TY  - JOUR
AU  - Radić, Jelena
AU  - Kožik, Bojana
AU  - Nikolić, Ivan
AU  - Kolarov-Bjelobrk, Ivana
AU  - Vasiljević, Tijana
AU  - Vranjković, Bojana
AU  - Despotović, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11377
AB  - LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic
target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked
with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the
mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development.
We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of
the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal
transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis,
and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2
inhibitors and discuss their potential in HCC precision treatment.
T2  - International Journal of Molecular Sciences
T1  - Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting
VL  - 24
IS  - 14
SP  - 11745
DO  - 10.3390/ijms241411745
ER  - 

@article{
author = "Radić, Jelena and Kožik, Bojana and Nikolić, Ivan and Kolarov-Bjelobrk, Ivana and Vasiljević, Tijana and Vranjković, Bojana and Despotović, Sanja",
year = "2023",
abstract = "LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic
target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked
with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the
mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development.
We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of
the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal
transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis,
and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2
inhibitors and discuss their potential in HCC precision treatment.",
journal = "International Journal of Molecular Sciences",
title = "Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting",
volume = "24",
number = "14",
pages = "11745",
doi = "10.3390/ijms241411745"
}

Radić, J., Kožik, B., Nikolić, I., Kolarov-Bjelobrk, I., Vasiljević, T., Vranjković, B.,& Despotović, S.. (2023). Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. in International Journal of Molecular Sciences, 24(14), 11745.
https://doi.org/10.3390/ijms241411745

Radić J, Kožik B, Nikolić I, Kolarov-Bjelobrk I, Vasiljević T, Vranjković B, Despotović S. Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. in International Journal of Molecular Sciences. 2023;24(14):11745.
doi:10.3390/ijms241411745 .

Radić, Jelena, Kožik, Bojana, Nikolić, Ivan, Kolarov-Bjelobrk, Ivana, Vasiljević, Tijana, Vranjković, Bojana, Despotović, Sanja, "Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting" in International Journal of Molecular Sciences, 24, no. 14 (2023):11745,
https://doi.org/10.3390/ijms241411745 . .

TY  - CONF
AU  - Đurić, Mladen
AU  - Kožik, Bojana
AU  - Vasiljević, Tijana
AU  - Đermanović, Aleksandar
AU  - Stanulović, Nevena
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12637
AB  - Background: Rectal carcinoma (RC), a common malignancy of the gastrointesƟ nal tract, remains a great clinical challenge due to the increased risk of local and/or systemic recurrence. The mechanism of primary tumor progression and disseminaƟ on may be the crucial prognosƟ c factor. Direct vascular spread, especially venous invasion, has been previously recognized and validated as an important predictor of adverse prognosis. Extramural venous invasion (EMVI) is characterized by the presence of tumor cells within veins outside the bowel wall and is strongly associated with poor survival, increased risk of local recurrence, systemic recurrence, and death. The aim of this study is to examine the prognosƟ c value of pathologically detected EMVI and its relaƟ onship with other available clinicopathological parameters of paƟ ents with RC. PaƟ ents and Methods: This retrospecƟ ve study included 100 untreated and non-metastaƟ c RC paƟ ents (50 EMVI+ and 50 EMVI-) who underwent curaƟ ve resecƟ on between January 2016 and June 2018 and were followed for the next fi ve years (median follow-up of 71.1 months). The presence of EMVI was assessed on standard hematoxylin and eosin-stained histolological secƟ ons of postoperaƟ ve tumor specimens samples, confi rmed by a consultant pathologist in arbitrary cases, and in accordance with validated College of American Pathologist (CAP) guidelines. Results: The presence of EMVI within a selected cohort of RC paƟ ents signifi cantly associated with female gender (p=0.039), T4 stage (p=<0.001), N2 stage (p=<0.001), less number (n≤3) of involved lymph nodes (p=<0.001), excessive lymphaƟ c infi ltraƟ on (p=0.044), presence of perineural invasion (p=0.002), posiƟ ve circumferenƟ al margin (CRM) (p=0.003), and TNMIII stage (p=<0.001). In addiƟ on, within EMVI+ paƟ ents, metastases, dominantly in the liver (13/19, 68%), and death outcomes were more frequent events (p=0.013 and p=0.032, respecƟ vely), while survival analyses revealed that EMVI+ paƟ ents had signifi cantly shorter overall survival (OS, p=0.035) and disease-free survival (DFS, p=0.030). Conclusion: Obtained results strongly suggest that the EMVI type of vascular invasion, considered independently of classical stage parameters and separately from lymphaƟ c invasion, has the potenƟ al to be a reliable predictor of the course and outcome of the disease, which should be confi rmed on a larger cohort of paƟ ents with RC.
PB  - Belgrade : Serbian Association for Cancer Research
C3  - Oncology Insights
T1  - Prognostic significance of pathologically detected extramural venous invasion (EMVI) in rectal carcinoma
IS  - 1
SP  - 90
EP  - 90
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12637
ER  - 

@conference{
author = "Đurić, Mladen and Kožik, Bojana and Vasiljević, Tijana and Đermanović, Aleksandar and Stanulović, Nevena",
year = "2023",
abstract = "Background: Rectal carcinoma (RC), a common malignancy of the gastrointesƟ nal tract, remains a great clinical challenge due to the increased risk of local and/or systemic recurrence. The mechanism of primary tumor progression and disseminaƟ on may be the crucial prognosƟ c factor. Direct vascular spread, especially venous invasion, has been previously recognized and validated as an important predictor of adverse prognosis. Extramural venous invasion (EMVI) is characterized by the presence of tumor cells within veins outside the bowel wall and is strongly associated with poor survival, increased risk of local recurrence, systemic recurrence, and death. The aim of this study is to examine the prognosƟ c value of pathologically detected EMVI and its relaƟ onship with other available clinicopathological parameters of paƟ ents with RC. PaƟ ents and Methods: This retrospecƟ ve study included 100 untreated and non-metastaƟ c RC paƟ ents (50 EMVI+ and 50 EMVI-) who underwent curaƟ ve resecƟ on between January 2016 and June 2018 and were followed for the next fi ve years (median follow-up of 71.1 months). The presence of EMVI was assessed on standard hematoxylin and eosin-stained histolological secƟ ons of postoperaƟ ve tumor specimens samples, confi rmed by a consultant pathologist in arbitrary cases, and in accordance with validated College of American Pathologist (CAP) guidelines. Results: The presence of EMVI within a selected cohort of RC paƟ ents signifi cantly associated with female gender (p=0.039), T4 stage (p=<0.001), N2 stage (p=<0.001), less number (n≤3) of involved lymph nodes (p=<0.001), excessive lymphaƟ c infi ltraƟ on (p=0.044), presence of perineural invasion (p=0.002), posiƟ ve circumferenƟ al margin (CRM) (p=0.003), and TNMIII stage (p=<0.001). In addiƟ on, within EMVI+ paƟ ents, metastases, dominantly in the liver (13/19, 68%), and death outcomes were more frequent events (p=0.013 and p=0.032, respecƟ vely), while survival analyses revealed that EMVI+ paƟ ents had signifi cantly shorter overall survival (OS, p=0.035) and disease-free survival (DFS, p=0.030). Conclusion: Obtained results strongly suggest that the EMVI type of vascular invasion, considered independently of classical stage parameters and separately from lymphaƟ c invasion, has the potenƟ al to be a reliable predictor of the course and outcome of the disease, which should be confi rmed on a larger cohort of paƟ ents with RC.",
publisher = "Belgrade : Serbian Association for Cancer Research",
journal = "Oncology Insights",
title = "Prognostic significance of pathologically detected extramural venous invasion (EMVI) in rectal carcinoma",
number = "1",
pages = "90-90",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12637"
}

Đurić, M., Kožik, B., Vasiljević, T., Đermanović, A.,& Stanulović, N.. (2023). Prognostic significance of pathologically detected extramural venous invasion (EMVI) in rectal carcinoma. in Oncology Insights
Belgrade : Serbian Association for Cancer Research.(1), 90-90.
https://hdl.handle.net/21.15107/rcub_vinar_12637

Đurić M, Kožik B, Vasiljević T, Đermanović A, Stanulović N. Prognostic significance of pathologically detected extramural venous invasion (EMVI) in rectal carcinoma. in Oncology Insights. 2023;(1):90-90.
https://hdl.handle.net/21.15107/rcub_vinar_12637 .

Đurić, Mladen, Kožik, Bojana, Vasiljević, Tijana, Đermanović, Aleksandar, Stanulović, Nevena, "Prognostic significance of pathologically detected extramural venous invasion (EMVI) in rectal carcinoma" in Oncology Insights, no. 1 (2023):90-90,
https://hdl.handle.net/21.15107/rcub_vinar_12637 .