TY  - JOUR
AU  - Dugalić, Predrag
AU  - Đuranović, Srđan
AU  - Pavlović-Marković, Aleksandra
AU  - Dugalić, Vladimir
AU  - Tomašević, Ratko
AU  - Gluvić, Zoran
AU  - Obradović, Milan M.
AU  - Bajić, Vladan P.
AU  - Isenović, Esma R.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9104
AB  - Gastroesophageal Reflux Disease (GERD) is characterized by acid and bile reflux in the dis-tal oesophagus, and this may cause the development of reflux esophagitis and Barrett’s oesophagus (BE). The natural histological course of untreated BE is non-dysplastic or benign BE (ND), then low-grade (LGD) and High-Grade Dysplastic (HGD) BE, with the expected increase in malignancy transfer to oesophagal adenocarcinoma (EAC). The gold standard for BE diagnostics involves high-resolution white-light endoscopy, followed by uniform endoscopy findings description (Prague classification) with biopsy performance according to Seattle protocol. The medical treatment of GERD and BE includes the use of proton pump inhibitors (PPIs) regarding symptoms control. It is noteworthy that long-term use of PPIs increases gastrin level, which can contribute to transfer from BE to EAC, as a result of its effects on the proliferation of BE epithelium. Endoscopy treatment includes a wide range of re-section and ablative techniques, such as radio-frequency ablation (RFA), often concomitantly used in everyday endoscopy practice (multimodal therapy). RFA promotes mucosal necrosis of treated oesophagal region via high-frequency energy. Laparoscopic surgery, partial or total fundoplication, is reserved for PPIs and endoscopy indolent patients or in those with progressive disease. This review aims to explain distinct effects of PPIs and RFA modalities, illuminate certain aspects of molecular mechanisms involved, as well as the effects of their concomitant use regarding the treatment of BE and prevention of its transfer to EAC.
T2  - Mini-Reviews in Medicinal Chemistry
T1  - Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus
VL  - 20
IS  - 11
SP  - 975
EP  - 987
DO  - 10.2174/1389557519666191015203636
ER  - 

@article{
author = "Dugalić, Predrag and Đuranović, Srđan and Pavlović-Marković, Aleksandra and Dugalić, Vladimir and Tomašević, Ratko and Gluvić, Zoran and Obradović, Milan M. and Bajić, Vladan P. and Isenović, Esma R.",
year = "2020",
abstract = "Gastroesophageal Reflux Disease (GERD) is characterized by acid and bile reflux in the dis-tal oesophagus, and this may cause the development of reflux esophagitis and Barrett’s oesophagus (BE). The natural histological course of untreated BE is non-dysplastic or benign BE (ND), then low-grade (LGD) and High-Grade Dysplastic (HGD) BE, with the expected increase in malignancy transfer to oesophagal adenocarcinoma (EAC). The gold standard for BE diagnostics involves high-resolution white-light endoscopy, followed by uniform endoscopy findings description (Prague classification) with biopsy performance according to Seattle protocol. The medical treatment of GERD and BE includes the use of proton pump inhibitors (PPIs) regarding symptoms control. It is noteworthy that long-term use of PPIs increases gastrin level, which can contribute to transfer from BE to EAC, as a result of its effects on the proliferation of BE epithelium. Endoscopy treatment includes a wide range of re-section and ablative techniques, such as radio-frequency ablation (RFA), often concomitantly used in everyday endoscopy practice (multimodal therapy). RFA promotes mucosal necrosis of treated oesophagal region via high-frequency energy. Laparoscopic surgery, partial or total fundoplication, is reserved for PPIs and endoscopy indolent patients or in those with progressive disease. This review aims to explain distinct effects of PPIs and RFA modalities, illuminate certain aspects of molecular mechanisms involved, as well as the effects of their concomitant use regarding the treatment of BE and prevention of its transfer to EAC.",
journal = "Mini-Reviews in Medicinal Chemistry",
title = "Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus",
volume = "20",
number = "11",
pages = "975-987",
doi = "10.2174/1389557519666191015203636"
}

Dugalić, P., Đuranović, S., Pavlović-Marković, A., Dugalić, V., Tomašević, R., Gluvić, Z., Obradović, M. M., Bajić, V. P.,& Isenović, E. R.. (2020). Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus. in Mini-Reviews in Medicinal Chemistry, 20(11), 975-987.
https://doi.org/10.2174/1389557519666191015203636

Dugalić P, Đuranović S, Pavlović-Marković A, Dugalić V, Tomašević R, Gluvić Z, Obradović MM, Bajić VP, Isenović ER. Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus. in Mini-Reviews in Medicinal Chemistry. 2020;20(11):975-987.
doi:10.2174/1389557519666191015203636 .

Dugalić, Predrag, Đuranović, Srđan, Pavlović-Marković, Aleksandra, Dugalić, Vladimir, Tomašević, Ratko, Gluvić, Zoran, Obradović, Milan M., Bajić, Vladan P., Isenović, Esma R., "Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus" in Mini-Reviews in Medicinal Chemistry, 20, no. 11 (2020):975-987,
https://doi.org/10.2174/1389557519666191015203636 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Mitrović, Bojan
AU  - Lačković, Milena
AU  - Samardžić, Vladimir
AU  - Jakšić, Dunja
AU  - Pavlović, Aleksandar
AU  - Tomašević, Ratko
AU  - Obradović, Milan M.
AU  - Isenović, Esma R.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10153
AB  - Staphylococcal toxic shock syndrome (STSS) is typically detected in newborns and children but can be seen in adults occasionally. In such a case, it points out usually on some immune system dysfunction. We present a case of a critically-ill adult male with STSS and symptoms and signs of serious systemic infection (hemodynamic instability, acute renal failure, mental confusion). After the completion of applied treatment (antistaphylococcal antimicrobials, hemodialysis, vasopressor, supportive, and symptomatic therapy), complete restoration of presented patients' derangements was achieved. Timely diagnosis and appropriate treatment is the mainstay in the management of STSS in adults.
AB  - Stafilokokni toksični šok sindrom (STŠS) se obično javlja kod novorođenčadi i dece, ali se povremeno može javiti i kod odraslih. U tom slučaju, obično ukazuje na disfunkciju imunog sistema. Prikazan je slučaj kritično-obolelog odraslog muškarca sa STŠS i simptomima i znacima životno-ugrožavajuće sistemske infekcije (hemodinamska nestabilnost, akutna insuficijencija bubrega, konfuzija). Nakon završenog lečenja (anti-stafilokoni antibiotici, hemodijaliza, vazopresori, suportivna i simptomatska terapija), postignuta je potpuna remisija kod obolelog. Pravovremena dijagnostika i adekvatan tretman je glavno uporište u lečenju STŠS kod odraslih.
T2  - Materia medica
T1  - An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report
T1  - Uhvaćen je stari lisac - stafilokokni toksični šok sindrom kod odraslog muškarca - prikaz slučaja
VL  - 34
IS  - 3
SP  - 1608
EP  - 1612
DO  - 10.5937/MatMed1801608G
ER  - 

@article{
author = "Gluvić, Zoran and Mitrović, Bojan and Lačković, Milena and Samardžić, Vladimir and Jakšić, Dunja and Pavlović, Aleksandar and Tomašević, Ratko and Obradović, Milan M. and Isenović, Esma R.",
year = "2018",
abstract = "Staphylococcal toxic shock syndrome (STSS) is typically detected in newborns and children but can be seen in adults occasionally. In such a case, it points out usually on some immune system dysfunction. We present a case of a critically-ill adult male with STSS and symptoms and signs of serious systemic infection (hemodynamic instability, acute renal failure, mental confusion). After the completion of applied treatment (antistaphylococcal antimicrobials, hemodialysis, vasopressor, supportive, and symptomatic therapy), complete restoration of presented patients' derangements was achieved. Timely diagnosis and appropriate treatment is the mainstay in the management of STSS in adults., Stafilokokni toksični šok sindrom (STŠS) se obično javlja kod novorođenčadi i dece, ali se povremeno može javiti i kod odraslih. U tom slučaju, obično ukazuje na disfunkciju imunog sistema. Prikazan je slučaj kritično-obolelog odraslog muškarca sa STŠS i simptomima i znacima životno-ugrožavajuće sistemske infekcije (hemodinamska nestabilnost, akutna insuficijencija bubrega, konfuzija). Nakon završenog lečenja (anti-stafilokoni antibiotici, hemodijaliza, vazopresori, suportivna i simptomatska terapija), postignuta je potpuna remisija kod obolelog. Pravovremena dijagnostika i adekvatan tretman je glavno uporište u lečenju STŠS kod odraslih.",
journal = "Materia medica",
title = "An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report, Uhvaćen je stari lisac - stafilokokni toksični šok sindrom kod odraslog muškarca - prikaz slučaja",
volume = "34",
number = "3",
pages = "1608-1612",
doi = "10.5937/MatMed1801608G"
}

Gluvić, Z., Mitrović, B., Lačković, M., Samardžić, V., Jakšić, D., Pavlović, A., Tomašević, R., Obradović, M. M.,& Isenović, E. R.. (2018). An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report. in Materia medica, 34(3), 1608-1612.
https://doi.org/10.5937/MatMed1801608G

Gluvić Z, Mitrović B, Lačković M, Samardžić V, Jakšić D, Pavlović A, Tomašević R, Obradović MM, Isenović ER. An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report. in Materia medica. 2018;34(3):1608-1612.
doi:10.5937/MatMed1801608G .

Gluvić, Zoran, Mitrović, Bojan, Lačković, Milena, Samardžić, Vladimir, Jakšić, Dunja, Pavlović, Aleksandar, Tomašević, Ratko, Obradović, Milan M., Isenović, Esma R., "An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report" in Materia medica, 34, no. 3 (2018):1608-1612,
https://doi.org/10.5937/MatMed1801608G . .

TY  - JOUR
AU  - Popin-Tarić, Marija
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Vasić-Vlaisavljević, Anita
AU  - Tica-Jevtić, Jelena
AU  - Panić, Anastasija
AU  - Sudar-Milovanović, Emina
AU  - Tomašević, Ratko
AU  - Isenović, Esma R.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10313
AB  - Uvod: Poznat je uticaj manifestnih tireoidnih disfunkcija na promene u koštanoj masi koji se ispoljava kroz izmene u koštanom prometu, koje dovode do promena koštane gustine i mogućeg povećanog rizika od pada i preloma. Takođe, uticajem na metaboličke parametre, prevashodno na lipide, tireoidne disfunkcije predstavljaju važan uzrok akceleracije ateroskleroze i povećanja cerebrovaskularnog i kardiovaskularnog rizika. Ovom studijom je ispitivan metabolički profil i koštana gustina kod pacijenata sa dijagnostikovanom supkliničkom tireoidnom disfunkcijom. Materijal i metode: Pilot studija preseka obuhvatila je 45 selektovanih ispitanica, koje su ispunile inkluzione kriterijume. Na osnovu nivoa tireo-stimulišućeg hormona (TSH) i slobodnog tiroksina (fT4) ispitanice su svrstane u 3 grupe, po 15 ispitanica u svakoj grupi: -grupa: supklinička hipotireoza (SHipo), grupa: supklinička hipertireoza (SHiper), i grupa: eutireodna-tj. kontrolna grupa. Od faktora rizika, praćeni su godine života, podaci o menopauzi i prethodnim prelomima, a od metaboličkih parametara indeks telesne mase (engl. Body Mass Index, BMI), obim struka (OS), obim kuka (OK), nivo tri-glicerida i nivo ukupnog holesterola. Kod svih ispitanica je merena koštana gustina na lumbalnoj kičmi i levom kuku (LK) i izražena u T skorovima. Dobijeni podaci su analizirani koriščćenjem statističkog paketa SPSS za Windows. Statistički značajnom je smatrana verovatnoća manja od 0,05 (p<0,05). Rezultati: Grupe ispitanica su se značajno razlikovale po nivoima ukupnog holesterola, kao i T skorovima lumbalne kičme i LK. Smanjena koštana gustina je registrovana kod 35 (77,8%) ispitanica. Vrednosti T skorova lumbalne kičme i LK su unutargrupno međusobno korelisali. Od faktora rizika, postojanje prethodnih preloma i menopauze, značajno utiču na T skorove, što nije slučaj ni sa jednim metaboličkim parametrom. Najniži T skorovi, kao i sa kliničkog aspekta najznačajnija dislipidemija, su registrovani u grupi SHipo. Diskusija: U okviru ove pilot studije pokazano je smanjenje koštane gustine u populaciji ispitanica sa supkliničkim tireoidopatijama, najviše izražena u SHipo grupi. U istoj grupi je zabeležen i klinički najaterogeniji lipidni profil (hiperholesterolemija). Metabolički parametri kao i hormoni nisu uticali na T skorove lumbalne kičme i LK. Zaključak: Supkliničke tireoidne disfunkcije su povezane sa smanjenjem koštane gustine, izražene kroz T skorove na lumbalnoj kičmi i LK, i na njih nisu uticali metabolički parametri. Pravovremenom dijagnostikom i lečenjem tireoidnih disfunkcija, moguće je usporiti gubitak koštane mase, smanjiti rizik kako od pada tako i od preloma, pri čemu korekcijom lipidnog disbalansa se može smanjiti potencijalni cerebrovaskularni i kardiovaskularni rizik.
AB  - Introduction. It is well-known that overt thyroid dysfunctions have an influence on bone mineral density (BMD). It is noticed as a change in bone turnover and BMD, with subsequent increased risk of fall-induced fractures. Additionally, promoting the lipid profile derangement, subclinical thyroid dysfunction seems to be an important factor of atherosclerosis acceleration and the risk of cerebrovascular and cardiovascular incidents. In this study we examined the relationship between some of osteoporosis risk factors, metabolic parameters and BMD, in subclinical thyroidopathies. Material and Methods. Pilot cross-sectional study involved 45 females selected on fulfilled inclusion criteria. Three groups of 15 examinees were formed, based on TSH and fT4 serum levels (SHypo, SHyper, and euthyroid-control). As for risk factors, age, records on menopause and history of past fractures as well as metabolic parameters Body Mass Index (BMI), waist and hip circumference, cholesterol and triglyceride levels were observed. The entire study population was referred to DEXA (Dual Energy X Ray Absorptiometry) scan for BMD measurement on lumbar spine (LS) and left hip (LH), expressed through T scores. The obtained data were analyzed by SPSS for Windows 18.0 statistical package. The level of statistical significance was 0.05. Results. The groups of patients differed on cholesterol levels and LS/LH T scores. Decreased BMD was detected in 35 (77.4%) patients. Intergroup correlations of LS/LH T scores were registered. A history of past fractures and records on menopause significantly influenced LS/LH T scores, which was not the case with metabolic parameters. Both the lowest T scores and clinically important dyslipidemia were presented in SHypo group. Discussion. The pilot study pointed out a decrease in BMD (mostly on osteopenia level) in subclinical, presumably hypothyroid disorder. The presence of hypercholesterolemia was detected in the same group. Metabolic parameters and thyroid hormones (TSH and fT4) did not have an effect on BMD. Conclusion. Subclinical thyroid dysfunctions are associated with a decrease in BMD, mostly presented as osteopenia, with a higher degree of severity in SHypo group. There is no registered influence of metabolic parameters on LS/LH T scores. It can be possible to slow down progression of decrease in BMD and subsequent fracture risk, with proper diagnostics and management of subclinical thyroid dysfunctions. Additionally, with correction of lipid disorders, cardiovascular and cerebrovascular risk could be minimized.
T2  - Medicinska istraživanja
T1  - Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija
T1  - Correlation of metabolic profile and Bone mineral density in treatment: Naive females with subclinical thyroid dysfunction: A pilot study
VL  - 49
IS  - 2
SP  - 50
EP  - 57
DO  - 10.5937/MedIst1502050P
ER  - 

@article{
author = "Popin-Tarić, Marija and Gluvić, Zoran and Samardžić, Vladimir and Vasić-Vlaisavljević, Anita and Tica-Jevtić, Jelena and Panić, Anastasija and Sudar-Milovanović, Emina and Tomašević, Ratko and Isenović, Esma R.",
year = "2015",
abstract = "Uvod: Poznat je uticaj manifestnih tireoidnih disfunkcija na promene u koštanoj masi koji se ispoljava kroz izmene u koštanom prometu, koje dovode do promena koštane gustine i mogućeg povećanog rizika od pada i preloma. Takođe, uticajem na metaboličke parametre, prevashodno na lipide, tireoidne disfunkcije predstavljaju važan uzrok akceleracije ateroskleroze i povećanja cerebrovaskularnog i kardiovaskularnog rizika. Ovom studijom je ispitivan metabolički profil i koštana gustina kod pacijenata sa dijagnostikovanom supkliničkom tireoidnom disfunkcijom. Materijal i metode: Pilot studija preseka obuhvatila je 45 selektovanih ispitanica, koje su ispunile inkluzione kriterijume. Na osnovu nivoa tireo-stimulišućeg hormona (TSH) i slobodnog tiroksina (fT4) ispitanice su svrstane u 3 grupe, po 15 ispitanica u svakoj grupi: -grupa: supklinička hipotireoza (SHipo), grupa: supklinička hipertireoza (SHiper), i grupa: eutireodna-tj. kontrolna grupa. Od faktora rizika, praćeni su godine života, podaci o menopauzi i prethodnim prelomima, a od metaboličkih parametara indeks telesne mase (engl. Body Mass Index, BMI), obim struka (OS), obim kuka (OK), nivo tri-glicerida i nivo ukupnog holesterola. Kod svih ispitanica je merena koštana gustina na lumbalnoj kičmi i levom kuku (LK) i izražena u T skorovima. Dobijeni podaci su analizirani koriščćenjem statističkog paketa SPSS za Windows. Statistički značajnom je smatrana verovatnoća manja od 0,05 (p<0,05). Rezultati: Grupe ispitanica su se značajno razlikovale po nivoima ukupnog holesterola, kao i T skorovima lumbalne kičme i LK. Smanjena koštana gustina je registrovana kod 35 (77,8%) ispitanica. Vrednosti T skorova lumbalne kičme i LK su unutargrupno međusobno korelisali. Od faktora rizika, postojanje prethodnih preloma i menopauze, značajno utiču na T skorove, što nije slučaj ni sa jednim metaboličkim parametrom. Najniži T skorovi, kao i sa kliničkog aspekta najznačajnija dislipidemija, su registrovani u grupi SHipo. Diskusija: U okviru ove pilot studije pokazano je smanjenje koštane gustine u populaciji ispitanica sa supkliničkim tireoidopatijama, najviše izražena u SHipo grupi. U istoj grupi je zabeležen i klinički najaterogeniji lipidni profil (hiperholesterolemija). Metabolički parametri kao i hormoni nisu uticali na T skorove lumbalne kičme i LK. Zaključak: Supkliničke tireoidne disfunkcije su povezane sa smanjenjem koštane gustine, izražene kroz T skorove na lumbalnoj kičmi i LK, i na njih nisu uticali metabolički parametri. Pravovremenom dijagnostikom i lečenjem tireoidnih disfunkcija, moguće je usporiti gubitak koštane mase, smanjiti rizik kako od pada tako i od preloma, pri čemu korekcijom lipidnog disbalansa se može smanjiti potencijalni cerebrovaskularni i kardiovaskularni rizik., Introduction. It is well-known that overt thyroid dysfunctions have an influence on bone mineral density (BMD). It is noticed as a change in bone turnover and BMD, with subsequent increased risk of fall-induced fractures. Additionally, promoting the lipid profile derangement, subclinical thyroid dysfunction seems to be an important factor of atherosclerosis acceleration and the risk of cerebrovascular and cardiovascular incidents. In this study we examined the relationship between some of osteoporosis risk factors, metabolic parameters and BMD, in subclinical thyroidopathies. Material and Methods. Pilot cross-sectional study involved 45 females selected on fulfilled inclusion criteria. Three groups of 15 examinees were formed, based on TSH and fT4 serum levels (SHypo, SHyper, and euthyroid-control). As for risk factors, age, records on menopause and history of past fractures as well as metabolic parameters Body Mass Index (BMI), waist and hip circumference, cholesterol and triglyceride levels were observed. The entire study population was referred to DEXA (Dual Energy X Ray Absorptiometry) scan for BMD measurement on lumbar spine (LS) and left hip (LH), expressed through T scores. The obtained data were analyzed by SPSS for Windows 18.0 statistical package. The level of statistical significance was 0.05. Results. The groups of patients differed on cholesterol levels and LS/LH T scores. Decreased BMD was detected in 35 (77.4%) patients. Intergroup correlations of LS/LH T scores were registered. A history of past fractures and records on menopause significantly influenced LS/LH T scores, which was not the case with metabolic parameters. Both the lowest T scores and clinically important dyslipidemia were presented in SHypo group. Discussion. The pilot study pointed out a decrease in BMD (mostly on osteopenia level) in subclinical, presumably hypothyroid disorder. The presence of hypercholesterolemia was detected in the same group. Metabolic parameters and thyroid hormones (TSH and fT4) did not have an effect on BMD. Conclusion. Subclinical thyroid dysfunctions are associated with a decrease in BMD, mostly presented as osteopenia, with a higher degree of severity in SHypo group. There is no registered influence of metabolic parameters on LS/LH T scores. It can be possible to slow down progression of decrease in BMD and subsequent fracture risk, with proper diagnostics and management of subclinical thyroid dysfunctions. Additionally, with correction of lipid disorders, cardiovascular and cerebrovascular risk could be minimized.",
journal = "Medicinska istraživanja",
title = "Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija, Correlation of metabolic profile and Bone mineral density in treatment: Naive females with subclinical thyroid dysfunction: A pilot study",
volume = "49",
number = "2",
pages = "50-57",
doi = "10.5937/MedIst1502050P"
}

Popin-Tarić, M., Gluvić, Z., Samardžić, V., Vasić-Vlaisavljević, A., Tica-Jevtić, J., Panić, A., Sudar-Milovanović, E., Tomašević, R.,& Isenović, E. R.. (2015). Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija. in Medicinska istraživanja, 49(2), 50-57.
https://doi.org/10.5937/MedIst1502050P

Popin-Tarić M, Gluvić Z, Samardžić V, Vasić-Vlaisavljević A, Tica-Jevtić J, Panić A, Sudar-Milovanović E, Tomašević R, Isenović ER. Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija. in Medicinska istraživanja. 2015;49(2):50-57.
doi:10.5937/MedIst1502050P .

Popin-Tarić, Marija, Gluvić, Zoran, Samardžić, Vladimir, Vasić-Vlaisavljević, Anita, Tica-Jevtić, Jelena, Panić, Anastasija, Sudar-Milovanović, Emina, Tomašević, Ratko, Isenović, Esma R., "Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija" in Medicinska istraživanja, 49, no. 2 (2015):50-57,
https://doi.org/10.5937/MedIst1502050P . .