TY  - JOUR
AU  - Đurić, Biljana
AU  - Suzić, Slavica
AU  - Stojadinović, Bojana
AU  - Nestorović, Zorica
AU  - Ivanović, Marija D.
AU  - Suzić-Lazić, Jelena
AU  - Nešić, Dejan
AU  - Mazić, Sanja
AU  - Tenne, Tamar
AU  - Zikich, Dragoslav
AU  - Žikić, Dejan
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1655
AB  - We present here the improved design and development of optical sensor for non-invasive measurements of arterial blood flow waveform. The sensor is based on a physical principle of reflective photoplethysmography (PPG). As the light source we used serially connected infrared diodes whereas NPN silicon phototransistors were used as light detectors. The electronic components were molded into square package and poured with silicone. Such preparation produced an elastic superficies that allowed excellent attachment of the sensor on the skins surface. Moreover, a serial connection of infrared diodes and phototransistors completely eliminated signal artifacts caused by minor muscle contractions. The sensor recording performances were examined at the photoplethysmographic sites on three different arteries; the commune carotid, femoral and radial and, on each site the sensor demonstrated remarkable capability to make a consistent, reproducible measurements. Because of the advantageous physical and electrical properties, the new sensor is suitable for various cardiovascular diagnostics procedures, especially when long-term measurements of arterial blood flow waveform are required, for monitoring of different parameters in cardiovascular units and for research.
T2  - Biomedical Microdevices
T1  - An improved design of optical sensor for long-term measurement of arterial blood flow waveform
VL  - 19
IS  - 3
DO  - 10.1007/s10544-017-0196-x
ER  - 

@article{
author = "Đurić, Biljana and Suzić, Slavica and Stojadinović, Bojana and Nestorović, Zorica and Ivanović, Marija D. and Suzić-Lazić, Jelena and Nešić, Dejan and Mazić, Sanja and Tenne, Tamar and Zikich, Dragoslav and Žikić, Dejan",
year = "2017",
abstract = "We present here the improved design and development of optical sensor for non-invasive measurements of arterial blood flow waveform. The sensor is based on a physical principle of reflective photoplethysmography (PPG). As the light source we used serially connected infrared diodes whereas NPN silicon phototransistors were used as light detectors. The electronic components were molded into square package and poured with silicone. Such preparation produced an elastic superficies that allowed excellent attachment of the sensor on the skins surface. Moreover, a serial connection of infrared diodes and phototransistors completely eliminated signal artifacts caused by minor muscle contractions. The sensor recording performances were examined at the photoplethysmographic sites on three different arteries; the commune carotid, femoral and radial and, on each site the sensor demonstrated remarkable capability to make a consistent, reproducible measurements. Because of the advantageous physical and electrical properties, the new sensor is suitable for various cardiovascular diagnostics procedures, especially when long-term measurements of arterial blood flow waveform are required, for monitoring of different parameters in cardiovascular units and for research.",
journal = "Biomedical Microdevices",
title = "An improved design of optical sensor for long-term measurement of arterial blood flow waveform",
volume = "19",
number = "3",
doi = "10.1007/s10544-017-0196-x"
}

Đurić, B., Suzić, S., Stojadinović, B., Nestorović, Z., Ivanović, M. D., Suzić-Lazić, J., Nešić, D., Mazić, S., Tenne, T., Zikich, D.,& Žikić, D.. (2017). An improved design of optical sensor for long-term measurement of arterial blood flow waveform. in Biomedical Microdevices, 19(3).
https://doi.org/10.1007/s10544-017-0196-x

Đurić B, Suzić S, Stojadinović B, Nestorović Z, Ivanović MD, Suzić-Lazić J, Nešić D, Mazić S, Tenne T, Zikich D, Žikić D. An improved design of optical sensor for long-term measurement of arterial blood flow waveform. in Biomedical Microdevices. 2017;19(3).
doi:10.1007/s10544-017-0196-x .

Đurić, Biljana, Suzić, Slavica, Stojadinović, Bojana, Nestorović, Zorica, Ivanović, Marija D., Suzić-Lazić, Jelena, Nešić, Dejan, Mazić, Sanja, Tenne, Tamar, Zikich, Dragoslav, Žikić, Dejan, "An improved design of optical sensor for long-term measurement of arterial blood flow waveform" in Biomedical Microdevices, 19, no. 3 (2017),
https://doi.org/10.1007/s10544-017-0196-x . .

TY  - JOUR
AU  - Stevanović, Darko
AU  - Starčević, Vesna
AU  - Vilimanovich, Urosh
AU  - Nešić, Dejan
AU  - Vucicevic, Ljubica
AU  - Misirkić, Maja
AU  - Janjetović, Kristina D.
AU  - Savić, Emina
AU  - Popadic, Dusan
AU  - Sudar, Emina
AU  - Micic, Dragan
AU  - Šumarac-Dumanović, Mirjana
AU  - Trajković, Vladimir S.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4590
AB  - We investigated the effects of centrally administered orexigenic hormone ghrelin on energy imbalance-induced inflammation. Rats were subjected for four weeks to three different dietary regimes: normal (standard food), high-fat (standard food with 30% lard) or food-restricted (70%, 50%, 40% and 40% of the expected food intake in 1st, 2nd, 3rd and 4th week, respectively). Compared to normal-weight controls, starved, but not obese rats had significantly higher levels of proinflammatory cytokines (TNF, IL-1 beta, IFN-gamma) in the blood. When compared to normally fed animals, the hearts of starved and obese animals expressed higher levels of mRNAs encoding proinflammatory mediators (TNF, IL-1 beta, IL-6, IFN-gamma, IL-17, IL-12, iNOS), while mRNA levels of the anti-inflammatory TGF-beta remained unchanged. Intracerebroventricular (ICV) injection of ghrelin (1 mu g/day) for five consecutive days significantly reduced TNF, IL-1 beta and IFN-gamma levels in the blood of starved rats, as well as TNF, IL-17 and IL-12p40 mRNA expression in the hearts of obese rats. Conversely, ICV ghrelin increased the levels of 1FN-gamma, IL-17,1L-12p35 and IL-12p40 mRNA in the heart tissue of food-restricted animals. This was associated with an increase of immunosuppressive ACTH/corticosterone production in starved animals and a decrease of the immunostimulatory adipokine leptin both in food-restricted and high-fat groups. Ghrelin activated the energy sensor AMP-activated protein kinase (AMPK) in the hypothalamus and inhibited extracellular signal-regulated kinase (ERK) in the hearts of obese, but not starved rats. Therefore, central ghrelin may play a complex role in energy imbalance-induced inflammation by modulating HPA axis, leptin and AMPK/ERK signaling pathways. (C) 2011 Elsevier Inc. All rights reserved.
T2  - Brain Behavior and Immunity
T1  - Immunomodulatory actions of central ghrelin in diet-induced energy imbalance
VL  - 26
IS  - 1
SP  - 150
EP  - 158
DO  - 10.1016/j.bbi.2011.08.009
ER  - 

@article{
author = "Stevanović, Darko and Starčević, Vesna and Vilimanovich, Urosh and Nešić, Dejan and Vucicevic, Ljubica and Misirkić, Maja and Janjetović, Kristina D. and Savić, Emina and Popadic, Dusan and Sudar, Emina and Micic, Dragan and Šumarac-Dumanović, Mirjana and Trajković, Vladimir S.",
year = "2012",
abstract = "We investigated the effects of centrally administered orexigenic hormone ghrelin on energy imbalance-induced inflammation. Rats were subjected for four weeks to three different dietary regimes: normal (standard food), high-fat (standard food with 30% lard) or food-restricted (70%, 50%, 40% and 40% of the expected food intake in 1st, 2nd, 3rd and 4th week, respectively). Compared to normal-weight controls, starved, but not obese rats had significantly higher levels of proinflammatory cytokines (TNF, IL-1 beta, IFN-gamma) in the blood. When compared to normally fed animals, the hearts of starved and obese animals expressed higher levels of mRNAs encoding proinflammatory mediators (TNF, IL-1 beta, IL-6, IFN-gamma, IL-17, IL-12, iNOS), while mRNA levels of the anti-inflammatory TGF-beta remained unchanged. Intracerebroventricular (ICV) injection of ghrelin (1 mu g/day) for five consecutive days significantly reduced TNF, IL-1 beta and IFN-gamma levels in the blood of starved rats, as well as TNF, IL-17 and IL-12p40 mRNA expression in the hearts of obese rats. Conversely, ICV ghrelin increased the levels of 1FN-gamma, IL-17,1L-12p35 and IL-12p40 mRNA in the heart tissue of food-restricted animals. This was associated with an increase of immunosuppressive ACTH/corticosterone production in starved animals and a decrease of the immunostimulatory adipokine leptin both in food-restricted and high-fat groups. Ghrelin activated the energy sensor AMP-activated protein kinase (AMPK) in the hypothalamus and inhibited extracellular signal-regulated kinase (ERK) in the hearts of obese, but not starved rats. Therefore, central ghrelin may play a complex role in energy imbalance-induced inflammation by modulating HPA axis, leptin and AMPK/ERK signaling pathways. (C) 2011 Elsevier Inc. All rights reserved.",
journal = "Brain Behavior and Immunity",
title = "Immunomodulatory actions of central ghrelin in diet-induced energy imbalance",
volume = "26",
number = "1",
pages = "150-158",
doi = "10.1016/j.bbi.2011.08.009"
}

Stevanović, D., Starčević, V., Vilimanovich, U., Nešić, D., Vucicevic, L., Misirkić, M., Janjetović, K. D., Savić, E., Popadic, D., Sudar, E., Micic, D., Šumarac-Dumanović, M.,& Trajković, V. S.. (2012). Immunomodulatory actions of central ghrelin in diet-induced energy imbalance. in Brain Behavior and Immunity, 26(1), 150-158.
https://doi.org/10.1016/j.bbi.2011.08.009

Stevanović D, Starčević V, Vilimanovich U, Nešić D, Vucicevic L, Misirkić M, Janjetović KD, Savić E, Popadic D, Sudar E, Micic D, Šumarac-Dumanović M, Trajković VS. Immunomodulatory actions of central ghrelin in diet-induced energy imbalance. in Brain Behavior and Immunity. 2012;26(1):150-158.
doi:10.1016/j.bbi.2011.08.009 .

Stevanović, Darko, Starčević, Vesna, Vilimanovich, Urosh, Nešić, Dejan, Vucicevic, Ljubica, Misirkić, Maja, Janjetović, Kristina D., Savić, Emina, Popadic, Dusan, Sudar, Emina, Micic, Dragan, Šumarac-Dumanović, Mirjana, Trajković, Vladimir S., "Immunomodulatory actions of central ghrelin in diet-induced energy imbalance" in Brain Behavior and Immunity, 26, no. 1 (2012):150-158,
https://doi.org/10.1016/j.bbi.2011.08.009 . .