TY  - CONF
AU  - Jakovljević, Teodora
AU  - Stanisavljević, Jelena
AU  - Matić, Tamara
AU  - Tadić, Julijana
AU  - Veljović, Đorđe
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12301
AB  - In recent years, scientists have been working on developing biocompatible materials that closely mimic the structure and properties of natural biological tissues for their application in hard tissue regeneration and controlled drug release. Human bones and teeth primarily consist of calcium-phosphate crystals with small amounts of various ions incorporated into their crystal structure. The aim of this study was to examine the possibility of processing macroporous bioceramic scaffolds based on calcium-hydroxyapatite (HAp) doped with magnesium (Mg), strontium (Sr) and fluorine (F) ions, subsequently coated with polymer chitosan. In this study, the doped HAp powder was synthesized by a hydrothermal process, and scaffolds were made using the sponge replica method, sintered and then coated with the chitosan. The influence of dopant ions and chitosan on the scaffold's microstructure, mechanical properties, bioactivity, cytotoxicity and drug release properties was examined. Energy dispersive spectroscopy confirmed that Mg and Sr are incorporated in all powder samples, while the presence of F was confirmed in samples synthesized with 1 and 2 mol.% F in the precursor solution. The phase composition of powders and scaffolds determined by X-ray analysis showed the presence of HAp and β-tricalcium phosphate phase (β-TCP) in scaffolds. In the compressive strength (CS) test, coated scaffolds showed significantly higher CS compared to uncoated scaffolds. Scanning electron microscopy was used to examine the morphology of nanostructured powders, microstructure, and the bioactivity of the scaffolds. The uncoated scaffolds showed satisfactory bioactivity after being immersed in simulated body fluid for 28 days, while lower bioactivity was observed in the coated scaffolds due to the slow degradation of chitosan. The synthesized scaffolds also demonstrated to have a positive impact on cell viability, even slightly stimulating the cell proliferation. Additionally, scaffolds were shown to successfully release drug. In concusion, the addition of ions and chitosan polymer significantly improved the properties of the obtained scaffolds, which indicates their potential application in tissue engineering and controlled drug release.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
T1  - Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan
SP  - 2
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12301
ER  - 

@conference{
author = "Jakovljević, Teodora and Stanisavljević, Jelena and Matić, Tamara and Tadić, Julijana and Veljović, Đorđe",
year = "2023",
abstract = "In recent years, scientists have been working on developing biocompatible materials that closely mimic the structure and properties of natural biological tissues for their application in hard tissue regeneration and controlled drug release. Human bones and teeth primarily consist of calcium-phosphate crystals with small amounts of various ions incorporated into their crystal structure. The aim of this study was to examine the possibility of processing macroporous bioceramic scaffolds based on calcium-hydroxyapatite (HAp) doped with magnesium (Mg), strontium (Sr) and fluorine (F) ions, subsequently coated with polymer chitosan. In this study, the doped HAp powder was synthesized by a hydrothermal process, and scaffolds were made using the sponge replica method, sintered and then coated with the chitosan. The influence of dopant ions and chitosan on the scaffold's microstructure, mechanical properties, bioactivity, cytotoxicity and drug release properties was examined. Energy dispersive spectroscopy confirmed that Mg and Sr are incorporated in all powder samples, while the presence of F was confirmed in samples synthesized with 1 and 2 mol.% F in the precursor solution. The phase composition of powders and scaffolds determined by X-ray analysis showed the presence of HAp and β-tricalcium phosphate phase (β-TCP) in scaffolds. In the compressive strength (CS) test, coated scaffolds showed significantly higher CS compared to uncoated scaffolds. Scanning electron microscopy was used to examine the morphology of nanostructured powders, microstructure, and the bioactivity of the scaffolds. The uncoated scaffolds showed satisfactory bioactivity after being immersed in simulated body fluid for 28 days, while lower bioactivity was observed in the coated scaffolds due to the slow degradation of chitosan. The synthesized scaffolds also demonstrated to have a positive impact on cell viability, even slightly stimulating the cell proliferation. Additionally, scaffolds were shown to successfully release drug. In concusion, the addition of ions and chitosan polymer significantly improved the properties of the obtained scaffolds, which indicates their potential application in tissue engineering and controlled drug release.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts",
title = "Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12301"
}

Jakovljević, T., Stanisavljević, J., Matić, T., Tadić, J.,& Veljović, Đ.. (2023). Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
Belgrade : Institute of Technical Sciences of SASA., 2-2.
https://hdl.handle.net/21.15107/rcub_vinar_12301

Jakovljević T, Stanisavljević J, Matić T, Tadić J, Veljović Đ. Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:2-2.
https://hdl.handle.net/21.15107/rcub_vinar_12301 .

Jakovljević, Teodora, Stanisavljević, Jelena, Matić, Tamara, Tadić, Julijana, Veljović, Đorđe, "Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):2-2,
https://hdl.handle.net/21.15107/rcub_vinar_12301 .

TY  - JOUR
AU  - Pijović, Milena
AU  - Manić, Nebojša G.
AU  - Vasić Anićijević, Dragana D.
AU  - Krstić, Aleksandar
AU  - Mitrić, Miodrag
AU  - Matić, Tamara
AU  - Janković, Bojan Ž.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10077
AB  - Pyrolytic tire (PT) chars were first produced from waste car tires (WCT) through carbonization process at 800 °C, for different retention times. Then, best PT-char sample by its physicochemical properties (WCT 800(1 h)) was further tested for its ability to adsorb Rhodamine B (RhB) dye from aqueous solutions. Structural characterization of synthesized material showed existence of graphene-based material, with average pore diameter of 22.8 nm and specific surface area of 55.8 m2·g−1. Obtained carbon material meets specifications of commercial carbon black (CB). The yield of 33.6% of CB recovered has been achieved. Under the optimal conditions, 99.57% of RhB was removed. Adsorption of RhB obeys pseudo second-order model and Langmuir isotherm model. DFT (the density functional theory) was revealed that effective bonding of RhB onto WCT 800 originates from π-electron interactions with aromatic moieties and chemical (or at least the electrostatic) interactions, between positive nitrogen and electron-rich surface groups.
T2  - Diamond and Related Materials
T1  - Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study
VL  - 121
SP  - 108768
DO  - 10.1016/j.diamond.2021.108768
ER  - 

@article{
author = "Pijović, Milena and Manić, Nebojša G. and Vasić Anićijević, Dragana D. and Krstić, Aleksandar and Mitrić, Miodrag and Matić, Tamara and Janković, Bojan Ž.",
year = "2022",
abstract = "Pyrolytic tire (PT) chars were first produced from waste car tires (WCT) through carbonization process at 800 °C, for different retention times. Then, best PT-char sample by its physicochemical properties (WCT 800(1 h)) was further tested for its ability to adsorb Rhodamine B (RhB) dye from aqueous solutions. Structural characterization of synthesized material showed existence of graphene-based material, with average pore diameter of 22.8 nm and specific surface area of 55.8 m2·g−1. Obtained carbon material meets specifications of commercial carbon black (CB). The yield of 33.6% of CB recovered has been achieved. Under the optimal conditions, 99.57% of RhB was removed. Adsorption of RhB obeys pseudo second-order model and Langmuir isotherm model. DFT (the density functional theory) was revealed that effective bonding of RhB onto WCT 800 originates from π-electron interactions with aromatic moieties and chemical (or at least the electrostatic) interactions, between positive nitrogen and electron-rich surface groups.",
journal = "Diamond and Related Materials",
title = "Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study",
volume = "121",
pages = "108768",
doi = "10.1016/j.diamond.2021.108768"
}

Pijović, M., Manić, N. G., Vasić Anićijević, D. D., Krstić, A., Mitrić, M., Matić, T.,& Janković, B. Ž.. (2022). Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study. in Diamond and Related Materials, 121, 108768.
https://doi.org/10.1016/j.diamond.2021.108768

Pijović M, Manić NG, Vasić Anićijević DD, Krstić A, Mitrić M, Matić T, Janković BŽ. Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study. in Diamond and Related Materials. 2022;121:108768.
doi:10.1016/j.diamond.2021.108768 .

Pijović, Milena, Manić, Nebojša G., Vasić Anićijević, Dragana D., Krstić, Aleksandar, Mitrić, Miodrag, Matić, Tamara, Janković, Bojan Ž., "Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study" in Diamond and Related Materials, 121 (2022):108768,
https://doi.org/10.1016/j.diamond.2021.108768 . .

TY  - JOUR
AU  - Matić, Tamara
AU  - Zebić, M. Ležaja
AU  - Miletić, Vesna
AU  - Cvijović-Alagić, Ivana
AU  - Petrović, Rada D.
AU  - Janaćković, Đorđe T.
AU  - Veljović, Đorđe N.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10114
AB  - The aim of this study was to investigate the influence of binary Sr, Mg ion-doping compared to the single-ion doping effects on the phase composition and morphology of hydrothermally obtained calcium hydroxyapatite (HAP) powders and on the phase composition, microstructure, and mechanical properties of the sintered materials. Additionally, the focus of this study was to investigate the possible utilization of the binary doped Sr,Mg-HAP compacts as dentin substitutes in restorative dentistry by evaluating their bonding ability with commercially available restorative materials using the shear bond strength test (SBS). The hydrothermally obtained mono-doped Mg5 and Sr5 showed the monophasic apatite structure, while in all co-doped samples β-TCP phase was formed, resulting in biphasic calcium phosphate (BCP) powders. It was confirmed that co-doping with Sr and Mg ions led to the thermal stabilization of the β-TCP phase by suppressing the phase transition into α-TCP when sintered at 1200 °C. Moreover, the co-presence of Mg ions significantly improved the hardness of Sr-doped HAP from 3.74 to 5.02 GPa. Sr,Mg-HAP dental inserts were found to achieve sufficient bonding (13.53 MPa) through the micromechanical interlocking with Z250 dental composite and Single Bond Universal dental adhesive applied with a total etch approach. The SBS values obtained for the SrMg-HAP insert were similar to the literature data on bonding ability with human dentin, indicating that binary doped Sr,Mg-HAP ceramics present a promising material for application in restorative dentistry as dentin substitutes.
T2  - Ceramics International
T1  - Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes
DO  - 10.1016/j.ceramint.2021.12.335
ER  - 

@article{
author = "Matić, Tamara and Zebić, M. Ležaja and Miletić, Vesna and Cvijović-Alagić, Ivana and Petrović, Rada D. and Janaćković, Đorđe T. and Veljović, Đorđe N.",
year = "2022",
abstract = "The aim of this study was to investigate the influence of binary Sr, Mg ion-doping compared to the single-ion doping effects on the phase composition and morphology of hydrothermally obtained calcium hydroxyapatite (HAP) powders and on the phase composition, microstructure, and mechanical properties of the sintered materials. Additionally, the focus of this study was to investigate the possible utilization of the binary doped Sr,Mg-HAP compacts as dentin substitutes in restorative dentistry by evaluating their bonding ability with commercially available restorative materials using the shear bond strength test (SBS). The hydrothermally obtained mono-doped Mg5 and Sr5 showed the monophasic apatite structure, while in all co-doped samples β-TCP phase was formed, resulting in biphasic calcium phosphate (BCP) powders. It was confirmed that co-doping with Sr and Mg ions led to the thermal stabilization of the β-TCP phase by suppressing the phase transition into α-TCP when sintered at 1200 °C. Moreover, the co-presence of Mg ions significantly improved the hardness of Sr-doped HAP from 3.74 to 5.02 GPa. Sr,Mg-HAP dental inserts were found to achieve sufficient bonding (13.53 MPa) through the micromechanical interlocking with Z250 dental composite and Single Bond Universal dental adhesive applied with a total etch approach. The SBS values obtained for the SrMg-HAP insert were similar to the literature data on bonding ability with human dentin, indicating that binary doped Sr,Mg-HAP ceramics present a promising material for application in restorative dentistry as dentin substitutes.",
journal = "Ceramics International",
title = "Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes",
doi = "10.1016/j.ceramint.2021.12.335"
}

Matić, T., Zebić, M. L., Miletić, V., Cvijović-Alagić, I., Petrović, R. D., Janaćković, Đ. T.,& Veljović, Đ. N.. (2022). Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. in Ceramics International.
https://doi.org/10.1016/j.ceramint.2021.12.335

Matić T, Zebić ML, Miletić V, Cvijović-Alagić I, Petrović RD, Janaćković ĐT, Veljović ĐN. Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. in Ceramics International. 2022;.
doi:10.1016/j.ceramint.2021.12.335 .

Matić, Tamara, Zebić, M. Ležaja, Miletić, Vesna, Cvijović-Alagić, Ivana, Petrović, Rada D., Janaćković, Đorđe T., Veljović, Đorđe N., "Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes" in Ceramics International (2022),
https://doi.org/10.1016/j.ceramint.2021.12.335 . .

TY  - CONF
AU  - Matić, Tamara
AU  - Cvijović-Alagić, Ivana
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10843
AB  - Calcium hydroxyapatite (HAP) presents the main mineral component of human bones and teeth, and thus is widely used bioceramic material for thehard tissue repair and regeneration. The biological HAP is never found pure in nature butdoped with multiple therapeutic ions, such as Cu, Mg, Sr, Zn, etc., which are found to play important roles in bone metabolism and growth. Hence, foreign cations have been introduced into the synthetic calcium hydroxyapatite, in order to induce a specific biological response after implementation, such as osteogenesis, angiogenesis, improved cell attachment and proliferation. However, the presence of the cations leads to the lattice distortion of the calcium-hydroxyapatite, resulting in different physico-chemical and mechanical properties. The hydrothermal synthesis of calcium hydroxyapatite leads to nanosized rod-like particles, which were found to possess properties close to those of the biological HAP. The aim of this study was to investigate the effect of hydrothermal synthesis parameters on physico-chemical and mechanical properties of mono- and binary cation-doped calcium hydroxyapatite by employing XRD, SEM and Hardness by Vickers tests. The temperature applied during the hydrothermal synthesis (150- 180 °C) was found to influence the hardness of the HAP based compacts sintered at 1200 °C.
PB  - Belgrade : Serbian Ceramic Society
C3  - Advanced Ceramics and Application : 9th Serbian Ceramic Society Conference : program and the book of abstracts; September 20-21, 2021; Belgrade
T1  - The effect of hydrothermal synthesis parameters on cation-doped calciumhydroxyapatite
SP  - 84
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10843
ER  - 

@conference{
author = "Matić, Tamara and Cvijović-Alagić, Ivana and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2021",
abstract = "Calcium hydroxyapatite (HAP) presents the main mineral component of human bones and teeth, and thus is widely used bioceramic material for thehard tissue repair and regeneration. The biological HAP is never found pure in nature butdoped with multiple therapeutic ions, such as Cu, Mg, Sr, Zn, etc., which are found to play important roles in bone metabolism and growth. Hence, foreign cations have been introduced into the synthetic calcium hydroxyapatite, in order to induce a specific biological response after implementation, such as osteogenesis, angiogenesis, improved cell attachment and proliferation. However, the presence of the cations leads to the lattice distortion of the calcium-hydroxyapatite, resulting in different physico-chemical and mechanical properties. The hydrothermal synthesis of calcium hydroxyapatite leads to nanosized rod-like particles, which were found to possess properties close to those of the biological HAP. The aim of this study was to investigate the effect of hydrothermal synthesis parameters on physico-chemical and mechanical properties of mono- and binary cation-doped calcium hydroxyapatite by employing XRD, SEM and Hardness by Vickers tests. The temperature applied during the hydrothermal synthesis (150- 180 °C) was found to influence the hardness of the HAP based compacts sintered at 1200 °C.",
publisher = "Belgrade : Serbian Ceramic Society",
journal = "Advanced Ceramics and Application : 9th Serbian Ceramic Society Conference : program and the book of abstracts; September 20-21, 2021; Belgrade",
title = "The effect of hydrothermal synthesis parameters on cation-doped calciumhydroxyapatite",
pages = "84-85",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10843"
}

Matić, T., Cvijović-Alagić, I., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2021). The effect of hydrothermal synthesis parameters on cation-doped calciumhydroxyapatite. in Advanced Ceramics and Application : 9th Serbian Ceramic Society Conference : program and the book of abstracts; September 20-21, 2021; Belgrade
Belgrade : Serbian Ceramic Society., 84-85.
https://hdl.handle.net/21.15107/rcub_vinar_10843

Matić T, Cvijović-Alagić I, Petrović R, Janaćković Đ, Veljović Đ. The effect of hydrothermal synthesis parameters on cation-doped calciumhydroxyapatite. in Advanced Ceramics and Application : 9th Serbian Ceramic Society Conference : program and the book of abstracts; September 20-21, 2021; Belgrade. 2021;:84-85.
https://hdl.handle.net/21.15107/rcub_vinar_10843 .

Matić, Tamara, Cvijović-Alagić, Ivana, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "The effect of hydrothermal synthesis parameters on cation-doped calciumhydroxyapatite" in Advanced Ceramics and Application : 9th Serbian Ceramic Society Conference : program and the book of abstracts; September 20-21, 2021; Belgrade (2021):84-85,
https://hdl.handle.net/21.15107/rcub_vinar_10843 .