TY  - JOUR
AU  - Ganesan, Minu Karthika
AU  - Jovanović, Miloš
AU  - Šećerov, Bojana Lj.
AU  - Ignjatović, Marija
AU  - Bilban, Martin
AU  - Anđus, Pavle R.
AU  - El Refaei, Amal
AU  - Jung, Gangsoo
AU  - Li, Lin
AU  - Sase, Ajinkya
AU  - Chen, Weiqiang
AU  - Bačić, Goran
AU  - Lubec, Gert
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/133
T2  - Amino Acids
T1  - Erratum to: Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat (vol 46, pg 1681, 2014)
VL  - 46
IS  - 10
SP  - 2445
EP  - 2445
DO  - 10.1007/s00726-014-1791-2
ER  - 

@article{
author = "Ganesan, Minu Karthika and Jovanović, Miloš and Šećerov, Bojana Lj. and Ignjatović, Marija and Bilban, Martin and Anđus, Pavle R. and El Refaei, Amal and Jung, Gangsoo and Li, Lin and Sase, Ajinkya and Chen, Weiqiang and Bačić, Goran and Lubec, Gert",
year = "2014",
journal = "Amino Acids",
title = "Erratum to: Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat (vol 46, pg 1681, 2014)",
volume = "46",
number = "10",
pages = "2445-2445",
doi = "10.1007/s00726-014-1791-2"
}

Ganesan, M. K., Jovanović, M., Šećerov, B. Lj., Ignjatović, M., Bilban, M., Anđus, P. R., El Refaei, A., Jung, G., Li, L., Sase, A., Chen, W., Bačić, G.,& Lubec, G.. (2014). Erratum to: Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat (vol 46, pg 1681, 2014). in Amino Acids, 46(10), 2445-2445.
https://doi.org/10.1007/s00726-014-1791-2

Ganesan MK, Jovanović M, Šećerov BL, Ignjatović M, Bilban M, Anđus PR, El Refaei A, Jung G, Li L, Sase A, Chen W, Bačić G, Lubec G. Erratum to: Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat (vol 46, pg 1681, 2014). in Amino Acids. 2014;46(10):2445-2445.
doi:10.1007/s00726-014-1791-2 .

Ganesan, Minu Karthika, Jovanović, Miloš, Šećerov, Bojana Lj., Ignjatović, Marija, Bilban, Martin, Anđus, Pavle R., El Refaei, Amal, Jung, Gangsoo, Li, Lin, Sase, Ajinkya, Chen, Weiqiang, Bačić, Goran, Lubec, Gert, "Erratum to: Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat (vol 46, pg 1681, 2014)" in Amino Acids, 46, no. 10 (2014):2445-2445,
https://doi.org/10.1007/s00726-014-1791-2 . .

TY  - JOUR
AU  - Ganesan, Minu Karthika
AU  - Jovanović, Miloš
AU  - Šećerov, Bojana Lj.
AU  - Ignjatović, Marija
AU  - Bilban, Martin
AU  - Anđus, Pavle R.
AU  - El Refaei, Amal
AU  - Jung, Gangsoo
AU  - Li, Lin
AU  - Sase, Ajinkya
AU  - Chen, Weiqiang
AU  - Bačić, Goran
AU  - Lubec, Gert
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6052
AB  - GL2011 is a naturally occurring thiol compound and a series of thiol compounds have been proposed as radioprotectors. Radioprotective efficacy of a triple intraperitoneal dose of GL2011 of 100 mg/kg body weight of Wistar rats, 30 min prior to and 3 and 6 h following irradiation (6.7 Gy) was evaluated. Four groups of animals were used, vehicle-treated non-irradiated (VN), GL2011-treated and irradiated (GI), GL2011-treated and non-irradiated (GN) and vehicle-treated and irradiated (VI) (n = 30 per group). The radioprotective efficacy of GL2011 was determined by measuring 28-day survival and intestinal crypt cell survival. Neuroprotection in terms of behaviour was evaluated using the behavioural observational battery, open field test and elevated plus maze paradigm. An RNA microarray was carried out in order to show differences at the RNA level between VI and VN groups. Brain protein changes were identified using a gel-based proteomics method and major brain receptor complex levels were determined by blue-native gels followed by immunoblotting. 28-Day survival rate in VI was 30 %, in GI survival was 93 %, survival of VN and GN was 100 %. Jejunal crypt cell survival was significantly enhanced in GI. Protein-level changes of peroxiredoxin-5, Mn-superoxide dismutase 2, voltage-dependent anion-selective channel protein 1, septin 5 and dopamine D2 receptor complex levels were paralleling radiation damage and protection. Taken together, the findings demonstrate that GL2011 improves survival rates and jejunal crypt survival, provides partial neuroprotection at the behavioural level and modulates proteins known to be involved in protection against oxidative stress-mediated cell damage.
T2  - Amino Acids
T1  - Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat
VL  - 46
IS  - 7
SP  - 1681
EP  - 1696
DO  - 10.1007/s00726-014-1728-9
ER  - 

@article{
author = "Ganesan, Minu Karthika and Jovanović, Miloš and Šećerov, Bojana Lj. and Ignjatović, Marija and Bilban, Martin and Anđus, Pavle R. and El Refaei, Amal and Jung, Gangsoo and Li, Lin and Sase, Ajinkya and Chen, Weiqiang and Bačić, Goran and Lubec, Gert",
year = "2014",
abstract = "GL2011 is a naturally occurring thiol compound and a series of thiol compounds have been proposed as radioprotectors. Radioprotective efficacy of a triple intraperitoneal dose of GL2011 of 100 mg/kg body weight of Wistar rats, 30 min prior to and 3 and 6 h following irradiation (6.7 Gy) was evaluated. Four groups of animals were used, vehicle-treated non-irradiated (VN), GL2011-treated and irradiated (GI), GL2011-treated and non-irradiated (GN) and vehicle-treated and irradiated (VI) (n = 30 per group). The radioprotective efficacy of GL2011 was determined by measuring 28-day survival and intestinal crypt cell survival. Neuroprotection in terms of behaviour was evaluated using the behavioural observational battery, open field test and elevated plus maze paradigm. An RNA microarray was carried out in order to show differences at the RNA level between VI and VN groups. Brain protein changes were identified using a gel-based proteomics method and major brain receptor complex levels were determined by blue-native gels followed by immunoblotting. 28-Day survival rate in VI was 30 %, in GI survival was 93 %, survival of VN and GN was 100 %. Jejunal crypt cell survival was significantly enhanced in GI. Protein-level changes of peroxiredoxin-5, Mn-superoxide dismutase 2, voltage-dependent anion-selective channel protein 1, septin 5 and dopamine D2 receptor complex levels were paralleling radiation damage and protection. Taken together, the findings demonstrate that GL2011 improves survival rates and jejunal crypt survival, provides partial neuroprotection at the behavioural level and modulates proteins known to be involved in protection against oxidative stress-mediated cell damage.",
journal = "Amino Acids",
title = "Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat",
volume = "46",
number = "7",
pages = "1681-1696",
doi = "10.1007/s00726-014-1728-9"
}

Ganesan, M. K., Jovanović, M., Šećerov, B. Lj., Ignjatović, M., Bilban, M., Anđus, P. R., El Refaei, A., Jung, G., Li, L., Sase, A., Chen, W., Bačić, G.,& Lubec, G.. (2014). Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat. in Amino Acids, 46(7), 1681-1696.
https://doi.org/10.1007/s00726-014-1728-9

Ganesan MK, Jovanović M, Šećerov BL, Ignjatović M, Bilban M, Anđus PR, El Refaei A, Jung G, Li L, Sase A, Chen W, Bačić G, Lubec G. Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat. in Amino Acids. 2014;46(7):1681-1696.
doi:10.1007/s00726-014-1728-9 .

Ganesan, Minu Karthika, Jovanović, Miloš, Šećerov, Bojana Lj., Ignjatović, Marija, Bilban, Martin, Anđus, Pavle R., El Refaei, Amal, Jung, Gangsoo, Li, Lin, Sase, Ajinkya, Chen, Weiqiang, Bačić, Goran, Lubec, Gert, "Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat" in Amino Acids, 46, no. 7 (2014):1681-1696,
https://doi.org/10.1007/s00726-014-1728-9 . .