TY  - JOUR
AU  - Bukonjić, Andriana M.
AU  - Tomović, Dušan Lj.
AU  - Nikolić, Miloš V.
AU  - Mijajlović, Marina Ž.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Radojevic, Ivana D.
AU  - Maksimović, Jovana Z.
AU  - Vasić, Sava M.
AU  - Čomić, Ljiljana R.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1296
AB  - The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of thiosalicylic acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of thiosalicylic acid, [Cu-2(S-et-thiosal)(4)(H2O)(2)] (C3) and copper(II)-complex with S-butyl derivative of thiosalicylic acid, [Cu-2(S-bu-thiosal)(4)(H2O)(2)] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa. ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay). (C) 2016 Elsevier B.V. All rights reserved.
T2  - Journal of Molecular Structure
T1  - Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid
VL  - 1128
SP  - 330
EP  - 337
DO  - 10.1016/j.molstruc.2016.08.086
ER  - 

@article{
author = "Bukonjić, Andriana M. and Tomović, Dušan Lj. and Nikolić, Miloš V. and Mijajlović, Marina Ž. and Jevtić, Verica V. and Ratković, Zoran R. and Novaković, Slađana B. and Bogdanović, Goran A. and Radojevic, Ivana D. and Maksimović, Jovana Z. and Vasić, Sava M. and Čomić, Ljiljana R. and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2017",
abstract = "The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of thiosalicylic acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of thiosalicylic acid, [Cu-2(S-et-thiosal)(4)(H2O)(2)] (C3) and copper(II)-complex with S-butyl derivative of thiosalicylic acid, [Cu-2(S-bu-thiosal)(4)(H2O)(2)] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa. ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay). (C) 2016 Elsevier B.V. All rights reserved.",
journal = "Journal of Molecular Structure",
title = "Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid",
volume = "1128",
pages = "330-337",
doi = "10.1016/j.molstruc.2016.08.086"
}

Bukonjić, A. M., Tomović, D. Lj., Nikolić, M. V., Mijajlović, M. Ž., Jevtić, V. V., Ratković, Z. R., Novaković, S. B., Bogdanović, G. A., Radojevic, I. D., Maksimović, J. Z., Vasić, S. M., Čomić, L. R., Trifunović, S. R.,& Radić, G. P.. (2017). Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid. in Journal of Molecular Structure, 1128, 330-337.
https://doi.org/10.1016/j.molstruc.2016.08.086

Bukonjić AM, Tomović DL, Nikolić MV, Mijajlović MŽ, Jevtić VV, Ratković ZR, Novaković SB, Bogdanović GA, Radojevic ID, Maksimović JZ, Vasić SM, Čomić LR, Trifunović SR, Radić GP. Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid. in Journal of Molecular Structure. 2017;1128:330-337.
doi:10.1016/j.molstruc.2016.08.086 .

Bukonjić, Andriana M., Tomović, Dušan Lj., Nikolić, Miloš V., Mijajlović, Marina Ž., Jevtić, Verica V., Ratković, Zoran R., Novaković, Slađana B., Bogdanović, Goran A., Radojevic, Ivana D., Maksimović, Jovana Z., Vasić, Sava M., Čomić, Ljiljana R., Trifunović, Srećko R., Radić, Gordana P., "Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid" in Journal of Molecular Structure, 1128 (2017):330-337,
https://doi.org/10.1016/j.molstruc.2016.08.086 . .