TY  - JOUR
AU  - Pavlović, S.
AU  - Artiko, V.
AU  - Sobic-Saranovic, D.
AU  - Damjanović, Svetozar S.
AU  - Popovic, B.
AU  - Jakovic, R.
AU  - Petrasinovic, Z.
AU  - Jaksic, E.
AU  - Todorović-Tirnanić, M.
AU  - Saranovic, D. J.
AU  - Micev, Marjan T.
AU  - Novosel, S.
AU  - Nikolic, N.
AU  - Obradović, V.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3995
AB  - Our aim was to assess clinical utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for evaluation of lung lesions in patients with neuroendocrine tumors (NETs). Single photon emission computed tomography (SPECT) of the thorax and whole body scintigraphy were performed in 34 patients using Tc-99m-EDDA/HYNIC-TOC. Visual assessment was complemented by semiquantitative evaluation based on tumor to non-tumor (TINT) ratio. Clinical, laboratory, and histological findings served as the standard for comparison. Enhanced tracer uptake was observed on both SPECT and whole body scintigraphy in 29 of 34 patients (88% sensitivity). TINT ratios were significantly higher on SPECT than whole body images (2.96 +/- 1.07 vs. 1.70 +/- 0.43, p LT 0.01) and did not correlate with NET proliferation index Ki-67 (r= - 0.36, p=0.27). Conclusion: Tc-99m-EDDA/HYNIC-TOC scintigraphy is useful for evaluation of NET tissue in the lungs. SPECT provides better visualization of lung lesions than whole body scintigraphy. The intensity of tracer uptake, however, does not relate to the proliferation rate of NETs. Tc-99m-EDDA/HYNIC-TOC scintigraphy may be helpful for selecting and monitoring treatment options, particularly when radiolabeled somatostatin analogue therapy becomes available.
T2  - Neoplasma
T1  - The utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors
VL  - 57
IS  - 1
SP  - 68
EP  - 73
DO  - 10.4149/neo_2010_01_068
ER  - 

@article{
author = "Pavlović, S. and Artiko, V. and Sobic-Saranovic, D. and Damjanović, Svetozar S. and Popovic, B. and Jakovic, R. and Petrasinovic, Z. and Jaksic, E. and Todorović-Tirnanić, M. and Saranovic, D. J. and Micev, Marjan T. and Novosel, S. and Nikolic, N. and Obradović, V.",
year = "2010",
abstract = "Our aim was to assess clinical utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for evaluation of lung lesions in patients with neuroendocrine tumors (NETs). Single photon emission computed tomography (SPECT) of the thorax and whole body scintigraphy were performed in 34 patients using Tc-99m-EDDA/HYNIC-TOC. Visual assessment was complemented by semiquantitative evaluation based on tumor to non-tumor (TINT) ratio. Clinical, laboratory, and histological findings served as the standard for comparison. Enhanced tracer uptake was observed on both SPECT and whole body scintigraphy in 29 of 34 patients (88% sensitivity). TINT ratios were significantly higher on SPECT than whole body images (2.96 +/- 1.07 vs. 1.70 +/- 0.43, p LT 0.01) and did not correlate with NET proliferation index Ki-67 (r= - 0.36, p=0.27). Conclusion: Tc-99m-EDDA/HYNIC-TOC scintigraphy is useful for evaluation of NET tissue in the lungs. SPECT provides better visualization of lung lesions than whole body scintigraphy. The intensity of tracer uptake, however, does not relate to the proliferation rate of NETs. Tc-99m-EDDA/HYNIC-TOC scintigraphy may be helpful for selecting and monitoring treatment options, particularly when radiolabeled somatostatin analogue therapy becomes available.",
journal = "Neoplasma",
title = "The utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors",
volume = "57",
number = "1",
pages = "68-73",
doi = "10.4149/neo_2010_01_068"
}

Pavlović, S., Artiko, V., Sobic-Saranovic, D., Damjanović, S. S., Popovic, B., Jakovic, R., Petrasinovic, Z., Jaksic, E., Todorović-Tirnanić, M., Saranovic, D. J., Micev, M. T., Novosel, S., Nikolic, N.,& Obradović, V.. (2010). The utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors. in Neoplasma, 57(1), 68-73.
https://doi.org/10.4149/neo_2010_01_068

Pavlović S, Artiko V, Sobic-Saranovic D, Damjanović SS, Popovic B, Jakovic R, Petrasinovic Z, Jaksic E, Todorović-Tirnanić M, Saranovic DJ, Micev MT, Novosel S, Nikolic N, Obradović V. The utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors. in Neoplasma. 2010;57(1):68-73.
doi:10.4149/neo_2010_01_068 .

Pavlović, S., Artiko, V., Sobic-Saranovic, D., Damjanović, Svetozar S., Popovic, B., Jakovic, R., Petrasinovic, Z., Jaksic, E., Todorović-Tirnanić, M., Saranovic, D. J., Micev, Marjan T., Novosel, S., Nikolic, N., Obradović, V., "The utility of Tc-99m-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors" in Neoplasma, 57, no. 1 (2010):68-73,
https://doi.org/10.4149/neo_2010_01_068 . .

TY  - CONF
AU  - Jaksic, E.
AU  - Beatovic, S.
AU  - Artiko, V.
AU  - Saranovic, D. Sobic
AU  - Pavlović, Suncan
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Obradović, V.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2733
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Comparison between Tc-99m p-Aminohippuric acid and Tc-99m MAG3 renography
VL  - 36
SP  - S437
EP  - S437
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2733
ER  - 

@conference{
author = "Jaksic, E. and Beatovic, S. and Artiko, V. and Saranovic, D. Sobic and Pavlović, Suncan and Đokić, Divna Đ. and Janković, Drina and Obradović, V.",
year = "2009",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Comparison between Tc-99m p-Aminohippuric acid and Tc-99m MAG3 renography",
volume = "36",
pages = "S437-S437",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2733"
}

Jaksic, E., Beatovic, S., Artiko, V., Saranovic, D. S., Pavlović, S., Đokić, D. Đ., Janković, D.,& Obradović, V.. (2009). Comparison between Tc-99m p-Aminohippuric acid and Tc-99m MAG3 renography. in European Journal of Nuclear Medicine and Molecular Imaging, 36, S437-S437.
https://hdl.handle.net/21.15107/rcub_vinar_2733

Jaksic E, Beatovic S, Artiko V, Saranovic DS, Pavlović S, Đokić DĐ, Janković D, Obradović V. Comparison between Tc-99m p-Aminohippuric acid and Tc-99m MAG3 renography. in European Journal of Nuclear Medicine and Molecular Imaging. 2009;36:S437-S437.
https://hdl.handle.net/21.15107/rcub_vinar_2733 .

Jaksic, E., Beatovic, S., Artiko, V., Saranovic, D. Sobic, Pavlović, Suncan, Đokić, Divna Đ., Janković, Drina, Obradović, V., "Comparison between Tc-99m p-Aminohippuric acid and Tc-99m MAG3 renography" in European Journal of Nuclear Medicine and Molecular Imaging, 36 (2009):S437-S437,
https://hdl.handle.net/21.15107/rcub_vinar_2733 .

TY  - CONF
AU  - Jaksic, E.
AU  - Beatovic, S.
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Lezaic, V.
AU  - Han, R.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2734
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Tc-99m PAH Renography: Clinical Studies
VL  - 32
SP  - S246
EP  - S246
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2734
ER  - 

@conference{
author = "Jaksic, E. and Beatovic, S. and Đokić, Divna Đ. and Janković, Drina and Lezaic, V. and Han, R.",
year = "2005",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Tc-99m PAH Renography: Clinical Studies",
volume = "32",
pages = "S246-S246",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2734"
}

Jaksic, E., Beatovic, S., Đokić, D. Đ., Janković, D., Lezaic, V.,& Han, R.. (2005). Tc-99m PAH Renography: Clinical Studies. in European Journal of Nuclear Medicine and Molecular Imaging, 32, S246-S246.
https://hdl.handle.net/21.15107/rcub_vinar_2734

Jaksic E, Beatovic S, Đokić DĐ, Janković D, Lezaic V, Han R. Tc-99m PAH Renography: Clinical Studies. in European Journal of Nuclear Medicine and Molecular Imaging. 2005;32:S246-S246.
https://hdl.handle.net/21.15107/rcub_vinar_2734 .

Jaksic, E., Beatovic, S., Đokić, Divna Đ., Janković, Drina, Lezaic, V., Han, R., "Tc-99m PAH Renography: Clinical Studies" in European Journal of Nuclear Medicine and Molecular Imaging, 32 (2005):S246-S246,
https://hdl.handle.net/21.15107/rcub_vinar_2734 .