TY  - JOUR
AU  - Rajković, Katarina M.
AU  - Đurašević, Mirjana
AU  - Markićević, Milan
AU  - Milanović, Zorana
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Stanković, Dragana
AU  - Obradović, Zorica
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12239
AB  - J. nigra leaf contains mixture of various pharmacologically active compounds and it is assumed that they may have the potential radioprotective effect. The purpose of this work was to predict radioprotective doses by correlating changes in organ distribution of radiopharmaceuticals with extract dose levels and rat body weight using response surface methodology (RSM) based on a second-order polynomial equation. The extract was administered daily by oral gavage to rats at dose of 6.9, 10.3, or 13.7 mg kg−1 body weight (bw) day−1 for 10 days. On the eleventh day, 0.1 ml of the one radiopharmaceutical (Na99mTcO4, 99mTc-dimercaptosuccinic acid and 99mTc-tin colloid) was injected into the tail vein. The statistical parameters: the coefficient of determination (0.81–0.95), the coefficient of variation (3.05–11.1), the adequate precision (8.82–19.12) and the mean relative percentage deviation (± 2.3–8.2) were indicated the precision and reliability of RSM. Using RSM, the predicted daily dose of leaf extract ranging from 11.19 to 11.99 mg kg−1 bw may be considered as an optimal daily radiopotective dose for protection of organs from radiation in cases of planned radiation exposures.
T2  - Journal of Environmental Radioactivity
T1  - Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology
VL  - 272
SP  - 107333
DO  - 10.1016/j.jenvrad.2023.107333
ER  - 

@article{
author = "Rajković, Katarina M. and Đurašević, Mirjana and Markićević, Milan and Milanović, Zorana and Vranješ-Đurić, Sanja and Janković, Drina and Stanković, Dragana and Obradović, Zorica",
year = "2024",
abstract = "J. nigra leaf contains mixture of various pharmacologically active compounds and it is assumed that they may have the potential radioprotective effect. The purpose of this work was to predict radioprotective doses by correlating changes in organ distribution of radiopharmaceuticals with extract dose levels and rat body weight using response surface methodology (RSM) based on a second-order polynomial equation. The extract was administered daily by oral gavage to rats at dose of 6.9, 10.3, or 13.7 mg kg−1 body weight (bw) day−1 for 10 days. On the eleventh day, 0.1 ml of the one radiopharmaceutical (Na99mTcO4, 99mTc-dimercaptosuccinic acid and 99mTc-tin colloid) was injected into the tail vein. The statistical parameters: the coefficient of determination (0.81–0.95), the coefficient of variation (3.05–11.1), the adequate precision (8.82–19.12) and the mean relative percentage deviation (± 2.3–8.2) were indicated the precision and reliability of RSM. Using RSM, the predicted daily dose of leaf extract ranging from 11.19 to 11.99 mg kg−1 bw may be considered as an optimal daily radiopotective dose for protection of organs from radiation in cases of planned radiation exposures.",
journal = "Journal of Environmental Radioactivity",
title = "Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology",
volume = "272",
pages = "107333",
doi = "10.1016/j.jenvrad.2023.107333"
}

Rajković, K. M., Đurašević, M., Markićević, M., Milanović, Z., Vranješ-Đurić, S., Janković, D., Stanković, D.,& Obradović, Z.. (2024). Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology. in Journal of Environmental Radioactivity, 272, 107333.
https://doi.org/10.1016/j.jenvrad.2023.107333

Rajković KM, Đurašević M, Markićević M, Milanović Z, Vranješ-Đurić S, Janković D, Stanković D, Obradović Z. Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology. in Journal of Environmental Radioactivity. 2024;272:107333.
doi:10.1016/j.jenvrad.2023.107333 .

Rajković, Katarina M., Đurašević, Mirjana, Markićević, Milan, Milanović, Zorana, Vranješ-Đurić, Sanja, Janković, Drina, Stanković, Dragana, Obradović, Zorica, "Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology" in Journal of Environmental Radioactivity, 272 (2024):107333,
https://doi.org/10.1016/j.jenvrad.2023.107333 . .

TY  - JOUR
AU  - Karageorgou, Maria-Argyro
AU  - Apostolopoulou, Adamantia
AU  - Tomazinaki, Mina-Ermioni
AU  - Stanković, Dragana
AU  - Stiliaris, Efstathios
AU  - Bouziotis, Penelope
AU  - Stamopoulos, Dimosthenis
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12719
AB  - The radiolabeled iron oxide nanoparticles constitute an attractive choice to be used as dual-modality contrast agents (DMCAs) in nuclear medical diagnosis, due to their ability to combine the benefits of two imaging modalities, for instance single photon emission computed tomography (SPECT) with magnetic resonance imaging (MRI). Before the use of any DMCA, the investigation of its plasma extra- and on/intra cellular distribution in peripheral human blood is of paramount importance. Here, we focus on the in vitro investigation of the distribution of 99mTc-DPD-Fe3O4 DMCA in donated peripheral human blood (the ligand 2-3-dicarboxypropane-1-1-diphosphonic-acid is denoted as DPD). Initially, we described the experimental methods we performed for the radiosynthesis of the 99mTc-DPD-Fe3O4, the preparation of whole blood and blood plasma samples, and their incubation conditions with 99mTc-DPD-Fe3O4. More importantly, we employed a gamma-camera apparatus for the direct imaging of the 99mTc-DPD-Fe3O4-loaded whole blood and blood plasma samples when subjected to specialized centrifugation protocols. The direct comparison of the gamma-camera data obtained at the exact same samples before and after their centrifugation enabled us to clearly identify the distribution of the 99mTc-DPD-Fe3O4 in the two components, plasma and cells, of peripheral human blood.
T2  - Materials
T1  - Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood
VL  - 17
IS  - 2
SP  - 335
DO  - 10.3390/ma17020335
ER  - 

@article{
author = "Karageorgou, Maria-Argyro and Apostolopoulou, Adamantia and Tomazinaki, Mina-Ermioni and Stanković, Dragana and Stiliaris, Efstathios and Bouziotis, Penelope and Stamopoulos, Dimosthenis",
year = "2024",
abstract = "The radiolabeled iron oxide nanoparticles constitute an attractive choice to be used as dual-modality contrast agents (DMCAs) in nuclear medical diagnosis, due to their ability to combine the benefits of two imaging modalities, for instance single photon emission computed tomography (SPECT) with magnetic resonance imaging (MRI). Before the use of any DMCA, the investigation of its plasma extra- and on/intra cellular distribution in peripheral human blood is of paramount importance. Here, we focus on the in vitro investigation of the distribution of 99mTc-DPD-Fe3O4 DMCA in donated peripheral human blood (the ligand 2-3-dicarboxypropane-1-1-diphosphonic-acid is denoted as DPD). Initially, we described the experimental methods we performed for the radiosynthesis of the 99mTc-DPD-Fe3O4, the preparation of whole blood and blood plasma samples, and their incubation conditions with 99mTc-DPD-Fe3O4. More importantly, we employed a gamma-camera apparatus for the direct imaging of the 99mTc-DPD-Fe3O4-loaded whole blood and blood plasma samples when subjected to specialized centrifugation protocols. The direct comparison of the gamma-camera data obtained at the exact same samples before and after their centrifugation enabled us to clearly identify the distribution of the 99mTc-DPD-Fe3O4 in the two components, plasma and cells, of peripheral human blood.",
journal = "Materials",
title = "Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood",
volume = "17",
number = "2",
pages = "335",
doi = "10.3390/ma17020335"
}

Karageorgou, M., Apostolopoulou, A., Tomazinaki, M., Stanković, D., Stiliaris, E., Bouziotis, P.,& Stamopoulos, D.. (2024). Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood. in Materials, 17(2), 335.
https://doi.org/10.3390/ma17020335

Karageorgou M, Apostolopoulou A, Tomazinaki M, Stanković D, Stiliaris E, Bouziotis P, Stamopoulos D. Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood. in Materials. 2024;17(2):335.
doi:10.3390/ma17020335 .

Karageorgou, Maria-Argyro, Apostolopoulou, Adamantia, Tomazinaki, Mina-Ermioni, Stanković, Dragana, Stiliaris, Efstathios, Bouziotis, Penelope, Stamopoulos, Dimosthenis, "Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood" in Materials, 17, no. 2 (2024):335,
https://doi.org/10.3390/ma17020335 . .

TY  - JOUR
AU  - Stanković, Dragana
AU  - Radović, Magdalena
AU  - Stanković, Aljoša
AU  - Mirković, Marija
AU  - Vukadinović, Aleksandar
AU  - Mijović, Milica
AU  - Milanović, Zorana
AU  - Ognjanović, Miloš
AU  - Janković, Drina
AU  - Antić, Bratislav
AU  - Vranješ-Đurić, Sanja
AU  - Savić, Miroslav
AU  - Prijović, Željko
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11387
AB  - As an alternative to classical brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) has been investigated as a superior delivery method over an intravenous route for radionuclide therapy of solid tumors. We created superparamagnetic iron oxide nanoparticles (SPIONs) coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled with Lutetium-177 (177Lu), generating 177Lu-DMSA@SPIONs as a potential antitumor agent for nanobrachytherapy. Efficient radiolabeling of DMSA@SPIONS by 177Lu resulted in a stable bond with minimal leakage in vitro. After an intratumoral injection to mouse colorectal CT-26 or breast 4T1 subcutaneous tumors, the nanoparticles remained well localized at the injection site for weeks, with limited leakage. The dose of 3.70 MBq/100 µg/50 µL of 177Lu-DMSA@SPIONs applied intratumorally resulted in a high therapeutic efficacy, without signs of general toxicity. A decreased dose of 1.85 MBq/100 µg/50 µL still retained therapeutic efficacy, while an increased dose of 9.25 MBq/100 µg/50 µL did not significantly benefit the therapy. Histopathology analysis revealed that the 177Lu-DMSA@SPIONs act within a limited range around the injection site, which explains the good therapeutic efficacy achieved by a single administration of a relatively low dose without the need for increased or repeated dosing. Overall, 177Lu-DMSA@SPIONs are safe and potent agents suitable for intra-tumoral administration for localized tumor radionuclide therapy
T2  - Pharmaceutics
T1  - Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors
VL  - 15
IS  - 7
SP  - 1943
DO  - 10.3390/pharmaceutics15071943
ER  - 

@article{
author = "Stanković, Dragana and Radović, Magdalena and Stanković, Aljoša and Mirković, Marija and Vukadinović, Aleksandar and Mijović, Milica and Milanović, Zorana and Ognjanović, Miloš and Janković, Drina and Antić, Bratislav and Vranješ-Đurić, Sanja and Savić, Miroslav and Prijović, Željko",
year = "2023",
abstract = "As an alternative to classical brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) has been investigated as a superior delivery method over an intravenous route for radionuclide therapy of solid tumors. We created superparamagnetic iron oxide nanoparticles (SPIONs) coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled with Lutetium-177 (177Lu), generating 177Lu-DMSA@SPIONs as a potential antitumor agent for nanobrachytherapy. Efficient radiolabeling of DMSA@SPIONS by 177Lu resulted in a stable bond with minimal leakage in vitro. After an intratumoral injection to mouse colorectal CT-26 or breast 4T1 subcutaneous tumors, the nanoparticles remained well localized at the injection site for weeks, with limited leakage. The dose of 3.70 MBq/100 µg/50 µL of 177Lu-DMSA@SPIONs applied intratumorally resulted in a high therapeutic efficacy, without signs of general toxicity. A decreased dose of 1.85 MBq/100 µg/50 µL still retained therapeutic efficacy, while an increased dose of 9.25 MBq/100 µg/50 µL did not significantly benefit the therapy. Histopathology analysis revealed that the 177Lu-DMSA@SPIONs act within a limited range around the injection site, which explains the good therapeutic efficacy achieved by a single administration of a relatively low dose without the need for increased or repeated dosing. Overall, 177Lu-DMSA@SPIONs are safe and potent agents suitable for intra-tumoral administration for localized tumor radionuclide therapy",
journal = "Pharmaceutics",
title = "Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors",
volume = "15",
number = "7",
pages = "1943",
doi = "10.3390/pharmaceutics15071943"
}

Stanković, D., Radović, M., Stanković, A., Mirković, M., Vukadinović, A., Mijović, M., Milanović, Z., Ognjanović, M., Janković, D., Antić, B., Vranješ-Đurić, S., Savić, M.,& Prijović, Ž.. (2023). Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors. in Pharmaceutics, 15(7), 1943.
https://doi.org/10.3390/pharmaceutics15071943

Stanković D, Radović M, Stanković A, Mirković M, Vukadinović A, Mijović M, Milanović Z, Ognjanović M, Janković D, Antić B, Vranješ-Đurić S, Savić M, Prijović Ž. Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors. in Pharmaceutics. 2023;15(7):1943.
doi:10.3390/pharmaceutics15071943 .

Stanković, Dragana, Radović, Magdalena, Stanković, Aljoša, Mirković, Marija, Vukadinović, Aleksandar, Mijović, Milica, Milanović, Zorana, Ognjanović, Miloš, Janković, Drina, Antić, Bratislav, Vranješ-Đurić, Sanja, Savić, Miroslav, Prijović, Željko, "Synthesis, Characterization, and Therapeutic Efficacy of 177Lu-DMSA@SPIONs in Nanobrachytherapy of Solid Tumors" in Pharmaceutics, 15, no. 7 (2023):1943,
https://doi.org/10.3390/pharmaceutics15071943 . .

TY  - CONF
AU  - Rajković, Katarina M.
AU  - Đurašević, Mirjana
AU  - Obradović, Zorica
AU  - Milanović, Zorana
AU  - Vukadinović, Aleksandar
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Janković, Drina
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12184
AB  - Tc-99m-radiofarmaceutici se koriste u različitim dijagnostičkim procedurama u nuklearnoj medicini. Da bi se minimizirali štetni efekti jonizujućeg zračenja na zdrava tkiva, intenzivno se istražuju radioprotektivne osobine biljnih ekstrakata. Ljuska ploda crnog oraha sadrži mešavinu različitih farmakološki aktivnih jedinjenja kojа imaju antioksidativno dejstvo i za koje se pretpostavlja da mogu imati i potencijalno radioprotektivno dejstvo. U tom kontekstu, cilj rada je bio da se proceni radioprotektivni efekat ekstrakta ljuske ploda crnog oraha. U ovoj studiji primenjen je eksperimentalni model koji se zasnivao na proceni uticaja ekstrakta na biodistribuciju Tc-99m-radiofarmaceutika po organima eksperimentalnih životinja (pacovi). Ekstrakt ljuske crnog oraha doveo je do smanjenognakupljanja Tc-99m-radiofarmaceutika u pojedinim organimapacova. Rezultati dobijeni na osnovu eksperimentalnog modela sugerišu moguću upotrebu ekstrakta ljuske ploda crnog oraha kao radioprotektivnog sredstva u slučajevima planiranog izlaganja jonizujućem zračenju u nuklearnoj medicini.
AB  - Tc-99m-radiopharmaceuticals are used in various diagnostic procedures in nuclear medicine. In order to minimize the harmful effects of ionizing radiation on healthy tissues, the radioprotective properties of plant extracts are intensively researched. J. nigra husk contains a mixture of various pharmacologically active compounds that have an antioxidant effect and which are assumed to have a potential radioprotective effect. In this context, the aim of the work was to evaluate the radioprotective effect of black walnut husk extract. In this study, an experimental model was applied, which was based on the assessment of the effect of the extract on the biodistribution of Tc-99m-radiopharmaceuticals in the organs of experimental animals (rats). Black walnut husk extract led to a decrease in the accumulation of Tc-99m-radiopharmaceutical in certain organs of rats. The results obtained on the basis of the experimental model suggest that it is possible to use black walnut husk extract as a radioprotective agent in cases of planned exposure to ionizing radiation in diagnosticsnuclear medicine.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta
T1  - Experimental Model for Assessing the Possible Radioprotective Effect of Plant Extract
SP  - 321
EP  - 327
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12184
ER  - 

@conference{
author = "Rajković, Katarina M. and Đurašević, Mirjana and Obradović, Zorica and Milanović, Zorana and Vukadinović, Aleksandar and Perić, Marko and Stanković, Dragana and Janković, Drina",
year = "2023",
abstract = "Tc-99m-radiofarmaceutici se koriste u različitim dijagnostičkim procedurama u nuklearnoj medicini. Da bi se minimizirali štetni efekti jonizujućeg zračenja na zdrava tkiva, intenzivno se istražuju radioprotektivne osobine biljnih ekstrakata. Ljuska ploda crnog oraha sadrži mešavinu različitih farmakološki aktivnih jedinjenja kojа imaju antioksidativno dejstvo i za koje se pretpostavlja da mogu imati i potencijalno radioprotektivno dejstvo. U tom kontekstu, cilj rada je bio da se proceni radioprotektivni efekat ekstrakta ljuske ploda crnog oraha. U ovoj studiji primenjen je eksperimentalni model koji se zasnivao na proceni uticaja ekstrakta na biodistribuciju Tc-99m-radiofarmaceutika po organima eksperimentalnih životinja (pacovi). Ekstrakt ljuske crnog oraha doveo je do smanjenognakupljanja Tc-99m-radiofarmaceutika u pojedinim organimapacova. Rezultati dobijeni na osnovu eksperimentalnog modela sugerišu moguću upotrebu ekstrakta ljuske ploda crnog oraha kao radioprotektivnog sredstva u slučajevima planiranog izlaganja jonizujućem zračenju u nuklearnoj medicini., Tc-99m-radiopharmaceuticals are used in various diagnostic procedures in nuclear medicine. In order to minimize the harmful effects of ionizing radiation on healthy tissues, the radioprotective properties of plant extracts are intensively researched. J. nigra husk contains a mixture of various pharmacologically active compounds that have an antioxidant effect and which are assumed to have a potential radioprotective effect. In this context, the aim of the work was to evaluate the radioprotective effect of black walnut husk extract. In this study, an experimental model was applied, which was based on the assessment of the effect of the extract on the biodistribution of Tc-99m-radiopharmaceuticals in the organs of experimental animals (rats). Black walnut husk extract led to a decrease in the accumulation of Tc-99m-radiopharmaceutical in certain organs of rats. The results obtained on the basis of the experimental model suggest that it is possible to use black walnut husk extract as a radioprotective agent in cases of planned exposure to ionizing radiation in diagnosticsnuclear medicine.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta, Experimental Model for Assessing the Possible Radioprotective Effect of Plant Extract",
pages = "321-327",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12184"
}

Rajković, K. M., Đurašević, M., Obradović, Z., Milanović, Z., Vukadinović, A., Perić, M., Stanković, D.,& Janković, D.. (2023). Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 321-327.
https://hdl.handle.net/21.15107/rcub_vinar_12184

Rajković KM, Đurašević M, Obradović Z, Milanović Z, Vukadinović A, Perić M, Stanković D, Janković D. Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta. in 32. simpozijum DZZSCG : zbornik radova. 2023;:321-327.
https://hdl.handle.net/21.15107/rcub_vinar_12184 .

Rajković, Katarina M., Đurašević, Mirjana, Obradović, Zorica, Milanović, Zorana, Vukadinović, Aleksandar, Perić, Marko, Stanković, Dragana, Janković, Drina, "Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta" in 32. simpozijum DZZSCG : zbornik radova (2023):321-327,
https://hdl.handle.net/21.15107/rcub_vinar_12184 .

TY  - CONF
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Vukadinović, Aleksandar
AU  - Vranješ-Đurić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12185
AB  - Prisustvo radiohemijske nečistoće C u 99mTc-MIBI injekciji utiče na kvalitet skena, jer se radiofarmaceutik nedovoljno nakuplja u organu od interesa, dok je aktivnost okolnih organa i tkiva velika. Zbog toga je i doza zračenja koju prime okolni organi i tkiva iznad propisanih granica. Da bi se obezbedilo da je planirano izlaganje zračenju pacijenata svedeno na minimum, farmakopeja zahteva ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji neposredno pre primene radiofarmaceutika u pacijenta. Za ova ispitivanja se koriste metode hromatografije. U radu je predstavljena brza i osetljiva ITLC metoda namenjena za rutinsko ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. ITLC metoda je validirana, a ispitivani su pogodnost sistema, tačnost, preciznost, ponovljivost, specifičnost, limit detekcije, limit kvantifikacije, linearnost, robustnost i osetljivost metode. Dobre "recovery" vrednosti i niska relativna standardna devijacija potvrđuju da je predložena ITLC metoda pogodna za rutinsko određivanje nečistoće C u 99mTc-MIBI u injekciji.
AB  - The European Pharmacopoeia mandates that all radiopharmaceuticals used in nuclear medicine for diagnostic and therapeutic purposes must be of the correct radiochemical and radionuclidic purity and have the correct radioactivity present at the stated time of injection to ensure that the intended radiation exposure of patients is kept to a minimum. These factors have an effect on the overall radiation dose to the patient, as impurities of the radionuclide and/or its chemical composition may affect the biodistribution of the injected radiopharmaceutical and consequently the radiation dose to any one particular organ or the whole body dose. The presence of radiochemical impurity C in 99mTc-MIBI injection affects the quality of the image, because 99mTc-MIBI accumulates insufficiently in the organ of interest, while the activity of the surrounding organs and tissues is high. Therefore, the radiation dose received by the surrounding organs and tissues is above the permitted level. In order to avoid unnecessary irradiation of surrounding organs and tissues, the pharmacopoeia requires examination of the content of radiochemical impurity C immediately before administering of 99mTc-MIBI to the patient. Chromatographic methods are used for these tests. The paper presents a fast and sensitive ITLC method intended for routine examination of the content of radiochemical impurity C in 99mTc-MIBI injection. The ITLC method was validated, and the suitability of the system, accuracy, precision, repeatability, specificity, limit of detection, limit of quantification, linearity, robustness and sensitivity of the method were examined. Good "recovery" values and low relative standard deviation confirm that the proposed ITLC method is suitable for routine determination of impurity C in 99mTc-MIBI in injection.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji
T1  - Validation of an ITLC Method for the Determination of Radiochemical Impurities C in 99mTc-MIBI Injection
SP  - 342
EP  - 349
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12185
ER  - 

@conference{
author = "Janković, Drina and Mirković, Marija D. and Radović, Magdalena and Milanović, Zorana and Perić, Marko and Stanković, Dragana and Vukadinović, Aleksandar and Vranješ-Đurić, Sanja",
year = "2023",
abstract = "Prisustvo radiohemijske nečistoće C u 99mTc-MIBI injekciji utiče na kvalitet skena, jer se radiofarmaceutik nedovoljno nakuplja u organu od interesa, dok je aktivnost okolnih organa i tkiva velika. Zbog toga je i doza zračenja koju prime okolni organi i tkiva iznad propisanih granica. Da bi se obezbedilo da je planirano izlaganje zračenju pacijenata svedeno na minimum, farmakopeja zahteva ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji neposredno pre primene radiofarmaceutika u pacijenta. Za ova ispitivanja se koriste metode hromatografije. U radu je predstavljena brza i osetljiva ITLC metoda namenjena za rutinsko ispitivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. ITLC metoda je validirana, a ispitivani su pogodnost sistema, tačnost, preciznost, ponovljivost, specifičnost, limit detekcije, limit kvantifikacije, linearnost, robustnost i osetljivost metode. Dobre "recovery" vrednosti i niska relativna standardna devijacija potvrđuju da je predložena ITLC metoda pogodna za rutinsko određivanje nečistoće C u 99mTc-MIBI u injekciji., The European Pharmacopoeia mandates that all radiopharmaceuticals used in nuclear medicine for diagnostic and therapeutic purposes must be of the correct radiochemical and radionuclidic purity and have the correct radioactivity present at the stated time of injection to ensure that the intended radiation exposure of patients is kept to a minimum. These factors have an effect on the overall radiation dose to the patient, as impurities of the radionuclide and/or its chemical composition may affect the biodistribution of the injected radiopharmaceutical and consequently the radiation dose to any one particular organ or the whole body dose. The presence of radiochemical impurity C in 99mTc-MIBI injection affects the quality of the image, because 99mTc-MIBI accumulates insufficiently in the organ of interest, while the activity of the surrounding organs and tissues is high. Therefore, the radiation dose received by the surrounding organs and tissues is above the permitted level. In order to avoid unnecessary irradiation of surrounding organs and tissues, the pharmacopoeia requires examination of the content of radiochemical impurity C immediately before administering of 99mTc-MIBI to the patient. Chromatographic methods are used for these tests. The paper presents a fast and sensitive ITLC method intended for routine examination of the content of radiochemical impurity C in 99mTc-MIBI injection. The ITLC method was validated, and the suitability of the system, accuracy, precision, repeatability, specificity, limit of detection, limit of quantification, linearity, robustness and sensitivity of the method were examined. Good "recovery" values and low relative standard deviation confirm that the proposed ITLC method is suitable for routine determination of impurity C in 99mTc-MIBI in injection.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji, Validation of an ITLC Method for the Determination of Radiochemical Impurities C in 99mTc-MIBI Injection",
pages = "342-349",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12185"
}

Janković, D., Mirković, M. D., Radović, M., Milanović, Z., Perić, M., Stanković, D., Vukadinović, A.,& Vranješ-Đurić, S.. (2023). Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 342-349.
https://hdl.handle.net/21.15107/rcub_vinar_12185

Janković D, Mirković MD, Radović M, Milanović Z, Perić M, Stanković D, Vukadinović A, Vranješ-Đurić S. Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji. in 32. simpozijum DZZSCG : zbornik radova. 2023;:342-349.
https://hdl.handle.net/21.15107/rcub_vinar_12185 .

Janković, Drina, Mirković, Marija D., Radović, Magdalena, Milanović, Zorana, Perić, Marko, Stanković, Dragana, Vukadinović, Aleksandar, Vranješ-Đurić, Sanja, "Validacija ITLC metode za određivanje sadržaja radiohemijske nečistoće C u 99mTc-MIBI injekciji" in 32. simpozijum DZZSCG : zbornik radova (2023):342-349,
https://hdl.handle.net/21.15107/rcub_vinar_12185 .

TY  - CONF
AU  - Milanović, Zorana
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Vukadinović, Aleksandar
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12186
AB  - Radiofarmaceutici koji se koriste za ispitivanje skeletnog sistema od neprocenjivog su značaja u nuklearnoj medicini, kako za dijagnostiku primarnih tumora koštanog tkiva, tako i metastaza. Pre primene na pacijentima, ovi radiofarmaceutici podležu različitim fizičko-hemijskim i biološkim ispitivanjima. Ispitivanje fiziološke raspodele leka in vivo je od presudnog značaja jer od akumulacije leka u odgovarajućoj meri u ciljnom organu (skeletu) zavisi kvalitet dobijenog scintigrama, kao i doza zračenja koje će primiti pojedinačni organi i tkiva. U evropskoj farmakopeji (Ph.Eur.) date su metode kontrole kvaliteta kao i parametri kvaliteta sa granicama prihvatljivosti (specifikacijske granice) za 99mTc-metilendifosfonat (99mTc-MDP). Cilj ovog rada je prikaz metode ispitivanja fiziološke raspodele 99mTc-DPD koja je razvijena u Laboratoriji za radioizotope po smernicama evropske farmakopeje za 99mTc-MDP, uz manje modifikacije. Rezultati biodistribucije na Wistar pacovima su pokazali da je 99mTc-DPD proizveden u Laboratoriji za radioizotope zadovoljio sve postavljene kriterijume, kako odmah nakon proizvodnje, tako i nakon šest i dvanaest meseci od proizvodnje.
AB  - Radiopharmaceuticals used to examine the skeletal system are of invaluable importance in nuclear medicine, both for the diagnosis of primary bone tissue tumors and metastases. Before administration to patients, these radiopharmaceuticals undergo various physico-chemical and biological tests. Investigation of the physiological distribution of the drug in vivo is of crucial importance because the quality of the obtained scintigram depends on the accumulation of the drug in the target organ (skeleton), as well as the radiation dose received by individual organs and tissues. The European pharmacopoeia (Ph.Eur.) provides quality control methods and quality parameters with acceptance limits (specification limits) for 99mTc-methylenediphosphonate (99mTc-MDP). The method of testing the physiological distribution of 99mTc-DPD in the Laboratory for Radioisotopes, which is presented in this paper, is done according to the guidelines of the European Pharmacopoeia for 99mTc-MDP, with minor modifications. Results of biodistribution on Wistar rats showed that 99mTc-DPD produced in the Laboratory for Radioisotopes met all the set criteria, both immediately after the production and after six and twelve months from production.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Metoda ispitivanja fiziološke raspodele 99mTc-DPD
T1  - Method for Investigation of Physiological Distribution of 99mTc DPD
SP  - 350
EP  - 355
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12186
ER  - 

@conference{
author = "Milanović, Zorana and Mirković, Marija D. and Radović, Magdalena and Perić, Marko and Stanković, Dragana and Vukadinović, Aleksandar and Vranješ-Đurić, Sanja and Janković, Drina",
year = "2023",
abstract = "Radiofarmaceutici koji se koriste za ispitivanje skeletnog sistema od neprocenjivog su značaja u nuklearnoj medicini, kako za dijagnostiku primarnih tumora koštanog tkiva, tako i metastaza. Pre primene na pacijentima, ovi radiofarmaceutici podležu različitim fizičko-hemijskim i biološkim ispitivanjima. Ispitivanje fiziološke raspodele leka in vivo je od presudnog značaja jer od akumulacije leka u odgovarajućoj meri u ciljnom organu (skeletu) zavisi kvalitet dobijenog scintigrama, kao i doza zračenja koje će primiti pojedinačni organi i tkiva. U evropskoj farmakopeji (Ph.Eur.) date su metode kontrole kvaliteta kao i parametri kvaliteta sa granicama prihvatljivosti (specifikacijske granice) za 99mTc-metilendifosfonat (99mTc-MDP). Cilj ovog rada je prikaz metode ispitivanja fiziološke raspodele 99mTc-DPD koja je razvijena u Laboratoriji za radioizotope po smernicama evropske farmakopeje za 99mTc-MDP, uz manje modifikacije. Rezultati biodistribucije na Wistar pacovima su pokazali da je 99mTc-DPD proizveden u Laboratoriji za radioizotope zadovoljio sve postavljene kriterijume, kako odmah nakon proizvodnje, tako i nakon šest i dvanaest meseci od proizvodnje., Radiopharmaceuticals used to examine the skeletal system are of invaluable importance in nuclear medicine, both for the diagnosis of primary bone tissue tumors and metastases. Before administration to patients, these radiopharmaceuticals undergo various physico-chemical and biological tests. Investigation of the physiological distribution of the drug in vivo is of crucial importance because the quality of the obtained scintigram depends on the accumulation of the drug in the target organ (skeleton), as well as the radiation dose received by individual organs and tissues. The European pharmacopoeia (Ph.Eur.) provides quality control methods and quality parameters with acceptance limits (specification limits) for 99mTc-methylenediphosphonate (99mTc-MDP). The method of testing the physiological distribution of 99mTc-DPD in the Laboratory for Radioisotopes, which is presented in this paper, is done according to the guidelines of the European Pharmacopoeia for 99mTc-MDP, with minor modifications. Results of biodistribution on Wistar rats showed that 99mTc-DPD produced in the Laboratory for Radioisotopes met all the set criteria, both immediately after the production and after six and twelve months from production.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Metoda ispitivanja fiziološke raspodele 99mTc-DPD, Method for Investigation of Physiological Distribution of 99mTc DPD",
pages = "350-355",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12186"
}

Milanović, Z., Mirković, M. D., Radović, M., Perić, M., Stanković, D., Vukadinović, A., Vranješ-Đurić, S.,& Janković, D.. (2023). Metoda ispitivanja fiziološke raspodele 99mTc-DPD. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 350-355.
https://hdl.handle.net/21.15107/rcub_vinar_12186

Milanović Z, Mirković MD, Radović M, Perić M, Stanković D, Vukadinović A, Vranješ-Đurić S, Janković D. Metoda ispitivanja fiziološke raspodele 99mTc-DPD. in 32. simpozijum DZZSCG : zbornik radova. 2023;:350-355.
https://hdl.handle.net/21.15107/rcub_vinar_12186 .

Milanović, Zorana, Mirković, Marija D., Radović, Magdalena, Perić, Marko, Stanković, Dragana, Vukadinović, Aleksandar, Vranješ-Đurić, Sanja, Janković, Drina, "Metoda ispitivanja fiziološke raspodele 99mTc-DPD" in 32. simpozijum DZZSCG : zbornik radova (2023):350-355,
https://hdl.handle.net/21.15107/rcub_vinar_12186 .

TY  - CONF
AU  - Vukadinović, Aleksandar
AU  - Ravlić, Miroslav
AU  - Matović, Milovan
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Jevremović, Milutin
AU  - Vranješ-Đurić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12187
AB  - Laboratorija za radioizotope Instituta Vinča je jedinstven centar u regionu koji poseduje Rešenja Ministarstva zdravlja Republike Srbije i Direktorata za radijacionu i nuklearnu sigurnost i bezbednost Srbije za proizvodnju radiofarmaceutika. Radiofarmaceutik koji se proizvodi više od 40 godina u Laboratoriji za radioizotope, a primenjuje u terapiji tumora štitaste žlezde, kao i hipertireozi su kapsule natrijum-jodida (I-131). Radijacioni efekti I-131 na ćelije štitaste žlezde potiču od beta-zračenja koje emituje I-131 tokom radioaktivnog raspada u samoj štitastoj žlezdi jer se I-131 nakon oralne primene nakuplja prvenstveno u štitastoj žlezdi u kojoj ima dugu retenciju. Za efikasnu terapiju, ali u isto vreme u cilju smanjenja izloženosti nepotrebnim dozama, za svakog pacijenta određuje se odgovarajuća doza I-131 koju je neophodno da primi, odnosno primenjuje se tzv. personalizovana terapija. U radu je opisan postupak proizvodnje kapsula I-131 u Laboratoriji za radioizotope putem manuelnog punjenja kapsula rastvorom I-131, kao i osnovni zahtevi koje je neophodno da sistem za automatsku proizvodnju radiofarmaceutika ispuni, a to su pre svih, odgovarajuća zaštita operatera od zračenja, jednostavna upotreba i kompjuterska kontrola.
AB  - The Laboratory for radioisotopes of the Vinča Institute is a unique center in the region with licences of the Ministry of Health of the Republic of Serbia and the Directorate for Radiation and Nuclear Safety and Security of Serbia for the production of radiopharmaceuticals. Sodium iodide (I-131) capsules are radiopharmaceuticals that have been produced for more than 40 years in the Laboratory for Radioisotopes, and are used in the treatment of tumors of thyroid gland, as well as in hyperthyroidism. The radiation effects of I-131 on thyroid cells originate from beta-radiation emitted by I-131 during radioactive decay in the thyroid gland itself because I-131 after oral administration accumulates primarily in the thyroid gland where it has a long retention. For the effective therapy, but at the same time in order to reduce exposure to unnecessary high doses, the appropriate dose of I-131 is determined for each patient, in the so-called personalized therapy. The paper describes the current procedure for the production of I-131 capsules in the Laboratory for Radioisotopes by manually filling the capsules with I-131 solution and the basic requirements for design the system for automating the production of radiopharmaceuticals, which above all must provide adequate protection for the operator from radiation, must be user friendly and computer-controlled.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera
T1  - Automation of the Production of Radiopharmaceutical with the Aim to Reduce the Operator's Radiation Dose
SP  - 356
EP  - 360
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12187
ER  - 

@conference{
author = "Vukadinović, Aleksandar and Ravlić, Miroslav and Matović, Milovan and Janković, Drina and Mirković, Marija D. and Radović, Magdalena and Milanović, Zorana and Perić, Marko and Stanković, Dragana and Jevremović, Milutin and Vranješ-Đurić, Sanja",
year = "2023",
abstract = "Laboratorija za radioizotope Instituta Vinča je jedinstven centar u regionu koji poseduje Rešenja Ministarstva zdravlja Republike Srbije i Direktorata za radijacionu i nuklearnu sigurnost i bezbednost Srbije za proizvodnju radiofarmaceutika. Radiofarmaceutik koji se proizvodi više od 40 godina u Laboratoriji za radioizotope, a primenjuje u terapiji tumora štitaste žlezde, kao i hipertireozi su kapsule natrijum-jodida (I-131). Radijacioni efekti I-131 na ćelije štitaste žlezde potiču od beta-zračenja koje emituje I-131 tokom radioaktivnog raspada u samoj štitastoj žlezdi jer se I-131 nakon oralne primene nakuplja prvenstveno u štitastoj žlezdi u kojoj ima dugu retenciju. Za efikasnu terapiju, ali u isto vreme u cilju smanjenja izloženosti nepotrebnim dozama, za svakog pacijenta određuje se odgovarajuća doza I-131 koju je neophodno da primi, odnosno primenjuje se tzv. personalizovana terapija. U radu je opisan postupak proizvodnje kapsula I-131 u Laboratoriji za radioizotope putem manuelnog punjenja kapsula rastvorom I-131, kao i osnovni zahtevi koje je neophodno da sistem za automatsku proizvodnju radiofarmaceutika ispuni, a to su pre svih, odgovarajuća zaštita operatera od zračenja, jednostavna upotreba i kompjuterska kontrola., The Laboratory for radioisotopes of the Vinča Institute is a unique center in the region with licences of the Ministry of Health of the Republic of Serbia and the Directorate for Radiation and Nuclear Safety and Security of Serbia for the production of radiopharmaceuticals. Sodium iodide (I-131) capsules are radiopharmaceuticals that have been produced for more than 40 years in the Laboratory for Radioisotopes, and are used in the treatment of tumors of thyroid gland, as well as in hyperthyroidism. The radiation effects of I-131 on thyroid cells originate from beta-radiation emitted by I-131 during radioactive decay in the thyroid gland itself because I-131 after oral administration accumulates primarily in the thyroid gland where it has a long retention. For the effective therapy, but at the same time in order to reduce exposure to unnecessary high doses, the appropriate dose of I-131 is determined for each patient, in the so-called personalized therapy. The paper describes the current procedure for the production of I-131 capsules in the Laboratory for Radioisotopes by manually filling the capsules with I-131 solution and the basic requirements for design the system for automating the production of radiopharmaceuticals, which above all must provide adequate protection for the operator from radiation, must be user friendly and computer-controlled.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera, Automation of the Production of Radiopharmaceutical with the Aim to Reduce the Operator's Radiation Dose",
pages = "356-360",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12187"
}

Vukadinović, A., Ravlić, M., Matović, M., Janković, D., Mirković, M. D., Radović, M., Milanović, Z., Perić, M., Stanković, D., Jevremović, M.,& Vranješ-Đurić, S.. (2023). Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 356-360.
https://hdl.handle.net/21.15107/rcub_vinar_12187

Vukadinović A, Ravlić M, Matović M, Janković D, Mirković MD, Radović M, Milanović Z, Perić M, Stanković D, Jevremović M, Vranješ-Đurić S. Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera. in 32. simpozijum DZZSCG : zbornik radova. 2023;:356-360.
https://hdl.handle.net/21.15107/rcub_vinar_12187 .

Vukadinović, Aleksandar, Ravlić, Miroslav, Matović, Milovan, Janković, Drina, Mirković, Marija D., Radović, Magdalena, Milanović, Zorana, Perić, Marko, Stanković, Dragana, Jevremović, Milutin, Vranješ-Đurić, Sanja, "Automatizacija procesa proizvodnje radiofarmaceutika u cilju smanjenja doze zračenja operatera" in 32. simpozijum DZZSCG : zbornik radova (2023):356-360,
https://hdl.handle.net/21.15107/rcub_vinar_12187 .

TY  - JOUR
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Mirković, Marija D.
AU  - Stanković, Dragana
AU  - Vranješ-Đurić, Sanja
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8652
AB  - Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd
T2  - Applied Radiation and Isotopes
T1  - Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres
VL  - 156
SP  - 108984
DO  - 10.1016/j.apradiso.2019.108984
ER  - 

@article{
author = "Vukadinović, Aleksandar and Janković, Drina and Radović, Magdalena and Milanović, Zorana and Mirković, Marija D. and Stanković, Dragana and Vranješ-Đurić, Sanja",
year = "2020",
abstract = "Biologically stable 90Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of 90Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide 90Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide 90Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy. © 2019 Elsevier Ltd",
journal = "Applied Radiation and Isotopes",
title = "Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres",
volume = "156",
pages = "108984",
doi = "10.1016/j.apradiso.2019.108984"
}

Vukadinović, A., Janković, D., Radović, M., Milanović, Z., Mirković, M. D., Stanković, D.,& Vranješ-Đurić, S.. (2020). Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres. in Applied Radiation and Isotopes, 156, 108984.
https://doi.org/10.1016/j.apradiso.2019.108984

Vukadinović A, Janković D, Radović M, Milanović Z, Mirković MD, Stanković D, Vranješ-Đurić S. Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres. in Applied Radiation and Isotopes. 2020;156:108984.
doi:10.1016/j.apradiso.2019.108984 .

Vukadinović, Aleksandar, Janković, Drina, Radović, Magdalena, Milanović, Zorana, Mirković, Marija D., Stanković, Dragana, Vranješ-Đurić, Sanja, "Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90Y-albumin microspheres" in Applied Radiation and Isotopes, 156 (2020):108984,
https://doi.org/10.1016/j.apradiso.2019.108984 . .

TY  - JOUR
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Stanković, Dragana
AU  - Milanović, Zorana
AU  - Janković, Drina
AU  - Matović, Milovan D.
AU  - Jeremić, Marija
AU  - Antić, Bratislav
AU  - Vranješ-Đurić, Sanja
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8156
AB  - Novel theranostic nanoplatform is expected to integrate imaging for guiding and monitoring of the tumor therapy with great therapeutic efficacy and fewer side effects. Here we describe the preparation of a multifunctional 99mTc–bisphosphonate–coated magnetic nanoparticles (MNPs) based on Fe3O4 and coated with two hydrophilic bisphosphonate ligands, i.e., methylene diphosphonate (MDP) and 1–hydroxyethane-1,1- diphosphonate (HEDP). The presence of the bisphosphonates on the MNPs surface, enabled their biocompatibility, colloidal stability and successful binding of the radionuclide. The morphology, size, structure, surface charge and magnetic properties of obtained bisphosphonate–coated Fe3O4 MNPs were characterized by transmission electron microscopy, X–ray powder diffraction, dynamic light scattering, laser Doppler electrophoresis, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The specific power absorption values for Fe3O4–MDP and Fe3O4–HEDP were 113 W/g and 141 W/g, respectively, indicated their heating ability under applied magnetic field. Coated MNPs were radiolabeled with 99mTc using stannous chloride as the reducing agent in a reproducible high yield (95% for Fe3O4–MDP and 97% for Fe3O4–HEDP MNPs) and were remained stable in saline and human serum for 24 h. Ex vivo biodistribution studies presented significant liver and spleen uptake in healthy Wistar rats after intravenous administration at all examined time points due to the colloidal nature of both 99mTc–MNPs. Results of scintigraphy studies are in accordance with ex vivo biodistribution studies, demonstrating high in vivo stability of radiolabeled MNPs and therefore results of both methods were proved as accurate information on the biodistribution profile of investigated MNPs. Overall, in vitro and in vivo stability as well as heating ability, indicate that biocompatible radiolabeled bisphosphonate magnetic nanoparticles exhibit promising potential as a theranostic nanoagent. © 2019 Elsevier B.V.
T2  - Materials Science and Engineering: C
T1  - 99mTc–bisphosphonate–coated magnetic nanoparticles as potential theranostic nanoagent
VL  - 102
SP  - 124
EP  - 133
DO  - 10.1016/j.msec.2019.04.034
ER  - 

@article{
author = "Mirković, Marija D. and Radović, Magdalena and Stanković, Dragana and Milanović, Zorana and Janković, Drina and Matović, Milovan D. and Jeremić, Marija and Antić, Bratislav and Vranješ-Đurić, Sanja",
year = "2019",
abstract = "Novel theranostic nanoplatform is expected to integrate imaging for guiding and monitoring of the tumor therapy with great therapeutic efficacy and fewer side effects. Here we describe the preparation of a multifunctional 99mTc–bisphosphonate–coated magnetic nanoparticles (MNPs) based on Fe3O4 and coated with two hydrophilic bisphosphonate ligands, i.e., methylene diphosphonate (MDP) and 1–hydroxyethane-1,1- diphosphonate (HEDP). The presence of the bisphosphonates on the MNPs surface, enabled their biocompatibility, colloidal stability and successful binding of the radionuclide. The morphology, size, structure, surface charge and magnetic properties of obtained bisphosphonate–coated Fe3O4 MNPs were characterized by transmission electron microscopy, X–ray powder diffraction, dynamic light scattering, laser Doppler electrophoresis, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The specific power absorption values for Fe3O4–MDP and Fe3O4–HEDP were 113 W/g and 141 W/g, respectively, indicated their heating ability under applied magnetic field. Coated MNPs were radiolabeled with 99mTc using stannous chloride as the reducing agent in a reproducible high yield (95% for Fe3O4–MDP and 97% for Fe3O4–HEDP MNPs) and were remained stable in saline and human serum for 24 h. Ex vivo biodistribution studies presented significant liver and spleen uptake in healthy Wistar rats after intravenous administration at all examined time points due to the colloidal nature of both 99mTc–MNPs. Results of scintigraphy studies are in accordance with ex vivo biodistribution studies, demonstrating high in vivo stability of radiolabeled MNPs and therefore results of both methods were proved as accurate information on the biodistribution profile of investigated MNPs. Overall, in vitro and in vivo stability as well as heating ability, indicate that biocompatible radiolabeled bisphosphonate magnetic nanoparticles exhibit promising potential as a theranostic nanoagent. © 2019 Elsevier B.V.",
journal = "Materials Science and Engineering: C",
title = "99mTc–bisphosphonate–coated magnetic nanoparticles as potential theranostic nanoagent",
volume = "102",
pages = "124-133",
doi = "10.1016/j.msec.2019.04.034"
}

Mirković, M. D., Radović, M., Stanković, D., Milanović, Z., Janković, D., Matović, M. D., Jeremić, M., Antić, B.,& Vranješ-Đurić, S.. (2019). 99mTc–bisphosphonate–coated magnetic nanoparticles as potential theranostic nanoagent. in Materials Science and Engineering: C, 102, 124-133.
https://doi.org/10.1016/j.msec.2019.04.034

Mirković MD, Radović M, Stanković D, Milanović Z, Janković D, Matović MD, Jeremić M, Antić B, Vranješ-Đurić S. 99mTc–bisphosphonate–coated magnetic nanoparticles as potential theranostic nanoagent. in Materials Science and Engineering: C. 2019;102:124-133.
doi:10.1016/j.msec.2019.04.034 .

Mirković, Marija D., Radović, Magdalena, Stanković, Dragana, Milanović, Zorana, Janković, Drina, Matović, Milovan D., Jeremić, Marija, Antić, Bratislav, Vranješ-Đurić, Sanja, "99mTc–bisphosphonate–coated magnetic nanoparticles as potential theranostic nanoagent" in Materials Science and Engineering: C, 102 (2019):124-133,
https://doi.org/10.1016/j.msec.2019.04.034 . .

TY  - JOUR
AU  - Stanković, Dragana
AU  - Ristić, Slavica M.
AU  - Vukadinović, Aleksandar
AU  - Mirković, Marija D.
AU  - Vladimirov, Sandra S.
AU  - Milanović, Zorana
AU  - Radović, Magdalena
AU  - Mijović, Milica
AU  - Stanković, Dalibor M.
AU  - Sabo, Tibor J.
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8492
AB  - It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes. © The Author(s) 2018.
T2  - Human and Experimental Toxicology
T1  - Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP
VL  - 38
IS  - 4
SP  - 466
EP  - 481
DO  - 10.1177/0960327118819047
ER  - 

@article{
author = "Stanković, Dragana and Ristić, Slavica M. and Vukadinović, Aleksandar and Mirković, Marija D. and Vladimirov, Sandra S. and Milanović, Zorana and Radović, Magdalena and Mijović, Milica and Stanković, Dalibor M. and Sabo, Tibor J. and Vranješ-Đurić, Sanja and Janković, Drina",
year = "2019",
abstract = "It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes. © The Author(s) 2018.",
journal = "Human and Experimental Toxicology",
title = "Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP",
volume = "38",
number = "4",
pages = "466-481",
doi = "10.1177/0960327118819047"
}

Stanković, D., Ristić, S. M., Vukadinović, A., Mirković, M. D., Vladimirov, S. S., Milanović, Z., Radović, M., Mijović, M., Stanković, D. M., Sabo, T. J., Vranješ-Đurić, S.,& Janković, D.. (2019). Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. in Human and Experimental Toxicology, 38(4), 466-481.
https://doi.org/10.1177/0960327118819047

Stanković D, Ristić SM, Vukadinović A, Mirković MD, Vladimirov SS, Milanović Z, Radović M, Mijović M, Stanković DM, Sabo TJ, Vranješ-Đurić S, Janković D. Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. in Human and Experimental Toxicology. 2019;38(4):466-481.
doi:10.1177/0960327118819047 .

Stanković, Dragana, Ristić, Slavica M., Vukadinović, Aleksandar, Mirković, Marija D., Vladimirov, Sandra S., Milanović, Zorana, Radović, Magdalena, Mijović, Milica, Stanković, Dalibor M., Sabo, Tibor J., Vranješ-Đurić, Sanja, Janković, Drina, "Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP" in Human and Experimental Toxicology, 38, no. 4 (2019):466-481,
https://doi.org/10.1177/0960327118819047 . .

TY  - JOUR
AU  - Radović, Magdalena
AU  - Mirković, Marija D.
AU  - Perić, Marko R.
AU  - Janković, Drina
AU  - Vukadinović, Aleksandar
AU  - Stanković, Dragana
AU  - Bošković, Marko
AU  - Antić, Bratislav
AU  - Marković, Mirjana
AU  - Vranješ-Đurić, Sanja
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1830
AB  - Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.
T2  - Journal of Materials Chemistry. B
T1  - Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications
VL  - 5
IS  - 44
SP  - 8738
EP  - 8747
DO  - 10.1039/c7tb02075a
ER  - 

@article{
author = "Radović, Magdalena and Mirković, Marija D. and Perić, Marko R. and Janković, Drina and Vukadinović, Aleksandar and Stanković, Dragana and Bošković, Marko and Antić, Bratislav and Marković, Mirjana and Vranješ-Đurić, Sanja",
year = "2017",
abstract = "Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.",
journal = "Journal of Materials Chemistry. B",
title = "Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications",
volume = "5",
number = "44",
pages = "8738-8747",
doi = "10.1039/c7tb02075a"
}

Radović, M., Mirković, M. D., Perić, M. R., Janković, D., Vukadinović, A., Stanković, D., Bošković, M., Antić, B., Marković, M.,& Vranješ-Đurić, S.. (2017). Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications. in Journal of Materials Chemistry. B, 5(44), 8738-8747.
https://doi.org/10.1039/c7tb02075a

Radović M, Mirković MD, Perić MR, Janković D, Vukadinović A, Stanković D, Bošković M, Antić B, Marković M, Vranješ-Đurić S. Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications. in Journal of Materials Chemistry. B. 2017;5(44):8738-8747.
doi:10.1039/c7tb02075a .

Radović, Magdalena, Mirković, Marija D., Perić, Marko R., Janković, Drina, Vukadinović, Aleksandar, Stanković, Dragana, Bošković, Marko, Antić, Bratislav, Marković, Mirjana, Vranješ-Đurić, Sanja, "Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications" in Journal of Materials Chemistry. B, 5, no. 44 (2017):8738-8747,
https://doi.org/10.1039/c7tb02075a . .

TY  - CONF
AU  - Tomić, Zoran D.
AU  - Mirković, Marija D.
AU  - Nikolić, Nadežda S.
AU  - Stanković, Dragana
AU  - Mijin, Dušan Ž.
AU  - Kapor, Agneš
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9258
AB  - The structure of binuclear Cu(II) complex containing double oximato
bridges was determined by the single-crystal X-ray diffraction analysis.
Copper is five-coordinated with perchlorato anion present at the borderline
of semi-coordination. Comparison with the structurally related diiminedioxime
Cu(II) complexes revealed the influence of the weak
Cu···O(perchlorate) interaction on the geometry of the metallocycle.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Influence of the weak interaction on the structure of metallocycle in binuclear copper(II) complex
VL  - M-05-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9258
ER  - 

@conference{
author = "Tomić, Zoran D. and Mirković, Marija D. and Nikolić, Nadežda S. and Stanković, Dragana and Mijin, Dušan Ž. and Kapor, Agneš",
year = "2014",
abstract = "The structure of binuclear Cu(II) complex containing double oximato
bridges was determined by the single-crystal X-ray diffraction analysis.
Copper is five-coordinated with perchlorato anion present at the borderline
of semi-coordination. Comparison with the structurally related diiminedioxime
Cu(II) complexes revealed the influence of the weak
Cu···O(perchlorate) interaction on the geometry of the metallocycle.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Influence of the weak interaction on the structure of metallocycle in binuclear copper(II) complex",
volume = "M-05-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9258"
}

Tomić, Z. D., Mirković, M. D., Nikolić, N. S., Stanković, D., Mijin, D. Ž.,& Kapor, A.. (2014). Influence of the weak interaction on the structure of metallocycle in binuclear copper(II) complex. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., M-05-P.
https://hdl.handle.net/21.15107/rcub_vinar_9258

Tomić ZD, Mirković MD, Nikolić NS, Stanković D, Mijin DŽ, Kapor A. Influence of the weak interaction on the structure of metallocycle in binuclear copper(II) complex. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;M-05-P.
https://hdl.handle.net/21.15107/rcub_vinar_9258 .

Tomić, Zoran D., Mirković, Marija D., Nikolić, Nadežda S., Stanković, Dragana, Mijin, Dušan Ž., Kapor, Agneš, "Influence of the weak interaction on the structure of metallocycle in binuclear copper(II) complex" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, M-05-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9258 .

TY  - CONF
AU  - Sandić, Zvijezdana
AU  - Momčilović, Milan Z.
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Stanković, Dragana
AU  - Suručić, Ljiljana T.
AU  - Maksin, Danijela D.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9229
AB  - Sorption of radioactive 99Tc-pertechnetate onto activated carbon prepared
from pinecones was investigated. The parameters of contact time and Tc-99
concentration were varied. It was established that the sorption half-life, t1/2,
was very short ~ 2.2 min, thus making this sorbent an excellent candidate
for immediate pollution remediation, which is very important in the case of
nuclear accidents. The kinetic data were found to follow closely the pseudosecond-
order (PSO) kinetic model. Boyd model established the sorption
dependence only on film diffusion. The partitioning/distribution coefficient,
Kd, attained was 2729 cm3 g-1. The equilibration time was 3 h at room
temperature (T=298 K).
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Efficient separation of Tc-99 from aqueous solution using pinecone activated carbon
VL  - G-04-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9229
ER  - 

@conference{
author = "Sandić, Zvijezdana and Momčilović, Milan Z. and Mirković, Marija D. and Radović, Magdalena and Stanković, Dragana and Suručić, Ljiljana T. and Maksin, Danijela D.",
year = "2014",
abstract = "Sorption of radioactive 99Tc-pertechnetate onto activated carbon prepared
from pinecones was investigated. The parameters of contact time and Tc-99
concentration were varied. It was established that the sorption half-life, t1/2,
was very short ~ 2.2 min, thus making this sorbent an excellent candidate
for immediate pollution remediation, which is very important in the case of
nuclear accidents. The kinetic data were found to follow closely the pseudosecond-
order (PSO) kinetic model. Boyd model established the sorption
dependence only on film diffusion. The partitioning/distribution coefficient,
Kd, attained was 2729 cm3 g-1. The equilibration time was 3 h at room
temperature (T=298 K).",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Efficient separation of Tc-99 from aqueous solution using pinecone activated carbon",
volume = "G-04-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9229"
}

Sandić, Z., Momčilović, M. Z., Mirković, M. D., Radović, M., Stanković, D., Suručić, L. T.,& Maksin, D. D.. (2014). Efficient separation of Tc-99 from aqueous solution using pinecone activated carbon. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., G-04-P.
https://hdl.handle.net/21.15107/rcub_vinar_9229

Sandić Z, Momčilović MZ, Mirković MD, Radović M, Stanković D, Suručić LT, Maksin DD. Efficient separation of Tc-99 from aqueous solution using pinecone activated carbon. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;G-04-P.
https://hdl.handle.net/21.15107/rcub_vinar_9229 .

Sandić, Zvijezdana, Momčilović, Milan Z., Mirković, Marija D., Radović, Magdalena, Stanković, Dragana, Suručić, Ljiljana T., Maksin, Danijela D., "Efficient separation of Tc-99 from aqueous solution using pinecone activated carbon" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, G-04-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9229 .

TY  - JOUR
AU  - Mirković, Marija D.
AU  - Janković, Drina
AU  - Vranješ-Đurić, Sanja
AU  - Radović, Magdalena
AU  - Stanković, Dragana
AU  - Mijin, Dušan Ž.
AU  - Nikolić, Nadežda S.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4899
AB  - Two novel diamine dioxime ligands, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime (3) and 4,9-diaza-3,10-diethyldodecane-2,11-dione bis oxime (5), were synthesized in order to develop new brain perfusion imaging agents, based on 99mTc(V)-complexes. The synthesis involved condensation of 2-hydroxyimino-3-pentanone with appropriate diamine in protic solvent which afforded the bis imine adducts. Subsequent reduction of imine functional groups yielded a diastereoisomeric mixture of 3 and 5. UVvisible, IR, 1H NMR, 13C NMR and elemental analysis were used to characterize the structures of the synthesized compounds. 99mTc-complexes of both diamine dioximes were prepared and radiolabeling conditions optimized to give the maximum yield. Physicochemical parameters of the labeled complexes as well as and their biodistribution in rats were investigated. Both compounds (3 and 5) formed 99mTc-complexes with a net charge of zero, determined by electrophoresis. The resultant lipophilic 99mTc-complexes of 3 and 5 were readily formed at pH similar to 9.0 within 10?min at room temperature with yields of 90% and 95%, respectively. The 99mTc-3 complex was found to be stable within 1 similar to h, while 99mTc-5 was stable for a few hours. A significant brain uptake of 99mTc-3 (2.1% injected dose) and 99mTc-5 (1.8% injected dose) complexes, 2?min after injection, is in accordance with their lipophilicity. The present study suggests that both ligands are promising candidates as new 99mTc-based brain-imaging agents. Copyright (c) 2012 John Wiley and Sons, Ltd.
T2  - Applied Organometallic Chemistry
T1  - Novel tetradentate diamine dioxime ligands: synthesis, characterization and in vivo behavior of their 99mTc-complexes
VL  - 26
IS  - 7
SP  - 347
EP  - 355
DO  - 10.1002/aoc.2870
ER  - 

@article{
author = "Mirković, Marija D. and Janković, Drina and Vranješ-Đurić, Sanja and Radović, Magdalena and Stanković, Dragana and Mijin, Dušan Ž. and Nikolić, Nadežda S.",
year = "2012",
abstract = "Two novel diamine dioxime ligands, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime (3) and 4,9-diaza-3,10-diethyldodecane-2,11-dione bis oxime (5), were synthesized in order to develop new brain perfusion imaging agents, based on 99mTc(V)-complexes. The synthesis involved condensation of 2-hydroxyimino-3-pentanone with appropriate diamine in protic solvent which afforded the bis imine adducts. Subsequent reduction of imine functional groups yielded a diastereoisomeric mixture of 3 and 5. UVvisible, IR, 1H NMR, 13C NMR and elemental analysis were used to characterize the structures of the synthesized compounds. 99mTc-complexes of both diamine dioximes were prepared and radiolabeling conditions optimized to give the maximum yield. Physicochemical parameters of the labeled complexes as well as and their biodistribution in rats were investigated. Both compounds (3 and 5) formed 99mTc-complexes with a net charge of zero, determined by electrophoresis. The resultant lipophilic 99mTc-complexes of 3 and 5 were readily formed at pH similar to 9.0 within 10?min at room temperature with yields of 90% and 95%, respectively. The 99mTc-3 complex was found to be stable within 1 similar to h, while 99mTc-5 was stable for a few hours. A significant brain uptake of 99mTc-3 (2.1% injected dose) and 99mTc-5 (1.8% injected dose) complexes, 2?min after injection, is in accordance with their lipophilicity. The present study suggests that both ligands are promising candidates as new 99mTc-based brain-imaging agents. Copyright (c) 2012 John Wiley and Sons, Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Novel tetradentate diamine dioxime ligands: synthesis, characterization and in vivo behavior of their 99mTc-complexes",
volume = "26",
number = "7",
pages = "347-355",
doi = "10.1002/aoc.2870"
}

Mirković, M. D., Janković, D., Vranješ-Đurić, S., Radović, M., Stanković, D., Mijin, D. Ž.,& Nikolić, N. S.. (2012). Novel tetradentate diamine dioxime ligands: synthesis, characterization and in vivo behavior of their 99mTc-complexes. in Applied Organometallic Chemistry, 26(7), 347-355.
https://doi.org/10.1002/aoc.2870

Mirković MD, Janković D, Vranješ-Đurić S, Radović M, Stanković D, Mijin DŽ, Nikolić NS. Novel tetradentate diamine dioxime ligands: synthesis, characterization and in vivo behavior of their 99mTc-complexes. in Applied Organometallic Chemistry. 2012;26(7):347-355.
doi:10.1002/aoc.2870 .

Mirković, Marija D., Janković, Drina, Vranješ-Đurić, Sanja, Radović, Magdalena, Stanković, Dragana, Mijin, Dušan Ž., Nikolić, Nadežda S., "Novel tetradentate diamine dioxime ligands: synthesis, characterization and in vivo behavior of their 99mTc-complexes" in Applied Organometallic Chemistry, 26, no. 7 (2012):347-355,
https://doi.org/10.1002/aoc.2870 . .

TY  - JOUR
AU  - Petrović, Đorđe
AU  - Nikolić, Nadežda S.
AU  - Stanković, Dragana
AU  - Đokić, Divna Đ.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5069
AB  - Radiopharmaceuticals based on Y-90 are widely used in the treatment of malignant deseases. In order to meet the requirements for their future application, a Sr-90/Y-90 generator was developed and 90Y eluted from this locally produced generator was used for the radiolabelling of the DOTA-conjugated somatostatin analog [DOTA(0),Tyr(3)] octreotate and the preparation of [Y-90-DOTA(0),Tyr(3)] octreotate (Y-90-DOTATATE) for peptide receptore radionuclide therapy. Sr-90/Y-90 generator was based on the electrochemical separation of Y-90 from Sr-90 in a two-cycle electrolysis procedure. Three electrode cells were used to perform both electrolyses. In both cycles, working electrodes were kept on constant potential. The pH of the solution was adjusted to 2.7 of the value before the electrolyses. The radionucliclic purity of the Y-90 solution was analysed by ITLC and extraction paper chromatography. The labelling of peptide (100 mu g DOTATATE) with (YCl3)-Y-90 was performed at 95 degrees C for 30 minutes. Radiochemical purity was determined by HPLC and chromatographic separation, using a solid SepPak C-18 column. Results obtained confirmed the efficiency of our electrochemical separation technique and quality control methods for Y-90. The achieved efficiency of the Sr-90/Y-90 generator above 96% of the theoretical value represents a good basis for the further development of this generator. The labelling of the DOTATATE with Y-90 exhibited a high efficiency, too: there was less than 1% of Y-90(3+) in the Y-90-DOTATATE.
T2  - Nuclear technology and radiation protection
T1  - Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate
VL  - 27
IS  - 3
SP  - 260
EP  - 268
DO  - 10.2298/NTRP1203260P
ER  - 

@article{
author = "Petrović, Đorđe and Nikolić, Nadežda S. and Stanković, Dragana and Đokić, Divna Đ.",
year = "2012",
abstract = "Radiopharmaceuticals based on Y-90 are widely used in the treatment of malignant deseases. In order to meet the requirements for their future application, a Sr-90/Y-90 generator was developed and 90Y eluted from this locally produced generator was used for the radiolabelling of the DOTA-conjugated somatostatin analog [DOTA(0),Tyr(3)] octreotate and the preparation of [Y-90-DOTA(0),Tyr(3)] octreotate (Y-90-DOTATATE) for peptide receptore radionuclide therapy. Sr-90/Y-90 generator was based on the electrochemical separation of Y-90 from Sr-90 in a two-cycle electrolysis procedure. Three electrode cells were used to perform both electrolyses. In both cycles, working electrodes were kept on constant potential. The pH of the solution was adjusted to 2.7 of the value before the electrolyses. The radionucliclic purity of the Y-90 solution was analysed by ITLC and extraction paper chromatography. The labelling of peptide (100 mu g DOTATATE) with (YCl3)-Y-90 was performed at 95 degrees C for 30 minutes. Radiochemical purity was determined by HPLC and chromatographic separation, using a solid SepPak C-18 column. Results obtained confirmed the efficiency of our electrochemical separation technique and quality control methods for Y-90. The achieved efficiency of the Sr-90/Y-90 generator above 96% of the theoretical value represents a good basis for the further development of this generator. The labelling of the DOTATATE with Y-90 exhibited a high efficiency, too: there was less than 1% of Y-90(3+) in the Y-90-DOTATATE.",
journal = "Nuclear technology and radiation protection",
title = "Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate",
volume = "27",
number = "3",
pages = "260-268",
doi = "10.2298/NTRP1203260P"
}

Petrović, Đ., Nikolić, N. S., Stanković, D.,& Đokić, D. Đ.. (2012). Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate. in Nuclear technology and radiation protection, 27(3), 260-268.
https://doi.org/10.2298/NTRP1203260P

Petrović Đ, Nikolić NS, Stanković D, Đokić DĐ. Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate. in Nuclear technology and radiation protection. 2012;27(3):260-268.
doi:10.2298/NTRP1203260P .

Petrović, Đorđe, Nikolić, Nadežda S., Stanković, Dragana, Đokić, Divna Đ., "Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate" in Nuclear technology and radiation protection, 27, no. 3 (2012):260-268,
https://doi.org/10.2298/NTRP1203260P . .

TY  - CONF
AU  - Petrović, Đorđe
AU  - Đokić, Divna Đ.
AU  - Dobrijević, R.
AU  - Stanković, Dragana
AU  - Glodić, Pavle
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9298
AB  - Using of radiopharmaceuticals based on 90Y in the treatment of solid cancer is
increasing in recent years. Therefore, generators have been developed for obtaining
the 90Y using a feature of 90Sr for spontaneous breakthrough and its equilibrium
with 90Y. Electrochemical separation of 90Y from 90Sr has become the basic method
for obtaining 90Y in high radiochemical yield. For the preliminary study, we used
the electrochemical system with two electrochemical cells. Quality control was
performed using extraction paper chromatography (EPC). Preliminary results
showed that the separation completed successfully in both ways, quantity and
quality.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Development of 90Sr/90Y generator using electrochemical separation
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9298
ER  - 

@conference{
author = "Petrović, Đorđe and Đokić, Divna Đ. and Dobrijević, R. and Stanković, Dragana and Glodić, Pavle",
year = "2010",
abstract = "Using of radiopharmaceuticals based on 90Y in the treatment of solid cancer is
increasing in recent years. Therefore, generators have been developed for obtaining
the 90Y using a feature of 90Sr for spontaneous breakthrough and its equilibrium
with 90Y. Electrochemical separation of 90Y from 90Sr has become the basic method
for obtaining 90Y in high radiochemical yield. For the preliminary study, we used
the electrochemical system with two electrochemical cells. Quality control was
performed using extraction paper chromatography (EPC). Preliminary results
showed that the separation completed successfully in both ways, quantity and
quality.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Development of 90Sr/90Y generator using electrochemical separation",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9298"
}

Petrović, Đ., Đokić, D. Đ., Dobrijević, R., Stanković, D.,& Glodić, P.. (2010). Development of 90Sr/90Y generator using electrochemical separation. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9298

Petrović Đ, Đokić DĐ, Dobrijević R, Stanković D, Glodić P. Development of 90Sr/90Y generator using electrochemical separation. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9298 .

Petrović, Đorđe, Đokić, Divna Đ., Dobrijević, R., Stanković, Dragana, Glodić, Pavle, "Development of 90Sr/90Y generator using electrochemical separation" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9298 .

TY  - CONF
AU  - Lazarević, Magdalena
AU  - Vranješ, Sanja
AU  - Nikolić, Nadežda S.
AU  - Mirković, Marija D.
AU  - Janković, Drina
AU  - Stanković, Dragana
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9340
AB  - In this paper the results of a stability of [131I]mIBG, stored under various
conditions, are presented. The stability was followed during 14 days. The most
important radiochemical impurity in [131I]mIBG is free [131I]iodide, formed by
radiolysis. The results indicate that the rate of radiolytic decomposition of
[131I]mIBG is much slower at higher concentration of ascorbic acid (20 mg/mCi)
and at lower storage temperature (40C).
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Application of ascorbic acid as a radiolytic stabilizer for [131I]mibg
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9340
ER  - 

@conference{
author = "Lazarević, Magdalena and Vranješ, Sanja and Nikolić, Nadežda S. and Mirković, Marija D. and Janković, Drina and Stanković, Dragana",
year = "2010",
abstract = "In this paper the results of a stability of [131I]mIBG, stored under various
conditions, are presented. The stability was followed during 14 days. The most
important radiochemical impurity in [131I]mIBG is free [131I]iodide, formed by
radiolysis. The results indicate that the rate of radiolytic decomposition of
[131I]mIBG is much slower at higher concentration of ascorbic acid (20 mg/mCi)
and at lower storage temperature (40C).",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Application of ascorbic acid as a radiolytic stabilizer for [131I]mibg",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9340"
}

Lazarević, M., Vranješ, S., Nikolić, N. S., Mirković, M. D., Janković, D.,& Stanković, D.. (2010). Application of ascorbic acid as a radiolytic stabilizer for [131I]mibg. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9340

Lazarević M, Vranješ S, Nikolić NS, Mirković MD, Janković D, Stanković D. Application of ascorbic acid as a radiolytic stabilizer for [131I]mibg. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9340 .

Lazarević, Magdalena, Vranješ, Sanja, Nikolić, Nadežda S., Mirković, Marija D., Janković, Drina, Stanković, Dragana, "Application of ascorbic acid as a radiolytic stabilizer for [131I]mibg" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9340 .