Expression of estrogen receptor α and estrogen receptor β mRNAs in matched tumor and normal thyroid tissue",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12456"
}

Todorović, L., Mandušić, V., Stanojević, B., Petrović, N., Živaljević, V., Paunović, I.,& Dimitrijević, B.. (2015). Expression of estrogen receptor α and estrogen receptor β mRNAs in matched tumor and normal thyroid tissue. in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program.
https://hdl.handle.net/21.15107/rcub_vinar_12456

Todorović L, Mandušić V, Stanojević B, Petrović N, Živaljević V, Paunović I, Dimitrijević B. Expression of estrogen receptor α and estrogen receptor β mRNAs in matched tumor and normal thyroid tissue. in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program. 2015;.
https://hdl.handle.net/21.15107/rcub_vinar_12456 .

Todorović, Lidija, Mandušić, Vesna, Stanojević, Boban, Petrović, Nina, Živaljević, Vladan, Paunović, Ivan, Dimitrijević, Bogomir, "Expression of estrogen receptor α and estrogen receptor β mRNAs in matched tumor and normal thyroid tissue" in 1st Belgrade International Molecular Life Science Conference for Students : Abstract book & Program (2015),
https://hdl.handle.net/21.15107/rcub_vinar_12456 .

TY  - JOUR
AU  - Stanojević, Boban
AU  - Saenko, Vladimir
AU  - Todorović, Lidija
AU  - Petrović, Nina
AU  - Nikolić, Dragan
AU  - Živaljević, Vladan R.
AU  - Paunović, Ivan R.
AU  - Nakashima, Masahiro
AU  - Yamashita, Shunichi
AU  - Džodić, Radan R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/340
AB  - Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR=5.78, 95% CI 3.17-10.53, P LT 0.0001), classical papillary morphology of the tumor (OR=2.92, 95% CI 1.33-6.44, P=0.008) and multifocality (OR=1.96, 95% CI 1.06-3.62, P=0.031). In disease-free survival analysis, low VHL expression had marginal significance (P=0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated.
T2  - PLOS One
T1  - Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma
VL  - 9
IS  - 12
DO  - 10.1371/journal.pone.0114511
ER  - 

@article{
author = "Stanojević, Boban and Saenko, Vladimir and Todorović, Lidija and Petrović, Nina and Nikolić, Dragan and Živaljević, Vladan R. and Paunović, Ivan R. and Nakashima, Masahiro and Yamashita, Shunichi and Džodić, Radan R.",
year = "2014",
abstract = "Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR=5.78, 95% CI 3.17-10.53, P LT 0.0001), classical papillary morphology of the tumor (OR=2.92, 95% CI 1.33-6.44, P=0.008) and multifocality (OR=1.96, 95% CI 1.06-3.62, P=0.031). In disease-free survival analysis, low VHL expression had marginal significance (P=0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated.",
journal = "PLOS One",
title = "Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma",
volume = "9",
number = "12",
doi = "10.1371/journal.pone.0114511"
}

Stanojević, B., Saenko, V., Todorović, L., Petrović, N., Nikolić, D., Živaljević, V. R., Paunović, I. R., Nakashima, M., Yamashita, S.,& Džodić, R. R.. (2014). Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma. in PLOS One, 9(12).
https://doi.org/10.1371/journal.pone.0114511

Stanojević B, Saenko V, Todorović L, Petrović N, Nikolić D, Živaljević VR, Paunović IR, Nakashima M, Yamashita S, Džodić RR. Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma. in PLOS One. 2014;9(12).
doi:10.1371/journal.pone.0114511 .

Stanojević, Boban, Saenko, Vladimir, Todorović, Lidija, Petrović, Nina, Nikolić, Dragan, Živaljević, Vladan R., Paunović, Ivan R., Nakashima, Masahiro, Yamashita, Shunichi, Džodić, Radan R., "Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma" in PLOS One, 9, no. 12 (2014),
https://doi.org/10.1371/journal.pone.0114511 . .

TY  - JOUR
AU  - Petrović, Nina
AU  - Mandušić, Vesna
AU  - Stanojević, Boban
AU  - Lukić, Silvana
AU  - Todorović, Lidija
AU  - Roganović, Jelena
AU  - Dimitrijević, Bogomir B.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6041
AB  - MicroRNA-21 (miR-21) overexpression is characteristic for various types of tumors, but it is still unknown whether its expression levels differ between invasive and non-invasive breast carcinomas. The main goal of the study was to determine the difference in miR-21 expression among normal tissue, non-invasive, invasive with non-invasive component, and pure invasive breast cancer samples, to explain its potential role and significance in breast cancer invasiveness. The second goal was to propose miR-21 as molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis. In order to reveal the role of miR-21 in breast cancer invasiveness, we measured miR-21 expression levels in 44 breast cancer and four normal samples by stem-loop real-time RT-PCR using TaqMan technology. Relative expression levels of miR-21 were significantly higher in invasive than in other groups (P = 0.002) and significantly higher in invasive compared with invasive with non-invasive component group in histological (P = 0.043) and nuclear grade 2 (P = 0.036), estrogen-receptor-positive (ER+) (P = 0.006), progesterone-receptor-positive (PR+) (P = 0.008), ER+ PR+ (P = 0.007), and proliferation index (Ki-67) LT = 20 % (P = 0.036) tumors. Our findings suggest that miR-21 could be independent molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis.
T2  - Medical Oncology
T1  - The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion
VL  - 31
IS  - 3
DO  - 10.1007/s12032-014-0867-x
ER  - 

@article{
author = "Petrović, Nina and Mandušić, Vesna and Stanojević, Boban and Lukić, Silvana and Todorović, Lidija and Roganović, Jelena and Dimitrijević, Bogomir B.",
year = "2014",
abstract = "MicroRNA-21 (miR-21) overexpression is characteristic for various types of tumors, but it is still unknown whether its expression levels differ between invasive and non-invasive breast carcinomas. The main goal of the study was to determine the difference in miR-21 expression among normal tissue, non-invasive, invasive with non-invasive component, and pure invasive breast cancer samples, to explain its potential role and significance in breast cancer invasiveness. The second goal was to propose miR-21 as molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis. In order to reveal the role of miR-21 in breast cancer invasiveness, we measured miR-21 expression levels in 44 breast cancer and four normal samples by stem-loop real-time RT-PCR using TaqMan technology. Relative expression levels of miR-21 were significantly higher in invasive than in other groups (P = 0.002) and significantly higher in invasive compared with invasive with non-invasive component group in histological (P = 0.043) and nuclear grade 2 (P = 0.036), estrogen-receptor-positive (ER+) (P = 0.006), progesterone-receptor-positive (PR+) (P = 0.008), ER+ PR+ (P = 0.007), and proliferation index (Ki-67) LT = 20 % (P = 0.036) tumors. Our findings suggest that miR-21 could be independent molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis.",
journal = "Medical Oncology",
title = "The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion",
volume = "31",
number = "3",
doi = "10.1007/s12032-014-0867-x"
}

Petrović, N., Mandušić, V., Stanojević, B., Lukić, S., Todorović, L., Roganović, J.,& Dimitrijević, B. B.. (2014). The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion. in Medical Oncology, 31(3).
https://doi.org/10.1007/s12032-014-0867-x

Petrović N, Mandušić V, Stanojević B, Lukić S, Todorović L, Roganović J, Dimitrijević BB. The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion. in Medical Oncology. 2014;31(3).
doi:10.1007/s12032-014-0867-x .

Petrović, Nina, Mandušić, Vesna, Stanojević, Boban, Lukić, Silvana, Todorović, Lidija, Roganović, Jelena, Dimitrijević, Bogomir B., "The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion" in Medical Oncology, 31, no. 3 (2014),
https://doi.org/10.1007/s12032-014-0867-x . .

TY  - JOUR
AU  - Petrović, Nina
AU  - Mandušić, Vesna
AU  - Dimitrijević, Bogomir B.
AU  - Roganović, Jelena
AU  - Lukić, Silvana
AU  - Todorović, Lidija
AU  - Stanojević, Boban
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6070
AB  - MicroRNAs play essential role in breast carcinoma progression and invasion. Our principal goals were to assess clinicopathological and prognostic correlations of microRNA-21 (miR-21) expression levels in a group of 39 Serbian breast cancer patients with invasive lobular (ILC), ductal (IDC), or mixed (ILC-IDC) breast carcinomas and in order to discover the role of miR-21 in potential novel form of stratification of the patients with different estrogen receptor (ER) and progesterone receptor (PR) status. MiR-21 expression levels were measured by stem-loop real-time RT-PCR using TaqMan technology. ER, PR, human epidermal growth factor 2 receptor (Her-2), and proliferative index (Ki-67) were evaluated by immunohistochemistry. MiR-21 levels do not vary among ILC, IDC, and ILC-IDC subgroups. MiR-21 expression levels varied significantly in the age, tumor size, Ki-67, and different grade (p = 0.030, p = 0.036, p = 0.027 and p = 0.032, respectively) subgroups. ER? and PR? showed higher miR-21 levels than their negative receptor status paired groups ER-and PR-with p = 0.012 and p = 0.018, respectively. MiR-21 positively correlated with ER and PR status (p = 0.018, rho = 0.379 and p = 0.034, rho = 0.345, respectively). Our findings suggest that miR-21 emulates transitional form of expression and that the levels of expression might be useful for stratification of the patients with different receptor status with the purpose to seek for new therapy approaches especially for the patients with the lack of response to conventional endocrine therapy.
T2  - Medical Oncology
T1  - Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia
VL  - 31
IS  - 6
DO  - 10.1007/s12032-014-0977-5
ER  - 

@article{
author = "Petrović, Nina and Mandušić, Vesna and Dimitrijević, Bogomir B. and Roganović, Jelena and Lukić, Silvana and Todorović, Lidija and Stanojević, Boban",
year = "2014",
abstract = "MicroRNAs play essential role in breast carcinoma progression and invasion. Our principal goals were to assess clinicopathological and prognostic correlations of microRNA-21 (miR-21) expression levels in a group of 39 Serbian breast cancer patients with invasive lobular (ILC), ductal (IDC), or mixed (ILC-IDC) breast carcinomas and in order to discover the role of miR-21 in potential novel form of stratification of the patients with different estrogen receptor (ER) and progesterone receptor (PR) status. MiR-21 expression levels were measured by stem-loop real-time RT-PCR using TaqMan technology. ER, PR, human epidermal growth factor 2 receptor (Her-2), and proliferative index (Ki-67) were evaluated by immunohistochemistry. MiR-21 levels do not vary among ILC, IDC, and ILC-IDC subgroups. MiR-21 expression levels varied significantly in the age, tumor size, Ki-67, and different grade (p = 0.030, p = 0.036, p = 0.027 and p = 0.032, respectively) subgroups. ER? and PR? showed higher miR-21 levels than their negative receptor status paired groups ER-and PR-with p = 0.012 and p = 0.018, respectively. MiR-21 positively correlated with ER and PR status (p = 0.018, rho = 0.379 and p = 0.034, rho = 0.345, respectively). Our findings suggest that miR-21 emulates transitional form of expression and that the levels of expression might be useful for stratification of the patients with different receptor status with the purpose to seek for new therapy approaches especially for the patients with the lack of response to conventional endocrine therapy.",
journal = "Medical Oncology",
title = "Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia",
volume = "31",
number = "6",
doi = "10.1007/s12032-014-0977-5"
}

Petrović, N., Mandušić, V., Dimitrijević, B. B., Roganović, J., Lukić, S., Todorović, L.,& Stanojević, B.. (2014). Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia. in Medical Oncology, 31(6).
https://doi.org/10.1007/s12032-014-0977-5

Petrović N, Mandušić V, Dimitrijević BB, Roganović J, Lukić S, Todorović L, Stanojević B. Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia. in Medical Oncology. 2014;31(6).
doi:10.1007/s12032-014-0977-5 .

Petrović, Nina, Mandušić, Vesna, Dimitrijević, Bogomir B., Roganović, Jelena, Lukić, Silvana, Todorović, Lidija, Stanojević, Boban, "Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia" in Medical Oncology, 31, no. 6 (2014),
https://doi.org/10.1007/s12032-014-0977-5 . .

TY  - JOUR
AU  - Tadić, Marin
AU  - Panjan, Matjaž
AU  - Marković, Dragana
AU  - Stanojević, Boban
AU  - Jovanovic, Djordje
AU  - Milošević, Irena
AU  - Spasojević, Vojislav
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5787
AB  - We report on ferromagnetic-like magnetic properties, at room temperature, of spherical nickel oxide core-shell nanoparticles synthesized by sol-gel combustion method. The sample is characterized by using transmission electron microscopy (TEM), selected electron area diffraction (SAED), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy (RS) and superconducting quantum interference device (SQUID) magnetometer. The SAED, EDX and RS show high quality and purity of the sample. The TEM images point to core-shell NiO nanostructure with a well crystallized NiO core and surface disorder shell. The size of the nanoparticles of about 5 nm and thickness of the surface shell below 1 nm are estimated from the TEM and HRTEM measurements. The measurements of the magnetization reveals ferromagnetic-like behavior of the sample at room temperature with remanent magnetization M-r = 0.0087 emu/g and coercive field H-C = 115 Oe. These magnetic properties are quite different than in NiO bulk materials and uncommon for nanosized NiO materials. These results also indicate that the synthesized NiO core-shell nanostructure is suitable for spin-valve applications. (C) 2012 Elsevier B. V. All rights reserved.
T2  - Journal of Alloys and Compounds
T1  - NiO core-shell nanostructure with ferromagnetic-like behavior at room temperature
VL  - 586
SP  - S322
EP  - S325
DO  - 10.1016/j.jallcom.2012.10.166
ER  - 

@article{
author = "Tadić, Marin and Panjan, Matjaž and Marković, Dragana and Stanojević, Boban and Jovanovic, Djordje and Milošević, Irena and Spasojević, Vojislav",
year = "2014",
abstract = "We report on ferromagnetic-like magnetic properties, at room temperature, of spherical nickel oxide core-shell nanoparticles synthesized by sol-gel combustion method. The sample is characterized by using transmission electron microscopy (TEM), selected electron area diffraction (SAED), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy (RS) and superconducting quantum interference device (SQUID) magnetometer. The SAED, EDX and RS show high quality and purity of the sample. The TEM images point to core-shell NiO nanostructure with a well crystallized NiO core and surface disorder shell. The size of the nanoparticles of about 5 nm and thickness of the surface shell below 1 nm are estimated from the TEM and HRTEM measurements. The measurements of the magnetization reveals ferromagnetic-like behavior of the sample at room temperature with remanent magnetization M-r = 0.0087 emu/g and coercive field H-C = 115 Oe. These magnetic properties are quite different than in NiO bulk materials and uncommon for nanosized NiO materials. These results also indicate that the synthesized NiO core-shell nanostructure is suitable for spin-valve applications. (C) 2012 Elsevier B. V. All rights reserved.",
journal = "Journal of Alloys and Compounds",
title = "NiO core-shell nanostructure with ferromagnetic-like behavior at room temperature",
volume = "586",
pages = "S322-S325",
doi = "10.1016/j.jallcom.2012.10.166"
}

Tadić, M., Panjan, M., Marković, D., Stanojević, B., Jovanovic, D., Milošević, I.,& Spasojević, V.. (2014). NiO core-shell nanostructure with ferromagnetic-like behavior at room temperature. in Journal of Alloys and Compounds, 586, S322-S325.
https://doi.org/10.1016/j.jallcom.2012.10.166

Tadić M, Panjan M, Marković D, Stanojević B, Jovanovic D, Milošević I, Spasojević V. NiO core-shell nanostructure with ferromagnetic-like behavior at room temperature. in Journal of Alloys and Compounds. 2014;586:S322-S325.
doi:10.1016/j.jallcom.2012.10.166 .

Tadić, Marin, Panjan, Matjaž, Marković, Dragana, Stanojević, Boban, Jovanovic, Djordje, Milošević, Irena, Spasojević, Vojislav, "NiO core-shell nanostructure with ferromagnetic-like behavior at room temperature" in Journal of Alloys and Compounds, 586 (2014):S322-S325,
https://doi.org/10.1016/j.jallcom.2012.10.166 . .

TY  - JOUR
AU  - Mussazhanova, Zhanna
AU  - Miura, Shiro
AU  - Stanojević, Boban
AU  - Rougounovitch, Tatiana
AU  - Saenko, Vladimir
AU  - Shiraishi, Toshio
AU  - Kurashige, Tomomi
AU  - Shichijo, Kazuko
AU  - Kaneko, Kenichi
AU  - Takahashi, Haruo
AU  - Ito, Masahiro
AU  - Nakashima, Masahiro
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5911
AB  - Background: Neuroendocrine tumor (NET) of the thyroid other than medullary carcinoma is extremely rare. We describe here a case of calcitonin-negative small cell neuroendocrine carcinoma (SCNEC), which occurred in a thyroid gland that had previously been irradiated at high dose (60Gy) for pharyngeal cancer, with molecular analyses for follicular cell origin. Patient Findings: The tumor cells were small with fine chromatin, inconspicuous nucleoli, and inapparent cytoplasm, and showed neuroendocrine architectures such as palisading, rosettes, and trabeculae. Mitotic figures were numerous exceeding 10 mitoses per 10 high-power fields. The tumor cells invaded into several vessels and metastasized to regional lymph nodes. Immunohistochemically, the tumor cells were strongly positive for neuroendocrine markers and thyroglobulin (Tg), a marker of thyroid follicular cells but negative for calcitonin and carcinoembryonic antigen (CEA). Expression of Tg and thyrotropin receptor (TSHR) were confirmed by quantitative real-time polymerase chain reaction (RT-PCR). Ki-67 labeling index was more than 70% in the tumor cells. Taken together, the tumor was diagnosed as SCNEC of the thyroid. Genetic analyses also revealed microsatellite abnormalities of the phosphatase and tensin homolog (PTEN) gene, suggesting that functional loss of PTEN contributes to carcinogenesis. Conclusions: This is the first report describing a SCNEC of the thyroid with molecular analyses that provide evidence for a follicular epithelial origin.
T2  - Thyroid
T1  - Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses
VL  - 24
IS  - 3
SP  - 593
EP  - 598
DO  - 10.1089/thy.2013.0214
ER  - 

@article{
author = "Mussazhanova, Zhanna and Miura, Shiro and Stanojević, Boban and Rougounovitch, Tatiana and Saenko, Vladimir and Shiraishi, Toshio and Kurashige, Tomomi and Shichijo, Kazuko and Kaneko, Kenichi and Takahashi, Haruo and Ito, Masahiro and Nakashima, Masahiro",
year = "2014",
abstract = "Background: Neuroendocrine tumor (NET) of the thyroid other than medullary carcinoma is extremely rare. We describe here a case of calcitonin-negative small cell neuroendocrine carcinoma (SCNEC), which occurred in a thyroid gland that had previously been irradiated at high dose (60Gy) for pharyngeal cancer, with molecular analyses for follicular cell origin. Patient Findings: The tumor cells were small with fine chromatin, inconspicuous nucleoli, and inapparent cytoplasm, and showed neuroendocrine architectures such as palisading, rosettes, and trabeculae. Mitotic figures were numerous exceeding 10 mitoses per 10 high-power fields. The tumor cells invaded into several vessels and metastasized to regional lymph nodes. Immunohistochemically, the tumor cells were strongly positive for neuroendocrine markers and thyroglobulin (Tg), a marker of thyroid follicular cells but negative for calcitonin and carcinoembryonic antigen (CEA). Expression of Tg and thyrotropin receptor (TSHR) were confirmed by quantitative real-time polymerase chain reaction (RT-PCR). Ki-67 labeling index was more than 70% in the tumor cells. Taken together, the tumor was diagnosed as SCNEC of the thyroid. Genetic analyses also revealed microsatellite abnormalities of the phosphatase and tensin homolog (PTEN) gene, suggesting that functional loss of PTEN contributes to carcinogenesis. Conclusions: This is the first report describing a SCNEC of the thyroid with molecular analyses that provide evidence for a follicular epithelial origin.",
journal = "Thyroid",
title = "Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses",
volume = "24",
number = "3",
pages = "593-598",
doi = "10.1089/thy.2013.0214"
}

Mussazhanova, Z., Miura, S., Stanojević, B., Rougounovitch, T., Saenko, V., Shiraishi, T., Kurashige, T., Shichijo, K., Kaneko, K., Takahashi, H., Ito, M.,& Nakashima, M.. (2014). Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses. in Thyroid, 24(3), 593-598.
https://doi.org/10.1089/thy.2013.0214

Mussazhanova Z, Miura S, Stanojević B, Rougounovitch T, Saenko V, Shiraishi T, Kurashige T, Shichijo K, Kaneko K, Takahashi H, Ito M, Nakashima M. Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses. in Thyroid. 2014;24(3):593-598.
doi:10.1089/thy.2013.0214 .

Mussazhanova, Zhanna, Miura, Shiro, Stanojević, Boban, Rougounovitch, Tatiana, Saenko, Vladimir, Shiraishi, Toshio, Kurashige, Tomomi, Shichijo, Kazuko, Kaneko, Kenichi, Takahashi, Haruo, Ito, Masahiro, Nakashima, Masahiro, "Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses" in Thyroid, 24, no. 3 (2014):593-598,
https://doi.org/10.1089/thy.2013.0214 . .

TY  - JOUR
AU  - Nikolić, Dragana
AU  - Djordjevic, P. B.
AU  - Lackovic, V. B.
AU  - Stojiljković, Vesna
AU  - Stanojević, Boban
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5409
AB  - The experiment compared the physiological function (insulin secretory capacity) and membrane integrity of human adult pancreatic islets incubated in culture at 37 degrees C and 24 degrees C. Pancreatic tissue was digested with Collagenase XI, using a non-automated method. Cultures were incubated at 37 degrees C and 24 degrees C. Secretory capacity of the islets is determined by measuring of the stimulation index (SI) on the 3rd and 7th day of cultivation. Membrane integrity of the islets was determined by dithizone staining. Both groups of examined cultures show a slight increase in SI during the incubation. However islets incubated at 24 degrees C show higher SI values than those incubated at 37 degrees C on the 1st, 3rd and 7th day of incubation. And on the first day of incubation, this difference was statistically significant (p LT 0.05). Islets incubated at 37 degrees C showed preservation of membrane integrity, the islets are regular spherical shape, while those incubated at 24 degrees C lose such an organization. During the seven-day cultivation, islets incubated at a standard temperature of 37 degrees C show less preserve physiological functions in relation to cultures incubated at 24 degrees C, but islets incubated at 37 degrees C show more regular morphological forms.
T2  - Journal of Biological Regulators and Homeostatic Agents
T1  - Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets
VL  - 27
IS  - 1
SP  - 35
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5409
ER  - 

@article{
author = "Nikolić, Dragana and Djordjevic, P. B. and Lackovic, V. B. and Stojiljković, Vesna and Stanojević, Boban",
year = "2013",
abstract = "The experiment compared the physiological function (insulin secretory capacity) and membrane integrity of human adult pancreatic islets incubated in culture at 37 degrees C and 24 degrees C. Pancreatic tissue was digested with Collagenase XI, using a non-automated method. Cultures were incubated at 37 degrees C and 24 degrees C. Secretory capacity of the islets is determined by measuring of the stimulation index (SI) on the 3rd and 7th day of cultivation. Membrane integrity of the islets was determined by dithizone staining. Both groups of examined cultures show a slight increase in SI during the incubation. However islets incubated at 24 degrees C show higher SI values than those incubated at 37 degrees C on the 1st, 3rd and 7th day of incubation. And on the first day of incubation, this difference was statistically significant (p LT 0.05). Islets incubated at 37 degrees C showed preservation of membrane integrity, the islets are regular spherical shape, while those incubated at 24 degrees C lose such an organization. During the seven-day cultivation, islets incubated at a standard temperature of 37 degrees C show less preserve physiological functions in relation to cultures incubated at 24 degrees C, but islets incubated at 37 degrees C show more regular morphological forms.",
journal = "Journal of Biological Regulators and Homeostatic Agents",
title = "Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets",
volume = "27",
number = "1",
pages = "35-44",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5409"
}

Nikolić, D., Djordjevic, P. B., Lackovic, V. B., Stojiljković, V.,& Stanojević, B.. (2013). Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets. in Journal of Biological Regulators and Homeostatic Agents, 27(1), 35-44.
https://hdl.handle.net/21.15107/rcub_vinar_5409

Nikolić D, Djordjevic PB, Lackovic VB, Stojiljković V, Stanojević B. Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets. in Journal of Biological Regulators and Homeostatic Agents. 2013;27(1):35-44.
https://hdl.handle.net/21.15107/rcub_vinar_5409 .

Nikolić, Dragana, Djordjevic, P. B., Lackovic, V. B., Stojiljković, Vesna, Stanojević, Boban, "Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets" in Journal of Biological Regulators and Homeostatic Agents, 27, no. 1 (2013):35-44,
https://hdl.handle.net/21.15107/rcub_vinar_5409 .