TY  - JOUR
AU  - Micić, Milutin
AU  - Antonijević, Đorđe
AU  - Milutinović-Smiljanić, Sanja
AU  - Trišić, Dijana
AU  - Čolović, Božana M.
AU  - Kosanović, Dejana
AU  - Prokić, Bogomir Bolka
AU  - Vasić, Jugoslav
AU  - Živković, Slavoljub
AU  - Milašin, Jelena
AU  - Danilović, Vesna
AU  - Đurić, Marija P.
AU  - Jokanović, Vukoman R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10363
AB  - Article Corrigendum to: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: physicochemical and biological characterization and proof of concept in segmental rabbit’s ulna reconstruction was published on June 28, 2022 in the journal Biomedical Engineering / Biomedizinische Technik
T2  - Biomedical Engineering / Biomedizinische Technik
T1  - Corrigendum: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: Physicochemical and biological characterization and proof of concept in segmental rabbit's ulna reconstruction (Biomedical Engineering / Biomedizinische Technik 65:4 (491-505) DOI: 10.1515/bmt-2019-0218)
DO  - 10.1515/bmt-2022-0188
ER  - 

@article{
author = "Micić, Milutin and Antonijević, Đorđe and Milutinović-Smiljanić, Sanja and Trišić, Dijana and Čolović, Božana M. and Kosanović, Dejana and Prokić, Bogomir Bolka and Vasić, Jugoslav and Živković, Slavoljub and Milašin, Jelena and Danilović, Vesna and Đurić, Marija P. and Jokanović, Vukoman R.",
year = "2022",
abstract = "Article Corrigendum to: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: physicochemical and biological characterization and proof of concept in segmental rabbit’s ulna reconstruction was published on June 28, 2022 in the journal Biomedical Engineering / Biomedizinische Technik",
journal = "Biomedical Engineering / Biomedizinische Technik",
title = "Corrigendum: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: Physicochemical and biological characterization and proof of concept in segmental rabbit's ulna reconstruction (Biomedical Engineering / Biomedizinische Technik 65:4 (491-505) DOI: 10.1515/bmt-2019-0218)",
doi = "10.1515/bmt-2022-0188"
}

Micić, M., Antonijević, Đ., Milutinović-Smiljanić, S., Trišić, D., Čolović, B. M., Kosanović, D., Prokić, B. B., Vasić, J., Živković, S., Milašin, J., Danilović, V., Đurić, M. P.,& Jokanović, V. R.. (2022). Corrigendum: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: Physicochemical and biological characterization and proof of concept in segmental rabbit's ulna reconstruction (Biomedical Engineering / Biomedizinische Technik 65:4 (491-505) DOI: 10.1515/bmt-2019-0218). in Biomedical Engineering / Biomedizinische Technik.
https://doi.org/10.1515/bmt-2022-0188

Micić M, Antonijević Đ, Milutinović-Smiljanić S, Trišić D, Čolović BM, Kosanović D, Prokić BB, Vasić J, Živković S, Milašin J, Danilović V, Đurić MP, Jokanović VR. Corrigendum: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: Physicochemical and biological characterization and proof of concept in segmental rabbit's ulna reconstruction (Biomedical Engineering / Biomedizinische Technik 65:4 (491-505) DOI: 10.1515/bmt-2019-0218). in Biomedical Engineering / Biomedizinische Technik. 2022;.
doi:10.1515/bmt-2022-0188 .

Micić, Milutin, Antonijević, Đorđe, Milutinović-Smiljanić, Sanja, Trišić, Dijana, Čolović, Božana M., Kosanović, Dejana, Prokić, Bogomir Bolka, Vasić, Jugoslav, Živković, Slavoljub, Milašin, Jelena, Danilović, Vesna, Đurić, Marija P., Jokanović, Vukoman R., "Corrigendum: Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: Physicochemical and biological characterization and proof of concept in segmental rabbit's ulna reconstruction (Biomedical Engineering / Biomedizinische Technik 65:4 (491-505) DOI: 10.1515/bmt-2019-0218)" in Biomedical Engineering / Biomedizinische Technik (2022),
https://doi.org/10.1515/bmt-2022-0188 . .

TY  - JOUR
AU  - Jokanović, Vukoman R.
AU  - Bundaleski, Nenad
AU  - Petrović, Božana
AU  - Ferarra, Manuela
AU  - Jokanović, Bojan
AU  - Živković, Slavoljub
AU  - Nasov, Ilija
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10029
AB  - Thin films on the base of titanium oxynitrides and copper doped titanium nitride were obtained by a combination of different PVD techniques on the surface of glass substrate and their physicochemical properties were analyzed in details. Phase composition of the samples was analyzed by XRD and FTIR methods, while microstructure of the samples was analyzed by SEM. XPS was used for depth profiling of the samples, which enabled determination of the oxidative state of titanium and corresponding phases through various film layers from the surface to the substrate. The depth of the various layers and their extinction coefficients and refractory indexes were estimated by spectroscopic ellipsometry.
T2  - Vacuum
T1  - Detailed phisyco-chemical characterization of the multilayered thin films based on titanium oxynitride and copper doped titanium nitride obtained by different PVD techniques
VL  - 195
SP  - 110708
DO  - 10.1016/j.vacuum.2021.110708
ER  - 

@article{
author = "Jokanović, Vukoman R. and Bundaleski, Nenad and Petrović, Božana and Ferarra, Manuela and Jokanović, Bojan and Živković, Slavoljub and Nasov, Ilija",
year = "2022",
abstract = "Thin films on the base of titanium oxynitrides and copper doped titanium nitride were obtained by a combination of different PVD techniques on the surface of glass substrate and their physicochemical properties were analyzed in details. Phase composition of the samples was analyzed by XRD and FTIR methods, while microstructure of the samples was analyzed by SEM. XPS was used for depth profiling of the samples, which enabled determination of the oxidative state of titanium and corresponding phases through various film layers from the surface to the substrate. The depth of the various layers and their extinction coefficients and refractory indexes were estimated by spectroscopic ellipsometry.",
journal = "Vacuum",
title = "Detailed phisyco-chemical characterization of the multilayered thin films based on titanium oxynitride and copper doped titanium nitride obtained by different PVD techniques",
volume = "195",
pages = "110708",
doi = "10.1016/j.vacuum.2021.110708"
}

Jokanović, V. R., Bundaleski, N., Petrović, B., Ferarra, M., Jokanović, B., Živković, S.,& Nasov, I.. (2022). Detailed phisyco-chemical characterization of the multilayered thin films based on titanium oxynitride and copper doped titanium nitride obtained by different PVD techniques. in Vacuum, 195, 110708.
https://doi.org/10.1016/j.vacuum.2021.110708

Jokanović VR, Bundaleski N, Petrović B, Ferarra M, Jokanović B, Živković S, Nasov I. Detailed phisyco-chemical characterization of the multilayered thin films based on titanium oxynitride and copper doped titanium nitride obtained by different PVD techniques. in Vacuum. 2022;195:110708.
doi:10.1016/j.vacuum.2021.110708 .

Jokanović, Vukoman R., Bundaleski, Nenad, Petrović, Božana, Ferarra, Manuela, Jokanović, Bojan, Živković, Slavoljub, Nasov, Ilija, "Detailed phisyco-chemical characterization of the multilayered thin films based on titanium oxynitride and copper doped titanium nitride obtained by different PVD techniques" in Vacuum, 195 (2022):110708,
https://doi.org/10.1016/j.vacuum.2021.110708 . .

TY  - JOUR
AU  - Jokanović, Vukoman R.
AU  - Živković, Slavoljub
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10421
AB  - Face masks serve to protect the respiratory system from unwanted aerosol droplets, in which various types of pathogens or pollutants are present. They are particularly important during a pandemic, like SARS-CoV-2 pandemic we are withessing. The efficiency of filtration of aerosol droplets, which contain the virus particles, is generally unsatisfactory, especially in conditions of extremely virulent environments, for the most of commercially available masks. Therefore, the challenge is to produce masks with increased filtration efficiency, in order to reduce the percentage of virus penetration through the mask. Hence, it is crucial to correctly define the possibilities and limitations of today's most commonly used epidemiological masks, in order to successfully define completely new concepts of face masks manufacturing, which would enable the most effective protection not only of medical workers but also patients, especially in areas where virus concentrations are extremely high. Also, it has been shown that, in addition to the concentrations of infectious pathogens in a given environment, the conditions in which infection with a given pathogen occurs, such as temperature and humidity within a given contaminated space, are also important.
T2  - Zaštita materijala
T1  - Controversies related to real protection against SARS-CoV-2 virus of the most frequently used face masks
VL  - 63
IS  - 3
SP  - 221
EP  - 229
DO  - 10.5937/zasmat2203221J
ER  - 

@article{
author = "Jokanović, Vukoman R. and Živković, Slavoljub",
year = "2022",
abstract = "Face masks serve to protect the respiratory system from unwanted aerosol droplets, in which various types of pathogens or pollutants are present. They are particularly important during a pandemic, like SARS-CoV-2 pandemic we are withessing. The efficiency of filtration of aerosol droplets, which contain the virus particles, is generally unsatisfactory, especially in conditions of extremely virulent environments, for the most of commercially available masks. Therefore, the challenge is to produce masks with increased filtration efficiency, in order to reduce the percentage of virus penetration through the mask. Hence, it is crucial to correctly define the possibilities and limitations of today's most commonly used epidemiological masks, in order to successfully define completely new concepts of face masks manufacturing, which would enable the most effective protection not only of medical workers but also patients, especially in areas where virus concentrations are extremely high. Also, it has been shown that, in addition to the concentrations of infectious pathogens in a given environment, the conditions in which infection with a given pathogen occurs, such as temperature and humidity within a given contaminated space, are also important.",
journal = "Zaštita materijala",
title = "Controversies related to real protection against SARS-CoV-2 virus of the most frequently used face masks",
volume = "63",
number = "3",
pages = "221-229",
doi = "10.5937/zasmat2203221J"
}

Jokanović, V. R.,& Živković, S.. (2022). Controversies related to real protection against SARS-CoV-2 virus of the most frequently used face masks. in Zaštita materijala, 63(3), 221-229.
https://doi.org/10.5937/zasmat2203221J

Jokanović VR, Živković S. Controversies related to real protection against SARS-CoV-2 virus of the most frequently used face masks. in Zaštita materijala. 2022;63(3):221-229.
doi:10.5937/zasmat2203221J .

Jokanović, Vukoman R., Živković, Slavoljub, "Controversies related to real protection against SARS-CoV-2 virus of the most frequently used face masks" in Zaštita materijala, 63, no. 3 (2022):221-229,
https://doi.org/10.5937/zasmat2203221J . .

TY  - JOUR
AU  - Opacic-Galic, Vanja
AU  - Petrović, Violeta
AU  - Jokanović, Vukoman R.
AU  - Zivkovic, Slavoljub
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1759
AB  - Introduction/Objective Development of materials which could be used as biological bone substitutes is one of the most valuable and active fields of biomaterial research. The goal of the study was to research the reaction of tissue on calcium silicate-(CS) and hydroxyapatite-based (CS-HA) newly synthesized nanomaterials, after being implanted into the subcutaneous tissue of a rats and direct pulp capping of rabbit teeth. Methods The tested materials were implanted in 40 Wistar male rats, sacrificed after seven, 15, 30, and 60 days. The direct pulp capping was performed on the teeth of rabbits. Cavities were prepared on the vestibular surface of the incisors. The animals were sacrificed after 10 and 15 days. The control material was mineral trioxide aggregate (MTA). Histological analysis covered the tracking of inflammatory reaction cellular components, presence of gigantic cells, and necrosis of the tissue. Results Seven days after the implantation, the strongest inflammatory response was given by the MTA (3.3 +/- 0.48), while CS and CS-HA scored 3 +/- 0.71. After 60 days, the rate of inflammatory reactions dropped, which was the least visible with CS-HA (0.2 +/- 0.45). The least visible inflammatory reaction of the rabbits pulp tissue was spotted with the CS (1.83 +/- 0.75), than with the MTA and CS-HA (2.67 +/- 1.53, 3 +/- 0.63). Conclusion The newly synthesized materials caused a slight reaction of the subcutaneous tissue. CS-HA showed the best tissue tolerance. Nanostructural biomaterials caused a slight to moderate inflammatory reaction of the rabbits pulp tissue only in the immediate vicinity of the implanted material.
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials - In vivo study
VL  - 145
IS  - 7-8
SP  - 370
EP  - 377
DO  - 10.2298/SARH160719063O
ER  - 

@article{
author = "Opacic-Galic, Vanja and Petrović, Violeta and Jokanović, Vukoman R. and Zivkovic, Slavoljub",
year = "2017",
abstract = "Introduction/Objective Development of materials which could be used as biological bone substitutes is one of the most valuable and active fields of biomaterial research. The goal of the study was to research the reaction of tissue on calcium silicate-(CS) and hydroxyapatite-based (CS-HA) newly synthesized nanomaterials, after being implanted into the subcutaneous tissue of a rats and direct pulp capping of rabbit teeth. Methods The tested materials were implanted in 40 Wistar male rats, sacrificed after seven, 15, 30, and 60 days. The direct pulp capping was performed on the teeth of rabbits. Cavities were prepared on the vestibular surface of the incisors. The animals were sacrificed after 10 and 15 days. The control material was mineral trioxide aggregate (MTA). Histological analysis covered the tracking of inflammatory reaction cellular components, presence of gigantic cells, and necrosis of the tissue. Results Seven days after the implantation, the strongest inflammatory response was given by the MTA (3.3 +/- 0.48), while CS and CS-HA scored 3 +/- 0.71. After 60 days, the rate of inflammatory reactions dropped, which was the least visible with CS-HA (0.2 +/- 0.45). The least visible inflammatory reaction of the rabbits pulp tissue was spotted with the CS (1.83 +/- 0.75), than with the MTA and CS-HA (2.67 +/- 1.53, 3 +/- 0.63). Conclusion The newly synthesized materials caused a slight reaction of the subcutaneous tissue. CS-HA showed the best tissue tolerance. Nanostructural biomaterials caused a slight to moderate inflammatory reaction of the rabbits pulp tissue only in the immediate vicinity of the implanted material.",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials - In vivo study",
volume = "145",
number = "7-8",
pages = "370-377",
doi = "10.2298/SARH160719063O"
}

Opacic-Galic, V., Petrović, V., Jokanović, V. R.,& Zivkovic, S.. (2017). Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials - In vivo study. in Srpski arhiv za celokupno lekarstvo, 145(7-8), 370-377.
https://doi.org/10.2298/SARH160719063O

Opacic-Galic V, Petrović V, Jokanović VR, Zivkovic S. Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials - In vivo study. in Srpski arhiv za celokupno lekarstvo. 2017;145(7-8):370-377.
doi:10.2298/SARH160719063O .

Opacic-Galic, Vanja, Petrović, Violeta, Jokanović, Vukoman R., Zivkovic, Slavoljub, "Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials - In vivo study" in Srpski arhiv za celokupno lekarstvo, 145, no. 7-8 (2017):370-377,
https://doi.org/10.2298/SARH160719063O . .

TY  - JOUR
AU  - Sjerobabin, Nikola
AU  - Čolović, Božana M.
AU  - Petrović, Milan
AU  - Marković, Dejan
AU  - Zivkovic, Slavoljub
AU  - Jokanović, Vukoman R.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1264
AB  - Introduction Biodegradable porous scaffolds are found to be very promising bone substitutes, acting as a temporary physical support to guide new tissue regeneration, until the entire scaffold is totally degraded and replaced by the new tissue. Objective The aim of this study was to investigate cytotoxicity of a synthesized calcium hydroxyapatite-based scaffold, named ALBO-OS, with high porosity and optimal topology. Methods The ALBO-OS scaffold was synthesized by the method of polymer foam template. The analysis of pore geometry and scaffold wallstopography was made by scanning electron microscope (SEM). The biological investigations assumed the examinations of ALBO-OS cytotoxicity to mouse L929 fibroblasts, using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor (MU) and lactate dehydrogenase (LDH) tests and inverse phase microscopy. Results The SEM analysis showed high porosity with fair pore distribution and interesting morphology from the biological standpoint. The biological investigations showed that the material is not cytotoxic to L929 cells. Comparison of ALBO-OS with Bio-Oss, as the global gold standard as a bone substitute, showed similar results in MTT test, while LDH test showed significantly higher rate of cell multiplication with ALBO-OS. Conclusion The scaffold design from the aspect of pore size, distribution, and topology seems to be very convenient for cell adhesion and occupation, which makes it a promising material as a bone substitute. The results of biological assays proved that ALBO-OS is not cytotoxic for L929 fibroblasts. In comparison with Bio-Oss, similar or even better results were obtained.
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design
VL  - 144
IS  - 5-6
SP  - 280
EP  - 287
DO  - 10.2298/SARH1606280S
ER  - 

@article{
author = "Sjerobabin, Nikola and Čolović, Božana M. and Petrović, Milan and Marković, Dejan and Zivkovic, Slavoljub and Jokanović, Vukoman R.",
year = "2016",
abstract = "Introduction Biodegradable porous scaffolds are found to be very promising bone substitutes, acting as a temporary physical support to guide new tissue regeneration, until the entire scaffold is totally degraded and replaced by the new tissue. Objective The aim of this study was to investigate cytotoxicity of a synthesized calcium hydroxyapatite-based scaffold, named ALBO-OS, with high porosity and optimal topology. Methods The ALBO-OS scaffold was synthesized by the method of polymer foam template. The analysis of pore geometry and scaffold wallstopography was made by scanning electron microscope (SEM). The biological investigations assumed the examinations of ALBO-OS cytotoxicity to mouse L929 fibroblasts, using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor (MU) and lactate dehydrogenase (LDH) tests and inverse phase microscopy. Results The SEM analysis showed high porosity with fair pore distribution and interesting morphology from the biological standpoint. The biological investigations showed that the material is not cytotoxic to L929 cells. Comparison of ALBO-OS with Bio-Oss, as the global gold standard as a bone substitute, showed similar results in MTT test, while LDH test showed significantly higher rate of cell multiplication with ALBO-OS. Conclusion The scaffold design from the aspect of pore size, distribution, and topology seems to be very convenient for cell adhesion and occupation, which makes it a promising material as a bone substitute. The results of biological assays proved that ALBO-OS is not cytotoxic for L929 fibroblasts. In comparison with Bio-Oss, similar or even better results were obtained.",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design",
volume = "144",
number = "5-6",
pages = "280-287",
doi = "10.2298/SARH1606280S"
}

Sjerobabin, N., Čolović, B. M., Petrović, M., Marković, D., Zivkovic, S.,& Jokanović, V. R.. (2016). Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design. in Srpski arhiv za celokupno lekarstvo, 144(5-6), 280-287.
https://doi.org/10.2298/SARH1606280S

Sjerobabin N, Čolović BM, Petrović M, Marković D, Zivkovic S, Jokanović VR. Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design. in Srpski arhiv za celokupno lekarstvo. 2016;144(5-6):280-287.
doi:10.2298/SARH1606280S .

Sjerobabin, Nikola, Čolović, Božana M., Petrović, Milan, Marković, Dejan, Zivkovic, Slavoljub, Jokanović, Vukoman R., "Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design" in Srpski arhiv za celokupno lekarstvo, 144, no. 5-6 (2016):280-287,
https://doi.org/10.2298/SARH1606280S . .

TY  - JOUR
AU  - Petrović, V.
AU  - Opacic-Galic, V.
AU  - Zivkovic, S.
AU  - Nikolić, Biljana
AU  - Danilovic, V.
AU  - Miletic, V.
AU  - Jokanović, Vukoman R.
AU  - Mitić-Ćulafić, Dragana
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/722
AB  - AimTo evaluate in vitro cytotoxicity and in vivo inflammatory response to new nanostructural materials based on active calcium silicate systems (CS) and hydroxyapatite (HA-CS). MethodologyCytotoxicity of eluates of new nanostructural noncommercial materials CS and HA-CS, and MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil) as a control, were tested using the MTT assay on MRC-5 cells. Eluates of set materials were tested in 100% and 50% concentrations, 24h, 7days and 21days post-elution. The pH values were determined for undiluted eluates of set materials. Polyethylene tubes containing the test materials (CS, HA-CS, MTA) were implanted in subcutaneous tissue of Wistar rats. Histopathological examinations were conducted at 7, 15, 30 and 60days after the implantation. Data were statistically analyzed using three-way and one-way anova Tukeys post hoc test as well as Kruskall-Wallis test with Dunns post hoc test at =0.05. ResultsAll materials significantly reduced cell viability; especially when undiluted eluates were used (P LT 0.001). After 24h elution, cell viability was 101.8%, 49.5 +/- 4.2% and 61 +/- 7.4%, for MTA, and HA-CS, respectively. However, CS and HA-CS were significantly less toxic than the control material MTA (P LT 0.05). Cytotoxicity could be at least partially attributed to pH kinetics over time. Dilution of eluates of all tested materials resulted in better cell survival. Histopathological examination indicated similar inflammatory reaction, vascular congestion and connective tissue integrity associated with CS, HA-CS and MTA at each observation period (P GT 0.05). The only significant difference was found for capsule thickness, that is thicker capsule was associated with HA-CS compared to MTA at 60days (P=0.0039). HA-CS induced moderately thick capsules (median score 3, score range 2-3), whereas MTA resulted in thin capsule formation (median score 2, score range 1-3). ConclusionsEvaluation of cytotoxicity and inflammatory response indicated better biocompatibility of CS and HA-CS, in comparison with MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil).
T2  - International Endodontic Journal
T1  - Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study
VL  - 48
IS  - 10
SP  - 966
EP  - 975
DO  - 10.1111/iej.12391
ER  - 

@article{
author = "Petrović, V. and Opacic-Galic, V. and Zivkovic, S. and Nikolić, Biljana and Danilovic, V. and Miletic, V. and Jokanović, Vukoman R. and Mitić-Ćulafić, Dragana",
year = "2015",
abstract = "AimTo evaluate in vitro cytotoxicity and in vivo inflammatory response to new nanostructural materials based on active calcium silicate systems (CS) and hydroxyapatite (HA-CS). MethodologyCytotoxicity of eluates of new nanostructural noncommercial materials CS and HA-CS, and MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil) as a control, were tested using the MTT assay on MRC-5 cells. Eluates of set materials were tested in 100% and 50% concentrations, 24h, 7days and 21days post-elution. The pH values were determined for undiluted eluates of set materials. Polyethylene tubes containing the test materials (CS, HA-CS, MTA) were implanted in subcutaneous tissue of Wistar rats. Histopathological examinations were conducted at 7, 15, 30 and 60days after the implantation. Data were statistically analyzed using three-way and one-way anova Tukeys post hoc test as well as Kruskall-Wallis test with Dunns post hoc test at =0.05. ResultsAll materials significantly reduced cell viability; especially when undiluted eluates were used (P LT 0.001). After 24h elution, cell viability was 101.8%, 49.5 +/- 4.2% and 61 +/- 7.4%, for MTA, and HA-CS, respectively. However, CS and HA-CS were significantly less toxic than the control material MTA (P LT 0.05). Cytotoxicity could be at least partially attributed to pH kinetics over time. Dilution of eluates of all tested materials resulted in better cell survival. Histopathological examination indicated similar inflammatory reaction, vascular congestion and connective tissue integrity associated with CS, HA-CS and MTA at each observation period (P GT 0.05). The only significant difference was found for capsule thickness, that is thicker capsule was associated with HA-CS compared to MTA at 60days (P=0.0039). HA-CS induced moderately thick capsules (median score 3, score range 2-3), whereas MTA resulted in thin capsule formation (median score 2, score range 1-3). ConclusionsEvaluation of cytotoxicity and inflammatory response indicated better biocompatibility of CS and HA-CS, in comparison with MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil).",
journal = "International Endodontic Journal",
title = "Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study",
volume = "48",
number = "10",
pages = "966-975",
doi = "10.1111/iej.12391"
}

Petrović, V., Opacic-Galic, V., Zivkovic, S., Nikolić, B., Danilovic, V., Miletic, V., Jokanović, V. R.,& Mitić-Ćulafić, D.. (2015). Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study. in International Endodontic Journal, 48(10), 966-975.
https://doi.org/10.1111/iej.12391

Petrović V, Opacic-Galic V, Zivkovic S, Nikolić B, Danilovic V, Miletic V, Jokanović VR, Mitić-Ćulafić D. Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study. in International Endodontic Journal. 2015;48(10):966-975.
doi:10.1111/iej.12391 .

Petrović, V., Opacic-Galic, V., Zivkovic, S., Nikolić, Biljana, Danilovic, V., Miletic, V., Jokanović, Vukoman R., Mitić-Ćulafić, Dragana, "Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study" in International Endodontic Journal, 48, no. 10 (2015):966-975,
https://doi.org/10.1111/iej.12391 . .

TY  - JOUR
AU  - Jokanović, Vukoman R.
AU  - Čolović, Božana M.
AU  - Jokanović, Bojan
AU  - Zivkovic, Slavoljub
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/541
AB  - The aim of this study was to synthesize and characterize new superplastic endodontic mixtures (named as ALBO-MPSA) with strongly accelerated hydration rate. Two different ALBO-MPSA mixtures were prepared using combination of hydrothermal and high-temperature self-propagating method. Phase analysis of the mixtures, before and after hydration, was carried out by X-ray diffraction (XRD), while morphological analysis was performed by scanning electron microscopy (SEM). Investigations of mechanical properties showed that new superplastic, quick-bonding endodontic mixtures with good mechanical properties were obtained (compressive strength after 28days aging was from 35.7 +/- 0.5 and 37.4 +/- 0.5 MPa). The final phase compositions after hydration of the mixtures were determined on the base of XRD data, assumed mechanism of hydration and rational chemical analysis. The constitutive phases were tobermorite, portlandite, and amorphous Ca(OH)(2), ettringite and amorphous like ettringite phase, gypsum, hydroxyapatite and barite.
T2  - International Journal of Applied Ceramic Technology
T1  - Superplastic, Quick-Bonding Endodontic Mixtures and Their Hydration
VL  - 12
IS  - SI
SP  - E83
EP  - E91
DO  - 10.1111/ijac.12234
ER  - 

@article{
author = "Jokanović, Vukoman R. and Čolović, Božana M. and Jokanović, Bojan and Zivkovic, Slavoljub",
year = "2015",
abstract = "The aim of this study was to synthesize and characterize new superplastic endodontic mixtures (named as ALBO-MPSA) with strongly accelerated hydration rate. Two different ALBO-MPSA mixtures were prepared using combination of hydrothermal and high-temperature self-propagating method. Phase analysis of the mixtures, before and after hydration, was carried out by X-ray diffraction (XRD), while morphological analysis was performed by scanning electron microscopy (SEM). Investigations of mechanical properties showed that new superplastic, quick-bonding endodontic mixtures with good mechanical properties were obtained (compressive strength after 28days aging was from 35.7 +/- 0.5 and 37.4 +/- 0.5 MPa). The final phase compositions after hydration of the mixtures were determined on the base of XRD data, assumed mechanism of hydration and rational chemical analysis. The constitutive phases were tobermorite, portlandite, and amorphous Ca(OH)(2), ettringite and amorphous like ettringite phase, gypsum, hydroxyapatite and barite.",
journal = "International Journal of Applied Ceramic Technology",
title = "Superplastic, Quick-Bonding Endodontic Mixtures and Their Hydration",
volume = "12",
number = "SI",
pages = "E83-E91",
doi = "10.1111/ijac.12234"
}

Jokanović, V. R., Čolović, B. M., Jokanović, B.,& Zivkovic, S.. (2015). Superplastic, Quick-Bonding Endodontic Mixtures and Their Hydration. in International Journal of Applied Ceramic Technology, 12(SI), E83-E91.
https://doi.org/10.1111/ijac.12234

Jokanović VR, Čolović BM, Jokanović B, Zivkovic S. Superplastic, Quick-Bonding Endodontic Mixtures and Their Hydration. in International Journal of Applied Ceramic Technology. 2015;12(SI):E83-E91.
doi:10.1111/ijac.12234 .

Jokanović, Vukoman R., Čolović, Božana M., Jokanović, Bojan, Zivkovic, Slavoljub, "Superplastic, Quick-Bonding Endodontic Mixtures and Their Hydration" in International Journal of Applied Ceramic Technology, 12, no. SI (2015):E83-E91,
https://doi.org/10.1111/ijac.12234 . .

TY  - JOUR
AU  - Opacic-Galic, V.
AU  - Petrovic, V.
AU  - Zivkovic, S.
AU  - Jokanović, Vukoman R.
AU  - Nikolić, Biljana
AU  - Knežević-Vukčević, Jelena
AU  - Mitić-Ćulafić, Dragana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5501
AB  - Aim To characterize and investigate the genotoxic effect of a new endodontic cement based on dicalcium- and tricalcium-silicate (CS) with hydroxyapatite (HA) on human lymphocytes. Methodology Hydrothermal treatment was applied for synthesis of CS and HA. The final mixture HA-CS, with potential to be used in endodontic practice, is composed of CS (34%) and HA (66%). Human lymphocytes were incubated with HA, HA-CS and CS for 1h, at 37 degrees C and 5% CO2. Cell viability was determined using the trypan blue exclusion assay. To evaluate the level of DNA damage comet assay (single cell gel electrophoresis) was performed. For the statistical analysis anova and Duncans Post Hoc Test were used. Results The SEM analysis indicated that CS consisted mostly of agglomerates of several micrometers in size, built up from smaller particles, with dimensions between 117 and 477nm. This is promising because dimensions of agglomerates are not comparable with channels inside the cell membranes, whereas their nano-elements provide evident activity, important for faster setting of these mixtures compared to MTA. Values of DNA damage obtained in the comet assay indicated low genotoxic risk of the new endodontic materials. Conclusions The significantly improved setting characteristics and low genotoxic risk of the new material support further research.
T2  - International Endodontic Journal
T1  - New nanostructural biomaterials based on active silicate systems and hydroxyapatite: characterization and genotoxicity in human peripheral blood lymphocytes
VL  - 46
IS  - 6
SP  - 506
EP  - 516
DO  - 10.1111/iej.12017
ER  - 

@article{
author = "Opacic-Galic, V. and Petrovic, V. and Zivkovic, S. and Jokanović, Vukoman R. and Nikolić, Biljana and Knežević-Vukčević, Jelena and Mitić-Ćulafić, Dragana",
year = "2013",
abstract = "Aim To characterize and investigate the genotoxic effect of a new endodontic cement based on dicalcium- and tricalcium-silicate (CS) with hydroxyapatite (HA) on human lymphocytes. Methodology Hydrothermal treatment was applied for synthesis of CS and HA. The final mixture HA-CS, with potential to be used in endodontic practice, is composed of CS (34%) and HA (66%). Human lymphocytes were incubated with HA, HA-CS and CS for 1h, at 37 degrees C and 5% CO2. Cell viability was determined using the trypan blue exclusion assay. To evaluate the level of DNA damage comet assay (single cell gel electrophoresis) was performed. For the statistical analysis anova and Duncans Post Hoc Test were used. Results The SEM analysis indicated that CS consisted mostly of agglomerates of several micrometers in size, built up from smaller particles, with dimensions between 117 and 477nm. This is promising because dimensions of agglomerates are not comparable with channels inside the cell membranes, whereas their nano-elements provide evident activity, important for faster setting of these mixtures compared to MTA. Values of DNA damage obtained in the comet assay indicated low genotoxic risk of the new endodontic materials. Conclusions The significantly improved setting characteristics and low genotoxic risk of the new material support further research.",
journal = "International Endodontic Journal",
title = "New nanostructural biomaterials based on active silicate systems and hydroxyapatite: characterization and genotoxicity in human peripheral blood lymphocytes",
volume = "46",
number = "6",
pages = "506-516",
doi = "10.1111/iej.12017"
}

Opacic-Galic, V., Petrovic, V., Zivkovic, S., Jokanović, V. R., Nikolić, B., Knežević-Vukčević, J.,& Mitić-Ćulafić, D.. (2013). New nanostructural biomaterials based on active silicate systems and hydroxyapatite: characterization and genotoxicity in human peripheral blood lymphocytes. in International Endodontic Journal, 46(6), 506-516.
https://doi.org/10.1111/iej.12017

Opacic-Galic V, Petrovic V, Zivkovic S, Jokanović VR, Nikolić B, Knežević-Vukčević J, Mitić-Ćulafić D. New nanostructural biomaterials based on active silicate systems and hydroxyapatite: characterization and genotoxicity in human peripheral blood lymphocytes. in International Endodontic Journal. 2013;46(6):506-516.
doi:10.1111/iej.12017 .

Opacic-Galic, V., Petrovic, V., Zivkovic, S., Jokanović, Vukoman R., Nikolić, Biljana, Knežević-Vukčević, Jelena, Mitić-Ćulafić, Dragana, "New nanostructural biomaterials based on active silicate systems and hydroxyapatite: characterization and genotoxicity in human peripheral blood lymphocytes" in International Endodontic Journal, 46, no. 6 (2013):506-516,
https://doi.org/10.1111/iej.12017 . .

TY  - JOUR
AU  - Marijana, Popovic Bajic
AU  - Prokic, B.
AU  - Prokic, B. B.
AU  - Jokanović, Vukoman R.
AU  - Vesna, Danilovic
AU  - Zivkovic, S.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5564
AB  - The aim of this study was to examine the effect of Biodentine (R) and two new nanostructured materials based on active silicate cements on exposed tooth pulp of Vietnamese pigs. The study comprised 40 teeth in two Vietnamese pigs (24 months old). After class V cavity preparation, the pulp on each tooth was exposed using a small round bur. The following materials were applied on pulp exposures: Biodentine (R) (10 teeth), ALBO MPCA-I (10 teeth), and ALBO MPCA-II (10 teeth). In the control group, exposed pulp was covered with ProRoot MTA (R) (10 teeth). After the observation period of 28 days, the animals were sacrificed and the teeth prepared for histological analysis. Light microscope was used for the analysis of dentin bridge formation, tissue reorganization and inflammation, and the presence of bacteria in the pulp. In the group of Biodentine (R), a complete dentin bridge was noted in 3 cases, while incomplete dentin bridge in the form of dental islets was detected in 4 cases. Nanostructured material ALBO-MPCA I provided complete dentin bridge formation in 5 teeth, in 3 teeth the formed dentin bridge was incomplete. ALBO MPCA-II showed complete closure of the pulp opening by dentin bridge in 4 samples, while in the same number of teeth it was incomplete. In the control group, 4 teeth showed a complete dentin bridge, whereas in 6 teeth it was incomplete. Histological analysis indicated favourable therapeutic effects of Biodentine (R) and the two materials ALBO-MPCA I and ALBO-MPCA II after teeth pulp capping in Vietnamese pigs. Pulp reaction was similar to that caused by ProRoot MTA (R).
T2  - Acta Veterinaria, Beograd
T1  - Histological Evaluation of Direct Pulp Capping with Novel Nanostructural Materials Based on Active Silicate Cements and Biodentine (R) on Pulp Tissue
VL  - 63
IS  - 2-3
SP  - 347
EP  - 360
DO  - 10.2298/AVB1303347P
ER  - 

@article{
author = "Marijana, Popovic Bajic and Prokic, B. and Prokic, B. B. and Jokanović, Vukoman R. and Vesna, Danilovic and Zivkovic, S.",
year = "2013",
abstract = "The aim of this study was to examine the effect of Biodentine (R) and two new nanostructured materials based on active silicate cements on exposed tooth pulp of Vietnamese pigs. The study comprised 40 teeth in two Vietnamese pigs (24 months old). After class V cavity preparation, the pulp on each tooth was exposed using a small round bur. The following materials were applied on pulp exposures: Biodentine (R) (10 teeth), ALBO MPCA-I (10 teeth), and ALBO MPCA-II (10 teeth). In the control group, exposed pulp was covered with ProRoot MTA (R) (10 teeth). After the observation period of 28 days, the animals were sacrificed and the teeth prepared for histological analysis. Light microscope was used for the analysis of dentin bridge formation, tissue reorganization and inflammation, and the presence of bacteria in the pulp. In the group of Biodentine (R), a complete dentin bridge was noted in 3 cases, while incomplete dentin bridge in the form of dental islets was detected in 4 cases. Nanostructured material ALBO-MPCA I provided complete dentin bridge formation in 5 teeth, in 3 teeth the formed dentin bridge was incomplete. ALBO MPCA-II showed complete closure of the pulp opening by dentin bridge in 4 samples, while in the same number of teeth it was incomplete. In the control group, 4 teeth showed a complete dentin bridge, whereas in 6 teeth it was incomplete. Histological analysis indicated favourable therapeutic effects of Biodentine (R) and the two materials ALBO-MPCA I and ALBO-MPCA II after teeth pulp capping in Vietnamese pigs. Pulp reaction was similar to that caused by ProRoot MTA (R).",
journal = "Acta Veterinaria, Beograd",
title = "Histological Evaluation of Direct Pulp Capping with Novel Nanostructural Materials Based on Active Silicate Cements and Biodentine (R) on Pulp Tissue",
volume = "63",
number = "2-3",
pages = "347-360",
doi = "10.2298/AVB1303347P"
}

Marijana, P. B., Prokic, B., Prokic, B. B., Jokanović, V. R., Vesna, D.,& Zivkovic, S.. (2013). Histological Evaluation of Direct Pulp Capping with Novel Nanostructural Materials Based on Active Silicate Cements and Biodentine (R) on Pulp Tissue. in Acta Veterinaria, Beograd, 63(2-3), 347-360.
https://doi.org/10.2298/AVB1303347P

Marijana PB, Prokic B, Prokic BB, Jokanović VR, Vesna D, Zivkovic S. Histological Evaluation of Direct Pulp Capping with Novel Nanostructural Materials Based on Active Silicate Cements and Biodentine (R) on Pulp Tissue. in Acta Veterinaria, Beograd. 2013;63(2-3):347-360.
doi:10.2298/AVB1303347P .

Marijana, Popovic Bajic, Prokic, B., Prokic, B. B., Jokanović, Vukoman R., Vesna, Danilovic, Zivkovic, S., "Histological Evaluation of Direct Pulp Capping with Novel Nanostructural Materials Based on Active Silicate Cements and Biodentine (R) on Pulp Tissue" in Acta Veterinaria, Beograd, 63, no. 2-3 (2013):347-360,
https://doi.org/10.2298/AVB1303347P . .