TY  - JOUR
AU  - Tadić, Julijana D.
AU  - Mihajlović, Marina
AU  - Jovanović, Mica
AU  - Mijin, Dušan Ž.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10891
AB  - In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.
T2  - Journal of the Serbian Chemical Society
T1  - Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones
VL  - 84
IS  - 6
SP  - 531
EP  - 538
DO  - 10.2298/JSC180703092T
ER  - 

@article{
author = "Tadić, Julijana D. and Mihajlović, Marina and Jovanović, Mica and Mijin, Dušan Ž.",
year = "2019",
abstract = "In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.",
journal = "Journal of the Serbian Chemical Society",
title = "Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones",
volume = "84",
number = "6",
pages = "531-538",
doi = "10.2298/JSC180703092T"
}

Tadić, J. D., Mihajlović, M., Jovanović, M.,& Mijin, D. Ž.. (2019). Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones. in Journal of the Serbian Chemical Society, 84(6), 531-538.
https://doi.org/10.2298/JSC180703092T

Tadić JD, Mihajlović M, Jovanović M, Mijin DŽ. Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones. in Journal of the Serbian Chemical Society. 2019;84(6):531-538.
doi:10.2298/JSC180703092T .

Tadić, Julijana D., Mihajlović, Marina, Jovanović, Mica, Mijin, Dušan Ž., "Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones" in Journal of the Serbian Chemical Society, 84, no. 6 (2019):531-538,
https://doi.org/10.2298/JSC180703092T . .