TY  - JOUR
AU  - Piotrowski, Wojciech M.
AU  - Szymczak, Maja
AU  - Rodríguez, Emma Martín
AU  - Marin, Riccardo
AU  - Henklewska, Marta
AU  - Poźniak, Błażej
AU  - Dramićanin, Miroslav
AU  - Marciniak, Lukasz
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11929
AB  - The increasing popularity of luminescent nanothermometry in recent years can be attributed to its application potential in biomedicine. In response to this need, we describe a biocompatible bimodal luminescent thermometer that operates in ratiometric and luminescence lifetime modes based on particles of MgTiO3:Cr3+,Nd3+@SiO2. The introduction of Cr3+ and Nd3+ dopants enabled the luminescence of Ti3+ ions to be observed, and the difference in the thermal quenching rates of Cr3+ (4T2→4A2), Ti3+ (2T2→2E) and Nd3+ (4F3/2 → 4I11/2) ions enabled the ratiometric thermometers. The highest sensitivity reaching SR = 1.00%K−1 was obtained for MgTiO3:0.1 % Cr3+, 0.1 % Nd3+ at 203 K. The shortening of the lifetime of the 4T2 level of Cr3+ ions associated with its thermal depopulation allows to develop a lifetime-based thermometer with a relative sensitivity reaching 0.85–1.18%K−1 in the physiological temperature range. The deposition of a SiO2 shell on a MgTiO3:Cr3+,Nd3+ did not introduce significant changes in the shape of the emission spectrum and slightly elongates the lifetime by reducing the probability of surface-related nonradiative processes. More importantly, the thermometric performance of this luminescence thermometer was preserved. The low cytotoxicity of the obtained materials underlines their potential in bioapplications of the described luminescent thermometers.
T2  - Materials Chemistry and Physics
T1  - Step by step optimization of luminescence thermometry in MgTiO3:Cr3+, Nd3+@SiO2 nanoparticles towards bioapplications
VL  - 312
SP  - 128623
DO  - 10.1016/j.matchemphys.2023.128623
ER  - 

@article{
author = "Piotrowski, Wojciech M. and Szymczak, Maja and Rodríguez, Emma Martín and Marin, Riccardo and Henklewska, Marta and Poźniak, Błażej and Dramićanin, Miroslav and Marciniak, Lukasz",
year = "2024",
abstract = "The increasing popularity of luminescent nanothermometry in recent years can be attributed to its application potential in biomedicine. In response to this need, we describe a biocompatible bimodal luminescent thermometer that operates in ratiometric and luminescence lifetime modes based on particles of MgTiO3:Cr3+,Nd3+@SiO2. The introduction of Cr3+ and Nd3+ dopants enabled the luminescence of Ti3+ ions to be observed, and the difference in the thermal quenching rates of Cr3+ (4T2→4A2), Ti3+ (2T2→2E) and Nd3+ (4F3/2 → 4I11/2) ions enabled the ratiometric thermometers. The highest sensitivity reaching SR = 1.00%K−1 was obtained for MgTiO3:0.1 % Cr3+, 0.1 % Nd3+ at 203 K. The shortening of the lifetime of the 4T2 level of Cr3+ ions associated with its thermal depopulation allows to develop a lifetime-based thermometer with a relative sensitivity reaching 0.85–1.18%K−1 in the physiological temperature range. The deposition of a SiO2 shell on a MgTiO3:Cr3+,Nd3+ did not introduce significant changes in the shape of the emission spectrum and slightly elongates the lifetime by reducing the probability of surface-related nonradiative processes. More importantly, the thermometric performance of this luminescence thermometer was preserved. The low cytotoxicity of the obtained materials underlines their potential in bioapplications of the described luminescent thermometers.",
journal = "Materials Chemistry and Physics",
title = "Step by step optimization of luminescence thermometry in MgTiO3:Cr3+, Nd3+@SiO2 nanoparticles towards bioapplications",
volume = "312",
pages = "128623",
doi = "10.1016/j.matchemphys.2023.128623"
}

Piotrowski, W. M., Szymczak, M., Rodríguez, E. M., Marin, R., Henklewska, M., Poźniak, B., Dramićanin, M.,& Marciniak, L.. (2024). Step by step optimization of luminescence thermometry in MgTiO3:Cr3+, Nd3+@SiO2 nanoparticles towards bioapplications. in Materials Chemistry and Physics, 312, 128623.
https://doi.org/10.1016/j.matchemphys.2023.128623

Piotrowski WM, Szymczak M, Rodríguez EM, Marin R, Henklewska M, Poźniak B, Dramićanin M, Marciniak L. Step by step optimization of luminescence thermometry in MgTiO3:Cr3+, Nd3+@SiO2 nanoparticles towards bioapplications. in Materials Chemistry and Physics. 2024;312:128623.
doi:10.1016/j.matchemphys.2023.128623 .

Piotrowski, Wojciech M., Szymczak, Maja, Rodríguez, Emma Martín, Marin, Riccardo, Henklewska, Marta, Poźniak, Błażej, Dramićanin, Miroslav, Marciniak, Lukasz, "Step by step optimization of luminescence thermometry in MgTiO3:Cr3+, Nd3+@SiO2 nanoparticles towards bioapplications" in Materials Chemistry and Physics, 312 (2024):128623,
https://doi.org/10.1016/j.matchemphys.2023.128623 . .

TY  - JOUR
AU  - Piotrowski, Wojciech M.
AU  - Marin, Riccardo
AU  - Szymczak, Maja
AU  - Martín Rodríguez, Emma
AU  - Ortgies, Dirk H.
AU  - Rodríguez-Sevilla, Paloma
AU  - Dramićanin, Miroslav
AU  - Jaque, Daniel
AU  - Marciniak, Lukasz
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10546
AB  - Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level.
T2  - Advanced Optical Materials
T1  - Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom
VL  - 11
IS  - 3
SP  - 2202366
DO  - 10.1002/adom.202202366
ER  - 

@article{
author = "Piotrowski, Wojciech M. and Marin, Riccardo and Szymczak, Maja and Martín Rodríguez, Emma and Ortgies, Dirk H. and Rodríguez-Sevilla, Paloma and Dramićanin, Miroslav and Jaque, Daniel and Marciniak, Lukasz",
year = "2023",
abstract = "Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level.",
journal = "Advanced Optical Materials",
title = "Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom",
volume = "11",
number = "3",
pages = "2202366",
doi = "10.1002/adom.202202366"
}

Piotrowski, W. M., Marin, R., Szymczak, M., Martín Rodríguez, E., Ortgies, D. H., Rodríguez-Sevilla, P., Dramićanin, M., Jaque, D.,& Marciniak, L.. (2023). Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom. in Advanced Optical Materials, 11(3), 2202366.
https://doi.org/10.1002/adom.202202366

Piotrowski WM, Marin R, Szymczak M, Martín Rodríguez E, Ortgies DH, Rodríguez-Sevilla P, Dramićanin M, Jaque D, Marciniak L. Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom. in Advanced Optical Materials. 2023;11(3):2202366.
doi:10.1002/adom.202202366 .

Piotrowski, Wojciech M., Marin, Riccardo, Szymczak, Maja, Martín Rodríguez, Emma, Ortgies, Dirk H., Rodríguez-Sevilla, Paloma, Dramićanin, Miroslav, Jaque, Daniel, Marciniak, Lukasz, "Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom" in Advanced Optical Materials, 11, no. 3 (2023):2202366,
https://doi.org/10.1002/adom.202202366 . .

TY  - JOUR
AU  - Piotrowski, Wojciech Michal
AU  - Marin, Riccardo
AU  - Szymczak, Maja
AU  - Martin Rodriguez, Emma
AU  - Ortgies, Dirk H.
AU  - Rodríguez-Sevilla, Paloma
AU  - Bolek, Paulina
AU  - Dramićanin, Miroslav
AU  - Jaque, Daniel
AU  - Marciniak, Lukasz
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11082
AB  - Near-infrared (NIR) luminescence thermometry has been brought to the fore as a reliable approach for remote thermal sensing and imaging. Lanthanide (Ln3+)-based nanophosphors are often proposed as NIR nanothermometers of choice. However, the combination of Ln3+ with transition metal (TM) ions has recently emerged as a strategy to introduce additional emission bands and/or TM ↔ Ln3+ energy transfer pathways whose temperature dependence can be harnessed to increase the sensitivity of the thermometric approach. Yet, the examples of the combination of luminescence nanothermometers working in the NIR and hosting simultaneously TM and Ln3+ are scarce, leaving plenty of space for the exploration of these systems. Herein, we report on the preparation and optimization of the thermometric performance of Ba3(VO4)2:Mn5+,Nd3+ nanophosphors. The different temperature dependences of the emission intensity of the two doped luminescent centers allow using the ratio between Mn5+ and Nd3+ as a reliable thermometric parameter with a relative thermal sensitivity of 1% K−1 close to room temperature. We then showcase the suitability of this nanophosphor for employment in 2D NIR luminescence thermal imaging. Lastly, we critically evaluate the possibility of using this thermal imaging approach through opaque media with the help of phantoms with tissue-like optical properties. As expected, a loss of reliability of the thermometric method is observed due to tissue-induced photon scattering and absorption that differentially affect the emission of Mn5+ and Nd3+. Overall, the reported results underscore the good performance of the newly developed nanothermometer, while consolidating the call for the use of luminescence nanothermometers working in the time-domain (rather than in the spectral domain) for deep-tissue thermal readout/imaging.
T2  - Journal of Materials Chemistry C
T1  - Critical evaluation of the thermometric performance of ratiometric luminescence thermometers based on Ba3(VO4)2:Mn5+,Nd3+ for deep-tissue thermal imaging
VL  - 11
IS  - 20
SP  - 6713
EP  - 6723
DO  - 10.1039/D3TC00249G
ER  - 

@article{
author = "Piotrowski, Wojciech Michal and Marin, Riccardo and Szymczak, Maja and Martin Rodriguez, Emma and Ortgies, Dirk H. and Rodríguez-Sevilla, Paloma and Bolek, Paulina and Dramićanin, Miroslav and Jaque, Daniel and Marciniak, Lukasz",
year = "2023",
abstract = "Near-infrared (NIR) luminescence thermometry has been brought to the fore as a reliable approach for remote thermal sensing and imaging. Lanthanide (Ln3+)-based nanophosphors are often proposed as NIR nanothermometers of choice. However, the combination of Ln3+ with transition metal (TM) ions has recently emerged as a strategy to introduce additional emission bands and/or TM ↔ Ln3+ energy transfer pathways whose temperature dependence can be harnessed to increase the sensitivity of the thermometric approach. Yet, the examples of the combination of luminescence nanothermometers working in the NIR and hosting simultaneously TM and Ln3+ are scarce, leaving plenty of space for the exploration of these systems. Herein, we report on the preparation and optimization of the thermometric performance of Ba3(VO4)2:Mn5+,Nd3+ nanophosphors. The different temperature dependences of the emission intensity of the two doped luminescent centers allow using the ratio between Mn5+ and Nd3+ as a reliable thermometric parameter with a relative thermal sensitivity of 1% K−1 close to room temperature. We then showcase the suitability of this nanophosphor for employment in 2D NIR luminescence thermal imaging. Lastly, we critically evaluate the possibility of using this thermal imaging approach through opaque media with the help of phantoms with tissue-like optical properties. As expected, a loss of reliability of the thermometric method is observed due to tissue-induced photon scattering and absorption that differentially affect the emission of Mn5+ and Nd3+. Overall, the reported results underscore the good performance of the newly developed nanothermometer, while consolidating the call for the use of luminescence nanothermometers working in the time-domain (rather than in the spectral domain) for deep-tissue thermal readout/imaging.",
journal = "Journal of Materials Chemistry C",
title = "Critical evaluation of the thermometric performance of ratiometric luminescence thermometers based on Ba3(VO4)2:Mn5+,Nd3+ for deep-tissue thermal imaging",
volume = "11",
number = "20",
pages = "6713-6723",
doi = "10.1039/D3TC00249G"
}

Piotrowski, W. M., Marin, R., Szymczak, M., Martin Rodriguez, E., Ortgies, D. H., Rodríguez-Sevilla, P., Bolek, P., Dramićanin, M., Jaque, D.,& Marciniak, L.. (2023). Critical evaluation of the thermometric performance of ratiometric luminescence thermometers based on Ba3(VO4)2:Mn5+,Nd3+ for deep-tissue thermal imaging. in Journal of Materials Chemistry C, 11(20), 6713-6723.
https://doi.org/10.1039/D3TC00249G

Piotrowski WM, Marin R, Szymczak M, Martin Rodriguez E, Ortgies DH, Rodríguez-Sevilla P, Bolek P, Dramićanin M, Jaque D, Marciniak L. Critical evaluation of the thermometric performance of ratiometric luminescence thermometers based on Ba3(VO4)2:Mn5+,Nd3+ for deep-tissue thermal imaging. in Journal of Materials Chemistry C. 2023;11(20):6713-6723.
doi:10.1039/D3TC00249G .

Piotrowski, Wojciech Michal, Marin, Riccardo, Szymczak, Maja, Martin Rodriguez, Emma, Ortgies, Dirk H., Rodríguez-Sevilla, Paloma, Bolek, Paulina, Dramićanin, Miroslav, Jaque, Daniel, Marciniak, Lukasz, "Critical evaluation of the thermometric performance of ratiometric luminescence thermometers based on Ba3(VO4)2:Mn5+,Nd3+ for deep-tissue thermal imaging" in Journal of Materials Chemistry C, 11, no. 20 (2023):6713-6723,
https://doi.org/10.1039/D3TC00249G . .

TY  - JOUR
AU  - Szymczak, Maja
AU  - Runowski, M.
AU  - Brik, Mikhail G.
AU  - Marciniak, Lukasz
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10922
AB  - The remote pressure readout is of vital application importance as it will facilitate and in many cases enable rapid diagnostics. For most of the luminescent manometers described to date, the sensitivity of the pressure readout is limited by the relatively small pressure-induced spectral shift of the emission band. In response to this limitation, in this work, we present a super-sensitive and temperature-invariant NIR emitting luminescent manometer based on LiScGeO4:Cr3+. The 4T2→4A2 emission band of Cr3+ ions undergoes in this manometer a linear spectral shift with a rate of dλ/dp = 23.63 nm/GPa, which is the highest value reported in the literature to date. In addition, by using a ratiometric approach, this manometer has a relative sensitivity exceeding 120%/GPa. Importantly, the developed optical manometer operates in the NIR spectral region, providing good light permeability in the non-transparent systems, having high absorption in the visible range. Moreover, in the case of high-pressure luminescence experiments, the use of the developed sensor will eliminate spectral overlapping issues, as the vast majority of the organic and inorganic phosphors emitting in the visible range.
T2  - Chemical Engineering Journal
T1  - Multimodal, super-sensitive luminescent manometer based on giant pressure-induced spectral shift of Cr3+ in the NIR range
VL  - 466
SP  - 143130
DO  - 10.1016/j.cej.2023.143130
ER  - 

@article{
author = "Szymczak, Maja and Runowski, M. and Brik, Mikhail G. and Marciniak, Lukasz",
year = "2023",
abstract = "The remote pressure readout is of vital application importance as it will facilitate and in many cases enable rapid diagnostics. For most of the luminescent manometers described to date, the sensitivity of the pressure readout is limited by the relatively small pressure-induced spectral shift of the emission band. In response to this limitation, in this work, we present a super-sensitive and temperature-invariant NIR emitting luminescent manometer based on LiScGeO4:Cr3+. The 4T2→4A2 emission band of Cr3+ ions undergoes in this manometer a linear spectral shift with a rate of dλ/dp = 23.63 nm/GPa, which is the highest value reported in the literature to date. In addition, by using a ratiometric approach, this manometer has a relative sensitivity exceeding 120%/GPa. Importantly, the developed optical manometer operates in the NIR spectral region, providing good light permeability in the non-transparent systems, having high absorption in the visible range. Moreover, in the case of high-pressure luminescence experiments, the use of the developed sensor will eliminate spectral overlapping issues, as the vast majority of the organic and inorganic phosphors emitting in the visible range.",
journal = "Chemical Engineering Journal",
title = "Multimodal, super-sensitive luminescent manometer based on giant pressure-induced spectral shift of Cr3+ in the NIR range",
volume = "466",
pages = "143130",
doi = "10.1016/j.cej.2023.143130"
}

Szymczak, M., Runowski, M., Brik, M. G.,& Marciniak, L.. (2023). Multimodal, super-sensitive luminescent manometer based on giant pressure-induced spectral shift of Cr3+ in the NIR range. in Chemical Engineering Journal, 466, 143130.
https://doi.org/10.1016/j.cej.2023.143130

Szymczak M, Runowski M, Brik MG, Marciniak L. Multimodal, super-sensitive luminescent manometer based on giant pressure-induced spectral shift of Cr3+ in the NIR range. in Chemical Engineering Journal. 2023;466:143130.
doi:10.1016/j.cej.2023.143130 .

Szymczak, Maja, Runowski, M., Brik, Mikhail G., Marciniak, Lukasz, "Multimodal, super-sensitive luminescent manometer based on giant pressure-induced spectral shift of Cr3+ in the NIR range" in Chemical Engineering Journal, 466 (2023):143130,
https://doi.org/10.1016/j.cej.2023.143130 . .