TY  - CONF
AU  - Lakić, Mladen
AU  - Janković, Drina
AU  - Savić, A.
AU  - Sabo, Lj.
AU  - Sabo, T.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9352
AB  - There is an increasing interest for the 99mTc labeling of biomolecules by using
bifunctional chelating agents like ethylenediamine-N,N´-di-3-propanoate diethyl
ester (deeddp). To find new ligand, which can be linked to the small biomolecules
and coordinated with [99mTc(CO)3(H2O)3]
+
 precursor, is a challenging task.
Radiolabeling of deeddp with [99mTc(CO)3(H2O)3]
+
 precursor, stability studies and
biodistribution of formed complexes were carried out, including challenge with
histidine. Radiochemical yield of 99mTc(I)-tricarbonyl-deeddp complexes was
higher than 95%. These complexes were stable in vitro and showed a very good
biological behavior. The radiochemical and biological features of the novel
99mTc(I)-complexes, as well as, the nature of the ligands, make them very
promising candidates for labeling of tumor specific biomolecules.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
T1  - 99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent
VL  - 2
SP  - 588
EP  - 590
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9352
ER  - 

@conference{
author = "Lakić, Mladen and Janković, Drina and Savić, A. and Sabo, Lj. and Sabo, T.",
year = "2012",
abstract = "There is an increasing interest for the 99mTc labeling of biomolecules by using
bifunctional chelating agents like ethylenediamine-N,N´-di-3-propanoate diethyl
ester (deeddp). To find new ligand, which can be linked to the small biomolecules
and coordinated with [99mTc(CO)3(H2O)3]
+
 precursor, is a challenging task.
Radiolabeling of deeddp with [99mTc(CO)3(H2O)3]
+
 precursor, stability studies and
biodistribution of formed complexes were carried out, including challenge with
histidine. Radiochemical yield of 99mTc(I)-tricarbonyl-deeddp complexes was
higher than 95%. These complexes were stable in vitro and showed a very good
biological behavior. The radiochemical and biological features of the novel
99mTc(I)-complexes, as well as, the nature of the ligands, make them very
promising candidates for labeling of tumor specific biomolecules.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry",
title = "99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent",
volume = "2",
pages = "588-590",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9352"
}

Lakić, M., Janković, D., Savić, A., Sabo, Lj.,& Sabo, T.. (2012). 99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 2, 588-590.
https://hdl.handle.net/21.15107/rcub_vinar_9352

Lakić M, Janković D, Savić A, Sabo L, Sabo T. 99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:588-590.
https://hdl.handle.net/21.15107/rcub_vinar_9352 .

Lakić, Mladen, Janković, Drina, Savić, A., Sabo, Lj., Sabo, T., "99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):588-590,
https://hdl.handle.net/21.15107/rcub_vinar_9352 .