TY  - JOUR
AU  - Jovasevic, J. S.
AU  - Dimitrijević, Suzana I.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6919
AB  - A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing green agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55 degrees C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogels composition and the type of microbes
T2  - Acta Physica Polonica A
T1  - Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels
VL  - 120
IS  - 2
SP  - 279
EP  - 283
DO  - 10.12693/APhysPolA.120.279
ER  - 

@article{
author = "Jovasevic, J. S. and Dimitrijević, Suzana I. and Filipović, Jovanka M. and Tomić, Simonida Lj. and Mićić, Maja M. and Suljovrujić, Edin H.",
year = "2011",
abstract = "A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing green agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55 degrees C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogels composition and the type of microbes",
journal = "Acta Physica Polonica A",
title = "Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels",
volume = "120",
number = "2",
pages = "279-283",
doi = "10.12693/APhysPolA.120.279"
}

Jovasevic, J. S., Dimitrijević, S. I., Filipović, J. M., Tomić, S. Lj., Mićić, M. M.,& Suljovrujić, E. H.. (2011). Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels. in Acta Physica Polonica A, 120(2), 279-283.
https://doi.org/10.12693/APhysPolA.120.279

Jovasevic JS, Dimitrijević SI, Filipović JM, Tomić SL, Mićić MM, Suljovrujić EH. Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels. in Acta Physica Polonica A. 2011;120(2):279-283.
doi:10.12693/APhysPolA.120.279 .

Jovasevic, J. S., Dimitrijević, Suzana I., Filipović, Jovanka M., Tomić, Simonida Lj., Mićić, Maja M., Suljovrujić, Edin H., "Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels" in Acta Physica Polonica A, 120, no. 2 (2011):279-283,
https://doi.org/10.12693/APhysPolA.120.279 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Dokic, D.
AU  - Vasiljević-Radović, D. G.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3907
AB  - Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.
T2  - Materials and Manufacturing Processes
T1  - Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application
VL  - 24
IS  - 10-11
SP  - 1197
EP  - 1201
DO  - 10.1080/10426910903022247
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Dokic, D. and Vasiljević-Radović, D. G. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2009",
abstract = "Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.",
journal = "Materials and Manufacturing Processes",
title = "Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application",
volume = "24",
number = "10-11",
pages = "1197-1201",
doi = "10.1080/10426910903022247"
}

Tomić, S. Lj., Mićić, M. M., Dokic, D., Vasiljević-Radović, D. G., Filipović, J. M.,& Suljovrujić, E. H.. (2009). Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application. in Materials and Manufacturing Processes, 24(10-11), 1197-1201.
https://doi.org/10.1080/10426910903022247

Tomić SL, Mićić MM, Dokic D, Vasiljević-Radović DG, Filipović JM, Suljovrujić EH. Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application. in Materials and Manufacturing Processes. 2009;24(10-11):1197-1201.
doi:10.1080/10426910903022247 .

Tomić, Simonida Lj., Mićić, Maja M., Dokic, D., Vasiljević-Radović, D. G., Filipović, Jovanka M., Suljovrujić, Edin H., "Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application" in Materials and Manufacturing Processes, 24, no. 10-11 (2009):1197-1201,
https://doi.org/10.1080/10426910903022247 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3181
AB  - The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks. (C) 2006 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation
VL  - 76
IS  - 5
SP  - 801
EP  - 810
DO  - 10.1016/j.radphyschem.2006.05.013
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks. (C) 2006 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation",
volume = "76",
number = "5",
pages = "801-810",
doi = "10.1016/j.radphyschem.2006.05.013"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. in Radiation Physics and Chemistry, 76(5), 801-810.
https://doi.org/10.1016/j.radphyschem.2006.05.013

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. in Radiation Physics and Chemistry. 2007;76(5):801-810.
doi:10.1016/j.radphyschem.2006.05.013 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation" in Radiation Physics and Chemistry, 76, no. 5 (2007):801-810,
https://doi.org/10.1016/j.radphyschem.2006.05.013 . .

TY  - CONF
AU  - Mićić, Maja M.
AU  - Tomić, Simonida Lj.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6695
AB  - Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.
C3  - Materials Science Forum
T1  - Release and diffusion studies of hydrogels based on itaconic acid
VL  - 555
SP  - 441
EP  - +
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6695
ER  - 

@conference{
author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.",
journal = "Materials Science Forum",
title = "Release and diffusion studies of hydrogels based on itaconic acid",
volume = "555",
pages = "441-+",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6695"
}

Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum, 555, 441-+.
https://hdl.handle.net/21.15107/rcub_vinar_6695

Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum. 2007;555:441-+.
https://hdl.handle.net/21.15107/rcub_vinar_6695 .

Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Release and diffusion studies of hydrogels based on itaconic acid" in Materials Science Forum, 555 (2007):441-+,
https://hdl.handle.net/21.15107/rcub_vinar_6695 .