TY  - JOUR
AU  - Hollo, B. Barta
AU  - Magyari, J.
AU  - Armaković, Sanja J.
AU  - Bogdanović, Goran A.
AU  - Rodic, M. V.
AU  - Armaković, Sanja J.
AU  - Molnar, J.
AU  - Spengler, G.
AU  - Leovac, Vukadin M.
AU  - Szecsenyi, K. Meszaros
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7115
AB  - A new hydrazone-type ligand with a five N-donor set and its coordination compounds with Co(III), Ni(II), Cu(II) and Zn(II) metal centres were synthesized. The crystal and molecular structure of the Co(III) complex was determined by X-ray structural analysis. All the compounds were characterized by elemental analysis, molar conductivity and FT-IR spectral data. The cobalt(III) compound is a neutral binuclear complex formed by coordination of two, doubly deprotonated ligand anions as bridges between the Co(III) centres. The metal centres are additionally connected by a peroxido bridge, which was observed for the first time in Co(III) complexes with similar ligands. The other coordination compounds are mononuclear complexes wherein only one doubly deprotonated ligand is coordinated to the central ion in a tetradentate fashion. The structures were theoretically investigated employing density functional theory (DFT) calculations with B3LYP exchange-correlation functional and LACV3P+(d,p) basis sets for the coordination compounds and 6-31+G(d,p) basis set for the ligand. Molecular electrostatic potential (MEP) and average local ionization energy (ALIE) surfaces were calculated to study the reactive properties of the compounds. The thermal behaviour of the compounds was determined by simultaneous thermogravimetric-differential scanning calorimetric (TG-DSC) measurements and the results were correlated to the proposed structures and to calculated MEP/ALIE surfaces. The compounds were tested in vitro for antiproliferative effects on parental (L5178Y) mouse T-cell lymphoma cells, on L5178Y transfected with pHa ABCB1/A retrovirus and for reversal of multidrug resistance (MDR) in tumor cells by flow cytometry. The preliminary measurements showed that the cobalt(III) compound was an effective inhibitor of the ABC transporter PGP drug efflux pump. The ligand was somewhat less effective, the zinc complex had a moderate inhibition activity, whereas the nickel(II) and copper(II) compounds were inactive.
T2  - New Journal of Chemistry
T1  - Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): synthesis, characterization, reactivity assessment and biological evaluation
VL  - 40
IS  - 7
SP  - 5885
EP  - 5895
DO  - 10.1039/c6nj00560h
ER  - 

@article{
author = "Hollo, B. Barta and Magyari, J. and Armaković, Sanja J. and Bogdanović, Goran A. and Rodic, M. V. and Armaković, Sanja J. and Molnar, J. and Spengler, G. and Leovac, Vukadin M. and Szecsenyi, K. Meszaros",
year = "2016",
abstract = "A new hydrazone-type ligand with a five N-donor set and its coordination compounds with Co(III), Ni(II), Cu(II) and Zn(II) metal centres were synthesized. The crystal and molecular structure of the Co(III) complex was determined by X-ray structural analysis. All the compounds were characterized by elemental analysis, molar conductivity and FT-IR spectral data. The cobalt(III) compound is a neutral binuclear complex formed by coordination of two, doubly deprotonated ligand anions as bridges between the Co(III) centres. The metal centres are additionally connected by a peroxido bridge, which was observed for the first time in Co(III) complexes with similar ligands. The other coordination compounds are mononuclear complexes wherein only one doubly deprotonated ligand is coordinated to the central ion in a tetradentate fashion. The structures were theoretically investigated employing density functional theory (DFT) calculations with B3LYP exchange-correlation functional and LACV3P+(d,p) basis sets for the coordination compounds and 6-31+G(d,p) basis set for the ligand. Molecular electrostatic potential (MEP) and average local ionization energy (ALIE) surfaces were calculated to study the reactive properties of the compounds. The thermal behaviour of the compounds was determined by simultaneous thermogravimetric-differential scanning calorimetric (TG-DSC) measurements and the results were correlated to the proposed structures and to calculated MEP/ALIE surfaces. The compounds were tested in vitro for antiproliferative effects on parental (L5178Y) mouse T-cell lymphoma cells, on L5178Y transfected with pHa ABCB1/A retrovirus and for reversal of multidrug resistance (MDR) in tumor cells by flow cytometry. The preliminary measurements showed that the cobalt(III) compound was an effective inhibitor of the ABC transporter PGP drug efflux pump. The ligand was somewhat less effective, the zinc complex had a moderate inhibition activity, whereas the nickel(II) and copper(II) compounds were inactive.",
journal = "New Journal of Chemistry",
title = "Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): synthesis, characterization, reactivity assessment and biological evaluation",
volume = "40",
number = "7",
pages = "5885-5895",
doi = "10.1039/c6nj00560h"
}

Hollo, B. B., Magyari, J., Armaković, S. J., Bogdanović, G. A., Rodic, M. V., Armaković, S. J., Molnar, J., Spengler, G., Leovac, V. M.,& Szecsenyi, K. M.. (2016). Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): synthesis, characterization, reactivity assessment and biological evaluation. in New Journal of Chemistry, 40(7), 5885-5895.
https://doi.org/10.1039/c6nj00560h

Hollo BB, Magyari J, Armaković SJ, Bogdanović GA, Rodic MV, Armaković SJ, Molnar J, Spengler G, Leovac VM, Szecsenyi KM. Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): synthesis, characterization, reactivity assessment and biological evaluation. in New Journal of Chemistry. 2016;40(7):5885-5895.
doi:10.1039/c6nj00560h .

Hollo, B. Barta, Magyari, J., Armaković, Sanja J., Bogdanović, Goran A., Rodic, M. V., Armaković, Sanja J., Molnar, J., Spengler, G., Leovac, Vukadin M., Szecsenyi, K. Meszaros, "Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): synthesis, characterization, reactivity assessment and biological evaluation" in New Journal of Chemistry, 40, no. 7 (2016):5885-5895,
https://doi.org/10.1039/c6nj00560h . .

TY  - JOUR
AU  - Hollo, Berta
AU  - Magyari, Jozsef
AU  - Ivkovic-Radovanovic, Vukosava
AU  - Vučković, Gordana
AU  - Tomić, Zoran D.
AU  - Szilagyi, Imre Miklos
AU  - Pokol, Gyorgy
AU  - Szecsenyi, Katalin Meszaros
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/100
AB  - Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine (Hz(2)DAP) ligand with Ni-II, Co-III, Cu-II and Zn-II metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz(2)DAP and the obtained complexes [Co(Hz(2)DAP-H)Cl-2]center dot MeOH, [Ni(Hz(2)DAP-H)]Cl center dot MeOH, [Cu(Hz(2)DAP-H)Cl] and [Zn(Hz(2)DAP-2H)]center dot H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with Ni-II, Co-III and Cu-II show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz(2)DAP-2H)]center dot H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II
VL  - 80
IS  - SI
SP  - 142
EP  - 150
DO  - 10.1016/j.poly.2014.03.007
ER  - 

@article{
author = "Hollo, Berta and Magyari, Jozsef and Ivkovic-Radovanovic, Vukosava and Vučković, Gordana and Tomić, Zoran D. and Szilagyi, Imre Miklos and Pokol, Gyorgy and Szecsenyi, Katalin Meszaros",
year = "2014",
abstract = "Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine (Hz(2)DAP) ligand with Ni-II, Co-III, Cu-II and Zn-II metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz(2)DAP and the obtained complexes [Co(Hz(2)DAP-H)Cl-2]center dot MeOH, [Ni(Hz(2)DAP-H)]Cl center dot MeOH, [Cu(Hz(2)DAP-H)Cl] and [Zn(Hz(2)DAP-2H)]center dot H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with Ni-II, Co-III and Cu-II show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz(2)DAP-2H)]center dot H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II",
volume = "80",
number = "SI",
pages = "142-150",
doi = "10.1016/j.poly.2014.03.007"
}

Hollo, B., Magyari, J., Ivkovic-Radovanovic, V., Vučković, G., Tomić, Z. D., Szilagyi, I. M., Pokol, G.,& Szecsenyi, K. M.. (2014). Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II. in Polyhedron, 80(SI), 142-150.
https://doi.org/10.1016/j.poly.2014.03.007

Hollo B, Magyari J, Ivkovic-Radovanovic V, Vučković G, Tomić ZD, Szilagyi IM, Pokol G, Szecsenyi KM. Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II. in Polyhedron. 2014;80(SI):142-150.
doi:10.1016/j.poly.2014.03.007 .

Hollo, Berta, Magyari, Jozsef, Ivkovic-Radovanovic, Vukosava, Vučković, Gordana, Tomić, Zoran D., Szilagyi, Imre Miklos, Pokol, Gyorgy, Szecsenyi, Katalin Meszaros, "Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II" in Polyhedron, 80, no. SI (2014):142-150,
https://doi.org/10.1016/j.poly.2014.03.007 . .