TY  - JOUR
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatović, Ivan A.
AU  - Lukić, Iva
AU  - Andrić-Petrović, Sanja
AU  - Mirjanić, Tijana
AU  - Stanković, Biljana
AU  - Žukić, Branka
AU  - Željić, Katarina
AU  - Gašić, Vladimir
AU  - Novaković, Ivana
AU  - Pavlović, Sonja
AU  - Adžić, Miroslav
AU  - Marić, Nađa P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9748
AB  - Hypothalamic–pituitary–adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation. © 2021 Elsevier Ltd
T2  - Psychoneuroendocrinology
T1  - The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls
VL  - 128
SP  - 105205
DO  - 10.1016/j.psyneuen.2021.105205
ER  - 

@article{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatović, Ivan A. and Lukić, Iva and Andrić-Petrović, Sanja and Mirjanić, Tijana and Stanković, Biljana and Žukić, Branka and Željić, Katarina and Gašić, Vladimir and Novaković, Ivana and Pavlović, Sonja and Adžić, Miroslav and Marić, Nađa P.",
year = "2021",
abstract = "Hypothalamic–pituitary–adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation. © 2021 Elsevier Ltd",
journal = "Psychoneuroendocrinology",
title = "The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls",
volume = "128",
pages = "105205",
doi = "10.1016/j.psyneuen.2021.105205"
}

Mihaljević, M., Franić, D., Soldatović, I. A., Lukić, I., Andrić-Petrović, S., Mirjanić, T., Stanković, B., Žukić, B., Željić, K., Gašić, V., Novaković, I., Pavlović, S., Adžić, M.,& Marić, N. P.. (2021). The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. in Psychoneuroendocrinology, 128, 105205.
https://doi.org/10.1016/j.psyneuen.2021.105205

Mihaljević M, Franić D, Soldatović IA, Lukić I, Andrić-Petrović S, Mirjanić T, Stanković B, Žukić B, Željić K, Gašić V, Novaković I, Pavlović S, Adžić M, Marić NP. The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. in Psychoneuroendocrinology. 2021;128:105205.
doi:10.1016/j.psyneuen.2021.105205 .

Mihaljević, Marina, Franić, Dušanka, Soldatović, Ivan A., Lukić, Iva, Andrić-Petrović, Sanja, Mirjanić, Tijana, Stanković, Biljana, Žukić, Branka, Željić, Katarina, Gašić, Vladimir, Novaković, Ivana, Pavlović, Sonja, Adžić, Miroslav, Marić, Nađa P., "The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls" in Psychoneuroendocrinology, 128 (2021):105205,
https://doi.org/10.1016/j.psyneuen.2021.105205 . .

TY  - CONF
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Mirjanic, Tijana
AU  - Novaković, Ivana
AU  - Adžić, Miroslav
AU  - Marić, Nađa
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7157
C3  - Schizophrenia Bulletin
T1  - Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls
VL  - 43
SP  - S195
EP  - S195
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7157
ER  - 

@conference{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Mirjanic, Tijana and Novaković, Ivana and Adžić, Miroslav and Marić, Nađa",
year = "2017",
journal = "Schizophrenia Bulletin",
title = "Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls",
volume = "43",
pages = "S195-S195",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7157"
}

Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Mirjanic, T., Novaković, I., Adžić, M.,& Marić, N.. (2017). Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls. in Schizophrenia Bulletin, 43, S195-S195.
https://hdl.handle.net/21.15107/rcub_vinar_7157

Mihaljević M, Franić D, Soldatovic I, Andrić S, Mirjanic T, Novaković I, Adžić M, Marić N. Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls. in Schizophrenia Bulletin. 2017;43:S195-S195.
https://hdl.handle.net/21.15107/rcub_vinar_7157 .

Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Mirjanic, Tijana, Novaković, Ivana, Adžić, Miroslav, Marić, Nađa, "Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls" in Schizophrenia Bulletin, 43 (2017):S195-S195,
https://hdl.handle.net/21.15107/rcub_vinar_7157 .

TY  - CONF
AU  - Marić, Nađa
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Lukić, Iva
AU  - Mirjanic, Tijana
AU  - Stankovic, Biljana
AU  - Zukic, Branka
AU  - Dobricic, Valerija
AU  - Novaković, Ivana
AU  - Pavlović, Sonja
AU  - Adžić, Miroslav
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7156
C3  - Schizophrenia Bulletin
T1  - The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation
VL  - 43
SP  - S66
EP  - S66
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7156
ER  - 

@conference{
author = "Marić, Nađa and Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Lukić, Iva and Mirjanic, Tijana and Stankovic, Biljana and Zukic, Branka and Dobricic, Valerija and Novaković, Ivana and Pavlović, Sonja and Adžić, Miroslav",
year = "2017",
journal = "Schizophrenia Bulletin",
title = "The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation",
volume = "43",
pages = "S66-S66",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7156"
}

Marić, N., Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Lukić, I., Mirjanic, T., Stankovic, B., Zukic, B., Dobricic, V., Novaković, I., Pavlović, S.,& Adžić, M.. (2017). The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation. in Schizophrenia Bulletin, 43, S66-S66.
https://hdl.handle.net/21.15107/rcub_vinar_7156

Marić N, Mihaljević M, Franić D, Soldatovic I, Andrić S, Lukić I, Mirjanic T, Stankovic B, Zukic B, Dobricic V, Novaković I, Pavlović S, Adžić M. The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation. in Schizophrenia Bulletin. 2017;43:S66-S66.
https://hdl.handle.net/21.15107/rcub_vinar_7156 .

Marić, Nađa, Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Lukić, Iva, Mirjanic, Tijana, Stankovic, Biljana, Zukic, Branka, Dobricic, Valerija, Novaković, Ivana, Pavlović, Sonja, Adžić, Miroslav, "The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation" in Schizophrenia Bulletin, 43 (2017):S66-S66,
https://hdl.handle.net/21.15107/rcub_vinar_7156 .

TY  - CONF
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Mirjanic, Tijana
AU  - Novaković, Ivana
AU  - Adžić, Miroslav
AU  - Nadja, Maric
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7185
C3  - European Neuropsychopharmacology
T1  - Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions
VL  - 27
SP  - S461
EP  - S462
DO  - 10.1016/j.euroneuro.2016.09.535
ER  - 

@conference{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Mirjanic, Tijana and Novaković, Ivana and Adžić, Miroslav and Nadja, Maric",
year = "2017",
journal = "European Neuropsychopharmacology",
title = "Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions",
volume = "27",
pages = "S461-S462",
doi = "10.1016/j.euroneuro.2016.09.535"
}

Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Mirjanic, T., Novaković, I., Adžić, M.,& Nadja, M.. (2017). Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions. in European Neuropsychopharmacology, 27, S461-S462.
https://doi.org/10.1016/j.euroneuro.2016.09.535

Mihaljević M, Franić D, Soldatovic I, Andrić S, Mirjanic T, Novaković I, Adžić M, Nadja M. Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions. in European Neuropsychopharmacology. 2017;27:S461-S462.
doi:10.1016/j.euroneuro.2016.09.535 .

Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Mirjanic, Tijana, Novaković, Ivana, Adžić, Miroslav, Nadja, Maric, "Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions" in European Neuropsychopharmacology, 27 (2017):S461-S462,
https://doi.org/10.1016/j.euroneuro.2016.09.535 . .