TY  - JOUR
AU  - Stepanović, Aleksandar
AU  - Nikitović, Marina
AU  - Stanojković, Tatjana P.
AU  - Grujičić, Danica
AU  - Bukumirić, Zoran
AU  - Srbljak, Ivana
AU  - Ilić, Rosanda
AU  - Milošević, Snežana
AU  - Arsenijević, Tatjana
AU  - Petrović, Nina
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10265
AB  - A personalized approach to chemoradiation is important in reducing its potential side effects and identifying a group of patients prone to toxicity. MicroRNAs have been shown to have a predictive potential for radiotoxicity. The goal of the study was to test if levels of miRNA in peripheral blood mononuclear cells of glioblastoma patients are associated with toxicity and to identify the peak time point for toxicity. MicroRNA-10b/21/34a levels were measured in 43 patients with and without toxicity, at baseline, at the 15th, and at the 30th fraction by Real-Time quantitative Polymerase Chain Reaction. MicroRNA-10b/21 levels increased with toxicity grade (p = 0.014; p = 0.013); miR-21/34a levels were significantly different between patients with and without toxicity at the 15th fraction (p = 0.030; p = 0.045), while miR-34a levels significantly changed during treatment (p < 0.001). All three miRNAs showed a significantly high positive correlation with one another. MiR-34a might be considered as a predictive factor for toxicity due to its changes during treatment, and differences between the groups with and without toxicity; miR-10b might be used to predict toxicity; miR-10b/21 might be used for predicting the grade of toxicity in GB patients.
T2  - Scientific Reports
T1  - Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide
VL  - 12
IS  - 1
SP  - 7505
DO  - 10.1038/s41598-022-11445-9
ER  - 

@article{
author = "Stepanović, Aleksandar and Nikitović, Marina and Stanojković, Tatjana P. and Grujičić, Danica and Bukumirić, Zoran and Srbljak, Ivana and Ilić, Rosanda and Milošević, Snežana and Arsenijević, Tatjana and Petrović, Nina",
year = "2022",
abstract = "A personalized approach to chemoradiation is important in reducing its potential side effects and identifying a group of patients prone to toxicity. MicroRNAs have been shown to have a predictive potential for radiotoxicity. The goal of the study was to test if levels of miRNA in peripheral blood mononuclear cells of glioblastoma patients are associated with toxicity and to identify the peak time point for toxicity. MicroRNA-10b/21/34a levels were measured in 43 patients with and without toxicity, at baseline, at the 15th, and at the 30th fraction by Real-Time quantitative Polymerase Chain Reaction. MicroRNA-10b/21 levels increased with toxicity grade (p = 0.014; p = 0.013); miR-21/34a levels were significantly different between patients with and without toxicity at the 15th fraction (p = 0.030; p = 0.045), while miR-34a levels significantly changed during treatment (p < 0.001). All three miRNAs showed a significantly high positive correlation with one another. MiR-34a might be considered as a predictive factor for toxicity due to its changes during treatment, and differences between the groups with and without toxicity; miR-10b might be used to predict toxicity; miR-10b/21 might be used for predicting the grade of toxicity in GB patients.",
journal = "Scientific Reports",
title = "Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide",
volume = "12",
number = "1",
pages = "7505",
doi = "10.1038/s41598-022-11445-9"
}

Stepanović, A., Nikitović, M., Stanojković, T. P., Grujičić, D., Bukumirić, Z., Srbljak, I., Ilić, R., Milošević, S., Arsenijević, T.,& Petrović, N.. (2022). Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide. in Scientific Reports, 12(1), 7505.
https://doi.org/10.1038/s41598-022-11445-9

Stepanović A, Nikitović M, Stanojković TP, Grujičić D, Bukumirić Z, Srbljak I, Ilić R, Milošević S, Arsenijević T, Petrović N. Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide. in Scientific Reports. 2022;12(1):7505.
doi:10.1038/s41598-022-11445-9 .

Stepanović, Aleksandar, Nikitović, Marina, Stanojković, Tatjana P., Grujičić, Danica, Bukumirić, Zoran, Srbljak, Ivana, Ilić, Rosanda, Milošević, Snežana, Arsenijević, Tatjana, Petrović, Nina, "Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide" in Scientific Reports, 12, no. 1 (2022):7505,
https://doi.org/10.1038/s41598-022-11445-9 . .

TY  - CONF
AU  - Stepanović, Aleksandar
AU  - Petrović, Nina
AU  - Ilić, Rosanda
AU  - Bogdanović, Ivan
AU  - Arsenijević, Tatjana
AU  - Grujičić, Danica
AU  - Nikitović, Marina
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12458
C3  - Annals of cancerology section : 59th Cancerology Week : Book of asbtracts
T1  - MikroRNK kao prediktori radiotoksičnosti kod pacijenata sa glioblastomom
SP  - 114
EP  - 115
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12458
ER  - 

@conference{
author = "Stepanović, Aleksandar and Petrović, Nina and Ilić, Rosanda and Bogdanović, Ivan and Arsenijević, Tatjana and Grujičić, Danica and Nikitović, Marina",
year = "2022",
journal = "Annals of cancerology section : 59th Cancerology Week : Book of asbtracts",
title = "MikroRNK kao prediktori radiotoksičnosti kod pacijenata sa glioblastomom",
pages = "114-115",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12458"
}

Stepanović, A., Petrović, N., Ilić, R., Bogdanović, I., Arsenijević, T., Grujičić, D.,& Nikitović, M.. (2022). MikroRNK kao prediktori radiotoksičnosti kod pacijenata sa glioblastomom. in Annals of cancerology section : 59th Cancerology Week : Book of asbtracts, 114-115.
https://hdl.handle.net/21.15107/rcub_vinar_12458

Stepanović A, Petrović N, Ilić R, Bogdanović I, Arsenijević T, Grujičić D, Nikitović M. MikroRNK kao prediktori radiotoksičnosti kod pacijenata sa glioblastomom. in Annals of cancerology section : 59th Cancerology Week : Book of asbtracts. 2022;:114-115.
https://hdl.handle.net/21.15107/rcub_vinar_12458 .

Stepanović, Aleksandar, Petrović, Nina, Ilić, Rosanda, Bogdanović, Ivan, Arsenijević, Tatjana, Grujičić, Danica, Nikitović, Marina, "MikroRNK kao prediktori radiotoksičnosti kod pacijenata sa glioblastomom" in Annals of cancerology section : 59th Cancerology Week : Book of asbtracts (2022):114-115,
https://hdl.handle.net/21.15107/rcub_vinar_12458 .

TY  - CONF
AU  - Stepanović, Aleksandar
AU  - Petrović, Nina
AU  - Arsenijević, Tatjana
AU  - Nikitović, Marina
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12412
AB  - Background: Standard treatment of the glioblastoma patients is implemented with Stupp’s protocol since 2005, but 2-years survival of the patients are still at low percentage. Even with implementation of modern radiotherapy techniques, acute radiotoxicity is still observed in these patients. Micro RNAs (miRNAs) expression patterns are introduced in recent years as factors that might predict survival in patients with glioblastoma, as well as cancer treatment related side effects. Material and methods: The data used in this review were conducted from research papers in PUBMED/MEDLINE databases with a special focus on role of miRNAs in cancer and with emphasis on brain tumors correlated to acute radiotoxicity. Results: Inflammation due to oxidative stress via free radicals is one of the mechanisms of radiation injury of irradiated cells and may correlate with toxicity. MiRNAs expression in prostate cancer patients may predict acute radiotoxicity, while miRNAs expression levels that could predict radiation toxicity in glioblastoma are still under investigation. However, it has been shown that miRNA levels like miR-16, miR 21, miR-19a and miR-22 are increased after radiation in glioma, while levels of miR-107, miR-181a are decreased. Conclusion: Recent studies have shown that miRNAs may have role as potent indicator of radiotoxicity in cancer patients. To date, there is no available data about acute brain radiotoxicity and its correlation with expression levels of mRNAs in patients with GB. There is a emerge need for further investigation on role of radioresponsive miRNAs in glioblastoma patients with acute radiotoxicity.
PB  - Belgrade : Serbian Association for Cancer Research (SDIR)
C3  - SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts
T1  - Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?
SP  - 19
EP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12412
ER  - 

@conference{
author = "Stepanović, Aleksandar and Petrović, Nina and Arsenijević, Tatjana and Nikitović, Marina",
year = "2021",
abstract = "Background: Standard treatment of the glioblastoma patients is implemented with Stupp’s protocol since 2005, but 2-years survival of the patients are still at low percentage. Even with implementation of modern radiotherapy techniques, acute radiotoxicity is still observed in these patients. Micro RNAs (miRNAs) expression patterns are introduced in recent years as factors that might predict survival in patients with glioblastoma, as well as cancer treatment related side effects. Material and methods: The data used in this review were conducted from research papers in PUBMED/MEDLINE databases with a special focus on role of miRNAs in cancer and with emphasis on brain tumors correlated to acute radiotoxicity. Results: Inflammation due to oxidative stress via free radicals is one of the mechanisms of radiation injury of irradiated cells and may correlate with toxicity. MiRNAs expression in prostate cancer patients may predict acute radiotoxicity, while miRNAs expression levels that could predict radiation toxicity in glioblastoma are still under investigation. However, it has been shown that miRNA levels like miR-16, miR 21, miR-19a and miR-22 are increased after radiation in glioma, while levels of miR-107, miR-181a are decreased. Conclusion: Recent studies have shown that miRNAs may have role as potent indicator of radiotoxicity in cancer patients. To date, there is no available data about acute brain radiotoxicity and its correlation with expression levels of mRNAs in patients with GB. There is a emerge need for further investigation on role of radioresponsive miRNAs in glioblastoma patients with acute radiotoxicity.",
publisher = "Belgrade : Serbian Association for Cancer Research (SDIR)",
journal = "SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts",
title = "Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?",
pages = "19-19",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12412"
}

Stepanović, A., Petrović, N., Arsenijević, T.,& Nikitović, M.. (2021). Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?. in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts
Belgrade : Serbian Association for Cancer Research (SDIR)., 19-19.
https://hdl.handle.net/21.15107/rcub_vinar_12412

Stepanović A, Petrović N, Arsenijević T, Nikitović M. Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?. in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts. 2021;:19-19.
https://hdl.handle.net/21.15107/rcub_vinar_12412 .

Stepanović, Aleksandar, Petrović, Nina, Arsenijević, Tatjana, Nikitović, Marina, "Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?" in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts (2021):19-19,
https://hdl.handle.net/21.15107/rcub_vinar_12412 .