TY  - CONF
AU  - Mitić, Miloš
AU  - Simić, Iva
AU  - Đorđević, Ana D.
AU  - Đorđević, J.
AU  - Radojčić, Marija
AU  - Adžić, Miroslav
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9320
AB  - Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the pathophysiology of depression and stress disorders.
Glucocorticoids, key regulators of stress response, have diverse effects on cellular
processes in the hippocampus. Beside non genomic pathways, glucocorticoids
effects are mediated through activation of the glucocorticoid receptor (GR), a
ligand activated transcriptional factor that belongs to the nuclear hormone receptor
superfamily. We analysed the GR protein level both, in the cytoplasmic and
nuclear compartments in Wistar rat hippocampus, exposed to 3 week social
isolation stress upon chronic fluoxetine treatment. Under chronic stress,
corticosterone level was decreased compared to the control and treatment with
fluoxetine did not change its level significantly in stressed animals. At the
molecular level, fluoxetine significantly decreased the level of nuclear GR protein
in the brain hippocampus of the chronically stressed rats. Fluoxetine reversed the
nuclear level of GR disrupted by chronic psychosocial isolation (CPSI), but it
failed to normalize HPA axis activity.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Fluoxetine decreases the level of nuclear glucocorticoid receptor in wistar rat hippocampus under chronic stress
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9320
ER  - 

@conference{
author = "Mitić, Miloš and Simić, Iva and Đorđević, Ana D. and Đorđević, J. and Radojčić, Marija and Adžić, Miroslav",
year = "2010",
abstract = "Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the pathophysiology of depression and stress disorders.
Glucocorticoids, key regulators of stress response, have diverse effects on cellular
processes in the hippocampus. Beside non genomic pathways, glucocorticoids
effects are mediated through activation of the glucocorticoid receptor (GR), a
ligand activated transcriptional factor that belongs to the nuclear hormone receptor
superfamily. We analysed the GR protein level both, in the cytoplasmic and
nuclear compartments in Wistar rat hippocampus, exposed to 3 week social
isolation stress upon chronic fluoxetine treatment. Under chronic stress,
corticosterone level was decreased compared to the control and treatment with
fluoxetine did not change its level significantly in stressed animals. At the
molecular level, fluoxetine significantly decreased the level of nuclear GR protein
in the brain hippocampus of the chronically stressed rats. Fluoxetine reversed the
nuclear level of GR disrupted by chronic psychosocial isolation (CPSI), but it
failed to normalize HPA axis activity.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Fluoxetine decreases the level of nuclear glucocorticoid receptor in wistar rat hippocampus under chronic stress",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9320"
}

Mitić, M., Simić, I., Đorđević, A. D., Đorđević, J., Radojčić, M.,& Adžić, M.. (2010). Fluoxetine decreases the level of nuclear glucocorticoid receptor in wistar rat hippocampus under chronic stress. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9320

Mitić M, Simić I, Đorđević AD, Đorđević J, Radojčić M, Adžić M. Fluoxetine decreases the level of nuclear glucocorticoid receptor in wistar rat hippocampus under chronic stress. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9320 .

Mitić, Miloš, Simić, Iva, Đorđević, Ana D., Đorđević, J., Radojčić, Marija, Adžić, Miroslav, "Fluoxetine decreases the level of nuclear glucocorticoid receptor in wistar rat hippocampus under chronic stress" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9320 .