TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Vukićević Ivan M.
AU  - Drmanic, Sasa Z.
AU  - Nikolic, Jasmina B.
AU  - Marinković, Aleksandar D.
AU  - Krstić, Sanja S.
AU  - Petrović, Slobodan D.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1055
AB  - The present study reports a new facile methodology for the synthesis of symmetrical and asymmetrical thioureas by a one-pot reaction of the required amine, carbon disulfide and an oxidant, i.e., hydrogen peroxide, ethylenediaminetetraacetic acid (EDTA)/sodium percarbonate system or air. The structures of the synthesized compounds were confirmed by IR, H-1- and C-13-NMR and MS methods. A reaction mechanism is proposed based on the isolation of reaction intermediate and the determination of their structure. The synthetic benefits of the presented methods are reflected in the operational simplicity, mild reaction conditions, short reaction times, solvent recycling, high purity and yield of the products, absence of dangerous by-products and technological applicability on an industrial scale. Considering the commercial importance of thioureas, it should be emphasized that implementation of the optimal synthesis of thiourea determined in this study for industrial production could provide a concurrent alternative to the existing technologies in use.
T2  - Journal of the Serbian Chemical Society
T1  - Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water
VL  - 81
IS  - 3
SP  - 219
EP  - 231
DO  - 10.2298/JSC150831087M
ER  - 

@article{
author = "Milosavljević, Milutin M. and Vukićević Ivan M. and Drmanic, Sasa Z. and Nikolic, Jasmina B. and Marinković, Aleksandar D. and Krstić, Sanja S. and Petrović, Slobodan D.",
year = "2016",
abstract = "The present study reports a new facile methodology for the synthesis of symmetrical and asymmetrical thioureas by a one-pot reaction of the required amine, carbon disulfide and an oxidant, i.e., hydrogen peroxide, ethylenediaminetetraacetic acid (EDTA)/sodium percarbonate system or air. The structures of the synthesized compounds were confirmed by IR, H-1- and C-13-NMR and MS methods. A reaction mechanism is proposed based on the isolation of reaction intermediate and the determination of their structure. The synthetic benefits of the presented methods are reflected in the operational simplicity, mild reaction conditions, short reaction times, solvent recycling, high purity and yield of the products, absence of dangerous by-products and technological applicability on an industrial scale. Considering the commercial importance of thioureas, it should be emphasized that implementation of the optimal synthesis of thiourea determined in this study for industrial production could provide a concurrent alternative to the existing technologies in use.",
journal = "Journal of the Serbian Chemical Society",
title = "Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water",
volume = "81",
number = "3",
pages = "219-231",
doi = "10.2298/JSC150831087M"
}

Milosavljević, M. M., Vukićević Ivan M., Drmanic, S. Z., Nikolic, J. B., Marinković, A. D., Krstić, S. S.,& Petrović, S. D.. (2016). Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water. in Journal of the Serbian Chemical Society, 81(3), 219-231.
https://doi.org/10.2298/JSC150831087M

Milosavljević MM, Vukićević Ivan M., Drmanic SZ, Nikolic JB, Marinković AD, Krstić SS, Petrović SD. Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water. in Journal of the Serbian Chemical Society. 2016;81(3):219-231.
doi:10.2298/JSC150831087M .

Milosavljević, Milutin M., Vukićević Ivan M., Drmanic, Sasa Z., Nikolic, Jasmina B., Marinković, Aleksandar D., Krstić, Sanja S., Petrović, Slobodan D., "Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water" in Journal of the Serbian Chemical Society, 81, no. 3 (2016):219-231,
https://doi.org/10.2298/JSC150831087M . .

TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Vukićević Ivan M.
AU  - Serifi, Veis
AU  - Markovski, Jasmina S.
AU  - Stojiljković, Ivana
AU  - Mijin, Dušan Ž.
AU  - Marinković, Aleksandar D.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/945
AB  - The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate
VL  - 21
IS  - 4
SP  - 501
EP  - 510
DO  - 10.2298/CICEQ141221006M
ER  - 

@article{
author = "Milosavljević, Milutin M. and Vukićević Ivan M. and Serifi, Veis and Markovski, Jasmina S. and Stojiljković, Ivana and Mijin, Dušan Ž. and Marinković, Aleksandar D.",
year = "2015",
abstract = "The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate",
volume = "21",
number = "4",
pages = "501-510",
doi = "10.2298/CICEQ141221006M"
}

Milosavljević, M. M., Vukićević Ivan M., Serifi, V., Markovski, J. S., Stojiljković, I., Mijin, D. Ž.,& Marinković, A. D.. (2015). Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate. in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21(4), 501-510.
https://doi.org/10.2298/CICEQ141221006M

Milosavljević MM, Vukićević Ivan M., Serifi V, Markovski JS, Stojiljković I, Mijin DŽ, Marinković AD. Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2015;21(4):501-510.
doi:10.2298/CICEQ141221006M .

Milosavljević, Milutin M., Vukićević Ivan M., Serifi, Veis, Markovski, Jasmina S., Stojiljković, Ivana, Mijin, Dušan Ž., Marinković, Aleksandar D., "Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21, no. 4 (2015):501-510,
https://doi.org/10.2298/CICEQ141221006M . .