Đokić, Ivana

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Pastoral care and religious support as a part of treatment of religious patient with the severe form of osteoarthritis

Đurović, Aleksandar; Sovilj, Saša; Đokić, Ivana; Brdareski, Zorica; Vukomanović, Aleksandra; Ilić, Nataša; Milavić-Vujković, Merica

(2017)

TY  - JOUR
AU  - Đurović, Aleksandar
AU  - Sovilj, Saša
AU  - Đokić, Ivana
AU  - Brdareski, Zorica
AU  - Vukomanović, Aleksandra
AU  - Ilić, Nataša
AU  - Milavić-Vujković, Merica
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1433
AB  - Introduction. Religious needs of patients are consistently being neglected in the clinical medicine. Pastoral care is a religious support which a religious patient receives from priests, chaplains, imams, rabbis or other religious authorities. Religious support, in terms of clinical medicine, is a spiritual support which religious patients obtain from religious and trained medical workers. The aim of this report was to present the effects of pastoral care and religious support in hospital treatment of a 73-year-old patient with the severe form of osteoarthritis. Case report. The 73 year-old, highly religious patient with severe form of osteoarthritis was admitted at the Clinic for Physical Medicine and Rehabilitation, Military Medical Academy in Belgrade, due to heterogeneous problems in the activities of daily living. The patient walked with difficulty using a stick, suffered pain, and was anxious and depressive. In order to objectively demonstrate effects of both pastoral care and religious support in this patient we performed multiple treatment with reversal design, in which the basic treatment consisting of hospital care, pharmacotherapy and physical therapy (the treatment A) was alternatively changed with the treatment that included combination of the basic treatment and religious support provided by religious physiatrist and physiotherapist (the treatment B) or combination of the basic treatment and pastoral care provided by military priest (the treatment C). The treatment A was applied three times and lasted two weeks, every time. Treatments B and C were applied once and lasted three weeks, each. The order of the treatments was: A - GT B - GT A - GT C - GT A. During the whole treatment period the patients condition was assessed by several measuring scale: the level of depression by The Hamilton Rang Scale for Depression and The Zung Self Rating Depression Scale; the level of anxiety by The Zung Self Rating Anxiety Scale; the functional capability of patient by The Barthel Index and The Functional Independent Measure. Measuring was carried out on a daily basis. In statistical analysis two nonparametric statistic were used: the percentage of non-overlapping data (PND) and the percentage of data points exceeding the median (PEM). PND and PEM values below 0.7 reflect questionable effectiveness of the treatment. The values between 0.7 and 0.9 reflect moderate effects. The values above 0.9 are considered as a highly effective treatment. The anxiety of the patient was moderately to significantly reduced after introducing religious support (treatment B: mean and mean deviation = 50.1 +/- 10.89; variability = 4.598653; mean shift = 0.219626; PND = 0.6; PEM = 0.9) and pastoral care (treatment C: mean and mean deviation = 53.5 +/- 5.90; variability = 9.062591; mean shift = 0.207407; PND = 0.9; PEM = 0.9); The patients depression was reduced after introducing pastoral care (treatment C: mean and mean deviation = 51.3 +/- 4.66; variability = 10.99005; mean shift = 0.08881; PND = 0; PEM = 0.9). On the contrary, the patients functional capability was not significantly improved. Conclusion. In the highly religious patient with severe osteoarthritis pastoral care and religious support, applied along with the standard medical treatment of this condition, produced some beneficial effects on anxiety and depressive mood, but with no significant effect on patients functional capability.
T2  - Vojnosanitetski pregled
T1  - Pastoral care and religious support as a part of treatment of religious patient with the severe form of osteoarthritis
VL  - 74
IS  - 1
SP  - 69
EP  - 77
DO  - 10.2298/VSP1508025059D
ER  - 
@article{
author = "Đurović, Aleksandar and Sovilj, Saša and Đokić, Ivana and Brdareski, Zorica and Vukomanović, Aleksandra and Ilić, Nataša and Milavić-Vujković, Merica",
year = "2017",
abstract = "Introduction. Religious needs of patients are consistently being neglected in the clinical medicine. Pastoral care is a religious support which a religious patient receives from priests, chaplains, imams, rabbis or other religious authorities. Religious support, in terms of clinical medicine, is a spiritual support which religious patients obtain from religious and trained medical workers. The aim of this report was to present the effects of pastoral care and religious support in hospital treatment of a 73-year-old patient with the severe form of osteoarthritis. Case report. The 73 year-old, highly religious patient with severe form of osteoarthritis was admitted at the Clinic for Physical Medicine and Rehabilitation, Military Medical Academy in Belgrade, due to heterogeneous problems in the activities of daily living. The patient walked with difficulty using a stick, suffered pain, and was anxious and depressive. In order to objectively demonstrate effects of both pastoral care and religious support in this patient we performed multiple treatment with reversal design, in which the basic treatment consisting of hospital care, pharmacotherapy and physical therapy (the treatment A) was alternatively changed with the treatment that included combination of the basic treatment and religious support provided by religious physiatrist and physiotherapist (the treatment B) or combination of the basic treatment and pastoral care provided by military priest (the treatment C). The treatment A was applied three times and lasted two weeks, every time. Treatments B and C were applied once and lasted three weeks, each. The order of the treatments was: A - GT B - GT A - GT C - GT A. During the whole treatment period the patients condition was assessed by several measuring scale: the level of depression by The Hamilton Rang Scale for Depression and The Zung Self Rating Depression Scale; the level of anxiety by The Zung Self Rating Anxiety Scale; the functional capability of patient by The Barthel Index and The Functional Independent Measure. Measuring was carried out on a daily basis. In statistical analysis two nonparametric statistic were used: the percentage of non-overlapping data (PND) and the percentage of data points exceeding the median (PEM). PND and PEM values below 0.7 reflect questionable effectiveness of the treatment. The values between 0.7 and 0.9 reflect moderate effects. The values above 0.9 are considered as a highly effective treatment. The anxiety of the patient was moderately to significantly reduced after introducing religious support (treatment B: mean and mean deviation = 50.1 +/- 10.89; variability = 4.598653; mean shift = 0.219626; PND = 0.6; PEM = 0.9) and pastoral care (treatment C: mean and mean deviation = 53.5 +/- 5.90; variability = 9.062591; mean shift = 0.207407; PND = 0.9; PEM = 0.9); The patients depression was reduced after introducing pastoral care (treatment C: mean and mean deviation = 51.3 +/- 4.66; variability = 10.99005; mean shift = 0.08881; PND = 0; PEM = 0.9). On the contrary, the patients functional capability was not significantly improved. Conclusion. In the highly religious patient with severe osteoarthritis pastoral care and religious support, applied along with the standard medical treatment of this condition, produced some beneficial effects on anxiety and depressive mood, but with no significant effect on patients functional capability.",
journal = "Vojnosanitetski pregled",
title = "Pastoral care and religious support as a part of treatment of religious patient with the severe form of osteoarthritis",
volume = "74",
number = "1",
pages = "69-77",
doi = "10.2298/VSP1508025059D"
}
Đurović, A., Sovilj, S., Đokić, I., Brdareski, Z., Vukomanović, A., Ilić, N.,& Milavić-Vujković, M.. (2017). Pastoral care and religious support as a part of treatment of religious patient with the severe form of osteoarthritis. in Vojnosanitetski pregled, 74(1), 69-77.
https://doi.org/10.2298/VSP1508025059D
Đurović A, Sovilj S, Đokić I, Brdareski Z, Vukomanović A, Ilić N, Milavić-Vujković M. Pastoral care and religious support as a part of treatment of religious patient with the severe form of osteoarthritis. in Vojnosanitetski pregled. 2017;74(1):69-77.
doi:10.2298/VSP1508025059D .
Đurović, Aleksandar, Sovilj, Saša, Đokić, Ivana, Brdareski, Zorica, Vukomanović, Aleksandra, Ilić, Nataša, Milavić-Vujković, Merica, "Pastoral care and religious support as a part of treatment of religious patient with the severe form of osteoarthritis" in Vojnosanitetski pregled, 74, no. 1 (2017):69-77,
https://doi.org/10.2298/VSP1508025059D . .
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Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells

Srdić-Rajić, Tatjana; Nikolić, Katarina M.; Čavić, Milena R.; Đokić, Ivana; Gemović, Branislava S.; Perović, Vladimir R.; Veljković, Nevena V.

(Elsevier, 2016)

TY  - JOUR
AU  - Srdić-Rajić, Tatjana
AU  - Nikolić, Katarina M.
AU  - Čavić, Milena R.
AU  - Đokić, Ivana
AU  - Gemović, Branislava S.
AU  - Perović, Vladimir R.
AU  - Veljković, Nevena V.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/884
AB  - Imidazoline I1 receptor signaling is associated with pathways that regulate cell viability leading to varied cell-type specific phenotypes. We demonstrated that the antihypertensive drug rilmenidine, a selective imidazoline I1 receptor agonist, modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells. Rilmenidine acts through a mechanism which involves deactivation of Ras/MAP kinases ERK, p38 and JNK. Moreover, rilmenidine renders K562 cells, which are particularly resistant to chemotherapeutic agents, susceptible to the DNA damaging drug doxorubicin. The rilmenidine co-treatment with doxorubicin reverses G2/M arrest and triggers apoptotic response to DNA damage. Our data offer new insights into the pathways associated with imidazoline I1 receptor activation in K562 cells suggesting rilmenidine as a valuable tool to deepen our understanding of imidazoline I1 receptor signaling in hematologic malignancies and to search for medicinally active agents. (C) 2015 Elsevier B.V. All rights reserved.
PB  - Elsevier
T2  - European Journal of Pharmaceutical Sciences
T1  - Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells
VL  - 81
SP  - 172
EP  - 180
DO  - 10.1016/j.ejps.2015.10.017
ER  - 
@article{
author = "Srdić-Rajić, Tatjana and Nikolić, Katarina M. and Čavić, Milena R. and Đokić, Ivana and Gemović, Branislava S. and Perović, Vladimir R. and Veljković, Nevena V.",
year = "2016",
abstract = "Imidazoline I1 receptor signaling is associated with pathways that regulate cell viability leading to varied cell-type specific phenotypes. We demonstrated that the antihypertensive drug rilmenidine, a selective imidazoline I1 receptor agonist, modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells. Rilmenidine acts through a mechanism which involves deactivation of Ras/MAP kinases ERK, p38 and JNK. Moreover, rilmenidine renders K562 cells, which are particularly resistant to chemotherapeutic agents, susceptible to the DNA damaging drug doxorubicin. The rilmenidine co-treatment with doxorubicin reverses G2/M arrest and triggers apoptotic response to DNA damage. Our data offer new insights into the pathways associated with imidazoline I1 receptor activation in K562 cells suggesting rilmenidine as a valuable tool to deepen our understanding of imidazoline I1 receptor signaling in hematologic malignancies and to search for medicinally active agents. (C) 2015 Elsevier B.V. All rights reserved.",
publisher = "Elsevier",
journal = "European Journal of Pharmaceutical Sciences",
title = "Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells",
volume = "81",
pages = "172-180",
doi = "10.1016/j.ejps.2015.10.017"
}
Srdić-Rajić, T., Nikolić, K. M., Čavić, M. R., Đokić, I., Gemović, B. S., Perović, V. R.,& Veljković, N. V.. (2016). Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. in European Journal of Pharmaceutical Sciences
Elsevier., 81, 172-180.
https://doi.org/10.1016/j.ejps.2015.10.017
Srdić-Rajić T, Nikolić KM, Čavić MR, Đokić I, Gemović BS, Perović VR, Veljković NV. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. in European Journal of Pharmaceutical Sciences. 2016;81:172-180.
doi:10.1016/j.ejps.2015.10.017 .
Srdić-Rajić, Tatjana, Nikolić, Katarina M., Čavić, Milena R., Đokić, Ivana, Gemović, Branislava S., Perović, Vladimir R., Veljković, Nevena V., "Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells" in European Journal of Pharmaceutical Sciences, 81 (2016):172-180,
https://doi.org/10.1016/j.ejps.2015.10.017 . .
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