TY  - JOUR
AU  - Arandjelovic, S
AU  - Tešić, Živoslav
AU  - Juranic, Z
AU  - Radulović, Siniša S.
AU  - Vrvić, Miroslav M.
AU  - Potkonjak, Branislav
AU  - Ilić, Z.
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2609
AB  - Purpose of this work was to synthesize several cis-/trans- isomer pairs of the platinum(II) complexes, and study the extent and the mode of their antiproliferative activity on HeLa cells. Six platinum(II) isomer pairs have a general formula cis-/trans-[PtA(2) X-2] where A is ligand: ammonia (NH3), pyridine (Py); and X is ligand: chloride ion (Cl-), bromide ion (Br-), iodide ion (I-), thiocyanato, ion (SCN-); four compounds have different structural formulas, and these are cis-/trans-[Pt(NH2OH)(2) (NH3)(2)]Cl-2, and cis-/trans- Pt(Gly)(2), where Gly is bidentate glycinato ligand. Results of the MTT assay, showed that six cis- and one trans-platinum(II) complexes exhibited cytotoxicity (IC50) ranging between 5 and 33 muM. Most of the cis-platinum(II) isomers caused significant alteration of cell cycle phases progression, and induced apoptosis in degree that varied among different compounds, as evaluated using flowcytometry and morphological study. Spectrophotometric analysis (AAS) indicated that there is no correlation between intracellular platinum(II) accumulation and cytotoxicity of tested complexes.
T2  - Journal of Experimental and Clinical Cancer Research
T1  - Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells
VL  - 21
IS  - 4
SP  - 519
EP  - 526
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2609
ER  - 

@article{
author = "Arandjelovic, S and Tešić, Živoslav and Juranic, Z and Radulović, Siniša S. and Vrvić, Miroslav M. and Potkonjak, Branislav and Ilić, Z.",
year = "2002",
abstract = "Purpose of this work was to synthesize several cis-/trans- isomer pairs of the platinum(II) complexes, and study the extent and the mode of their antiproliferative activity on HeLa cells. Six platinum(II) isomer pairs have a general formula cis-/trans-[PtA(2) X-2] where A is ligand: ammonia (NH3), pyridine (Py); and X is ligand: chloride ion (Cl-), bromide ion (Br-), iodide ion (I-), thiocyanato, ion (SCN-); four compounds have different structural formulas, and these are cis-/trans-[Pt(NH2OH)(2) (NH3)(2)]Cl-2, and cis-/trans- Pt(Gly)(2), where Gly is bidentate glycinato ligand. Results of the MTT assay, showed that six cis- and one trans-platinum(II) complexes exhibited cytotoxicity (IC50) ranging between 5 and 33 muM. Most of the cis-platinum(II) isomers caused significant alteration of cell cycle phases progression, and induced apoptosis in degree that varied among different compounds, as evaluated using flowcytometry and morphological study. Spectrophotometric analysis (AAS) indicated that there is no correlation between intracellular platinum(II) accumulation and cytotoxicity of tested complexes.",
journal = "Journal of Experimental and Clinical Cancer Research",
title = "Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells",
volume = "21",
number = "4",
pages = "519-526",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2609"
}

Arandjelovic, S., Tešić, Ž., Juranic, Z., Radulović, S. S., Vrvić, M. M., Potkonjak, B.,& Ilić, Z.. (2002). Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells. in Journal of Experimental and Clinical Cancer Research, 21(4), 519-526.
https://hdl.handle.net/21.15107/rcub_vinar_2609

Arandjelovic S, Tešić Ž, Juranic Z, Radulović SS, Vrvić MM, Potkonjak B, Ilić Z. Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells. in Journal of Experimental and Clinical Cancer Research. 2002;21(4):519-526.
https://hdl.handle.net/21.15107/rcub_vinar_2609 .

Arandjelovic, S, Tešić, Živoslav, Juranic, Z, Radulović, Siniša S., Vrvić, Miroslav M., Potkonjak, Branislav, Ilić, Z., "Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells" in Journal of Experimental and Clinical Cancer Research, 21, no. 4 (2002):519-526,
https://hdl.handle.net/21.15107/rcub_vinar_2609 .