TY  - JOUR
AU  - Batinić, Petar M.
AU  - Đorđević, Verica B.
AU  - Obradović, Nataša
AU  - Krstić, Aleksandar D.
AU  - Stevanović, Sanja I.
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Pjanović, Rada V.
AU  - Mijin, Dušan Ž.
AU  - Bugarski, Branko M.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10851
AB  - Liposome-encapsulated folic acid is incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of CMC and solagum (9:1 w/w) using the film-forming cast solution method. Histidine is used to increase solubility for folic acid in liposomes (1–5 mg mL−1), and propylene glycol is used as a film plasticizer (2.6 mas%). The obtained films (50–60 µm tick) containing 3.12–20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films are scrutinized. Folic acid gives yellow color to the films and contributes to stronger chemical bonds which result in improved strength of the film. Liposomes prolong the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degrade homogeneity of the films, which can be ascribed to its agglomeration within the film matrix as revealed by atomic force microscopy. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg mL−1 liposome-encapsulated folic acid is recommended. Practical Application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.
T2  - European Journal of Lipid Science and Technology
T1  - Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid
SP  - 2200169
DO  - 10.1002/ejlt.202200169
ER  - 

@article{
author = "Batinić, Petar M. and Đorđević, Verica B. and Obradović, Nataša and Krstić, Aleksandar D. and Stevanović, Sanja I. and Balanč, Bojana and Marković, Smilja and Pjanović, Rada V. and Mijin, Dušan Ž. and Bugarski, Branko M.",
year = "2023",
abstract = "Liposome-encapsulated folic acid is incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of CMC and solagum (9:1 w/w) using the film-forming cast solution method. Histidine is used to increase solubility for folic acid in liposomes (1–5 mg mL−1), and propylene glycol is used as a film plasticizer (2.6 mas%). The obtained films (50–60 µm tick) containing 3.12–20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films are scrutinized. Folic acid gives yellow color to the films and contributes to stronger chemical bonds which result in improved strength of the film. Liposomes prolong the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degrade homogeneity of the films, which can be ascribed to its agglomeration within the film matrix as revealed by atomic force microscopy. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg mL−1 liposome-encapsulated folic acid is recommended. Practical Application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.",
journal = "European Journal of Lipid Science and Technology",
title = "Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid",
pages = "2200169",
doi = "10.1002/ejlt.202200169"
}

Batinić, P. M., Đorđević, V. B., Obradović, N., Krstić, A. D., Stevanović, S. I., Balanč, B., Marković, S., Pjanović, R. V., Mijin, D. Ž.,& Bugarski, B. M.. (2023). Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. in European Journal of Lipid Science and Technology, 2200169.
https://doi.org/10.1002/ejlt.202200169

Batinić PM, Đorđević VB, Obradović N, Krstić AD, Stevanović SI, Balanč B, Marković S, Pjanović RV, Mijin DŽ, Bugarski BM. Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. in European Journal of Lipid Science and Technology. 2023;:2200169.
doi:10.1002/ejlt.202200169 .

Batinić, Petar M., Đorđević, Verica B., Obradović, Nataša, Krstić, Aleksandar D., Stevanović, Sanja I., Balanč, Bojana, Marković, Smilja, Pjanović, Rada V., Mijin, Dušan Ž., Bugarski, Branko M., "Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid" in European Journal of Lipid Science and Technology (2023):2200169,
https://doi.org/10.1002/ejlt.202200169 . .

TY  - JOUR
AU  - Dimić, Ivana 
AU  - Cvijović-Alagić, Ivana
AU  - Voelker, Bernhard
AU  - Hohenwarter, Anton
AU  - Pippan, Reinhard
AU  - Veljović, Đorđe N.
AU  - Rakin, Marko P.
AU  - Bugarski, Branko M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/871
AB  - Significant enhancement of mechanical properties of metallic biomaterials can be achieved by grain refinement obtained by severe plastic deformation. The purpose of this study was to determine metallic ion release from commercially pure titanium (CPTi) and Ti-13Nb-13Zr alloy processed by high pressure torsion (HPT). The materials microstructures, in the initial state and after HPT deformation, were examined by scanning and transmission electron microscopy. The microhardness was determined along the radius of the disc-shaped samples of ultrafine-grained (UFG) CPTi and Ti-13Nb-13Zr alloy in order to evaluate homogeneity of HPT-processed materials. The quantities of released ions were determined using inductively coupled plasma-mass spectrophotometer for samples immersed in artificial saliva at 37 degrees C for 7 days. Also, the effect of artificial saliva pH value on metallic ion release was estimated. Obtained results revealed that the quantities of released ions from UFG CPTi and Ti-13Nb-13Zr alloy obtained by HPT process were higher than the quantities of released ions from CPTi and Ti-13Nb-13Zr alloy produced by traditional casting. This behavior can be explained by the fact that metallic ions are easily released from microstructure with smaller grains achieved by HPT process. (C) 2015 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Materials and Design
T1  - Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion
VL  - 91
SP  - 340
EP  - 347
DO  - 10.1016/j.matdes.2015.11.088
ER  - 

@article{
author = "Dimić, Ivana  and Cvijović-Alagić, Ivana and Voelker, Bernhard and Hohenwarter, Anton and Pippan, Reinhard and Veljović, Đorđe N. and Rakin, Marko P. and Bugarski, Branko M.",
year = "2016",
abstract = "Significant enhancement of mechanical properties of metallic biomaterials can be achieved by grain refinement obtained by severe plastic deformation. The purpose of this study was to determine metallic ion release from commercially pure titanium (CPTi) and Ti-13Nb-13Zr alloy processed by high pressure torsion (HPT). The materials microstructures, in the initial state and after HPT deformation, were examined by scanning and transmission electron microscopy. The microhardness was determined along the radius of the disc-shaped samples of ultrafine-grained (UFG) CPTi and Ti-13Nb-13Zr alloy in order to evaluate homogeneity of HPT-processed materials. The quantities of released ions were determined using inductively coupled plasma-mass spectrophotometer for samples immersed in artificial saliva at 37 degrees C for 7 days. Also, the effect of artificial saliva pH value on metallic ion release was estimated. Obtained results revealed that the quantities of released ions from UFG CPTi and Ti-13Nb-13Zr alloy obtained by HPT process were higher than the quantities of released ions from CPTi and Ti-13Nb-13Zr alloy produced by traditional casting. This behavior can be explained by the fact that metallic ions are easily released from microstructure with smaller grains achieved by HPT process. (C) 2015 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Materials and Design",
title = "Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion",
volume = "91",
pages = "340-347",
doi = "10.1016/j.matdes.2015.11.088"
}

Dimić, I., Cvijović-Alagić, I., Voelker, B., Hohenwarter, A., Pippan, R., Veljović, Đ. N., Rakin, M. P.,& Bugarski, B. M.. (2016). Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion. in Materials and Design
Elsevier., 91, 340-347.
https://doi.org/10.1016/j.matdes.2015.11.088

Dimić I, Cvijović-Alagić I, Voelker B, Hohenwarter A, Pippan R, Veljović ĐN, Rakin MP, Bugarski BM. Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion. in Materials and Design. 2016;91:340-347.
doi:10.1016/j.matdes.2015.11.088 .

Dimić, Ivana , Cvijović-Alagić, Ivana, Voelker, Bernhard, Hohenwarter, Anton, Pippan, Reinhard, Veljović, Đorđe N., Rakin, Marko P., Bugarski, Branko M., "Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion" in Materials and Design, 91 (2016):340-347,
https://doi.org/10.1016/j.matdes.2015.11.088 . .

TY  - JOUR
AU  - Dimić, Ivana 
AU  - Cvijović-Alagić, Ivana
AU  - Obradović, Nataša
AU  - Petrović, Jelena
AU  - Putić, Slaviša S.
AU  - Rakin, Marko P.
AU  - Bugarski, Branko M.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/870
AB  - Metallic materials, such as Co-Cr-Mo alloys, are exposed to aggressive conditions in the oral cavity that represents an ideal environment for metallic ion release and biodegradation. The metallic ions released from dental materials can cause local and/or systemic adverse effects in the human body. Therefore, dental materials are required to possess appropriate mechanical, physical, chemical and biological properties. The biocompatibility of metallic materials is very important for dental applications. Accordingly, the aim of this study was to examine metallic ion release and cytotoxicity of Co-30Cr-5Mo cast alloy as the initial phase of biocompatibility evaluation. Determination of the viability of human (MRC-5) and animal (L929) fibroblast cells were conducted using three in vitro test methods: the colorimetric methyl-thiazol-tetrazolium (MTT) test, the dye exclusion test (DET) and the agar diffusion test (ADT). Furthermore, the morphology and growth of the cells were analyzed using scanning electron microscopy (SEM). The obtained results indicated that Co-30Cr-5Mo alloy did not release harmful elements in concentrations high enough to have detrimental effects on human and animal fibroblasts under the given experimental conditions. Moreover, the fibroblast cells showed good adhesion on the surface of the Co-30Cr-5Mo alloy. Therefore, it could be concluded that Co-30Cr-5Mo alloy is a biocompatible material that could be safely used in dentistry.
T2  - Journal of the Serbian Chemical Society
T1  - In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy
VL  - 80
IS  - 12
SP  - 1541
EP  - 1552
DO  - 10.2298/JSC150505070M
ER  - 

@article{
author = "Dimić, Ivana  and Cvijović-Alagić, Ivana and Obradović, Nataša and Petrović, Jelena and Putić, Slaviša S. and Rakin, Marko P. and Bugarski, Branko M.",
year = "2015",
abstract = "Metallic materials, such as Co-Cr-Mo alloys, are exposed to aggressive conditions in the oral cavity that represents an ideal environment for metallic ion release and biodegradation. The metallic ions released from dental materials can cause local and/or systemic adverse effects in the human body. Therefore, dental materials are required to possess appropriate mechanical, physical, chemical and biological properties. The biocompatibility of metallic materials is very important for dental applications. Accordingly, the aim of this study was to examine metallic ion release and cytotoxicity of Co-30Cr-5Mo cast alloy as the initial phase of biocompatibility evaluation. Determination of the viability of human (MRC-5) and animal (L929) fibroblast cells were conducted using three in vitro test methods: the colorimetric methyl-thiazol-tetrazolium (MTT) test, the dye exclusion test (DET) and the agar diffusion test (ADT). Furthermore, the morphology and growth of the cells were analyzed using scanning electron microscopy (SEM). The obtained results indicated that Co-30Cr-5Mo alloy did not release harmful elements in concentrations high enough to have detrimental effects on human and animal fibroblasts under the given experimental conditions. Moreover, the fibroblast cells showed good adhesion on the surface of the Co-30Cr-5Mo alloy. Therefore, it could be concluded that Co-30Cr-5Mo alloy is a biocompatible material that could be safely used in dentistry.",
journal = "Journal of the Serbian Chemical Society",
title = "In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy",
volume = "80",
number = "12",
pages = "1541-1552",
doi = "10.2298/JSC150505070M"
}

Dimić, I., Cvijović-Alagić, I., Obradović, N., Petrović, J., Putić, S. S., Rakin, M. P.,& Bugarski, B. M.. (2015). In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy. in Journal of the Serbian Chemical Society, 80(12), 1541-1552.
https://doi.org/10.2298/JSC150505070M

Dimić I, Cvijović-Alagić I, Obradović N, Petrović J, Putić SS, Rakin MP, Bugarski BM. In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy. in Journal of the Serbian Chemical Society. 2015;80(12):1541-1552.
doi:10.2298/JSC150505070M .

Dimić, Ivana , Cvijović-Alagić, Ivana, Obradović, Nataša, Petrović, Jelena, Putić, Slaviša S., Rakin, Marko P., Bugarski, Branko M., "In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy" in Journal of the Serbian Chemical Society, 80, no. 12 (2015):1541-1552,
https://doi.org/10.2298/JSC150505070M . .

TY  - JOUR
AU  - Dimić, Ivana 
AU  - Cvijović-Alagić, Ivana
AU  - Kostic, Ivana T.
AU  - Perić-Grujić, Aleksandra A.
AU  - Rakin, Marko P.
AU  - Putić, Slaviša S.
AU  - Bugarski, Branko M.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/310
AB  - Metallic biomaterials, which are mainly used for the damaged hard tissue replacements, are materials with high strength, excellent toughness and good wear resistance. The disadvantages of metals as implant materials are their susceptibility to corrosion, the elastic modulus mismatch between metals and human hard tissues, relatively high density and metallic ion release, which can cause serious health problems. The aim of this study was to examine metallic ion release from Co-Cr-Mo alloy in artificial saliva. In that purpose, alloy samples were immersed into artificial saliva with different pH values (4.0, 5.5 and 7.5). After a certain immersion period (1, 3 and 6 weeks) the concentrations of released ions were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The research findings were used in order to define the dependence between the concentration of released metallic ions, artificial saliva pH values and immersion time. The determined released metallic ions concentrations were compared with literature data in order to describe and better understand the phenomenon of metallic ion release from the biocom-patible cobalt-based alloy.
AB  - Metalni biomaterijali, koji se najčešće koriste za zamenu oštećenih čvrstih tkiva u organizmu čoveka, su materijali velike čvrstoće, žilavosti i otpornosti prema habanju. Nedostaci metala, kao implantnih materijala, su njihova podložnost koroziji, neusklađenost modula elastičnosti metala i čvrstih ljudskih tkiva, velika gustina i otpuštanje metalnih jona koje može da izazove ozbiljne zdravstvene probleme. Cilj ovog rada je bio da se ispita otpuštanje metalnih jona iz Co-Cr-Mo legure u rastvoru veštačke pljuvačke. Uzorci legure su potopljeni u rastvor veštačke pljuvačke različite pH vrednosti (4,0, 5,5 i 7,5). Nakon određenog vremena izlaganja legure veštačkoj pljuvačci (1, 3 i 6 nedelja) određene su koncentracije otpuštenih jona primenom indukcije spregnute plazme sa masenom spektrometrijom (ICP-MS). Dobijeni rezultati su iskorišćeni u cilju definisanja zavisnosti između koncentracije otpuštenih jona, pH vrednosti veštačke pljuvačke i dužine potapanja legure u rastvor veštačke pljuvačke. Osim toga, utvrđene koncentracije otpuštenih metalnih jona iz ispitivane legure su upoređene sa podacima dostupnim u literaturi u cilju što boljeg opisivanja i razumevanja fenomena otpuštanja metalnih jona iz biokompatibilne Co-Cr-Mo legure.
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Metallic Ion Release from Biocompatible Cobalt-Based Alloy
VL  - 20
IS  - 4
SP  - 571
EP  - 577
DO  - 10.2298/CICEQ130813039D
ER  - 

@article{
author = "Dimić, Ivana  and Cvijović-Alagić, Ivana and Kostic, Ivana T. and Perić-Grujić, Aleksandra A. and Rakin, Marko P. and Putić, Slaviša S. and Bugarski, Branko M.",
year = "2014",
abstract = "Metallic biomaterials, which are mainly used for the damaged hard tissue replacements, are materials with high strength, excellent toughness and good wear resistance. The disadvantages of metals as implant materials are their susceptibility to corrosion, the elastic modulus mismatch between metals and human hard tissues, relatively high density and metallic ion release, which can cause serious health problems. The aim of this study was to examine metallic ion release from Co-Cr-Mo alloy in artificial saliva. In that purpose, alloy samples were immersed into artificial saliva with different pH values (4.0, 5.5 and 7.5). After a certain immersion period (1, 3 and 6 weeks) the concentrations of released ions were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The research findings were used in order to define the dependence between the concentration of released metallic ions, artificial saliva pH values and immersion time. The determined released metallic ions concentrations were compared with literature data in order to describe and better understand the phenomenon of metallic ion release from the biocom-patible cobalt-based alloy., Metalni biomaterijali, koji se najčešće koriste za zamenu oštećenih čvrstih tkiva u organizmu čoveka, su materijali velike čvrstoće, žilavosti i otpornosti prema habanju. Nedostaci metala, kao implantnih materijala, su njihova podložnost koroziji, neusklađenost modula elastičnosti metala i čvrstih ljudskih tkiva, velika gustina i otpuštanje metalnih jona koje može da izazove ozbiljne zdravstvene probleme. Cilj ovog rada je bio da se ispita otpuštanje metalnih jona iz Co-Cr-Mo legure u rastvoru veštačke pljuvačke. Uzorci legure su potopljeni u rastvor veštačke pljuvačke različite pH vrednosti (4,0, 5,5 i 7,5). Nakon određenog vremena izlaganja legure veštačkoj pljuvačci (1, 3 i 6 nedelja) određene su koncentracije otpuštenih jona primenom indukcije spregnute plazme sa masenom spektrometrijom (ICP-MS). Dobijeni rezultati su iskorišćeni u cilju definisanja zavisnosti između koncentracije otpuštenih jona, pH vrednosti veštačke pljuvačke i dužine potapanja legure u rastvor veštačke pljuvačke. Osim toga, utvrđene koncentracije otpuštenih metalnih jona iz ispitivane legure su upoređene sa podacima dostupnim u literaturi u cilju što boljeg opisivanja i razumevanja fenomena otpuštanja metalnih jona iz biokompatibilne Co-Cr-Mo legure.",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Metallic Ion Release from Biocompatible Cobalt-Based Alloy",
volume = "20",
number = "4",
pages = "571-577",
doi = "10.2298/CICEQ130813039D"
}

Dimić, I., Cvijović-Alagić, I., Kostic, I. T., Perić-Grujić, A. A., Rakin, M. P., Putić, S. S.,& Bugarski, B. M.. (2014). Metallic Ion Release from Biocompatible Cobalt-Based Alloy. in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 20(4), 571-577.
https://doi.org/10.2298/CICEQ130813039D

Dimić I, Cvijović-Alagić I, Kostic IT, Perić-Grujić AA, Rakin MP, Putić SS, Bugarski BM. Metallic Ion Release from Biocompatible Cobalt-Based Alloy. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2014;20(4):571-577.
doi:10.2298/CICEQ130813039D .

Dimić, Ivana , Cvijović-Alagić, Ivana, Kostic, Ivana T., Perić-Grujić, Aleksandra A., Rakin, Marko P., Putić, Slaviša S., Bugarski, Branko M., "Metallic Ion Release from Biocompatible Cobalt-Based Alloy" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 20, no. 4 (2014):571-577,
https://doi.org/10.2298/CICEQ130813039D . .

TY  - JOUR
AU  - Lević, Steva
AU  - Obradović, Nina
AU  - Pavlović, Vladimir B.
AU  - Isailovic, Bojana
AU  - Kostic, Ivana
AU  - Mitrić, Miodrag
AU  - Bugarski, Branko M.
AU  - Nedovic, Viktor
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/183
AB  - In this study, polyvinyl alcohol (PVA) nanofibers with ethyl vanillin as an active compound were prepared using electrospinning technique. The final products of electrospinning process were in the form of nanofibers films. PVA/ethyl vanillin nanofibers, having fibers diameters in the range 100-1700 nm, were successfully electrospun from ethanol/water mixture of PVA and ethyl vanillin. The effects of immobilization process on ethyl vanillin thermal properties were investigated by differential scanning calorimetry (DSC). The results of DSC showed significant influence of immobilization process on thermal properties of ethyl vanillin. It was noticed that melting point of immobilized ethyl vanillin was lower (similar to 55 A degrees C) compared to free flavor (similar to 77 A degrees C). Our results showed that films based on PVA/ethyl vanillin nanofibers are mechanically stable.
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process
VL  - 118
IS  - 2
SP  - 661
EP  - 668
DO  - 10.1007/s10973-014-4060-4
ER  - 

@article{
author = "Lević, Steva and Obradović, Nina and Pavlović, Vladimir B. and Isailovic, Bojana and Kostic, Ivana and Mitrić, Miodrag and Bugarski, Branko M. and Nedovic, Viktor",
year = "2014",
abstract = "In this study, polyvinyl alcohol (PVA) nanofibers with ethyl vanillin as an active compound were prepared using electrospinning technique. The final products of electrospinning process were in the form of nanofibers films. PVA/ethyl vanillin nanofibers, having fibers diameters in the range 100-1700 nm, were successfully electrospun from ethanol/water mixture of PVA and ethyl vanillin. The effects of immobilization process on ethyl vanillin thermal properties were investigated by differential scanning calorimetry (DSC). The results of DSC showed significant influence of immobilization process on thermal properties of ethyl vanillin. It was noticed that melting point of immobilized ethyl vanillin was lower (similar to 55 A degrees C) compared to free flavor (similar to 77 A degrees C). Our results showed that films based on PVA/ethyl vanillin nanofibers are mechanically stable.",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process",
volume = "118",
number = "2",
pages = "661-668",
doi = "10.1007/s10973-014-4060-4"
}

Lević, S., Obradović, N., Pavlović, V. B., Isailovic, B., Kostic, I., Mitrić, M., Bugarski, B. M.,& Nedovic, V.. (2014). Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process. in Journal of Thermal Analysis and Calorimetry, 118(2), 661-668.
https://doi.org/10.1007/s10973-014-4060-4

Lević S, Obradović N, Pavlović VB, Isailovic B, Kostic I, Mitrić M, Bugarski BM, Nedovic V. Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process. in Journal of Thermal Analysis and Calorimetry. 2014;118(2):661-668.
doi:10.1007/s10973-014-4060-4 .

Lević, Steva, Obradović, Nina, Pavlović, Vladimir B., Isailovic, Bojana, Kostic, Ivana, Mitrić, Miodrag, Bugarski, Branko M., Nedovic, Viktor, "Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process" in Journal of Thermal Analysis and Calorimetry, 118, no. 2 (2014):661-668,
https://doi.org/10.1007/s10973-014-4060-4 . .

TY  - JOUR
AU  - Dimić, Ivana
AU  - Cvijović-Alagić, Ivana
AU  - Rakin, Marica
AU  - Perić-Grujić, Aleksandra
AU  - Rakin, Marko
AU  - Bugarski, Branko
AU  - Putić, Slaviša
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11338
AB  - Due to their excellent characteristics, such as chemical inertness, mechanical resistance, low Young's modulus, high corrosion resistance, and outstanding biocompatibility, titanium and its alloys are the most used metallic materials for biomedical applications. In dental practice, these materials have demonstrated success as biomedical devices which are used for repairing and replacing failed hard tissue. However, the oral cavity is constantly subjected to the changes in the pH value changes and such an environment is strongly corrosive for titanium dental implants. The objective of this study was to examine ion release from commercially pure titanium (cpTi) in artificial saliva with different pH values (4.0, 5.5 and 7.5). The concentrations of released titanium ions were determined after 1, 3 and 6 weeks using Inductively Coupled Plasma - Mass Spectrometry. The results indicate that the ion release from commercially pure titanium in the artificial saliva is dependent both on the pH of artificial saliva and duration of immersion.
AB  - Titan i njegove legure su najčešće korišćeni metalni materijali za biomedicinsku primenu zbog njihovih odličnih karakteristika, kao što su hemijska inertnost, mehanička otpornost, nizak Jungov modul, visoka otpornost na koroziju i izvanredna biokompatibilnost. U stomatološkoj praksi, titan i njegove legure su pokazali uspeh kao biomedicinski uređaji, koji se koriste za popravku ili zamenu oštećenih čvrstih tkiva. Međutim, usna duplja je stalno izložena promenama pH vrednosti i takva sredina je izuzetno koroziona za dentalne implantate izrađene od titana. Cilj ovog rada je bio da se ispita otpuštanje jona iz komercijalno čistog titana (cpTi) u veštačkoj pljuvačci različite pH vrednosti (4.0, 5.5 i 7.5). Koncentracije otpuštenih jona titana su određene posle 1, 3 i 6 nedelja korišćenjem induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Rezultati pokazuju da otpuštanje jona iz komercijalno čistog titana zavisi i od pH vrednosti veštačke pljuvačke i od dužine trajanja potapanja.
T2  - Acta periodica technologica
T1  - Effect of the pH of artificial saliva on ion release from commercially pure titanium
T1  - Uticaj pH vrednosti veštačke pljuvačke na otpuštanje jona iz komercijalno čistog titana
IS  - 44
SP  - 207
EP  - 215
DO  - 10.2298/APT1344207D
ER  - 

@article{
author = "Dimić, Ivana and Cvijović-Alagić, Ivana and Rakin, Marica and Perić-Grujić, Aleksandra and Rakin, Marko and Bugarski, Branko and Putić, Slaviša",
year = "2013",
abstract = "Due to their excellent characteristics, such as chemical inertness, mechanical resistance, low Young's modulus, high corrosion resistance, and outstanding biocompatibility, titanium and its alloys are the most used metallic materials for biomedical applications. In dental practice, these materials have demonstrated success as biomedical devices which are used for repairing and replacing failed hard tissue. However, the oral cavity is constantly subjected to the changes in the pH value changes and such an environment is strongly corrosive for titanium dental implants. The objective of this study was to examine ion release from commercially pure titanium (cpTi) in artificial saliva with different pH values (4.0, 5.5 and 7.5). The concentrations of released titanium ions were determined after 1, 3 and 6 weeks using Inductively Coupled Plasma - Mass Spectrometry. The results indicate that the ion release from commercially pure titanium in the artificial saliva is dependent both on the pH of artificial saliva and duration of immersion., Titan i njegove legure su najčešće korišćeni metalni materijali za biomedicinsku primenu zbog njihovih odličnih karakteristika, kao što su hemijska inertnost, mehanička otpornost, nizak Jungov modul, visoka otpornost na koroziju i izvanredna biokompatibilnost. U stomatološkoj praksi, titan i njegove legure su pokazali uspeh kao biomedicinski uređaji, koji se koriste za popravku ili zamenu oštećenih čvrstih tkiva. Međutim, usna duplja je stalno izložena promenama pH vrednosti i takva sredina je izuzetno koroziona za dentalne implantate izrađene od titana. Cilj ovog rada je bio da se ispita otpuštanje jona iz komercijalno čistog titana (cpTi) u veštačkoj pljuvačci različite pH vrednosti (4.0, 5.5 i 7.5). Koncentracije otpuštenih jona titana su određene posle 1, 3 i 6 nedelja korišćenjem induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Rezultati pokazuju da otpuštanje jona iz komercijalno čistog titana zavisi i od pH vrednosti veštačke pljuvačke i od dužine trajanja potapanja.",
journal = "Acta periodica technologica",
title = "Effect of the pH of artificial saliva on ion release from commercially pure titanium, Uticaj pH vrednosti veštačke pljuvačke na otpuštanje jona iz komercijalno čistog titana",
number = "44",
pages = "207-215",
doi = "10.2298/APT1344207D"
}

Dimić, I., Cvijović-Alagić, I., Rakin, M., Perić-Grujić, A., Rakin, M., Bugarski, B.,& Putić, S.. (2013). Effect of the pH of artificial saliva on ion release from commercially pure titanium. in Acta periodica technologica(44), 207-215.
https://doi.org/10.2298/APT1344207D

Dimić I, Cvijović-Alagić I, Rakin M, Perić-Grujić A, Rakin M, Bugarski B, Putić S. Effect of the pH of artificial saliva on ion release from commercially pure titanium. in Acta periodica technologica. 2013;(44):207-215.
doi:10.2298/APT1344207D .

Dimić, Ivana, Cvijović-Alagić, Ivana, Rakin, Marica, Perić-Grujić, Aleksandra, Rakin, Marko, Bugarski, Branko, Putić, Slaviša, "Effect of the pH of artificial saliva on ion release from commercially pure titanium" in Acta periodica technologica, no. 44 (2013):207-215,
https://doi.org/10.2298/APT1344207D . .

TY  - BOOK
AU  - Balać, Igor
AU  - Bugarski, Branko M.
AU  - Ćosić, Irena
AU  - Dramićanin, Miroslav
AU  - Đorđević, Drago
AU  - Filipović, Nenad D.
AU  - Ignjatović, Nenad L.
AU  - Janaćković, Đorđe T.
AU  - Kojić, Miloš
AU  - Manojlović, Verica
AU  - Marković, Zoran M.
AU  - Obradović, Bojana
AU  - Pajić-Lijaković, Ivana
AU  - Pavlović, Miodrag
AU  - Plavšić, Milenko
AU  - Raković, Dejan
AU  - Ranković, Vladimir
AU  - Stojanović, Boban
AU  - Trajković, Vladimir S.
AU  - Uskoković, Dragan
AU  - Uskoković, Petar
AU  - Veljković, Dejan
AU  - Vlastelica, Ivo
AU  - Vunjak Novaković, Gordana
PY  - 2010
UR  - http://dais.sanu.ac.rs/123456789/121
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7344
AB  - Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi.Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci.Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti.Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.
PB  - Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala
T1  - Biomaterijali
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7344
ER  - 

@book{
author = "Balać, Igor and Bugarski, Branko M. and Ćosić, Irena and Dramićanin, Miroslav and Đorđević, Drago and Filipović, Nenad D. and Ignjatović, Nenad L. and Janaćković, Đorđe T. and Kojić, Miloš and Manojlović, Verica and Marković, Zoran M. and Obradović, Bojana and Pajić-Lijaković, Ivana and Pavlović, Miodrag and Plavšić, Milenko and Raković, Dejan and Ranković, Vladimir and Stojanović, Boban and Trajković, Vladimir S. and Uskoković, Dragan and Uskoković, Petar and Veljković, Dejan and Vlastelica, Ivo and Vunjak Novaković, Gordana",
year = "2010",
abstract = "Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi.Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci.Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti.Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.",
publisher = "Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala",
title = "Biomaterijali",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7344"
}

Balać, I., Bugarski, B. M., Ćosić, I., Dramićanin, M., Đorđević, D., Filipović, N. D., Ignjatović, N. L., Janaćković, Đ. T., Kojić, M., Manojlović, V., Marković, Z. M., Obradović, B., Pajić-Lijaković, I., Pavlović, M., Plavšić, M., Raković, D., Ranković, V., Stojanović, B., Trajković, V. S., Uskoković, D., Uskoković, P., Veljković, D., Vlastelica, I.,& Vunjak Novaković, G.. (2010). Biomaterijali. 
Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala..
https://hdl.handle.net/21.15107/rcub_vinar_7344

Balać I, Bugarski BM, Ćosić I, Dramićanin M, Đorđević D, Filipović ND, Ignjatović NL, Janaćković ĐT, Kojić M, Manojlović V, Marković ZM, Obradović B, Pajić-Lijaković I, Pavlović M, Plavšić M, Raković D, Ranković V, Stojanović B, Trajković VS, Uskoković D, Uskoković P, Veljković D, Vlastelica I, Vunjak Novaković G. Biomaterijali. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_7344 .

Balać, Igor, Bugarski, Branko M., Ćosić, Irena, Dramićanin, Miroslav, Đorđević, Drago, Filipović, Nenad D., Ignjatović, Nenad L., Janaćković, Đorđe T., Kojić, Miloš, Manojlović, Verica, Marković, Zoran M., Obradović, Bojana, Pajić-Lijaković, Ivana, Pavlović, Miodrag, Plavšić, Milenko, Raković, Dejan, Ranković, Vladimir, Stojanović, Boban, Trajković, Vladimir S., Uskoković, Dragan, Uskoković, Petar, Veljković, Dejan, Vlastelica, Ivo, Vunjak Novaković, Gordana, "Biomaterijali" (2010),
https://hdl.handle.net/21.15107/rcub_vinar_7344 .