TY  - JOUR
AU  - Rosić, Mirko A.
AU  - Pantović, Suzana B.
AU  - Lučić, Aleksandra P.
AU  - Ribarac-Stepić, Nevena B.
AU  - Anđelković, Ivan Z.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2413
AB  - The dynamics and kinetics of thyroid hormone transport in the isolated rat heart were examined using the modified unidirectional paired tracer dilution method. The uptake of I-125-thyroxine (I-115-T-4) and I-125-triiodothyronine (I-125-T-3) from the extracellular space into heart cells was measured relative to the extracellular space marker H-3-mannitol. The thyroid hormone maximal uptake was 54.4 % for I-125-T-4 and 52.15 % for I-125-T-3. The thyroid hormone net uptake was 25.69 % for I-125-T-4 and 25.49 % for I-125-T-3. Backflux from the intracellular space was 53.17 % for I-125-T-4 and 61.59 % for I-125-T-3. In the presence of unlabelled thyroid hormones, I-125-T-4 and I-125-T-3 maximal uptakes were reduced from 10.1 to 59.74 % and from 34.6 to 65.3 %, respectively, depending on the concentration of the unlabelled hormone, suggesting a saturable mechanism of the thyroid hormone uptake by the heart cells, with K-m(T4) = 105.46 muM and the maximal rate of I-125-thyroid hormone flax from the extracellular space to heart cells (V-max(T4))= 177.84 nM min(-1) for I-125-T-4 uptake, and K-m(T3) = 80.0 muM and V-max(T3) = 118.5 nM min(-1) for I-125-T-3 uptake.
T2  - Experimental Physiology
T1  - Kinetics of thyroxine (T-4) and triiodothyronine (T-3) transport in the isolated rat heart
VL  - 86
IS  - 1
SP  - 13
EP  - 18
DO  - 10.1113/eph8601835
ER  - 

@article{
author = "Rosić, Mirko A. and Pantović, Suzana B. and Lučić, Aleksandra P. and Ribarac-Stepić, Nevena B. and Anđelković, Ivan Z.",
year = "2001",
abstract = "The dynamics and kinetics of thyroid hormone transport in the isolated rat heart were examined using the modified unidirectional paired tracer dilution method. The uptake of I-125-thyroxine (I-115-T-4) and I-125-triiodothyronine (I-125-T-3) from the extracellular space into heart cells was measured relative to the extracellular space marker H-3-mannitol. The thyroid hormone maximal uptake was 54.4 % for I-125-T-4 and 52.15 % for I-125-T-3. The thyroid hormone net uptake was 25.69 % for I-125-T-4 and 25.49 % for I-125-T-3. Backflux from the intracellular space was 53.17 % for I-125-T-4 and 61.59 % for I-125-T-3. In the presence of unlabelled thyroid hormones, I-125-T-4 and I-125-T-3 maximal uptakes were reduced from 10.1 to 59.74 % and from 34.6 to 65.3 %, respectively, depending on the concentration of the unlabelled hormone, suggesting a saturable mechanism of the thyroid hormone uptake by the heart cells, with K-m(T4) = 105.46 muM and the maximal rate of I-125-thyroid hormone flax from the extracellular space to heart cells (V-max(T4))= 177.84 nM min(-1) for I-125-T-4 uptake, and K-m(T3) = 80.0 muM and V-max(T3) = 118.5 nM min(-1) for I-125-T-3 uptake.",
journal = "Experimental Physiology",
title = "Kinetics of thyroxine (T-4) and triiodothyronine (T-3) transport in the isolated rat heart",
volume = "86",
number = "1",
pages = "13-18",
doi = "10.1113/eph8601835"
}

Rosić, M. A., Pantović, S. B., Lučić, A. P., Ribarac-Stepić, N. B.,& Anđelković, I. Z.. (2001). Kinetics of thyroxine (T-4) and triiodothyronine (T-3) transport in the isolated rat heart. in Experimental Physiology, 86(1), 13-18.
https://doi.org/10.1113/eph8601835

Rosić MA, Pantović SB, Lučić AP, Ribarac-Stepić NB, Anđelković IZ. Kinetics of thyroxine (T-4) and triiodothyronine (T-3) transport in the isolated rat heart. in Experimental Physiology. 2001;86(1):13-18.
doi:10.1113/eph8601835 .

Rosić, Mirko A., Pantović, Suzana B., Lučić, Aleksandra P., Ribarac-Stepić, Nevena B., Anđelković, Ivan Z., "Kinetics of thyroxine (T-4) and triiodothyronine (T-3) transport in the isolated rat heart" in Experimental Physiology, 86, no. 1 (2001):13-18,
https://doi.org/10.1113/eph8601835 . .

TY  - JOUR
AU  - Rosić, Mirko A.
AU  - Pantović, Suzana B.
AU  - Lučić, Aleksandra P.
AU  - Ribarac-Stepić, Nevena B.
AU  - Trtić, Tatjana M.
AU  - Anđelković, Ivan Z.
AU  - Segal, Malcolm B.
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2144
T2  - Pharmazie
T1  - Triiodothyronine uptake by the isolated rat heart
VL  - 53
IS  - 5
SP  - 351
EP  - 352
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2144
ER  - 

@article{
author = "Rosić, Mirko A. and Pantović, Suzana B. and Lučić, Aleksandra P. and Ribarac-Stepić, Nevena B. and Trtić, Tatjana M. and Anđelković, Ivan Z. and Segal, Malcolm B.",
year = "1998",
journal = "Pharmazie",
title = "Triiodothyronine uptake by the isolated rat heart",
volume = "53",
number = "5",
pages = "351-352",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2144"
}

Rosić, M. A., Pantović, S. B., Lučić, A. P., Ribarac-Stepić, N. B., Trtić, T. M., Anđelković, I. Z.,& Segal, M. B.. (1998). Triiodothyronine uptake by the isolated rat heart. in Pharmazie, 53(5), 351-352.
https://hdl.handle.net/21.15107/rcub_vinar_2144

Rosić MA, Pantović SB, Lučić AP, Ribarac-Stepić NB, Trtić TM, Anđelković IZ, Segal MB. Triiodothyronine uptake by the isolated rat heart. in Pharmazie. 1998;53(5):351-352.
https://hdl.handle.net/21.15107/rcub_vinar_2144 .

Rosić, Mirko A., Pantović, Suzana B., Lučić, Aleksandra P., Ribarac-Stepić, Nevena B., Trtić, Tatjana M., Anđelković, Ivan Z., Segal, Malcolm B., "Triiodothyronine uptake by the isolated rat heart" in Pharmazie, 53, no. 5 (1998):351-352,
https://hdl.handle.net/21.15107/rcub_vinar_2144 .